HST Photometry for the Halo Stars in the Leo Elliptical NGC 3377

We have used the ACS camera on HST to obtain (V,I) photometry for 57,000 red-giant stars in the halo of the Leo elliptical NGC 3377. We use this sample of stars to derive the metallicity distribution function (MDF) for its halo field stars, and comment on its chemical evolution history compared with both larger and smaller E galaxies. Our ACS/WFC field spans a radial range extending from 4 to 18 kpc projected distance from the center of NGC 3377 and thus covers a significant portion of this galaxy's halo. We find that the MDF is broad, reaching a peak at [m/H] ~ -0.6$, but containing virtually no stars more metal-poor than log [m/H] = -1.5$. It may, in addition, have relatively few stars more metal-rich than [m/H] = -0.3$, although interpretation of the high-metallicity end of the MDF is limited by photometric completeness that affects the detection of the reddest, most metal-rich stars. NGC 3377 appears to have an enrichment history intermediate between those of normal dwarf ellipticals and the much larger giants. As yet, we find no clear evidence that the halo of NGC 3377 contains a significant population of ``young'' (< 3 Gy) stars.Comment: 40 pages, 17 figure

Adherence to Nutrition and Physical Activity Cancer Prevention Guidelines and Development of Colorectal Adenoma.

Adherence to the American Cancer Society's (ACS) Nutrition and Physical Activity Cancer Prevention Guidelines is associated with reductions in overall cancer incidence and mortality, including site-specific cancers such as colorectal cancer. We examined the relationship between baseline adherence to the ACS guidelines and (1) baseline adenoma characteristics and (2) odds of recurrent colorectal adenomas over 3 years of follow-up. Cross-sectional and prospective analyses with a pooled sample of participants from the Wheat Bran Fiber (n = 503) and Ursodeoxycholic Acid (n = 854) trials were performed. A cumulative adherence score was constructed using baseline self-reported data regarding body size, diet, physical activity and alcohol consumption. Multivariable logistic regression demonstrated significantly reduced odds of having three or more adenomas at baseline for moderately adherent (odds ratio [OR] = 0.67, 95% confidence intervals [CI]: 0.46⁻0.99) and highly adherent (OR = 0.50, 95% CI: 0.31⁻0.81) participants compared to low adherers (p-trend = 0.005). Conversely, guideline adherence was not associated with development of recurrent colorectal adenoma (moderate adherence OR = 1.16, 95% CI: 0.85⁻1.59, high adherence OR = 1.23, 95% CI: 0.85⁻1.79)

Topological Sector Fluctuations and Curie Law Crossover in Spin Ice

At low temperatures, a spin ice enters a Coulomb phase - a state with algebraic correlations and topologically constrained spin configurations. In Ho2Ti2O7, we have observed experimentally that this process is accompanied by a non-standard temperature evolution of the wave vector dependent magnetic susceptibility, as measured by neutron scattering. Analytical and numerical approaches reveal signatures of a crossover between two Curie laws, one characterizing the high temperature paramagnetic regime, and the other the low temperature topologically constrained regime, which we call the spin liquid Curie law. The theory is shown to be in excellent agreement with neutron scattering experiments. On a more general footing, i) the existence of two Curie laws appears to be a general property of the emergent gauge field for a classical spin liquid, and ii) sheds light on the experimental difficulty of measuring a precise Curie-Weiss temperature in frustrated materials; iii) the mapping between gauge and spin degrees of freedom means that the susceptibility at finite wave vector can be used as a local probe of fluctuations among topological sectors.Comment: 10 pages, 5 figure

Effect of Surgical Fusion on Volitional Weight-Shifting in Individuals With Adolescent Idiopathic Scoliosis

