Guidelines for Safe Canning of Acid Foods in a Steam Canner

Steam canning, or atmospheric steam canning, can be a safe as well as energy efficient method for home preservation of most high-acid foods. This leaflet explains the differences between steam canners and boiling water canners and explains how to use a steam canner safely

Must Do @ VCU

Must Do @ VCU is a set of annual collegial activities that can be performed throughout the year, by faculty, staff and students. These VCU-centered activities are considered to be the things that give VCU its identity. The goal of Must Do @ VCU is to generate a sense of community and of belonging to the University. VCU is a relatively new University and its traditions are therefore not well-established. Must Do @ VCU aims to build on shared experiences as a method to establish VCU culture

Integration of Telehealth Education into the Health Care Provider Curriculum: A Review

Introduction: Telehealth is a rapidly expanding health care delivery modality with increasing utility in the health care community. It is imperative that telehealth education is provided during the training of health care providers to ensure the proper usage and application of this health care delivery system. A comprehensive literature review of telehealth education integrated into the curricula of physician, physician assistant, and advanced practiced registered nurse training programs has not been reported to date. Materials and Methods: An electronic literature search was performed using Scopus®, PubMed, and 17 of the 35 databases on the EBSCOHost platform. We included studies where telehealth concepts and components were integrated in the curriculum for primary care students. We extracted information pertinent to understanding the scope and sustainability of the curriculum and tabulated the results. Results: After a full-text screening of 164 articles and critically analyzing 34, eight articles were included in this review. Comparison of these articles showed no consistency in how telehealth was integrated into the various health care curricula. Content delivered usually included basic telehealth information, however, the depth and breadth of content varied significantly based on the interventions. Discussion: For the articles included in this review, there were no formal study designs regarding basic telehealth educational integration or competencies. While authors recommended conducting evaluation and determining the effectiveness of the interventions, they did not provide a clear picture as to how these efforts should be conducted. Conclusions: In addition to developing a standardized telehealth curriculum, national competencies need to be created, which will guide the development of standardized curriculum across health care training programs

Globular Clusters and X-ray Point Sources in Centaurus A (NGC 5128)

We detect 353 X-ray point sources, mostly low-mass X-ray binaries (LMXBs), in four Chandra observations of Centaurus A (NGC 5128), the nearest giant early-type galaxy, and correlate this point source population with the largest available ensemble of confirmed and likely globular clusters associated with this galaxy. Of the X-ray sources, 31 are coincident with 30 globular clusters that are confirmed members of the galaxy by radial velocity measurement (2 X-ray sources match one globular cluster within our search radius), while 1 X-ray source coincides with a globular cluster resolved by HST images. Another 36 X-ray point sources match probable, but spectroscopically unconfirmed, globular cluster candidates. The color distribution of globular clusters and cluster candidates in Cen A is bimodal, and the probability that a red, metal rich GC candidate contains an LMXB is at least 1.7 times that of a blue, metal poor one. If we consider only spectroscopically confirmed GCs, this ratio increases to ~3. We find that LMXBs appear preferentially in more luminous (massive) GCs. These two effects are independent, and the latter is likely a consequence of enhanced dynamical encounter rates in more massive clusters which have on average denser cores. The X-ray luminosity functions of the LMXBs found in GCs and of those that are unmatched with GCs reveal similar underlying populations, though there is some indication that fewer X-ray faint LMXBs are found in globular clusters than X-ray bright ones. Our results agree with previous observations of the connection of GCs and LMXBs in early-type galaxies and extend previous work on Centaurus A.Comment: 34 pages, 10 figures, 2 tables, Accepted for Publication in The Astrophysical Journa

Radio galaxy evolution: what you can learn from a Brief Encounter

We describe the pitfalls encountered in deducing from classical double radio source observables (luminosity, spectral index, redshift and linear size) the essential nature of how these objects evolve. We discuss the key role played by hotspots in governing the energy distribution of the lobes they feed, and subsequent spectral evolution. We present images obtained using the new 74 MHz receivers on the VLA and discuss constraints which these enforce on models of the backflow and ages in classical doubles.Comment: invited talk at `Lifecycles of Radio Galaxies' workshop; eds John Biretta et a

Assessing the effects of chemical mixtures using a Bayesian network-relative risk model (BN-RRM) integrating adverse outcome pathways (AOPs) in three Puget Sound watersheds

