Conceptual, sociological and materialistic view of innovation-translation dynamics in medicine: The need and directions for a novel multi-pronged initiative

The recent decades have witnessed overwhelming advancements in medical technologies and the quality of healthcare. A vast majority of the advancements which are capable of revolutionising healthcare still remain dormant within laboratories which is certainly due to the tardive translation and assimilation of these innovations. Innovation-translation is explained by an over-simplified linear model which provides the users with just two option- either to adopt or not. The translation of medical innovation is a cyclical and dynamic process which includes the conception of novel ideas, generation of proof of concept, adoption, post-adoption analysis and emergence of new innovations. Conceptual factors like principle, validity, contextual appropriateness and performance; sociological factors like political climate, professional involvement, interdisciplinary interaction and investment policies; and materialistic factors like resource availability, affordability and apt human resource management are the chief determinants of innovation translation. Loose knit configuration of national policies favour innovation translation than close knit configuration. India suffers from lack of drive for local innovation, lack of succinct aptitude, inadequate local investment and lack of efficient regulation. Innovation studies expose the determinants of successful and failed innovations. Ensuring a favourable political and financial environment that provides systematic innovation assessment, evaluation and regulation, valid operational guidelines, encourage local innovation, and promote intellectual aptitude can drive further innovation. Competitively promoting sustaining and disruptive innovation will enable remarkable advancements. Post-adoption analysis and feedback and Precision medicine are significant tools. Efforts should be made to introduce and ensure meticulous innovation surveillance. Keywords: Innovation-translation dynamics; Cyclic dynamic model; Innovation surveillance; Regulation

GANDHIAN PRINCIPLES ON HEALTH: EVIDENCES, RELEVANCE AND IMPLICATIONS IN THE MODERN CONTEXT OF HEALTH

Mohan Das Karamchand Gandhi, popularly known as Mahatma Gandhi is one of the greatest visionaries who is known for his anti-imperialistic views and strong political strategies. Right from his childhood till his last breath, he had a keen interest in practising medicine. In spite of the odds going against him to pursue a formal medical degree, he practiced medicine throughout his life. He recommended and followed strict principles on health that have valid scientific coherence. The objective of this article is to describe his principles on health and analyse it in the light of scientific literature. Vocational medical practice formed a major part of his activities in parallel to his political reforms. His service at Sevagram and his role in the lives of many sick are quiet evident. Gandhi believed in the power of will and hence emphasised on psychological support and reformation as the foremost principle. He followed and recommended natural therapy like- mud cures, fasting and Citrus diet. Throughout his life he strongly emphasised strict palatal control and regular physical exercises which would address the vast magnitude of non-communicable diseases today. He believed fasting not only as a political strategy but also as a therapy for many illnesses. He also recommended occasional fasting for healthy individuals. He followed chastity and believed it to be an important factor for physical and mental well-being. His views on euthanasia are controversial. Following Gandhian health principles will build a healthy human and thence a healthy nation. Keywords: Gandhian views; Natural cure; Palatal control; Fasting; Vegetarianism; Euthanasia

Conceptual, sociological and materialistic view of innovation-translation dynamics in medicine: The need and directions for a novel multi-pronged initiative

The recent decades have witnessed overwhelming advancements in medical technologies and the quality of healthcare. A vast majority of the advancements which are capable of revolutionising healthcare still remain dormant within laboratories which is certainly due to the tardive translation and assimilation of these innovations. Innovation-translation is explained by an over-simplified linear model which provides the users with just two option- either to adopt or not. The translation of medical innovation is a cyclical and dynamic process which includes the conception of novel ideas, generation of proof of concept, adoption, post-adoption analysis and emergence of new innovations. Conceptual factors like principle, validity, contextual appropriateness and performance; sociological factors like political climate, professional involvement, interdisciplinary interaction and investment policies; and materialistic factors like resource availability, affordability and apt human resource management are the chief determinants of innovation translation. Loose knit configuration of national policies favour innovation translation than close knit configuration. India suffers from lack of drive for local innovation, lack of succinct aptitude, inadequate local investment and lack of efficient regulation. Innovation studies expose the determinants of successful and failed innovations. Ensuring a favourable political and financial environment that provides systematic innovation assessment, evaluation and regulation, valid operational guidelines, encourage local innovation, and promote intellectual aptitude can drive further innovation. Competitively promoting sustaining and disruptive innovation will enable remarkable advancements. Post-adoption analysis and feedback and Precision medicine are significant tools. Efforts should be made to introduce and ensure meticulous innovation surveillance. Keywords: Innovation-translation dynamics; Cyclic dynamic model; Innovation surveillance; Regulation

