Sensor Based on Extending the Concept of Fidelity to Classical Waves

We propose and demonstrate a remote sensor scheme by applying the quantum mechanical concept of fidelity loss to classical waves. The sensor makes explicit use of time-reversal invariance and spatial reciprocity in a wave chaotic system to sensitively and remotely measure the presence of small perturbations. The loss of fidelity is measured through a classical wave-analog of the Loschmidt echo by employing a single-channel time-reversal mirror to rebroadcast a probe signal into the perturbed system. We also introduce the use of exponential amplification of the probe signal to partially overcome the effects of propagation losses and to vary the sensitivity.Comment: 4 pages, 2 figure

Scattering a pulse from a chaotic cavity: Transitioning from algebraic to exponential decay

The ensemble averaged power scattered in and out of lossless chaotic cavities decays as a power law in time for large times. In the case of a pulse with a finite duration, the power scattered from a single realization of a cavity closely tracks the power law ensemble decay initially, but eventually transitions to an exponential decay. In this paper, we explore the nature of this transition in the case of coupling to a single port. We find that for a given pulse shape, the properties of the transition are universal if time is properly normalized. We define the crossover time to be the time at which the deviations from the mean of the reflected power in individual realizations become comparable to the mean reflected power. We demonstrate numerically that, for randomly chosen cavity realizations and given pulse shapes, the probability distribution function of reflected power depends only on time, normalized to this crossover time.Comment: 23 pages, 5 figure

Restoration action effectiveness: employing the concept of net ecosystem improvement

The mission statement of the Northwest Straits Initiative includes ‘improving ecosystem health’ of the Strait of Juan de Fuca and Northern Puget Sound by restoring and protecting natural habitats and resources. For the Initiative, and many other programs, defining ‘ecosystem health’ and developing relevant and measureable health metrics is problematic, and yet critical to both assessing program action effectiveness as well as justifying investments. The Initiative is exploring utilizing the concept of net ecosystem improvement (NEI) to summarize results of actions and couch the results in a broader ecosystem perspective. Net improvement is defined as following development; there is an increase in the size and natural functions of an ecosystem or natural components of the ecosystem (Thom et al. 2005. Restoration Ecol. v. 13). Conceptual models are used to summarize knowledge and guide actions to improve the ecosystem. NEI is calculated by estimating the change in function times the change in area over which this change in function occurred including both temporal and spatial aspects. For example, the anchor out zone project managed by the Jefferson County Marine Resources Committee in Port Townsend protects 21.6ha (52 acres) of eelgrass. Without this protection most if not all of the eelgrass would be lost. Using data from other areas, we estimated that 3,998 - 66,077 Dungeness crab (primarily juveniles) and net production by eelgrass of 2,083 metric tons wet wt y-1, are protected. Based on WDNR monitoring (Christiaen et al. 2017), this area of eelgrass protected amounts to 0.5 – 0.8% of the total eelgrass area in the Straits, and 0.5% of the Puget Sound Partnership 2020 eelgrass recovery goal of ~4000ha. Estimating NEI and placing the results in a broader ecosystem perspective is possible for many actions taken by the Initiative’s Marine Resource Committees, and may be appropriate for other programs

Linking Demographic Effects of Habitat Fragmentation Across Landscapes to Continental Source-Sink Dynamics

Forest fragmentation may cause increased brood parasitism and nest predation of breeding birds. In North America, nest parasitism and predation are expected to increase closer to forest edges because the brood-parasitic Brown-headed Cowbird(Molothrus ater) and generalist nest predators often enter the forest from adjoining developed (largely agricultural) habitats. Yet the abundance of brood parasites and nest predators at the patch scale may be strongly constrained by the total area of developed habitat at landscape scales. The scale and extent of landscape effects are unclear, however, because past studies were mostly conducted within local landscapes rather than across independent landscapes. We report replicated studies from 30 independent landscapes across 17 states of the United States that show that nest parasitism is strongly affected by fragmentation at a 20 km radius scale, equivalent to the maximum foraging range of cowbirds. Nest predation is influenced by both edge and landscape effects, and increases with fragmentation at a 10 km radius scale. Predation is additive to parasitism mortality, and the two together yield decreased population growth potential with increasing forest fragmentation at a 10 km radius scale for 20 of 22 bird species. Mapping of population growth potential across continental landscapes displays broad impacts of fragmentation on population viability and allows geographic prioritization for conservation

A geometry optimization framework for photonic crystal design

AbstractThe performance of photonic crystal devices can depend strongly on their geometry. Alas, their fundamental physics offers relatively little by way of pointers in terms of optimum shapes, so numerical design search techniques must be used in an attempt to determine high performance layouts. We discuss strategies for solving this type of optimization problem, the main challenge of which is the conflict between the enormous size of the space of potentially useful designs and the relatively high computational cost of evaluating the performance of putative shapes. The optimization technique proposed here operates over increasing levels of fidelity, both in terms of the resolution of its non-parametric shape definition and in terms of the resolution of the numerical analysis of the performance of putative designs. This is a generic method, potentially applicable to any type of electromagnetic device shape design problem. We also consider a methodology for assessing the robustness of the optima generated through this process, investigating the impact of manufacturing errors on their performance. As an illustration, we apply this technology to the design of a two-dimensional photonic crystal structure; the result features a large complete band gap structure and a topology that is different from previously published designs

Is Therapeutic Drug Monitoring Relevant for Antidepressant Drug Therapy? Implications From a Systematic Review and Meta-Analysis With Focus on Moderating Factors

Inter-individual differences in antidepressant drug concentrations attained in blood may limit the efficacy of pharmacological treatment of depressive disorders. Therapeutic drug monitoring (TDM) enables to determine drug concentrations in blood and adjust antidepressant dosage accordingly. However, research on the underlying assumption of TDM, association between concentration and clinical effect, has yielded ambiguous results for antidepressants. It has been proposed that this ambiguity may be caused by methodological shortcomings in studies investigating the concentration-effect relationship. Guidelines recommend the use of TDM in antidepressant treatment as expert opinion. This reflects the lack of research, particularly systematic reviews and meta-analyses of randomized controlled trials, on the relationship between concentration and effect as well as on the benefits of the use of TDM in clinical practice. In this study, a systematic review and meta-analysis of randomized controlled trials has been performed to investigate the relationship between antidepressant concentration, efficacy, and side effects. It is the first meta-analytical approach to this subject and additionally considers methodological properties of primary studies as moderators of effect in quantitative analysis. Our results identified methodological shortcomings, namely the use of a flexible dose design and the exclusion of concentrations in lower- or subtherapeutic ranges, which significantly moderate the relationship between antidepressant concentration and efficacy. Such shortcomings obscure the evidence base of using TDM in clinical practice to guide antidepressant drug therapy. Further research should consider these findings to determine the relationship between concentration and efficacy and safety of antidepressant treatments, especially for newer antidepressants.Peer Reviewe