Study Design Prospective. Objectives The goals of this study were to (1) evaluate the differences in weightbearing symmetry between individuals with adolescent idiopathic scoliosis (AIS) and typically developing controls; (2) observe the effect of posterior spinal fusion and instrumentation (PSFI) on volitional weight-shifting at 1 and 2 years postoperatively; and (3) evaluate whether lowest instrumented fusion level (ie, lowest instrumented vertebra [LIV]) in PSFI has an effect on volitional weight-shifting. Summary of Background Data Previous studies have conflicting findings with regard to the effect of scoliosis on postural control tasks as well as the effect of surgery. They have also noted an inconsistent effect of PSFI at different LIVs, with more distal LIVs exhibiting greater reductions in postoperative range of motion. Methods The study was designed with an AIS group of 41 patients (8 males and 33 females) with AIS who underwent PSFI, along with a Control Group of 24 age-matched typically developing participants (12 male and 12 female). Both groups performed postural control tasks (static balance and volitional weight-shifting), with the AIS group repeating the tasks at 1 and 2 years postoperatively. Results At baseline, the AIS group showed increased weightbearing asymmetry than the Control Group (p = .01). The AIS group showed improvements in volitional weight-shifting at 2 years over baseline (p \u3c .01). There was no effect of LIV on volitional weight-shifting by the second postoperative year. Conclusions Individuals with AIS have greater weightbearing asymmetry but improved volitional weight-shifting over typically developing controls. PSFI improves volitional weight-shifting beyond preoperative baseline but does not differ significantly by LIV

Effect of Surgical Fusion on Volitional Weight-Shifting in Individuals With Adolescent Idiopathic Scoliosis

Study Design Prospective. Objectives The goals of this study were to (1) evaluate the differences in weightbearing symmetry between individuals with adolescent idiopathic scoliosis (AIS) and typically developing controls; (2) observe the effect of posterior spinal fusion and instrumentation (PSFI) on volitional weight-shifting at 1 and 2 years postoperatively; and (3) evaluate whether lowest instrumented fusion level (ie, lowest instrumented vertebra [LIV]) in PSFI has an effect on volitional weight-shifting. Summary of Background Data Previous studies have conflicting findings with regard to the effect of scoliosis on postural control tasks as well as the effect of surgery. They have also noted an inconsistent effect of PSFI at different LIVs, with more distal LIVs exhibiting greater reductions in postoperative range of motion. Methods The study was designed with an AIS group of 41 patients (8 males and 33 females) with AIS who underwent PSFI, along with a Control Group of 24 age-matched typically developing participants (12 male and 12 female). Both groups performed postural control tasks (static balance and volitional weight-shifting), with the AIS group repeating the tasks at 1 and 2 years postoperatively. Results At baseline, the AIS group showed increased weightbearing asymmetry than the Control Group (p = .01). The AIS group showed improvements in volitional weight-shifting at 2 years over baseline (p \u3c .01). There was no effect of LIV on volitional weight-shifting by the second postoperative year. Conclusions Individuals with AIS have greater weightbearing asymmetry but improved volitional weight-shifting over typically developing controls. PSFI improves volitional weight-shifting beyond preoperative baseline but does not differ significantly by LIV

A Generative Deep Learning Approach to Stochastic Downscaling of Precipitation Forecasts

Despite continuous improvements, precipitation forecasts are still not as accurate and reliable as those of other meteorological variables. A major contributing factor to this is that several key processes affecting precipitation distribution and intensity occur below the resolved scale of global weather models. Generative adversarial networks (GANs) have been demonstrated by the computer vision community to be successful at super-resolution problems, i.e., learning to add fine-scale structure to coarse images. Leinonen et al. (2020) previously applied a GAN to produce ensembles of reconstructed high-resolution atmospheric fields, given coarsened input data. In this paper, we demonstrate this approach can be extended to the more challenging problem of increasing the accuracy and resolution of comparatively low-resolution input from a weather forecasting model, using high-resolution radar measurements as a "ground truth". The neural network must learn to add resolution and structure whilst accounting for non-negligible forecast error. We show that GANs and VAE-GANs can match the statistical properties of state-of-the-art pointwise post-processing methods whilst creating high-resolution, spatially coherent precipitation maps. Our model compares favourably to the best existing downscaling methods in both pixel-wise and pooled CRPS scores, power spectrum information and rank histograms (used to assess calibration). We test our models and show that they perform in a range of scenarios, including heavy rainfall.Comment: Submitted to JAMES 4/4/2

