5 research outputs found
Desarrollo y evaluaci贸n de microesfera de seda Fibroin cargado de isoniacida
Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge, and hydrophobicity or subsequent in altered drug release profiles. Methods: In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase separation method. Microsphere was evaluated for Ultraviolet-visible spectroscopy, Fourier Transform infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies. Results: Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Entrapment Efficiency of Isoniazid loaded Microspheres of different Formulation from F1 to F5 was in range of 53 to 68 %. F3 showed 68.47 % entrapment Efficiency and the optimized formulation drug release was 93.56 % at 24 hours. Conclusion: Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nano formulation with elaborated studies.Objetivo: La investigaci贸n experimental en curso est谩 dedicada a la preparaci贸n de microesferas de peque帽o tama帽o y buena esfericidad mediante el m茅todo de separaci贸n de fases con isoniazida (INH) como f谩rmaco mod茅lo. La fibroina de seda tiene cualidades intr铆nsecas 煤nicas como la biodegradabilidad, biocompatibilidad o propiedades de liberaci贸n y su capacidad de carga de f谩rmacos ajustable. La aptitud de entrega de carga de las mol茅culas de f谩rmaco en las esferas de seda estar supeditada a su carga, y la hidrofobicidad o subsiguiente alteraci贸n en los perfiles de liberaci贸n de f谩rmacos. M茅todos: En el presente trabajo la microesfera de fibroina de seda cargada de isoniazida fue preparada utilizando el m茅todo de separaci贸n de fases. La microesfera fue evaluada por espectroscopia ultravioleta-visible, espectroscopia infrarroja con transformado de Fourier, se midi贸 la eficiencia de atrapamiento y se estudios mediante microscopia electr贸nica de barrido. Resultados: Estudios con el microscopio de escaneo de electrones revelaron que las microesferas de fibroina cargada de isoniazida eran esf茅ricas. La eficacia de atrapamiento de las microesferas de formulaci贸n diferente de F1 a F5 estuvo en el rango de 53 a 68 %. F3 mostr贸 un 68,47 % de eficiencia de atrapamiento y tras optimizar la formulaci贸n de liberaci贸n de f谩rmacos fue de 93,56 %, a las 24 horas. Conclusi贸n: Esta investigaci贸n revel贸 una nueva formulaci贸n de base acuosa para las esferas de seda con forma controlable o la forma y el tama帽o de la esfera. Las microesferas de seda cargadas de isoniazida pueden actuar como ideal formulaci贸n nano con estudios elaborados
Desarrollo y evaluaci贸n de microesfera de seda Fibroin cargado de isoniacida
Author is also grateful to the CT institute
of pharmaceutical sciences Shahpur,
Jalandhar, Punjab for making available
the research facilities usedObjetivo: La investigaci贸n experimental en curso est谩 dedicada a la preparaci贸n de microesferas de
peque帽o tama帽o y buena esfericidad mediante el m茅todo de separaci贸n de fases con isoniazida (INH)
como f谩rmaco mod茅lo. La fibroina de seda tiene cualidades intr铆nsecas 煤nicas como la biodegradabilidad,
biocompatibilidad o propiedades de liberaci贸n y su capacidad de carga de f谩rmacos ajustable. La
aptitud de entrega de carga de las mol茅culas de f谩rmaco en las esferas de seda estar supeditada a su
carga, y la hidrofobicidad o subsiguiente alteraci贸n en los perfiles de liberaci贸n de f谩rmacos.
M茅todos: En el presente trabajo la microesfera de fibroina de seda cargada de isoniazida fue preparada
utilizando el m茅todo de separaci贸n de fases. La microesfera fue evaluada por espectroscopia ultravioleta-
visible, espectroscopia infrarroja con transformado de Fourier, se midi贸 la eficiencia de atrapamiento
y se estudios mediante microscopia electr贸nica de barrido.
Resultados: Estudios con el microscopio de escaneo de electrones revelaron que las microesferas de
fibroina cargada de isoniazida eran esf茅ricas. La eficacia de atrapamiento de las microesferas de formulaci贸n
diferente de F1 a F5 estuvo en el rango de 53 a 68 %. F3 mostr贸 un 68,47 % de eficiencia de
atrapamiento y tras optimizar la formulaci贸n de liberaci贸n de f谩rmacos fue de 93,56 %, a las 24 horas.
