Reviews

The Making of a Mystic: New and Selected Letters of Evelyn Underhill. Ed. Carol Poston. Reviewed by Joe R. Christopher. From Girl to Goddess: The Heroine\u27s Journey through Myth and Legend. Valerie Estelle Frankel. Reviewed by Janet Brennan Croft. The Wizard of Oz and Philosophy: Wicked Wisdom of the West (Popular Culture and Philosophy, Vol. 37). Ed. Randall E. Auxier and Phillip S. Seng. Reviewed by Ruth Berman. C.S. Lewis\u27s Lost Aeneid: Arms and the Exile. Edited with an Introduction by A.T. Reyes. Reviewed by Richard C. West. The Ring and the Cross: Christianity and The Lord of the Rings. Edited by Paul E. Kerry. Reviewed by Harley J. Sims. Fastitocalon: Studies in Fantasticism Ancient to Modern. 1.2 (2010). Ed. Thomas Honegger and Fanfan Chen. Reviewed by Janet Brennan Croft. Journal of Inklings Studies. 1.1 (March 2011). Ed. Judith Wolfe. Reviewed by Janet Brennan Croft. VII: An Anglo-American Literary Review. 27 (2010). Ed. Marjorie Lamp Mead. Reviewed by Janet Brennan Croft. Tolkien Studies: An Annual Scholarly Review. 7 (2010). Ed. Douglas A. Anderson, Michael D.C. Drout, and Verlyn Flieger. Reviewed by Janet Brennan Croft. Tolkien and the Study of His Sources: Critical Essays. Edited by Jason Fisher. Reviewed by Mike Foster

Biodiversity 2020: climate change evaluation report

In 2011, the government published Biodiversity 2020: A strategy for England’s wildlife and ecosystem services [1]. This strategy for England builds on the 2011 Natural Environment White Paper - NEWP [2] and provides a comprehensive picture of how we are implementing our international and EU commitments. It sets out the strategic direction for biodiversity policy between 2011-2020 on land (including rivers and lakes) and at sea, and forms part of the UK’s commitments under the ‘the Aichi targets’ agreed in 2010 under the United Nations Convention of Biological Diversity’s Strategic Plan for Biodiversity 2011-2020 [3]. Defra is committed to evaluating the Biodiversity 2020 strategy and has a public commitment to assess climate change adaptation measures. This document sets out the information on assessing how action under Biodiversity 2020 has helped our wildlife and ecosystems to adapt to climate change. Biodiversity 2020 aims to halt the loss of biodiversity and restore functioning ecosystems for wildlife and for people. The outcomes and actions in Biodiversity 2020, although wider in scope, aimed to increase resilience of our wildlife and ecosystems in the face of a changing climate. In order to inform the assessment, we have defined which of the measurable outputs under Biodiversity 2020 contribute to resilience. Biodiversity 2020 included plans to develop and publish a dedicated set of indicators to assess progress towards the delivery of the strategy. The latest list (at the time of writing), published in 2017, contains 24 biodiversity indicators [4] that would help inform progress towards achieving specific outcomes, they are also highly relevant to the outputs (detailed below) that form the basis for this evaluation. The Adaptation Sub-Committee’s 2017 UK Climate Change Risk Assessment Evidence Report [5] sets out the priority climate change risks and opportunities for the UK. The ASC also produced a review of progress in the National Adaptation Programme - “Progress in preparing for climate change” [6], which highlights adaptation priorities and progress being made towards achieving them. The UK Government’s response to the ASC [7] review includes a set of recommendations, of which Recommendation 6 states that “Action should be taken to enhance the condition of priority habitats and the abundance and range of priority species”. The recommendation further iterated that “This action should maintain or extend the level of ambition that was included in Biodiversity 2020” and that “An evaluation should be undertaken of Biodiversity 2020 including the extent to which goals have been met and of the implications for resilience to climate change.” To this, end an evaluation process has been put in place to define: a. What worked and why? Which actions or activities have had the greatest benefit in terms of delivering the desired outcomes? And, conversely, what prevented progress? b. Where are the opportunities? What are the financial, political, scientific and social opportunities for furthering the desired outcomes in the future? These objectives underpin the evaluation process for actions to date, and will also inform future actions and the iteration of a new nature strategy for England