GANDHIAN PRINCIPLES ON HEALTH: EVIDENCES, RELEVANCE AND IMPLICATIONS IN THE MODERN CONTEXT OF HEALTH

Mohan Das Karamchand Gandhi, popularly known as Mahatma Gandhi is one of the greatest visionaries who is known for his anti-imperialistic views and strong political strategies. Right from his childhood till his last breath, he had a keen interest in practising medicine. In spite of the odds going against him to pursue a formal medical degree, he practiced medicine throughout his life. He recommended and followed strict principles on health that have valid scientific coherence. The objective of this article is to describe his principles on health and analyse it in the light of scientific literature. Vocational medical practice formed a major part of his activities in parallel to his political reforms. His service at Sevagram and his role in the lives of many sick are quiet evident. Gandhi believed in the power of will and hence emphasised on psychological support and reformation as the foremost principle. He followed and recommended natural therapy like- mud cures, fasting and Citrus diet. Throughout his life he strongly emphasised strict palatal control and regular physical exercises which would address the vast magnitude of non-communicable diseases today. He believed fasting not only as a political strategy but also as a therapy for many illnesses. He also recommended occasional fasting for healthy individuals. He followed chastity and believed it to be an important factor for physical and mental well-being. His views on euthanasia are controversial. Following Gandhian health principles will build a healthy human and thence a healthy nation. Keywords: Gandhian views; Natural cure; Palatal control; Fasting; Vegetarianism; Euthanasia

Isolation of Enterobacteriaceae and non-fermenting Gram-negative bacilli (NFGNB) from Dental Unit Water Lines (DUWL) in a tertiary care institutional setup

Background: The quality of dental unit water lines (DUWL) is of considerable importance since patients and dental staff are regularly exposed to water and aerosols generated from dental units which thereby influence the individual patient outcome and health-care associated morbidity. The aim of the present study was to determine the microbiological quality of water used, presence of biofilms and also the potential of isolated bacterial species in producing biofilms within DUWL. Methods: Thirty DUWL samples were collected from various departments of Manipal College of Dental Sciences, Mangalore. Bacteriological analysis was done for the presence of various bacterial contaminants. Presence of biofilms on DUWLs and potential of bacterial isolates to form biofilm were also determined. Results: Seven of 30 samples (23.3%), were found to be of unsatisfactory quality (coliform count > 200 CFU/ml), most frequently from air/water syringes. A total of 45 strains were isolated from 14 water samples. Genera isolated were Escherichia spp., Enterobacter spp., Klebsiella spp., Pseudomonas spp. and Acinetobacter spp. Four of 10 samples from DUWL tubing showed presence of biofilms (40%), formed mostly by Acinetobacter spp. and Pseudomonas spp. Out of 45 strains that were isolated, 19 strains displayed ability to form biofilms. Maximum number (10) isolates formed biofilms with 48 hours. Conclusion: Exposure to contaminated water from DUWL poses threat to the well-being of the patient and the health care personnel as well. Hence, measures should be initiated to ensure the optimum quality of DUWL water. DOI: http://dx.doi.org/10.5281/zenodo.131977

Child Postoperative Pain: Impact of Child Temperament and Parent Mood on Pain After Surgery

Around 80% of children who undergo surgery experience moderate to severe postoperative pain. Various psychosocial factors contribute to exacerbations of this pain. A child’s inborn personality traits and style of interaction with the environment are known as temperament. Children who are less sociable and more distress-prone (e.g., those who cry, throw tantrums) are more likely to have an anxious temperament. This anxiety before and after surgery may lead to an increase in postoperative pain levels as well. Parent pain ratings do not always reflect true child pain. Overtime, a parent’s emotional state and mood may change how they perceive child pain. Parents who have more negative moods or are more distressed tend to report their child’s pain as worse and have a negative impact on a child’s pain. Therefore, parents play a crucial role in treatment after surgery. Given this, the purpose of this study was to see how child temperament factors are associated with postoperative pain and how parent mood moderates this relationship. These specific factors are analyzed in a sample of children ages 2-13 who underwent elective surgery at the Children’s Hospital of Orange County (N = 112). Prior to the surgery, parents completed online surveys assessing child temperament and parent mood. Postoperative pain measures were reported by both children and parents after surgery on days 1, 3, and 7. Child temperament factors did not interact with parent mood to predict postoperative pain. Emotionality and sociability were not significantly associated with parent pain measures or child pain after surgery (ps \u3e 0.05). However, other studies have shown that child temperament does affect pain in a hospital setting more than they do at home. Interestingly, pain in children was low at home after surgery (less than 3 on a scale of 0 to 10). It is possible that the impact of temperament and mood on pain were less potent once the child is at home following the surgery and pain is lower. Further investigation on the influence of temperament and mood on child pain is important to obtain more clarity and discover optimal methods of treating pain in children. Future work may benefit from investigating different surgical procedures that might lead to a greater diversity of pain once children are home

