849 research outputs found
Large-scale drift and Rossby wave turbulence
We study drift/Rossby wave turbulence described by the large-scale limit of the Charney–Hasegawa–Mima equation. We define the zonal and meridional regions as and respectively, where is in a plane perpendicular to the magnetic field such that k x is along the isopycnals and k y is along the plasma density gradient. We prove that the only types of resonant triads allowed are and . Therefore, if the spectrum of weak large-scale drift/Rossby turbulence is initially in Z it will remain in Z indefinitely. We present a generalised Fjørtoft's argument to find transfer directions for the quadratic invariants in the two-dimensional -space. Using direct numerical simulations, we test and confirm our theoretical predictions for weak large-scale drift/Rossby turbulence, and establish qualitative differences with cases when turbulence is strong. We demonstrate that the qualitative features of the large-scale limit survive when the typical turbulent scale is only moderately greater than the Larmor/Rossby radius
Wave turbulence in the two-layer ocean model
This paper looks at the two-layer ocean model from a wave turbulence
perspective. A symmetric form of the two-layer kinetic equation for Rossby
waves is derived using canonical variables, allowing the turbulent cascade of
energy between the barotropic and baroclinic modes to be studied. It turns out
that energy is transferred via local triad interactions from the large-scale
baroclinic modes to the baroclinic and barotropic modes at the Rossby
deformation scale. From there it is then transferred to the large-scale
barotropic modes via a nonlocal inverse transfer. Using scale separation a sys-
tem of coupled equations were obtained for the small-scale baroclinic component
and the large-scale barotropic component. Since the total energy of the
small-scale component is not conserved, but the total barotropic plus
baroclinic energy is conserved, the baroclinic energy loss at small scales will
be compensated by the growth of the barotropic energy at large scales. It is
found that this transfer is mostly anisotropic and mostly to the zonal
component
Rossby wave turbulence
In this thesis, Rossby waves are considered within the one-layer Charney-Hasegawa-Mima (CHM) equation and two-layer quasi-geostrophic (QG) model. They are studied from a wave turbulence (WT) perspective. Since nonlinearity is quadratic, interactions take place between triplets of waves known as triads. A triad is said to be resonant if its wave vectors and frequencies satisfy k1 + k2 - k3 = 0 and w(k1)+w(k2)-w(k3) = 0 respectively. These triads can then be joined together to form resonant clusters of various sizes. The wave vectors can be continuous, in an unbounded domain, or discrete, in a bounded domain. Continuous, otherwise known as kinetic, WT has been extensively studied in the one-layer case. It is known that three quadratic invariants exist and they take part in a triple cascade in k-space. This thesis is interested in finding quadratic invariants, of which there can be many, in the discrete regime. It begins by considering discrete clusters of resonant triads arising from a Hamiltonian three-wave equation. A cluster consists of N modes forming a total of M connected triads. It is shown that that finding quadratic invariants is equivalent to a basic linear algebra problem, consisting of finding the null space of a rectangular M x N matrix A with entries 1, -1 and 0. An algorithm is then formulated for decomposing large clusters into smaller ones to show how the quadratic invariants are related to topological parts of the cluster. Specifc examples of clusters arising in the CHM wave model are considered.
The second part of this thesis focusses on the large-scale limit of the CHM equation. This limit has been studied the least; however, it would appear to be more relevant since Rossby waves in the ocean are large-scale. Recently a new quadratic invariant, known as semi-action, has been discovered in this limit. Its density is one in the meridional region |ky| /3kx: As a consequence of the conservation of semi-action, conditions are placed on the triad interactions involving zonal (Z) and meridional (M) modes. In this thesis it is proved directly, without appealing to conservation, that the following triad interactions are prohibited: M -> M +M,M -> Z + Z,Z -> M + Z and Z -> M +M: The cascade directions are studied of the three invariants, the energy, enstrophy and, depending whether the initial spectrum is in the meridional or zonal sector, the semi-action or zonsotrophy respectively. The results are interpreted to explain the formation of unisotropic turbulence with dominating zonal scales.