GABA\u3csub\u3eB\u3c/sub\u3e Receptor Attenuation of GABA\u3csub\u3eA\u3c/sub\u3e Currents in Neurons of the Mammalian Central Nervous System

Ionotropic receptors are tightly regulated by second messenger systems and are often present along with their metabotropic counterparts on a neuron\u27s plasma membrane. This leads to the hypothesis that the two receptor subtypes can interact, and indeed this has been observed in excitatory glutamate and inhibitory GABA receptors. In both systems the metabotropic pathway augments the ionotropic receptor response. However, we have found that the metabotropic GABAB receptor can suppress the ionotropic GABAA receptor current, in both the in vitro mouse retina and in human amygdala membrane fractions. Expression of amygdala membrane microdomains in Xenopus oocytes by microtransplantation produced functional ionotropic and metabotropic GABA receptors. Most GABAA receptors had properties of α‐subunit containing receptors, with ~5% having ρ‐subunit properties. Only GABAA receptors with α‐subunit‐like properties were regulated by GABAB receptors. In mouse retinal ganglion cells, where only α‐subunit‐containing GABAA receptors are expressed, GABAB receptors suppressed GABAA receptor currents. This suppression was blocked by GABAB receptor antagonists, G‐protein inhibitors, and GABAB receptor antibodies. Based on the kinetic differences between metabotropic and ionotropic receptors, their interaction would suppress repeated, rapid GABAergic inhibition

Holocene Sediment Records From the Continental Shelf of Mac. Robertson Land, East Antarctica

Geochemical records are presented for five sediment cores from basins on the continental shelf of Mac. Robertson Land, East Antarctica. The cores contain 2-4 m thick sequences of hemipelagic, siliceous mud and ooze (SMO) deposited under seasonally open marine conditions. The inner and middle shelf SMO sequences are massive dark olive green material, whereas the outer shelf SMO sequences are dark olive material interspersed with light olive green layers similar to1-10 cm thick. The biogenic material is dominated by marine diatoms including Fragilariopsis curta, Fragilariopsis cylindrus, and Chaetoceros spp. in the dark-colored SMO and Corethron criophilum in the light-colored layers. Radiocarbon dates suggest that the cores provide continuous accumulation records extending from \u3c 1 kyr before present (B.P.) back as far as 4-15 kyr B.P., with estimated accumulation rates of 0.07-5 mm yr(-1). The three core records from the middle and outer shelf suggest six episodes of increased accumulation of biogenic material at 5.5 kyr B.P. tall three cores), 1, 2, and 6.2 kyr B.P. (two of the three cores), and 3.8 and 10.8 kyr B.P. tone core), most of which coincide with Corethron layers. We interpret these features as the result of enhanced diatom production over the outer shelf, possibly related to climatic warm periods. The absence of such features in the inner shelf core records is thought to reflect a relatively constant level of seasonal diatom production in adjacent waters maintained by a coastal polynya

Effects of intervention upon precompetition state anxiety in elite junior tennis players: The relevance of the matching hypothesis

Reproduced with permission of publisher from: Terry, P., Coakley, L., & Karageorghis, C. Effects of intervention upon precompetition state anxiety in elite junior tennis players: the relevance of the matching hypothesis. Perceptual and Motor Skills, 1995, 81, 287-296. © Perceptual and Motor Skills 1995The matching hypothesis proposes that interventions for anxiety should be matched to the modality in which anxiety is experienced. This study investigated the relevance of the matching hypothesis for anxiety interventions in tennis. Elite junior tennis players (N = 100; Age: M = 13.9 yr., SD = 1.8 yr.) completed the Competitive State Anxiety Inventory-2 before and after one of four randomly assigned intervention strategies approximately one hour prior to competition at a National Junior Championship. A two-factor multivariate analysis of variance (group x time) with repeated measures on the time factor gave no significant main effect by group but indicated significant reductions in somatic anxiety and cognitive anxiety and a significant increase in self-confidence following intervention. A significant group by time interaction emerged for self-confidence. The results question the need to match intervention strategy to the mode of anxiety experienced