Interfacial bond strength and failure modes of traditional and modern repair materials for historic fibrous plaster

Many culturally important historic buildings contain fibrous plaster ceilings. The collapse at London’s Apollo Theatre in 2013, which injured 88 people, highlighted the importance of inspecting and restoring ceilings effectively. This study focuses on traditional and modern materials which are applied to the topsides of existing historic fibrous plaster ceiling elements during repair and maintenance. Fibrous plaster ceilings are commonly suspended from primary or secondary structural roof members using fibrous plaster wadding ties or ‘wads’. The application of additional repair material requires the formation of an interface, defining the strength of the repair. Properties of this interface were evaluated through a novel methodology employing pull-off tests’ of approximately 200 specimens consisting of Alpha plaster, Beta plaster, Jesmonite and Aramid gel. Notably, the effect of fibrous reinforcement, and compatibility with historic and degraded material was also investigated. This study has enabled quantification of interfacial properties and evaluated cohesive and adhesive failure modes. Importantly, the extent of redundancy within historic plaster ceiling practice has been demonstrated, with pull-off occurring from 0.5 kN to 2 kN loading, and the ductile behaviour of repair materials evaluated. Results highlight the importance of surface condition, with clean surfaces exhibiting double the tensile loading capacity compared to soiled (dirty) surfaces representative of those encountered on-site. The significance of this study lies in the quantification of repair material performances and consideration of variations in performance, methodology and in-situ environmental factors. Impact stems from the ability of practitioners to make informed decisions relating to adhesion performance when carrying out repairs. A key outcome is more effective preservation of historic elements in heritage buildings, higher levels of safety and serviceability.</p

A unidirectional transition from migratory to perivascular macrophage is required for tumor cell intravasation

Summary: Tumor-associated macrophages (TAMs) are critical for tumor metastasis. Two TAM subsets support cancer cell intravasation: migratory macrophages guide cancer cells toward blood vessels, where sessile perivascular macrophages assist their entry into the blood. However, little is known about the inter-relationship between these functionally distinct TAMs or their possible inter-conversion. We show that motile, streaming TAMs are newly arrived monocytes, recruited via CCR2 signaling, that then differentiate into the sessile perivascular macrophages. This unidirectional process is regulated by CXCL12 and CXCR4. Cancer cells induce TGF-β-dependent upregulation of CXCR4 in monocytes, while CXCL12 expressed by perivascular fibroblasts attracts these motile TAMs toward the blood vessels, bringing motile cancer cells with them. Once on the blood vessel, the migratory TAMs differentiate into perivascular macrophages, promoting vascular leakiness and intravasation. : Tumor-associated macrophages (TAMs) are essential for metastasis. Arwert et al. show that, following extravasation, monocytes initially become motile TAMs. Tumor-derived TGF-β then induces CXCR4 on TAMs, stimulating them to migrate toward CXCL12-expressing perivascular fibroblasts. Once adjacent to blood vessels, TAMs differentiate into metastasis-assisting perivascular TAMs. Keywords: tumor associated macrophages, TAMs, TGF beta, breast cancer, metastasis, CXCR4, CCR2, TMEM, Men

'Getting to Know Me': The second phase roll-out of a staff training programme for supporting people with dementia in general hospitals

Objectives The aims were to evaluate a second phase roll-out of a dementia care training programme for general hospital staff and to further develop two outcome scales: the Confidence in Dementia scale for measuring confidence in working with people with dementia and the Knowledge in Dementia scale for measuring knowledge in dementia. Method Following a 'training the trainers' phase, the study involved the delivery of the 'Getting to Know Me' training programme to a large number of staff (n = 517) across three National Health Service (NHS) Trusts situated in North-West England. The impact of the programme was evaluated using a pre-post design which explored: (i) changes in confidence in dementia, (ii) changes in knowledge in dementia, and (iii) changes in beliefs about behaviours that challenge. Results Statistically significant change was identified between pre-post training on all outcome measures (Confidence in Dementia: eight point increase, p < 0.001; Knowledge in Dementia: two point increase p < 0.001; controllability beliefs scale: four point decrease, p < 0.001). Medium to large effect sizes were demonstrated on all outcome measures. The psychometric properties of the Confidence in Dementia and Knowledge in Dementia scales are reported. Conclusion Staff knowledge in dementia and confidence in working with people with dementia significantly increased following attendance at the training sessions. The findings are consistent with preliminary findings and strengthen current knowledge about the impact of dementia care training in general hospitals. The Confidence in Dementia and Knowledge in Dementia scales continue to demonstrate psychometrically sound properties and demonstrate utility in the field of dementia research.The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by, and undertaken as part of, the Health Innovation and Education Cluster (HIEC) programme. The HIEC programme was developed to support the delivery of high quality health care, provide education and training, promote innovation in health care, and lead to adoption of research. One of the main aims of the HIEC programme was to produce sustainable change in practice within the NHS

'Getting to Know Me': the development and evaluation of a training programme for enhancing skills in the care of people with dementia in general hospital settings