In the final part of this thesis, a symmetric form of the two-layer kinetic equation for Rossby waves is derived using canonical variables, allowing the turbulent cascade of energy between the barotropic and baroclinic modes to be studied. It turns out that energy is transferred via local triad interactions from large-scale baroclinic modes to the baroclinic and barotropic modes at the Rossby deformation scale. From there it is transferred into large-scale barotropic modes via a non-local inverse transfer
Quadratic invariants for discrete clusters of weakly interacting waves
We consider discrete clusters of quasi-resonant triads arising from a Hamiltonian three-wave equation. A cluster consists of N modes forming a total of M connected triads. We investigate the problem of constructing a functionally independent set of quadratic constants of motion. We show that this problem is equivalent to an underlying basic linear problem, consisting of finding the null space of a rectangular M × N matrix with entries 1, −1 and 0. In particular, we prove that the number of independent quadratic invariants is equal to J ≡ N − M* ≥ N − M, where M* is the number of linearly independent rows in Thus, the problem of finding all independent quadratic invariants is reduced to a linear algebra problem in the Hamiltonian case. We establish that the properties of the quadratic invariants (e.g., locality) are related to the topological properties of the clusters (e.g., types of linkage). To do so, we formulate an algorithm for decomposing large clusters into smaller ones and show how various invariants are related to certain parts of a cluster, including the basic structures leading to M* < M. We illustrate our findings by presenting examples from the Charney–Hasegawa–Mima wave model, and by showing a classification of small (up to three-triad) clusters
Kv1.3-induced hyperpolarization is required for efficient Kaposi's sarcoma-associated herpesvirus lytic replication
Funding: This work was supported by a Rosetrees trust PhD studentship, M662, White Rose BBSRC Doctoral training Partnership in Mechanistic Biology (95519935), BBSRC project grant (BB/T00021X/1), and a Royal Society University Research Fellowship [g:480764 (to J.M.)].Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic herpesvirus that is linked directly to the development of Kaposi's sarcoma. KSHV establishes a latent infection in B cells, which can be reactivated to initiate lytic replication, producing infectious virions. Using pharmacological and genetic silencing approaches, we showed that the voltage-gated K+ channel Kv1.3 in B cells enhanced KSHV lytic replication. The KSHV replication and transcription activator (RTA) protein increased the abundance of Kv1.3 and led to enhanced K+ channel activity and hyperpolarization of the B cell membrane. Enhanced Kv1.3 activity promoted intracellular Ca2+ influx, leading to the Ca2+-driven nuclear localization of KSHV RTA and host nuclear factor of activated T cells (NFAT) proteins and subsequently increased the expression of NFAT1 target genes. KSHV lytic replication and infectious virion production were inhibited by Kv1.3 blockers or silencing. These findings highlight Kv1.3 as a druggable host factor that is key to the successful completion of KSHV lytic replication.Peer reviewe
Evidence for Extended Hydrogen-Poor CSM in the Three-Peaked Light Curve of Stripped Envelope Ib Supernova
We present multi-band ATLAS photometry for SN 2019tsf, a stripped-envelope
Type Ib supernova (SESN). The SN shows a triple-peaked light curve and a late
(re-)brightening, making it unique among stripped-envelope systems. The
re-brightening observations represent the latest photometric measurements of a
multi-peaked Type Ib SN to date. As late-time photometry and spectroscopy
suggest no hydrogen, the potential circumstellar material (CSM) must be H-poor.
Moreover, late (>150 days) spectra show no signs of narrow emission lines,
further disfavouring CSM interaction. On the contrary, an extended CSM
structure is seen through a follow-up radio campaign with Karl G. Jansky Very
Large Array (VLA), indicating a source of bright optically thick radio emission
at late times, which is highly unusual among H-poor SESNe. We attribute this
phenomenology to an interaction of the supernova ejecta with
spherically-asymmetric CSM, potentially disk-like, and we present several
models that can potentially explain the origin of this rare Type Ib supernova.
The warped disc model paints a novel picture, where the tertiary companion
perturbs the progenitors CSM, that can explain the multi-peaked light curves of
SNe, and here we apply it to SN 2019tsf. This SN 2019tsf is likely a member of
a new sub-class of Type Ib SNe and among the recently discovered class of SNe
that undergo mass transfer at the moment of explosionComment: 23 pages, Comments are welcome, Submitted to Ap
Food Insecurity Prevalence Across Diverse Sites During COVID-19: A Year of Comprehensive Data
Key Findings NFACT includes 18 study sites in 15 states as well as a national poll, collectively representing a sample size of more than 26,000 people. Some sites have implemented multiple survey rounds, here we report results from 22 separate surveys conducted during the year since the COVID-19 pandemic began in March 2020. 18 out of 19 surveys in 14 sites with data for before and since the pandemic began found an increase in food insecurity since the start of the COVID-19 pandemic as compared to before the pandemic. In nearly all surveys (18/19) that measured food insecurity both before and during the pandemic, more Black, Indigenous, and People of Color (BIPOC) were classified as food insecure during the pandemic as compared to before it began. Prevalence of food insecurity for BIPOC respondents was higher than the overall population in the majority of surveys (19/20) sampling a general population. In almost all surveys (21/22), the prevalence of food insecurity for households with children was higher than the overall prevalence of food insecurity. Food insecurity prevalence was higher for households experiencing a negative job impact during the pandemic (i.e. job loss, furlough, reduction in hours) in nearly all surveys and study sites (21/22). Food insecurity prevalence in most sites was significantly higher before COVID-19 than estimates from that time period. Reporting a percent change between pre and during COVID-19 prevalence may provide additional information about the rate of change in food insecurity since the start of the pandemic, which absolute prevalence of food insecurity may not capture. Results highlight consistent trends in food insecurity outcomes since the start of the COVID-19 pandemic, across diverse study sites, methodological approaches, and time
Flight of the Bumblebee: the Early Excess Flux of Type Ia Supernova 2023bee revealed by , and Young Supernova Experiment Observations
We present high-cadence ultraviolet through near-infrared observations of the
Type Ia supernova (SN Ia) 2023bee in NGC~2708 ( Mpc), finding
excess flux in the first days after explosion relative to the expected
power-law rise from an expanding fireball. This deviation from typical behavior
for SNe Ia is particularly obvious in our 10-minute cadence light curve
and UV data. Compared to a few other normal SNe Ia with detected early
excess flux, the excess flux in SN 2023bee is redder in the UV and less
luminous. We present optical spectra of SN 2023bee, including two spectra
during the period where the flux excess is dominant. At this time, the spectra
are similar to those of other SNe Ia but with weaker Si II, C II and Ca II
absorption lines, perhaps because the excess flux creates a stronger continuum.