Chemical mixtures are difficult to assess at the individual level, but more challenging at the population level. There is still little insight of the molecular pathway for numerous chemical mixtures. We have conducted a regional-scale ecological risk assessment by evaluating the effects chemical mixtures to populations with a Bayesian Network- Relative Risk Model (BN-RRM) incorporating a molecular pathway. We used this BN-RRM framework in a case study with organophosphate pesticide (OP) mixtures (diazinon, chlorpyrifos, and malathion) in three watersheds (Lower Skagit, Nooksack, Cedar) in the state of Washington (USA). Puget Sound Chinook salmon (Oncorhynchus tshawytscha) Evolutionary Significant Units (ESU) were chosen as population endpoints. These populations are a valuable ecosystem service in the Pacific Northwest because they benefit the region as a species that provide protection of biodiversity and are spiritually and culturally treasured by the local tribes. Laetz et al. (2009, 2013) indicated that organophosphate pesticide mixtures act synergistically to salmon and impair neurological molecular activity which leads to a change in swimming behavior and mortality, which then leads to changes in population productivity. Exposure response curves were generated for OP mixtures to connect the molecular pathway. Ecological stressors from dissolved oxygen and temperature were also included in our risk analysis. Synergism within the mixtures as well as increasing temperature and decreasing dissolve oxygen content lead to increasing risk to Puget Sound Chinook salmon populations. This research demonstrates a probabilistic approach with a multiple stressor framework to estimate the effects of mixtures through a molecular pathway and predict impacts to these valuable ecosystem services

Every Day a New Discovery: Share History

This project aims to strengthen the sense of community and shared identity within VCU through a historical understanding of the interconnectedness of the formerly standalone institutions (i.e., the Medical College of Virginia and the Richmond Professional Institute). Additionally, it will seek to cultivate a sense of pride and greater esteem for our community by facilitating knowledge of the significant contributions to innovation that were developed at VCU

Monitoring response to anti-angiogenic mTOR inhibitor therapy in vivo using 111In-bevacizumab

Abstract Background The ability to image vascular endothelial growth factor (VEGF) could enable prospective, non-invasive monitoring of patients receiving anti-angiogenic therapy. This study investigates the specificity and pharmacokinetics of 111In-bevacizumab binding to VEGF and its use for assessing response to anti-angiogenic therapy with rapamycin. Specificity of 111In-bevacizumab binding to VEGF was tested in vitro with unmodified radiolabelled bevacizumab in competitive inhibition assays. Uptake of 111In-bevacizumab in BALB/c nude mice bearing tumours with different amounts of VEGF expression was compared to that of isotype-matched control antibody (111In-IgG1κ) with an excess of unlabelled bevacizumab. Intratumoural VEGF was evaluated using ELISA and Western blot analysis. The effect of anti-angiogenesis therapy was tested by measuring tumour uptake of 111In-bevacizumab in comparison to 111In-IgG1κ following administration of rapamycin to mice bearing FaDu xenografts. Uptake was measured using gamma counting of ex vivo tumours and effect on vasculature by using anti-CD31 microscopy. Results Specific uptake of 111In-bevacizumab in VEGF-expressing tumours was observed. Rapamycin led to tumour growth delay associated with increased relative vessel size (8.5 to 10.3, P = 0.045) and decreased mean relative vessel density (0.27 to 0.22, P = 0.0015). Rapamycin treatment increased tumour uptake of 111In-bevacizumab (68%) but not 111In-IgGκ and corresponded with increased intratumoural VEGF165. Conclusions 111In-bevacizumab accumulates specifically in VEGF-expressing tumours, and changes after rapamycin therapy reflect changes in VEGF expression. Antagonism of mTOR may increase VEGF in vivo, and this new finding provides the basis to consider combination studies blocking both pathways and a way to monitor effects

Electronically available patient claims data improve models for comparing antibiotic use across hospitals: Results from 576 US facilities

BACKGROUND: The Centers for Disease Control and Prevention (CDC) uses standardized antimicrobial administration ratios (SAARs)-that is, observed-to-predicted ratios-to compare antibiotic use across facilities. CDC models adjust for facility characteristics when predicting antibiotic use but do not include patient diagnoses and comorbidities that may also affect utilization. This study aimed to identify comorbidities causally related to appropriate antibiotic use and to compare models that include these comorbidities and other patient-level claims variables to a facility model for risk-adjusting inpatient antibiotic utilization. METHODS: The study included adults discharged from Premier Database hospitals in 2016-2017. For each admission, we extracted facility, claims, and antibiotic data. We evaluated 7 models to predict an admission\u27s antibiotic days of therapy (DOTs): a CDC facility model, models that added patient clinical constructs in varying layers of complexity, and an external validation of a published patient-variable model. We calculated hospital-specific SAARs to quantify effects on hospital rankings. Separately, we used Delphi Consensus methodology to identify Elixhauser comorbidities associated with appropriate antibiotic use. RESULTS: The study included 11 701 326 admissions across 576 hospitals. Compared to a CDC-facility model, a model that added Delphi-selected comorbidities and a bacterial infection indicator was more accurate for all antibiotic outcomes. For total antibiotic use, it was 24% more accurate (respective mean absolute errors: 3.11 vs 2.35 DOTs), resulting in 31-33% more hospitals moving into bottom or top usage quartiles postadjustment. CONCLUSIONS: Adding electronically available patient claims data to facility models consistently improved antibiotic utilization predictions and yielded substantial movement in hospitals\u27 utilization rankings