OBJECTIVE: The aims of the study were to report on the development and evaluation of a staff training intervention in dementia care designed for use in the general hospital setting: the 'Getting to Know Me' training programme. The study also aimed to undertake initial psychometric analysis on two new outcome scales designed to measure knowledge and confidence in dementia care. METHODS: The study comprised two phases. The first phase comprised the design of two questionnaires which are shared within this paper: Confidence in Dementia (CODE) Scale and Knowledge in Dementia (KIDE) Scale. In phase two, staff undertook the 'Getting to Know Me' training programme (n=71). The impact of the programme was evaluated using a pre-post design which explored: (1) changes in confidence in dementia; (2) changes in knowledge in dementia; and (3) changes in beliefs about challenging behaviour. RESULTS: The psychometric properties of the CODE and KIDE scales are reported. Statistically significant change was identified pre-post training on all outcome measures. Clinically meaningful change was demonstrated on the CODE scale. CONCLUSIONS: The 'Getting to Know Me' programme was well received and had a significant impact on staff knowledge and confidence. Our findings add to a growing evidence base which will be strengthened by further robust studies, the exploration of the impact of staff training on direct patient outcomes, and further identification of ways in which to transfer principles of care from specialist dementia environments into general hospital settings.This study was funded by, and undertaken as part of, the Health Innovation and Education Cluster (HIEC) programme. The HIEC programme was developed to support the delivery of high quality healthcare, provide education and training, promote innovation in healthcare, and lead to adoption of research. One of the main aims of the HIEC programme was to produce sustainable change in practice within the NHS

Treaty of Fort Laramie, 1868 (Kappler)

This 1904 reprint of the Sioux Treaty of 1868, also known as the Treaty of Fort Laramie, 1868, was transcribed and published in vol. II of Charles Kappler’s Indian Affairs. Laws and Treaties. This treaty, between the United States government and the Sioux and Arapaho Nations, established the Great Sioux Reservation, promised the Sioux would own the Black Hills in perpetuity, and set aside the country north of the North Platte River and east of the summits of the Big Horn Mountains as unceded Indian territory. Furthermore, the U.S. government pledged to close the Bozeman Trail forts and provide food, clothing, and annuities to the tribes, given that they agreed to relinquish all rights to live outside the reservation.https://commons.und.edu/indigenous-gov-docs/1176/thumbnail.jp

Treaty Of Fort Laramie 1868

This treaty, signed on April 29, 1868, between the United States government and the Sioux and Arapaho Nations, established the Great Sioux Reservation, promised the Sioux would own the Black Hills in perpetuity, and set aside the country north of the North Platte River and east of the summits of the Big Horn Mountains as unceded Indian territory. Furthermore, the U.S. government pledged to close the Bozeman Trail forts and provide food, clothing, and annuities to the tribes, given that they agreed to relinquish all rights to live outside the reservation.https://commons.und.edu/indigenous-gov-docs/1000/thumbnail.jp

The Type 2 Iodothyronine Deiodinase is Essential for Adaptive Thermogenesis in Brown Adipose Tissue

Type 2 iodothyronine deiodinase (D2) is a selenoenzyme, the product of the recently cloned cAMP-dependent Dio2 gene, which increases 10- to 50-fold during cold stress only in brown adipose tissue (BAT). Here we report that despite a normal plasma 3,5,3′-triiodothyronine (T3) concentration, cold-exposed mice with targeted disruption of the Dio2 gene (Dio2–/–) become hypothermic due to impaired BAT thermogenesis and survive by compensatory shivering with consequent acute weight loss. This occurs despite normal basal mitochondrial uncoupling protein 1 (UCP1) concentration. In Dio2–/– brown adipocytes, the acute norepinephrine-, CL316,243-, or forskolin-induced increases in lipolysis, UCP1 mRNA, and O2 consumption are all reduced due to impaired cAMP generation. These hypothyroid-like abnormalities are completely reversed by a single injection of T3 14 hours earlier. Recent studies suggest that UCP1 is primarily dependent on thyroid hormone receptor β (TRβ) while the normal sympathetic response of brown adipocytes requires TRα. Intracellularly generated T3 may be required to saturate the TRα, which has an approximately fourfold lower T3-binding affinity than does TRβ. Thus, D2 is an essential component in the thyroid-sympathetic synergism required for thermal homeostasis in small mammals

Selitrichodes neseri n. sp, a new parasitoid of the eucalyptus gall wasp Leptocybe invasa Fisher & La Salle (Hymenoptera: Eulophidae: Tetrastichinae)

Selitrichodes neseri Kelly & La Salle n. sp. (Hymenoptera: Eulophidae: Tetrastichinae), is described as a parasitoid of the invasive eucalyptus gall wasp Leptocybe invasa Fisher & La Salle (Hymenoptera: Eulophidae: Tetrastichinae), which is causing substantial damage particularly in commercial Eucalyptus plantations. Selitrichodes neseri was originally collected in Australia in 2010 when searching for biological control agents of L. invasa. It has since been reared in quarantine in South Africa where it is being evaluated for release as a biological control agent of L. invasa.The University of Pretoria, Forestry and Agricultural Biotechnology Institute and the Tree Protection Co-operative Programme.http://www.mapress.com/zootaxa/ab201