3,608 research outputs found

    Slow-Wave Sleep Disruption in Adolescence: Brain Responses to Monetary Reward and Loss

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    Among adolescents, there is an association between sleep deprivation and reward seeking, but more work is needed to better understand this association. The goal of this study was to investigate slow-wave sleep disruption (SWD) and activity in the nucleus accumbens (NAcc) during a task measuring reward processing. Participants were 28 healthy adolescents aged 15–17 years (50% female; 57.1% White) who underwent functional magnetic resonance imaging while performing a monetary incentive delay task to measure reward anticipation and feedback after a baseline (BL) night and a SWD night. There was greater activation of the NAcc during feedback of large loss and less activation of the NAcc during anticipation of large loss after the SWD night relative to the BL night. These results support an association between SWD and reward processing among adolescents. Knowing more about SWD and reward responsivity may provide enhanced treatment and support to adolescents exhibiting sleep problems and risky reward-related behaviors.National Institute on Alcohol Abuse and Alcoholism (R21 AA022339)https://deepblue.lib.umich.edu/bitstream/2027.42/143845/1/Harris__Julia__Revised - Julia Harris.pdfDescription of Harris__Julia__Revised - Julia Harris.pdf : Julia Harris Senior Thesi

    The Role of the Basic Health Program in the Coverage Continuum: Opportunities, Risks and Considerations for States

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    Outlines issues for offering subsidized coverage to those eligible for insurance exchange subsidies by using federal dollars that would otherwise go to those subsidies, including continuity of coverage, impact on exchanges, and financial feasibility

    Effects of Simulated Student Interaction on Student Perceptions of Teaching Presence

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    The purpose of this study was to explore the impact of the instructor posting in online discussions as a simulated student; particularly the impact simulated student interaction (SSI) had on the instructor/student relationship. Student perceptions were examined using a modified version of the Community of Inquiry (CoI) survey to determine what impact SSI had on teaching presence, cognitive presence, and social presence within the online classroom. The full 34 item CoI Survey was piloted in the summer of 2014 at a small comprehensive university located in northeast Texas. A factor analysis was conducted on the data and the top items from each factor in the instrument extracted. The resulting 17 item instrument demonstrated both validity and reliability. This modified CoI Survey was used in the fall of 2014 with three special education courses making up a control group and an intervention group in a pre-post experimental design. An ANOVA was performed to compare the results of the pre-course and post-course surveys by group. The ANOVA showed a statistically significant difference for all three factors for the intervention group between the pre- and post-course survey, while no significance between surveys was shown for the control group

    Letter from Julia Harris to Leander Harris, February 26, 1865

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    A reproduction of the original and typed transcription of letter from Julia Harris to Leander Harris, dated February 26, 1865

    Input-Output Analysis, Linear Programming and Modified Multipliers

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    The input-output (IO) analysis explores changes in final demand through the regional economy using multipliers. However, it isn’t flexible to investigate the regional impact from the capacity limitations which are directly imposed on production, not final demand. This is because the multipliers are changing with exogenous restrictions on production. Conventionally, the IO analysis is performed assuming exogenous production restrictions being the changes in final demands or assuming the sector being exogenous sector like the final demand. If researchers or policy makers are interested in only economic impacts from production restrictions, there is no need to look into the modified multipliers. The modified multipliers should be considered when researchers and policy makers attempt to analyze the compensation of impact, especially recovery of loss using government expenditure. We suggest that the linear programming is a useful and efficient tool to derive modified multipliers and estimate correct regional impact from the policy changes.Input-Output Analysis, Multipliers, Regional Impact Analysis, Community/Rural/Urban Development, C67, R15, R5,

    Modeling US Counties’ Innovation Capacity with a Focus on Natural Amenities

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    Innovation Capacity, Natural Amenity, Community/Rural/Urban Development, O31, Q51,

    Measuring Regional Economic Impacts from Wildfire: Case Study of Southeast Oregon Cattle-Ranching Business

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    public grazing, regional economic impact, Social Accounting Matrix, Southeast Oregon, wildfire

    Neutralising antibody response in domestic cats immunised with a commercial feline immunodeficiency virus (FIV) vaccine

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    Across human and veterinary medicine, vaccines against only two retroviral infections have been brought to market successfully, the vaccines against feline leukaemia virus (FeLV) and feline immunodeficiency virus (FIV). FeLV vaccines have been a global success story, reducing virus prevalence in countries where uptake is high. In contrast, the more recent FIV vaccine was introduced in 2002 and the degree of protection afforded in the field remains to be established. However, given the similarities between FIV and HIV, field studies of FIV vaccine efficacy are likely to advise and inform the development of future approaches to HIV vaccination.<p></p> Here we assessed the neutralising antibody response induced by FIV vaccination against a panel of FIV isolates, by testing blood samples collected from client-owned vaccinated Australian cats. We examined the molecular and phenotypic properties of 24 envs isolated from one vaccinated cat that we speculated might have become infected following natural exposure to FIV. Cats vaccinated against FIV did not display broadly neutralising antibodies, suggesting that protection may not extend to some virulent recombinant strains of FIV circulating in Australia.<p></p&gt
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