Desarrollo y evaluación de microesfera de seda Fibroin cargado de isoniacida

Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge, and hydrophobicity or subsequent in altered drug release profiles. Methods: In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase separation method. Microsphere was evaluated for Ultraviolet-visible spectroscopy, Fourier Transform infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies. Results: Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Entrapment Efficiency of Isoniazid loaded Microspheres of different Formulation from F1 to F5 was in range of 53 to 68 %. F3 showed 68.47 % entrapment Efficiency and the optimized formulation drug release was 93.56 % at 24 hours. Conclusion: Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nano formulation with elaborated studies.Objetivo: La investigación experimental en curso está dedicada a la preparación de microesferas de pequeño tamaño y buena esfericidad mediante el método de separación de fases con isoniazida (INH) como fármaco modélo. La fibroina de seda tiene cualidades intrínsecas únicas como la biodegradabilidad, biocompatibilidad o propiedades de liberación y su capacidad de carga de fármacos ajustable. La aptitud de entrega de carga de las moléculas de fármaco en las esferas de seda estar supeditada a su carga, y la hidrofobicidad o subsiguiente alteración en los perfiles de liberación de fármacos. Métodos: En el presente trabajo la microesfera de fibroina de seda cargada de isoniazida fue preparada utilizando el método de separación de fases. La microesfera fue evaluada por espectroscopia ultravioleta-visible, espectroscopia infrarroja con transformado de Fourier, se midió la eficiencia de atrapamiento y se estudios mediante microscopia electrónica de barrido. Resultados: Estudios con el microscopio de escaneo de electrones revelaron que las microesferas de fibroina cargada de isoniazida eran esféricas. La eficacia de atrapamiento de las microesferas de formulación diferente de F1 a F5 estuvo en el rango de 53 a 68 %. F3 mostró un 68,47 % de eficiencia de atrapamiento y tras optimizar la formulación de liberación de fármacos fue de 93,56 %, a las 24 horas. Conclusión: Esta investigación reveló una nueva formulación de base acuosa para las esferas de seda con forma controlable o la forma y el tamaño de la esfera. Las microesferas de seda cargadas de isoniazida pueden actuar como ideal formulación nano con estudios elaborados

Desarrollo y evaluación de microesfera de seda Fibroin cargado de isoniacida

Author is also grateful to the CT institute of pharmaceutical sciences Shahpur, Jalandhar, Punjab for making available the research facilities usedObjetivo: La investigación experimental en curso está dedicada a la preparación de microesferas de pequeño tamaño y buena esfericidad mediante el método de separación de fases con isoniazida (INH) como fármaco modélo. La fibroina de seda tiene cualidades intrínsecas únicas como la biodegradabilidad, biocompatibilidad o propiedades de liberación y su capacidad de carga de fármacos ajustable. La aptitud de entrega de carga de las moléculas de fármaco en las esferas de seda estar supeditada a su carga, y la hidrofobicidad o subsiguiente alteración en los perfiles de liberación de fármacos. Métodos: En el presente trabajo la microesfera de fibroina de seda cargada de isoniazida fue preparada utilizando el método de separación de fases. La microesfera fue evaluada por espectroscopia ultravioleta- visible, espectroscopia infrarroja con transformado de Fourier, se midió la eficiencia de atrapamiento y se estudios mediante microscopia electrónica de barrido. Resultados: Estudios con el microscopio de escaneo de electrones revelaron que las microesferas de fibroina cargada de isoniazida eran esféricas. La eficacia de atrapamiento de las microesferas de formulación diferente de F1 a F5 estuvo en el rango de 53 a 68 %. F3 mostró un 68,47 % de eficiencia de atrapamiento y tras optimizar la formulación de liberación de fármacos fue de 93,56 %, a las 24 horas. Conclusión: Esta investigación reveló una nueva formulación de base acuosa para las esferas de seda con forma controlable o la forma y el tamaño de la esfera. Las microesferas de seda cargadas de isoniazida pueden actuar como ideal formulación nano con estudios elaborados.Aim: Current experimental investigation is dedicated to prepare microspheres with small size and good sphericity by Phase Separation method using Isoniazid (INH) as model drug. Silk fibroin has unique intrinsic qualities like biodegradability, biocompatibility or release properties and their tunable drug loading capacity. The delivery loading proficiency of the drug molecules in silk spheres be contingent on their charge, and hydrophobicity or subsequent in altered drug release profiles. Methods: In the present work Isoniazid loaded silk fibroin microsphere was prepared by using phase separation method. Microsphere was evaluated for Ultraviolet-visible spectroscopy, Fourier Transform infrared spectroscopy, Entrapment efficiency, Scanning electron microscopy Studies. Results: Scanning electron microscopy studies revealed that Isoniazid Loaded Silk Fibroin Microspheres were spherical. Entrapment Efficiency of Isoniazid loaded Microspheres of different Formulation from F1 to F5 was in range of 53 to 68 %. F3 showed 68.47 % entrapment Efficiency and the optimized formulation drug release was 93.56 % at 24 hours. Conclusion: Experimental report disclosed a new aqueous based formulation method for silk spheres with controllable shape or size and sphere. Isoniazid loaded silk microspheres may act as ideal nano formulation with elaborated studies

