Theoretical studies of solar-pumped lasers

The power output of a black body solar-pumped laser as a function of time (computer graphic solutions) and under steady state conditions (analytic conditions); computer analyses of polymerization using lasers; and metallic sodium as a laser medium were studied

Theoretcial studies of solar-pumped lasers

A method of pumping a COhZ laser by a hot cavity was demonstrated. The cavity, heated by solar radiation, should increase the efficiency of solar pumped lasers used for energy conversion. Kinetic modeling is used to examine the behavior of such a COhZ laser. The kinetic equations are solved numerically vs. time and, in addition, steady state solutions are obtained analytically. The effect of gas heating filling the lower laser level is included. The output power and laser efficiency are obtained as functions of black body temperature and gas ratios (COhZ-He-Ar) and pressures. The values are compared with experimental results

Radial and rotational velocities of young brown dwarfs and very low-mass stars in the Upper Scorpius OB association and the rho Ophiuchi cloud core

We present the results of a radial velocity (RV) survey of 14 brown dwarfs (BDs) and very low-mass (VLM) stars in the Upper Scorpius OB association (UScoOB) and 3 BD candidates in the rho Ophiuchi dark cloud core. We obtained high-resolution echelle spectra at the Very Large Telescope using Ultraviolet and Visual Echelle Spectrograph (UVES) at two different epochs for each object, and measured the shifts in their RVs to identify candidates for binary/multiple systems in the sample. The average time separation of the RV measurements is 21.6d, and our survey is sensitive to the binaries with separation < 0.1 au. We found that 4 out of 17 objects (or 24^{+16}_{-13} per cent by fraction) show a significant RV change in 4-33d time scale, and are considered as binary/multiple `candidates.' We found no double-lined spectroscopic binaries in our sample, based on the shape of cross-correlation curves. The RV dispersion of the objects in UScoOB is found to be very similar to that of the BD and VLM stars in Chamaeleon I (Cha I). We also found the distribution of the mean rotational velocities (v sin i) of the UScoOB objects is similar to that of the Cha I, but the dispersion of v sin i is much larger than that of the Cha I objects.Comment: 10 pages, 5 figures, accepted for publication in MNRA

Theoretical studies of solar-pumped lasers

In any lasing medium the emission wavelength should be chosen where there is little self absorption. As emission and absorption spectra for metallic vapors did not seem available, therefore, estimates were made of these cross sections for sodium vapor as functions of wavelength. Although absolute values were not obtained, information on where the emission wavelength should occur became evident. The method of obtaining quantities proportional to the cross sections versus wavelength is outlined. A further comparison based on alternative expressions for the absorption and emission cross sections over a limited wavelength range is made

To adopt is to adapt: The process of implementing the ICF with an acute stroke multidisciplinary team in England

Copyright @ 2012 Informa Plc. The article can be accessed from the link below.This article has been made available through the Brunel Open Access Publishing Fund.Purpose: The success of the International Classification of Functioning, Disability and Health (ICF) depends on its uptake in clinical practice. This project aimed to explore ways the ICF could be used with an acute stroke multidisciplinary team and identify key learning from the implementation process. Method: Using an action research approach, iterative cycles of observe, plan, act and evaluate were used within three phases: exploratory; innovatory and reflective. Thematic analysis was undertaken, using a model of immersion and crystallisation, on data collected via interview and focus groups, e-mail communications, minutes from relevant meetings, field notes and a reflective diary. Results: Two overall themes were determined from the data analysis which enabled implementation. There is a need to: (1) adopt the ICF in ways that meet local service needs; and (2) adapt the ICF language and format. Conclusions: The empirical findings demonstrate how to make the ICF classification a clinical reality. First, we need to adopt the ICF as a vehicle to implement local service priorities e.g. to structure a multidisciplinary team report, thus enabling ownership of the implementation process. Second, we need to adapt the ICF terminology and format to make it acceptable for use by clinicians.This study is funded by The Elizabeth Casson Trust. This article is made available through the Brunel Open Access Publishing Fund

The trajectory to diagnosis with pulmonary arterial hypertension: a qualitative study

Objectives To investigate the patient's experience of the trajectory to receiving a diagnosis of pulmonary arterial hypertension (PAH) and inform the provision of care for this patient group. Design Qualitative study using in-depth one-to-one interviews and pictorial representations. Data were analysed using thematic analysis. Setting Participants were interviewed in their own homes across England. Participants 30 patients with a diagnosis of pulmonary hypertension (18 participants were women, mean age 56 and range 26-80 02years and time since diagnosis ranged from a few months to more than 12 02years) participated. Results All participants, regardless of the time since diagnosis, vividly described the process from manifestation of symptoms to receiving a confirmed diagnosis. The authors present data using three major themes: (i) making sense of symptoms, (ii) process of elimination and (iii) being diagnosed with PAH. Making sense of symptoms represented an early period of perseverance 14people tried to carry-on as usual despite 18unexplained breathlessness 19. As time progressed, this period was punctuated by critical events that triggered seeking medical advice. Once medical contact had been made, patients described a period of 18elimination 19 and convoluted contact with the medical profession. Dyspnoea misdiagnosis was a key factor that delayed the PAH diagnosis. Diagnosis disclosure by some medical professionals was also viewed as lacking empathy. More positive experiences were relayed when the medical team disclosing the diagnosis acknowledged previous limitations. Conclusions A lack of awareness of this illness from both the sufferer themselves and the medical profession emerged as a central theme and led to prolonged periods of being misdiagnosed. The application of a diagnostic pathway for unexplained dyspnoea that alerts practitioners to rare conditions could expedite the process of correct diagnosis

Circular RNAs (circRNAs) in Health and Disease

This is the final version of the article. Available from MDPI via the DOI in this record.Splicing events do not always produce a linear transcript. Circular RNAs (circRNAs) are a class of RNA that are emerging as key new members of the gene regulatory milieu, which are produced by back-splicing events within genes. In circRNA formation, rather than being spliced in a linear fashion, exons can be circularised by use of the 3' acceptor splice site of an upstream exon, leading to the formation of a circular RNA species. circRNAs have been demonstrated across species and have the potential to present genetic information in new orientations distinct from their parent transcript. The importance of these RNA players in gene regulation and normal cellular homeostasis is now beginning to be recognised. They have several potential modes of action, from serving as sponges for micro RNAs and RNA binding proteins, to acting as transcriptional regulators. In accordance with an important role in the normal biology of the cell, perturbations of circRNA expression are now being reported in association with disease. Furthermore, the inherent stability of circRNAs conferred by their circular structure and exonuclease resistance, and their expression in blood and other peripheral tissues in association with endosomes and microvesicles, renders them excellent candidates as disease biomarkers. In this review, we explore the state of knowledge on this exciting class of transcripts in regulating gene expression and discuss their emerging role in health and disease.The Harries lab is funded by the Dunhill Medical Trust and Animal Free Research