Dynamic Control Flow in Large-Scale Machine Learning

Many recent machine learning models rely on fine-grained dynamic control flow for training and inference. In particular, models based on recurrent neural networks and on reinforcement learning depend on recurrence relations, data-dependent conditional execution, and other features that call for dynamic control flow. These applications benefit from the ability to make rapid control-flow decisions across a set of computing devices in a distributed system. For performance, scalability, and expressiveness, a machine learning system must support dynamic control flow in distributed and heterogeneous environments. This paper presents a programming model for distributed machine learning that supports dynamic control flow. We describe the design of the programming model, and its implementation in TensorFlow, a distributed machine learning system. Our approach extends the use of dataflow graphs to represent machine learning models, offering several distinctive features. First, the branches of conditionals and bodies of loops can be partitioned across many machines to run on a set of heterogeneous devices, including CPUs, GPUs, and custom ASICs. Second, programs written in our model support automatic differentiation and distributed gradient computations, which are necessary for training machine learning models that use control flow. Third, our choice of non-strict semantics enables multiple loop iterations to execute in parallel across machines, and to overlap compute and I/O operations. We have done our work in the context of TensorFlow, and it has been used extensively in research and production. We evaluate it using several real-world applications, and demonstrate its performance and scalability.Comment: Appeared in EuroSys 2018. 14 pages, 16 figure

Is the digital rectal exam any good as a prostate cancer screening test?

© The Author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/There is no shortage of references in popular culture to the prostate examination, with many a laugh built on the punchline of the finger up the bum. Interestingly, while cervical, breast, or bowel screening share barriers to uptake around the intimacy of the examination, ‘ick-factor’, or cultural taboos, they have never become comedy tropes — reflecting the uniquely emasculating perception of the rectal examination.Peer reviewe

The Grizzly, February 2, 1993

Cowboys Tame Buffalo, 52-17 • Upsilon Phi Delta Approved • AIDS Quilt • Al Eaton\u27s We Are the Dream • Day For a King • Power Plays • Bernie Bernie Headflap Wins Battle of the Bands • Lorelei at Chateau Granieri • Ice Skating Fun • The Case of the Disappearing Sevs (Or: Why Collegeville\u27s Most Famous Convenient Mart Upped & Left) • Senior Profile: Chris Kakacek • The New Zack\u27s: Why Hike to WaWa? • What\u27s Up in Wellness • Character was an Issue, Again • The Importance of Effort and A Dream • UC Baseball Preview \u2793 • Gymnasts Hoping For Powerful Season • Lady Bears Make Playoffs • Swimmers Working Hard • Football Awards Banquet Held • Wrestlers Continue Excellence • Men\u27s Basketball Split Twohttps://digitalcommons.ursinus.edu/grizzlynews/1308/thumbnail.jp

A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase

SummaryTelomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughput assay to identify human telomerase inhibitors. The reversibility of growth arrest induced by active human telomerase was assessed against a library of 678 compounds preselected for bioactivity in S. cerevisiae. Four of eight compounds identified reproducibly restored growth to strains expressing active human telomerase, and three of these four compounds also specifically inhibited purified human telomerase in vitro. These compounds represent probes for human telomerase function, and potential entry points for development of lead compounds against telomerase-positive cancers