Conclusi贸n: Esta investigaci贸n revel贸 una nueva formulaci贸n de base acuosa para las esferas de seda
con forma controlable o la forma y el tama帽o de la esfera. Las microesferas de seda cargadas de isoniazida
pueden actuar como ideal formulaci贸n nano con estudios elaborados.Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good
sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique
intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug
loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on
their charge, and hydrophobicity or subsequent in altered drug release profiles.
Methods: In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase
separation method. Microsphere was evaluated for Ultraviolet-visible spectroscopy, Fourier Transform
infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies.
Results: Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres
were spherical. Entrapment Efficiency of Isoniazid loaded Microspheres of different Formulation from
F1 to F5 was in range of 53 to 68 %. F3 showed 68.47 % entrapment Efficiency and the optimized formulation
drug release was 93.56 % at 24 hours.
Conclusion: Experimental report disclosed a new aqueous based formulation method for silk spheres
with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nano
formulation with elaborated studies
Intrinsic Medicinal Qualities and Current Status of Curcumin: an Incisive Review
Curcumin is polyphenol product collected from the ground rhizomes of Curcuma Longa, which are commonly known as Turmeric. Curcumin has been procured by solevent extraction of turmeric and the purification of the extract by crystallization method. Traditionally turmeric is used as colouring agent in foods and textiles. Colouring principles are present to an intensity of 3-5 percent in turmeric and lesser amount of oils and resins, proteins, sugars may be naturally present in turmeric. Curcumin is an oily pigment and contains volatile oils like tumerone and zingiberone that are practically insoluble at neutral pH and in water at acidic medium. It is freely soluble in alkali. It is stable in acids and at high temperatures, but unstable in presence of light and in alkaline conditions. It has the poor bioavailability. To improve of bioavailability of curcumin various approaches have been over taken. Curcimin has widely used in ancient Indian medicine to ailment anorexia, diabetic wounds, billary disorders and rheumatism and therapeutically significant for its Antiseptic Activity, Cardiovascular Effects, Anticarcinogenic Effects, Hepatoprotective Effects etc. Recent study showed that curcumin has Anticancer Activity
Matrix Tablet Dosages Form as Most Fascinating Member of Conventional Drug Delivery Sy Tem-a Review
In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosage forms. Disputes like patient consistence, drug focusing on, neighborhood reactions, successive organization and vacillations in blood fixation levels, connected with their partners, the routine measurements structures were amended. Several of the pharmaceutical dosage form are formulated as controlled release dosage form to delay the release of a therapeutic agent such that its appearance in the systemic course is delayed and its plasma profile is managed in term. Tablets offer the least cost way to deal with controlled sustained release dosage forms. Matrix tablet as controlled discharge has given another leap forward for novel medication conveyance framework in the field of pharmaceutical innovation. This review concentrates on the different sorts of lattice frameworks in light of polymer utilized and porosity of network framework i.e. hydrophilic, hydrophobic, fat wax, permeable, non-permeable, pH sensitive
Mouth Dissolving Tablets Highlighting Innovative Techniques and Use of Natural Super Disintegrant- A Concise Review
Mouth dissolving tablets are increasing more conspicuousness as a novel medication conveyance framework and develops as one of the prevalent and broadly acknowledged measurement shapes, particularly for pediatric patients in light of fragmented advancement of solid and sensory system and if there should be an occurrence of geriatric patients experiencing Parkinson's issue or hand tremors, frames like tablets and cases are presently days confronting the issues like dysphagia, bringing about the high incidence of rebelliousness and making the treatment incapable. From both pharmaceutical commercial enterprises as well as patients since they are advantageous to be fabricated and controlled, free of side impacts, offering quick discharge and improve bioavailability, in order to accomplish better patient compliance. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late analyst built up the quick deteriorating tablets with enhanced patient consistence and comfort. Fast dispersible tablets deteriorate either quickly in water, to shape a balanced out suspension, or scatter promptly in the mouth to be gulped without the guide of waters