I’ve Changed, I’m Smarter: Empowering Youth to Thrive Neurosequential Approach to Employment, Education and Training Outcomes for Youth

This paper explores the impact of a neurosequential brain development approach on employment, education and training outcomes of vulnerable long-term unemployed youth, aged 15-24 years. The Empowering Youth to Thrive (EYTT) program utilises neuroscience research, which underpin varied creative and sensory and regulatory experiences used to engage youth in social and emotional learning. The aim is to enhance brain pathways to increase youth’s higher order thinking functions such as problem solving, communication and critical thinking skills. These are considered necessary attributes for positive engagement in the current and future workforce. A bricolage methodology was used to evaluate the impact of the program, with findings determining the EYTT program had benefits for participants in gaining successful training, education and/or employment opportunities

Spectral identification and quantification of salts in the Atacama Desert

This work was part-funded by a Research Incentive Grant from The Carnegie Trust (REF: 70335) and a Royal Society of Edinburgh Research Fellowship to C. Cousins. J, Harris acknowledges funding from STFC (consolidated grant ST/N000528/1).Salt minerals are an important natural resource. The ability to quickly and remotely identify and quantify salt deposits and salt contaminated soils and sands is therefore a priority goal for the various industries and agencies that utilise salts. The advent of global hyperspectral imagery from instruments such as Hyperion on NASA’s Earth-Observing 1 satellite has opened up a new source of data that can potentially be used for just this task. This study aims to assess the ability of Visible and Near Infrared (VNIR) spectroscopy to identify and quantify salt minerals through the use of spectral mixture analysis. The surface and near-surface soils of the Atacama Desert in Chile contain a variety of well-studied salts, which together with low cloud coverage, and high aridity, makes this region an ideal testbed for this technique. Two forms of spectral data ranging 0.35 – 2.5 μm were collected: laboratory spectra acquired using an ASD FieldSpec Pro instrument on samples from four locations in the Atacama desert known to have surface concentrations of sulfates, nitrates, chlorides and perchlorates; and images from the EO-1 satellite’s Hyperion instrument taken over the same four locations. Mineral identifications and abundances were confirmed using quantitative XRD of the physical samples. Spectral endmembers were extracted from within the laboratory and Hyperion spectral datasets and together with additional spectral library endmembers fed into a linear mixture model. The resulting identification and abundances from both dataset types were verified against the sample XRD values. Issues of spectral scale, SNR and how different mineral spectra interact are considered, and the utility of VNIR spectroscopy and Hyperion in particular for mapping specific salt concentrations in desert environments is established. Overall, SMA was successful at estimating abundances of sulfate minerals, particularly calcium sulfate, from both hyperspectral image and laboratory sample spectra, while abundance estimation of other salt phase spectral end-members was achieved with a higher degree of error.Publisher PD

Patient perceptions in receiving LGBTQIA culturally competent health care

Background: There is a large amount of documented evidence demonstrating that health care providers are caring for diverse populations. This warrants a level of cultural competence (CC) when making health care decisions. Traditionally, Race and ethnicity have been the focus in CC. However, criteria such as sexual orientation and gender identity are often forgotten, or left out altogether. Because of this, patients whose sexual orientation or gender is a minority, may often receive inadequate treatment. This is in part due to the health care providers lack knowledge in this type of CC or present sexual prejudices. Because of this, research is needed to investigate the perceptions of patients that identify as lesbian, gay, bisexual, transgender, queer/questioning, intersex, ally (LGBTQIA) when receiving health care.Methods: Cross-sectional design consisting of 140 participants (male=78, female=50, transgender=5, other=7; heterosexual=16, gay/lesbian=72, bisexual=43, other=9, mean age=26.97 ± 7.67). Participants were recruited using a snowball sampling method via email and list-serves. A modified version of the Gay Affirmative Practice (GAP) (reliability a = 0.962), was delivered online to participants to determine need of LGBTQIA cultural competent treatment by health care providers. Means and standard deviations were calculated for each variable (gender, sexual orientation), as well as an overall GAP score (out of 150). Two, single one-way ANOVAs (gender and sexual orientation) were performed with GAP score as the dependent variable.Results: Calculated GAP scores: All=128.82 ± 18.48, male=128.49 ± 15.60, female=130.35 ± 17.10, transgender=129.80 ± 9.31, other=143. 57, heterosexual=129.33 ± 17.12, gay or lesbian=128.25 ± 15.85, bisexual/omni/pansexual/queer/non-monosexual=132.79 ± 14.99, other=131.38 ± 20.37. ANOVA results were modified with Kruskal-Wallis adjustments due to violation of normality and homogeneity of variance, and now are represented by Chi Squares. Gender was the single significant outcome, (X2(3) =8.01, p <0.05). Post hoc testing of gender demonstrated statistical significant in comparing males vs. other.Conclusions: Patients do find it necessary for health care providers to have specific training and/or knowledge in LGBTQIA CC. A majority of results demonstrate strongly agree that health care providers need better CC in LGBTQIA. In comparison of GAP scores in gender, the category of other demonstrates a great need for CC in LGBTQIA in health care providers. Males demonstrated a much lower score, indicating a low priority for LGBTQIA CC in health care. With an increasing LGBTQIA patient population, patients feel the ever increasing need for health care providers to provide knowledgeable, competent, and fair treatment/care