We compare the data to several theoretical models that have been proposed to
explain the early flux excess in SNe Ia. Interaction with either a nearby
companion star or close-in circumstellar material is expected to produce a
faster evolution than seen in the data. Radioactive material in the outer
layers of the ejecta, either from a double detonation explosion or simply an
explosion with a Ni clump near the surface, can not fully reproduce the
evolution either, likely due to the sensitivity of early UV observable to the
treatment of the outer part of ejecta in simulation. We conclude that no
current model can adequately explain the full set of observations. We find that
a relatively large fraction of nearby, bright SNe Ia with high-cadence
observations have some amount of excess flux within a few days of explosion.
Considering potential asymmetric emission, the physical cause of this excess
flux may be ubiquitous in normal SNe Ia.Comment: 21 pages, 12 figures. Accepted by the astrophysical journa
Newborn and child-like molecular signatures in older adults stem from TCR shifts across human lifespan
CD8+ T cells provide robust antiviral immunity, but how epitope-specific T cells evolve across the human lifespan is unclear. Here we defined CD8+ T cell immunity directed at the prominent influenza epitope HLA-A*02:01-M158–66 (A2/M158) across four age groups at phenotypic, transcriptomic, clonal and functional levels. We identify a linear differentiation trajectory from newborns to children then adults, followed by divergence and a clonal reset in older adults. Gene profiles in older adults closely resemble those of newborns and children, despite being clonally distinct. Only child-derived and adult-derived A2/M158+CD8+ T cells had the potential to differentiate into highly cytotoxic epitope-specific CD8+ T cells, which was linked to highly functional public T cell receptor (TCR)αβ signatures. Suboptimal TCRαβ signatures in older adults led to less proliferation, polyfunctionality, avidity and recognition of peptide mutants, although displayed no signs of exhaustion. These data suggest that priming T cells at different stages of life might greatly affect CD8+ T cell responses toward viral infections
ENIGMA-anxiety working group : Rationale for and organization of large-scale neuroimaging studies of anxiety disorders
Altres ajuts: Anxiety Disorders Research Network European College of Neuropsychopharmacology; Claude Leon Postdoctoral Fellowship; Deutsche Forschungsgemeinschaft (DFG, German Research Foundation, 44541416-TRR58); EU7th Frame Work Marie Curie Actions International Staff Exchange Scheme grant 'European and South African Research Network in Anxiety Disorders' (EUSARNAD); Geestkracht programme of the Netherlands Organization for Health Research and Development (ZonMw, 10-000-1002); Intramural Research Training Award (IRTA) program within the National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, MH002781); National Institute of Mental Health under the Intramural Research Program (NIMH-IRP, ZIA-MH-002782); SA Medical Research Council; U.S. National Institutes of Health grants (P01 AG026572, P01 AG055367, P41 EB015922, R01 AG060610, R56 AG058854, RF1 AG051710, U54 EB020403).Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the four subgroups studying generalized anxiety disorder, panic disorder, social anxiety disorder, and specific phobia. At present, the ENIGMA-Anxiety database contains information about more than 100 unique samples, from 16 countries and 59 institutes. Future directions include examining additional imaging modalities, integrating imaging and genetic data, and collaborating with other ENIGMA working groups. The ENIGMA consortium creates synergy at the intersection of global mental health and clinical neuroscience, and the ENIGMA-Anxiety Working Group extends the promise of this approach to neuroimaging research on anxiety disorders
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