691 research outputs found
Metaphase and Interphase Cytogenetics with Alu-PCR-amplified Yeast Artificial Chromosome Clones Containing the BCR Gene and the Protooncogenes c-raf-1, c-fms, and c-erbB-21
A human yeast artificial chromosome (YAC) library was screened by polymerase chain reaction with oligonucleotide primers defined for DNA sequences of the BCR gene and the protooncogenes c-raf-1, c-fms, and c-erB-2. Alu-PCR-generated human DNA sequences were obtained from the respective YAC clones and used for fluorescence in situ hybridization experiments under suppression conditions. After chromosomal in situ suppression hybridization to GTG-banded human prometaphase chromosomes, seven of nine initially isolated YAC clones yielded strong signals exclusively in the chromosome bands containing the respective genes. Two clones yielded additional signals on other chromosomes and were excluded from further tests. The band-specific YACs were successfully applied to visualize specific structural chromosome aberrations in peripheral blood cells from patients with myelodysplasia exhibiting del(5)(q13q34), chronic myeloid leukemia and acute lymphocytic leukemia with t(9;22)(q34;q11), acute promyelocytic leukemia (M3) with t(15;17)(q22;q21), and in a cell line established from a proband with the constitutional translocation t(3;8)(p14.2;q24). In addition to the analysis of metaphase spreads, we demonstrate the particular usefulness of these YAC clones in combination with whole chromosome painting to analyze specific chromosome aberrations directly in the interphase nucleus
Acousto-ultrasonic nondestructive evaluation of materials using laser beam generation and detection
Presented in viewgraph format, the possibility of using laser generation and detection of ultrasound to replace piezoelectric transducers for the acousto-ultrasonic technique is advanced. The advantages and disadvantages of laser acousto-ultrasonics are outlined. Laser acousto-ultrasonics complements standard piezoelectric acousto-ultrasonics and offers non-contact nondestructive evaluation
Comparative sequence analyses reveal sites of ancestral chromosomal fusions in the Indian muntjac genome
Comparative mapping and sequencing was used to characterize the sites of ancestral chromosomal fusions in the Indian muntjac genome
Wavy Strings: Black or Bright?
Recent developments in string theory have brought forth a considerable
interest in time-dependent hair on extended objects. This novel new hair is
typically characterized by a wave profile along the horizon and angular
momentum quantum numbers in the transverse space. In this work, we
present an extensive treatment of such oscillating black objects, focusing on
their geometric properties. We first give a theorem of purely geometric nature,
stating that such wavy hair cannot be detected by any scalar invariant built
out of the curvature and/or matter fields. However, we show that the tidal
forces detected by an infalling observer diverge at the `horizon' of a black
string superposed with a vibration in any mode with . The same
argument applied to longitudinal () waves detects only finite tidal
forces. We also provide an example with a manifestly smooth metric, proving
that at least a certain class of these longitudinal waves have regular
horizons.Comment: 45 pages, latex, no figure
Author Correction: A consensus-based transparency checklist.
An amendment to this paper has been published and can be accessed via a link at the top of the paper
Status of Muon Collider Research and Development and Future Plans
The status of the research on muon colliders is discussed and plans are
outlined for future theoretical and experimental studies. Besides continued
work on the parameters of a 3-4 and 0.5 TeV center-of-mass (CoM) energy
collider, many studies are now concentrating on a machine near 0.1 TeV (CoM)
that could be a factory for the s-channel production of Higgs particles. We
discuss the research on the various components in such muon colliders, starting
from the proton accelerator needed to generate pions from a heavy-Z target and
proceeding through the phase rotation and decay ()
channel, muon cooling, acceleration, storage in a collider ring and the
collider detector. We also present theoretical and experimental R & D plans for
the next several years that should lead to a better understanding of the design
and feasibility issues for all of the components. This report is an update of
the progress on the R & D since the Feasibility Study of Muon Colliders
presented at the Snowmass'96 Workshop [R. B. Palmer, A. Sessler and A.
Tollestrup, Proceedings of the 1996 DPF/DPB Summer Study on High-Energy Physics
(Stanford Linear Accelerator Center, Menlo Park, CA, 1997)].Comment: 95 pages, 75 figures. Submitted to Physical Review Special Topics,
Accelerators and Beam
Magnetism, FeS colloids, and Origins of Life
A number of features of living systems: reversible interactions and weak
bonds underlying motor-dynamics; gel-sol transitions; cellular connected
fractal organization; asymmetry in interactions and organization; quantum
coherent phenomena; to name some, can have a natural accounting via
interactions, which we therefore seek to incorporate by expanding the horizons
of `chemistry-only' approaches to the origins of life. It is suggested that the
magnetic 'face' of the minerals from the inorganic world, recognized to have
played a pivotal role in initiating Life, may throw light on some of these
issues. A magnetic environment in the form of rocks in the Hadean Ocean could
have enabled the accretion and therefore an ordered confinement of
super-paramagnetic colloids within a structured phase. A moderate H-field can
help magnetic nano-particles to not only overcome thermal fluctuations but also
harness them. Such controlled dynamics brings in the possibility of accessing
quantum effects, which together with frustrations in magnetic ordering and
hysteresis (a natural mechanism for a primitive memory) could throw light on
the birth of biological information which, as Abel argues, requires a
combination of order and complexity. This scenario gains strength from
observations of scale-free framboidal forms of the greigite mineral, with a
magnetic basis of assembly. And greigite's metabolic potential plays a key role
in the mound scenario of Russell and coworkers-an expansion of which is
suggested for including magnetism.Comment: 42 pages, 5 figures, to be published in A.R. Memorial volume, Ed
Krishnaswami Alladi, Springer 201
Dones i sabers : un recorregut per a recuperar el coneixement sobre plantes medicinals a la Vall d'Alinyà
Premi UAB de l'Observatori per a la Igualtat al millor Treball de Fi de Grau amb perspectiva de gènere, per grau i per àmbit de coneixement. 5a Edició, curs 2019-2020En aquest treball s'exposa el coneixement que posseeixen les dones sobre plantes medicinals, així com les seves propietats i remeis; després de molts anys de transmetre's oralment, generació rere generació, està quedant en l'oblit. Històricament, la labor de recol·lecció i, posteriorment, l'ús de les herbes ha estat directament relacionada amb les dones. No obstant, s'observa una mancança de reconeixement per part de la societat; fins i tot jutjant aquests sabers en termes pejoratius. Amb la finalitat de posar en valor aquest coneixement, s'identifiquen 14 plantes medicinals, es realitzen entrevistes tant a dones locals com a expertes, per tal d'obtenir propietats i remeis, i es duu a terme el disseny d'un itinerari botànic dins la ruta de l'Aiguaneix, a la Vall d'Alinyà. És a través de l'elaboració d'una Guia Suport de l'Itinerari que es connecten els objectius anteriors aconseguint reconeixement i, a més a més, documentant part d'aquests sabers. Finalment, considerem que es tracta d'un projecte innovador dins el territori català, ja que hibrida etnobotànica i perspectiva de gènere mitjançant el disseny d'un itinerari botànic. Aquesta eina permet educar i sensibilitzar tant dels límits de recol·lecció com re-apropar a les persones amb els orígens naturals
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