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin

AbstractThe establishment of relative size of organs and structures is paramount for attaining final form and function of an organism. Importantly, variation in the proportions of structures frequently underlies adaptive change in morphology in evolution and maybe a common mechanism underlying selection. However, the mechanism by which growth is integrated within tissues during development to achieve proper proportionality is poorly understood. We have shown that signaling by potassium channels mediates coordinated size regulation in zebrafish fins. Recently, calcineurin inhibitors were shown to elicit changes in zebrafish fin allometry as well. Here, we identify the potassium channelkcnk5bas a key player in integrating calcineurin’s growth effects, in part through regulation of the cytoplasmic C-terminus of the channel. We propose that the interaction between Kcnk5b and calcineurin acts as a signaling node to regulate allometric growth. Importantly, we find that this regulation is epistatic to inherent mechanisms instructing overall size as inhibition of calcineurin is able to bypass genetic instruction of size as seen insofand wild-type fins, however, it is not sufficient to re-specify positional memory of size of the fin. These findings integrate classic signaling mediators such as calcineurin with ion channel function in the regulation of size and proportion during growth.</jats:p

Association of Body Mass Index of HIV-1-Infected Pregnant Women and Infant Weight, Body Mass Index, Length, and Head Circumference: The NISDI Perinatal Study.

This study assessed the relationship between the body mass index (BMI) of HIV-1-infected women and their infants' perinatal outcomes. The study population consisted of women enrolled in the NICHD International Site Development Initiative (NISDI) Perinatal Study with data allowing calculation of the BMI adjusted for length of gestation (adjBMI), who delivered singleton infants. Outcome variables included infant growth parameters at birth (weight, BMI, length and head circumference) and gestational age. Of 697 women from Argentina, the Bahamas, Brazil and Mexico who were included in the analysis, the adjBMI was classified as underweight for 109 (15.6%), normal for 418 (60.0%), overweight for 88 (12.6%) and obese for 82 (11.8%). Median infant birth weight, BMI, birth length and head circumference differed significantly according to maternal adjBMI (P</=0.0002). Underweight mothers gave birth to infants with lower weight, lower BMI, shorter length and smaller head circumference, while infants born to normal, overweight and obese mothers were of similar size

Identification of early gene expression changes in primary cultured neurons treated with topoisomerase I poisons.

Topoisomerase 1 (TOP1) poisons like camptothecin (CPT) are currently used in cancer chemotherapy but these compounds can have damaging, off-target effects on neurons leading to cognitive, sensory and motor deficits. To understand the molecular basis for the enhanced sensitivity of neurons to CPT, we examined the effects of compounds that inhibit TOP1-CPT, actinomycin D (ActD) and β-lapachone (β-Lap)-on primary cultured rat motor (MN) and cortical (CN) neurons as well as fibroblasts. Neuronal cells expressed higher levels of Top1 mRNA than fibroblasts but transcript levels are reduced in all cell types after treatment with CPT. Microarray analysis was performed to identify differentially regulated transcripts in MNs in response to a brief exposure to CPT. Pathway analysis of the differentially expressed transcripts revealed activation of ERK and JNK signaling cascades in CPT-treated MNs. Immediate-early genes like Fos, Egr-1 and Gadd45b were upregulated in CPT-treated MNs. Fos mRNA levels were elevated in all cell types treated with CPT; Egr-1, Gadd45b and Dyrk3 transcript levels, however, increased in CPT-treated MNs and CNs but decreased in CPT-treated fibroblasts. These transcripts may represent new targets for the development of therapeutic agents that mitigate the off-target effects of chemotherapy on the nervous system

School Leadership Interventions Under the Every Student Succeeds Act: Evidence Review - Updated and Expanded

This RAND analysis offers guidance to states and districts on how they can choose to use the Every Student Succeeds Act to help achieve their school improvement goals by supporting principals and other school leaders