Intrinsic Medicinal Qualities and Current Status of Curcumin: an Incisive Review

Curcumin is polyphenol product collected from the ground rhizomes of Curcuma Longa, which are commonly known as Turmeric. Curcumin has been procured by solevent extraction of turmeric and the purification of the extract by crystallization method. Traditionally turmeric is used as colouring agent in foods and textiles. Colouring principles are present to an intensity of 3-5 percent in turmeric and lesser amount of oils and resins, proteins, sugars may be naturally present in turmeric. Curcumin is an oily pigment and contains volatile oils like tumerone and zingiberone that are practically insoluble at neutral pH and in water at acidic medium. It is freely soluble in alkali. It is stable in acids and at high temperatures, but unstable in presence of light and in alkaline conditions. It has the poor bioavailability. To improve of bioavailability of curcumin various approaches have been over taken. Curcimin has widely used in ancient Indian medicine to ailment anorexia, diabetic wounds, billary disorders and rheumatism and therapeutically significant for its Antiseptic Activity, Cardiovascular Effects, Anticarcinogenic Effects, Hepatoprotective Effects etc. Recent study showed that curcumin has Anticancer Activity

Matrix Tablet Dosages Form as Most Fascinating Member of Conventional Drug Delivery Sy Tem-a Review

In the present investigation Matrix tablets serves as a vital instrument for oral controlled dosage forms. Disputes like patient consistence, drug focusing on, neighborhood reactions, successive organization and vacillations in blood fixation levels, connected with their partners, the routine measurements structures were amended. Several of the pharmaceutical dosage form are formulated as controlled release dosage form to delay the release of a therapeutic agent such that its appearance in the systemic course is delayed and its plasma profile is managed in term. Tablets offer the least cost way to deal with controlled sustained release dosage forms. Matrix tablet as controlled discharge has given another leap forward for novel medication conveyance framework in the field of pharmaceutical innovation. This review concentrates on the different sorts of lattice frameworks in light of polymer utilized and porosity of network framework i.e. hydrophilic, hydrophobic, fat wax, permeable, non-permeable, pH sensitive

Mouth Dissolving Tablets Highlighting Innovative Techniques and Use of Natural Super Disintegrant- A Concise Review

Mouth dissolving tablets are increasing more conspicuousness as a novel medication conveyance framework and develops as one of the prevalent and broadly acknowledged measurement shapes, particularly for pediatric patients in light of fragmented advancement of solid and sensory system and if there should be an occurrence of geriatric patients experiencing Parkinson's issue or hand tremors, frames like tablets and cases are presently days confronting the issues like dysphagia, bringing about the high incidence of rebelliousness and making the treatment incapable. From both pharmaceutical commercial enterprises as well as patients since they are advantageous to be fabricated and controlled, free of side impacts, offering quick discharge and improve bioavailability, in order to accomplish better patient compliance. Oral course is the most favored course for organization of different medications since it is viewed as most secure, most helpful and temperate course. As of late analyst built up the quick deteriorating tablets with enhanced patient consistence and comfort. Fast dispersible tablets deteriorate either quickly in water, to shape a balanced out suspension, or scatter promptly in the mouth to be gulped without the guide of waters