GC-155 - Runbook Automation

Runbook is common terminology used in every IT organization which is maintained in Excel for taking the components to production in a particular time frame after making an agreement with the business for the downtime of systems (Freeze Period). Runbook Automation is a web application for delivering and tracking deliverables to production. It acts as an interface between Infrastructure teams responsible for deployments and runbook coordinator, development teams, and Business Analysts. The application consists of a home page consisting of a Dashboard where the user can edit the profile, and other employee tracking details and timesheets. In Employee tracking, the details of the employees and their backgrounds are displayed. In Timesheets, the hours of the project and the runbook actions are displayed. In Access Management, different users are allowed to request access to perform daily activities. In Employee Performance, the feedback and achievements of the employer are shown. The Objective of the application is to develop a web application using various technologies to bring all the stakeholders to a common page about the project execution and make them aware of top management activities ongoing in the organization. The Application will have an interface to tools for updating the status of Jobs in the application. The idea of the application will be provided to the project owner for approval before design and development. The scope of the project will include planning, design, development, testing, and documentation.stratosphere to provide wide coverage and strong computational capabilities. It is suitable to coordinate terrestrial resources and store the fundamental data associated with ITS-based applications. Performing task offloading and data caching at Roadside Units (RSUs) in a cooperative manner can reduce the heavy backhaul load and the retransmission of content downloading

A CLINICAL STUDY OF DRAKSHA GRITHA IN THE MANAGEMENT OF ANAEMIA IN PREGNANCY (GARBHINI PANDU)

A woman requires more nutrition during pregnancy, which is a physiological condition. When compared to non-pregnant women, a pregnant woman needs 2-3 times the amount of iron than usual. Pandu means pallor of body which can be correlated with 'Anemia' of modern science. Many references in Ayurvedic classics denote that Garbhini Pandu is available. Design: 30 patients of Garbhini Pandu were selected from OPD and IPD of Prasuti Tantra and Stree Roga department from Dr. BRKR GAMC, Hyderabad and were administered 15ml of Drakshaghrita twice daily (morning and evening) on empty stomach orally along with Anupana of Sukoshnadugdha consecutively for 90 days. Results: Statistically highly significant results were seen in Pallor, Glossitis, Bhrama, Hrudrava, Hb% and edema of the lower extremity with p< 0.001. Conclusions: The study showed that Draksha Gritha is effective in the management of Garbhini Pandu

EVALUATION OF ANTIPYRETIC ACTIVITY OF ETHANOLIC EXTRACT OF WEDELIA TRILOBATA

The aim of present study was to investigate antipyretic activity of ethanolic extract of leaves of Wedelia trilobata in yeast induced pyrexia in wistar albino rats. In which pyrexia was induced by an intraperitonial injection of 20% brewer’s yeast (10 ml/kg b.wt.). The body temperature of rats were measured before the injection of yeast and injected ethanolic extract of leaves of Wedelia trilobata (100 mg/kg b.wt.) and (200 mg/kg b.wt.) and followed by treatment with paracetamol (150 mg/kg b.wt.). The body temperature of experimental animals were recorded in the time interval of 0 hr, 1 hr, 2 hr and 3 hr with help of digital clinical thermometer which is placed in rectum in the depth of 2 cm and recorded body temperature values shown that the leaves extract of of Wedelia trilobata possess antipyretic activity

Knowledge, attitude and practices towards consumption of caffeine containing drinks among the student population of Ras al-Khaimah medical and health sciences university, UAE

Background: Caffeine, world’s most widely consumed and legally accepted psychoactive substance which is commonly found ingredient in many drinks like coffee, tea, carbonated drinks and energy drinks. The objective was to explore how much dependent are the teenagers and young adults on caffeine containing drinks, reasons and circumstances for the consumption and to know the knowledge and attitude of the consumers about the health effects of the caffeine containing drinks.Methods: A validated questionnaire was administered randomly to about 298 students from MBBS, BDS, B Pharma and Nursing programmes of RAK Medical and Health Sciences University (RAKMHSU).Results: Out of 298 students in the study, 97% (n=290) of them drink caffeinated beverages in the form of coffee (53%), tea (43%), energy drinks (17%), carbonated drinks (18%) and all of the above (11%). The major reasons for consuming varied, where more than half of them gave the reason as to keep them awake for study purpose (53%), to get refreshed (51%), taste and flavour (49%). About 56% were of an opinion that they do experience different symptoms if they don’t consume their daily caffeine intake. 54% students admitted their caffeine consumption has been increased after joining the university. When knowledge and attitude were questioned, 63% of them think caffeine addiction is a health issue and majority of them were aware of the ingredients of these drinks but not the safest amount.Conclusions: Drinking caffeine containing drinks by the students are variable from different sources, so monitoring is necessary for the daily intake and there is need for educational programmes about the health effects related to high consumption of caffeine.