Extending CMIP5 projections of global mean temperature change and sea level rise due to the thermal expansion using a physically-based emulator

We present a physically-based emulator approach to extending 21st century CMIP5 model simulations of global mean surface temperature (GMST) and global thermal expansion (TE) to 2300. A two-layer energy balance model that has been tuned to emulate the CO2 response of individual CMIP5 models is combined with model-specific radiative forcings to generate an emulated ensemble to 2300 for RCP2.6, RCP4.5 and RCP8.5. Errors in the emulated time series are quantified using a subset of CMIP5 models with data available to 2300 and factored into the ensemble uncertainty. The resulting projections show good agreement with 21st century ensemble projections reported in IPCC AR5 and also compare favourably with individual CMIP5 model simulations post-2100. There is a tendency for the two-layer model simulations to overestimate both GMST rise and TE under RCP2.6, which is suggestive of a systematic error in the applied radiative forcings. Overall, the framework shows promise as a basis for extending process-based projections of global sea level rise beyond the 21st century time horizon that typifies CMIP5 simulations. The results also serve to illustrate the differing responses of GMST and Earth's energy imbalance (EEI) to reductions in greenhouse gas emissions. GMST responds relatively quickly to changes in emissions, leading to a negative trend post-2100 for RCP2.6, although temperature remains substantially elevated compared to present day at 2300. In contrast, EEI remains positive under all RCPs, and results in ongoing sea level rise from TE

Temperature dependence of indentation size effects, pile-up and strain rate sensitivity in polycrystalline tungsten from 25-950 C

Elevated temperature nanoindentation measurements were performed on polycrystalline tungsten to 950 ºC. Tests were carried out under high vacuum conditions as tungsten oxidizes in air at \u3e500 ºC. The temperature dependence of the hardness, elastic modulus, strain rate sensitivity, activation volume and the indentation size effect in hardness were investigated at 25, 750, 800, 850, 900 and 950 ºC. Thermal drift assessed from the last 60% of a hold period at 90% unloading was typically ~0.05 nm/s and it did not vary significantly with load or temperature [1]. The hardness measurements were in good agreement with previous determinations by non-depth sensing hot microhardness. Please click Additional Files below to see the full abstract

MLA Research Agenda: Appraising the Best Available Evidence

Offers guidelines for the formation and self-governance of autonomous teams as they conduct systematic reviews related to the MLA Research Agenda

Muscle Activity and User-Perceived Exertion During Immersive Virtual Reality Exergaming Incorporating an Adaptive Cable Resistance System

International Journal of Exercise Science 15(7): 261-275, 2022. The purpose of this exploratory study was to characterize muscle activation via surface electromyography (sEMG), user-perceived exertion, and enjoyment during a 30-minute session of immersive virtual reality (IVR) cable resistance exergaming. Ten healthy, college-aged males completed a signature 30-minute exergaming session using an IVR adaptive cable resistance system that incorporated six traditional compound exercises. Muscle activation (sEMG) was captured during the session with a wearable sEMG system. Rated of Perceived Exertion (RPE) and Physical Activity Enjoyment Scale (PACES) were recorded following the session. Pectoralis major showed the highest activation during chest press, deltoids showed the highest activation on overhead press, latissimus dorsi showed the highest activation during lat pulldown and row exercises, hamstrings were the most activated muscles during Romanian deadlift, and glutes showed the highest activity during squats. RPE and PACES mean scores were 14 (1) and 4.27 (0.38), respectively. IVR exergaming with resistance cable training provides an enjoyable experience and distracts practitioners from exertion while exercising at a high intensity. Results from this study suggest similar muscle activation responses compared to traditional resistance exercises as demonstrated with prior evidence. This novel form of exercise might have important repercussions for improving health outcomes among those who find it challenging to adhere to and enjoy exercise routines, as well as with little knowledge on how to progress in their resistance training. Further investigations are needed to explore long-term adaptations and to assess if IVR exergaming has additional benefits compared to traditional resistance training

