Fatigue reliability and post-fracture residual capacity of a two-girder steel bridge

2016 Fall.Includes bibliographical references.Due to the immense and always increasing traffic volume, bridges are permanently subjected to repetitive loadings. These high numbers of cyclic loads can cause the initiation of fatigue cracks. If these flaws remain undetected they may become through-thickness cracks and further propagate, if left unrepaired, until they eventually lead to fracture of the entire member. The criticality of a full member fracture is not well defined nor agreed upon. Previous failure cases have demonstrated the ability of two-girder steel bridges to withstand full girder fracture of one of the two girders without structural collapse. Other cases, however, have shown the criticality of a complete girder failure on complete system collapse. Due to uncertainties in bridge redundancy and the ability to develop alternative load path, the American Association of State Highway and Transportation Officials (AASHTO) attempts to prevent fracture or collapse by classifying bridges with respect to their redundancy into fracture critical bridges (FCB) and decreasing their inspection periods. However, this leads to higher construction and maintenance costs for the owners of FCBs. Clearly, the level of uncertainty in bridge performance when one of its two girders suffer complete fracture should be represented in a probabilistic manner to evaluate the probability of fatigue crack growth and system collapse. To that end, thesis uses probabilistic analysis to assess the crack propagation behavior in a girder of a two-girder steel bridge by conducting finite element Monte Carlo simulations. The simulations account for the scatter in the load and the resistance by treating those uncertainties as random variables with predefined statistical distributions. Additionally, the post fracture redundancy is evaluated by comparing the resulting equivalent plastic strain to the failure strain of steel. The results show that the bridge provides sufficient redundancy to redistribute the load after full depth fracture a FC member. Furthermore, the results of the probabilistic analyses provide a basis for choosing the inspection intervals for FCBs

Inward Bound: Studying the Galactic Centre with NAOS/CONICA

We report on the first results obtained using adaptive optics measurements of the Galactic Centre done with NAOS/CONICA.Comment: 19 pages, 7 figure

Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity

Multiple sclerosis (MS) disease risk is associated with reduced sunexposure. This study assessed the relationship between measures of sun exposure (vitamin D [vitD], latitude) and MS severity in the setting of two multicenter cohort studies (n(NationMS) = 946, n(BIONAT) = 990). Additionally, effect-modification by medication and photosensitivity-associated MC1R variants was assessed. High serum vitD was associated with a reduced MS severity score (MSSS), reduced risk for relapses, and lower disability accumulation over time. Low latitude was associated with higher vitD, lower MSSS, fewer gadolinium-enhancing lesions, and lower disability accumulation. The association of latitude with disability was lacking in IFN-beta-treated patients. In carriers of MC1R:rs1805008(T), who reported increased sensitivity toward sunlight, lower latitude was associated with higher MRI activity, whereas for noncarriers there was less MRI activity at lower latitudes. In a further exploratory approach, the effect of ultraviolet (UV)-phototherapy on the transcriptome of immune cells of MS patients was assessed using samples from an earlier study. Phototherapy induced a vitD and type I IFN signature that was most apparent in monocytes but that could also be detected in B and T cells. In summary, our study suggests benefidal effects of sun exposure on established MS, as demonstrated by a correlative network between the three factors: Latitude, vitD, and disease severity. However, sun exposure might be detrimental for photosensitive patients. Furthermore, a direct induction of type I IFNs through sun exposure could be another mechanism of UV-mediated immune-modulation in MS