Impacts of Europe's Changing Climate - 2008 Indicator Based Assessment

Background and objective This report is an update and extension of the 2004 EEA report 'Impacts of Europe's changing climate'. Since 2004, there has been much progress in monitoring and assessing the impacts of climate change in Europe. The objectives of this report are to present this new information on past and projected climate change and its impacts through indicators, to identify the sectors and regions most vulnerable to climate change with a need for adaptation, and to highlight the need to enhance monitoring and reduce uncertainties in climate and impact modelling. To reflect the broadening of coverage of indicators and make use of the best available expertise, the report has been developed jointly by EEA, JRC and WHO Regional Office for Europe. Global developments in science and policy The Intergovernmental Panel on Climate Change (IPCC) in its 4th Assessment report reconfirmed and strengthened earlier scientific findings about key aspects of climate change. Increased monitoring and research efforts have enhanced understanding of climate change impacts and vulnerability. At the 2007 Bali climate change conference, the urgency of responding effectively to climate change through both adaptation and mitigation activities was recognised by a larger number of countries than ever before. The EU has proposed a target of a maximum global temperature increase of 2 °C above the pre-industrial level. A post-Kyoto regime that would include both adaptation and mitigation is expected to be agreed by end of 2009. There has been progress in implementing the Nairobi work programme on impacts, vulnerability and adaptation to climate change, developed to help countries improve their understanding of climate change impacts. European developments in science and policy European research on impacts and vulnerability in the context of national programmes and the 5th and 6th Framework Programmes has advanced considerably, making a major contribution to international assessments such as those of the IPCC, the Arctic Impact Assessment, the UNEP Global Outlook for Ice and Snow and WHO reports. New research programmes focusing on impacts, vulnerability and adaptation are currently being developed in many member countries and in the context of the 7th Framework Programme. On the policy side, the European Commission published its Green Paper on adaptation in 2007, to be followed by a White Paper by the end of 2008 with concrete proposals for action. This report The main part of this report summarises the relevance, past trends and future projections for about 40 indicators (from 22 in the 2004 report). The indicators address atmosphere and climate, the cryosphere, marine systems, terrestrial systems and biodiversity, agriculture and forestry, soil, water quantity (including floods and droughts), water quality and fresh water ecology, and human health. After a brief introduction, several chapters deal in a general way with the changes in the climate system and the observed and projected impacts. The report ends with chapters on adaptation and the economics of climate change impacts and adaptation strategies and policies, and data availability and uncertainty.JRC.H.7-Land management and natural hazard

OpTIIX: An ISS-Based Testbed Paving the Roadmap Toward a Next Generation Large Aperture UV/Optical Space Telescope

The next generation large aperture UV/Optical space telescope will need a diameter substantially larger than even that of JWST in order to address some of the most compelling unanswered scientific quests. These quests include understanding the earliest phases of the Universe and detecting life on exo-planets by studying spectra of their atmospheres. Such 8-16 meter telescopes face severe challenges in terms of cost and complexity and are unlikely to be affordable unless a new paradigm is adopted for their design and construction. The conventional approach is to use monolithic or preassembled segmented mirrors requiring complicated and risky deployments and relying on future heavy-lift vehicles, large fairings and complex geometry. The new paradigm is to launch component modules on relatively small vehicles and then perform in-orbit robotic assembly of those modules. The Optical Testbed and Integration on ISS eXperiment (OpTIIX) is designed to demonstrate, at low cost by leveraging the infrastructure provided by ISS, telescope assembly technologies and end-to-end optical system technologies. The use of ISS as a testbed permits the concentration of resources on reducing the technical risks associated with robotically integrating the components. These include laser metrology and wavefront sensing and control (WFS&C) systems, an imaging instrument, lightweight, low-cost deformable primary mirror segments and the secondary mirror. These elements are then aligned to a diffraction-limited optical system in space. The capability to assemble the optical system and remove and replace components via the existing ISS robotic systems like the Special Purpose Dexterous Manipulator (SPDM), or by the ISS flight crew, allows for future experimentation, as well as repair

Advanced Technology Large-Aperture Space Telescope (ATLAST): A Technology Roadmap for the Next Decade

The Advanced Technology Large-Aperture Space Telescope (ATLAST) is a set of mission concepts for the next generation of UVOIR space observatory with a primary aperture diameter in the 8-m to 16-m range that will allow us to perform some of the most challenging observations to answer some of our most compelling questions, including "Is there life elsewhere in the Galaxy?" We have identified two different telescope architectures, but with similar optical designs, that span the range in viable technologies. The architectures are a telescope with a monolithic primary mirror and two variations of a telescope with a large segmented primary mirror. This approach provides us with several pathways to realizing the mission, which will be narrowed to one as our technology development progresses. The concepts invoke heritage from HST and JWST design, but also take significant departures from these designs to minimize complexity, mass, or both. Our report provides details on the mission concepts, shows the extraordinary scientific progress they would enable, and describes the most important technology development items. These are the mirrors, the detectors, and the high-contrast imaging technologies, whether internal to the observatory, or using an external occulter. Experience with JWST has shown that determined competitors, motivated by the development contracts and flight opportunities of the new observatory, are capable of achieving huge advances in technical and operational performance while keeping construction costs on the same scale as prior great observatories.Comment: 22 pages, RFI submitted to Astro2010 Decadal Committe