Determining anion-quadrupole interactions among protein, DNA, and ligand molecules

Background An extensive search through the Protein Databank (about 4500 nonredundant structures) was previously completed within our lab to analyze the energetic and geometric characteristics of an understudied molecular interaction known as an anion-quadrupole (AQ) interaction. Such an interaction occurs when the positively charged edge of an aromatic ring, resulting from a quadruple moment (i.e., a dual dipole moment), renders the aromatic molecule noncovalently bound to a nearby anionic molecule. The study considered a very limited scenario of molecules that can participate in AQ interactions, consisting of the phenyl group of a phenylalanine (phe) amino acid as the aromatic participant and the carboxylate group of an aspartate (asp) or glutamate (glu) amino acid as the anionic participant. The results revealed anion-quadrupole pairs to be prevalent within most of the protein structures. It was also observed that the interaction energy for AQ pairs was heavily dependent on the angle between the anion and plane of the aromatic ring, favoring a more planar interaction. In light of these critical observations being made from such a limited scenario, only phe-glu and phe-asp pairs and in a reduced sample set of the PDB, we are now continuing this work of identifying AQ interactions using a greatly expanded strategy. We are following these four aims: 1. Optimizing the AQ-search program to run in a semi-parallel fashion and on a large cluster of processors in order to handle larger analyses, 2. Adding to our search additional anionic participants which will include non-protein structures such as DNA and small ligands, 3. Studying a subset of the AQ pairs with molecular dynamics simulations in buried and solvent exposed environments to observe non-static behavioral traits as well as the reproducibility of AQ interactions by force field parameters. 4. Building an online database for public access to our data and search program. Acknowledgments We would like to acknowledge the NSF-IGERT traineeship, Scalable Computing and Leading Edge Innovative Technologies (SCALE-IT), for providing the resources for this project

A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes

Securin inhibits the protease separase and must be removed before anaphase to ensure timely chromosome segregation. Here, the authors define a mechanism of securin destruction in prometaphase I in mouse oocytes and demonstrate its importance for successful meiotic progression

Discrimination of Methionine Sulfoxide and Sulfone by Human Neutrophil Elastase

Human neutrophil elastase (HNE) is a uniquely destructive serine protease with the ability to unleash a wave of proteolytic activity by destroying the inhibitors of other proteases. Although this phenomenon forms an important part of the innate immune response to invading pathogens, it is responsible for the collateral host tissue damage observed in chronic conditions such as chronic obstructive pulmonary disease (COPD), and in more acute disorders such as the lung injuries associated with COVID-19 infection. Previously, a combinatorially selected activity-based probe revealed an unexpected substrate preference for oxidised methionine, which suggests a link to oxida-tive pathogen clearance by neutrophils. Here we use oxidised model substrates and inhibitors to confirm this observation and to show that neutrophil elastase is specifically selective for the di-oxygenated methionine sulfone rather than the mono-oxygenated methionine sulfoxide. We also posit a critical role for ordered solvent in the mechanism of HNE discrimination between the two oxidised forms methionine residue. Preference for the sulfone form of oxidised methionine is especially significant. While both host and pathogens have the ability to reduce methionine sulfoxide back to methionine, a biological pathway to reduce methionine sulfone is not known. Taken to-gether, these data suggest that the oxidative activity of neutrophils may create rapidly cleaved elas-tase “super substrates” that directly damage tissue, while initiating a cycle of neutrophil oxidation that increases elastase tissue damage and further neutrophil recruitment

Polytetrahedral Clusters

By studying the structures of clusters bound by a model potential that favours polytetrahedral order, we find a previously unknown series of `magic numbers' (i.e. sizes of special stability) whose polytetrahedral structures are characterized by disclination networks that are analogous to hydrocarbons.Comment: 4 pages, 4 figure