416 research outputs found
Tik Sebagai Solusi Anak Pecandu Game On-line, E-class Dan Usulan Model Ujian Akhir Nasional Dalam Sudut Pandang Tik
Pemilihan judul diatas tidak hanya relevan dengan konteks kekinian yang ditandai dengan makinbertambahnya korban-korban game on-line terutama di kota-kota besar, tetapi juga terkait dengan upayakita melakukan inovasi pembelajaran khususnya bidang TIK, sehingga pembelajaran menjadi lebihbermakna dan menyenangkan. Selama ini, keberadaan TIK sangat berperan dalam meningkatkan kualitasSDM siswa. Melihat scope TIK yang luas dan terus berkembang, penulis melihat ada kesamaan scope antaraTIK dengan Game on-line, yaitu sama-sama menggunakan komputer. Hanya bedanya, dengan TIK anak bisamenjadiprodusen game, tapi lewat game online, anak hanya sebagai konsumen.Persoalanya adalah ketika Game online sudah tidak lagi berfungsi sebagai media hiburan, tapi lebihke candu bahkan dikomersialkan. Disatu sisi, game online bagus untuk perkembangan otak kanan mereka,namun jika porsinya terlalu besar, kedepannya bisa menghambat karier anak. Jika kompetensi siswa yangdijadikan acuan mutu sistem pendidikan, maka sistem pendidikan yang baik adalah jika inputannyabervariasi tetapi outputannya selalu ‚‘kompeten‘. Artinya sistem pendidikanlah yang mempu menerapi anakpecandu game online. Pengekangan anak, bukanlah solusi , TIK sebenarnya bisa dijadikan altenatif solusimasalah ini. Masalah lain bagi penggemar game online adalah UAN, karena otak kanan cenderung tidakmenyukai keteraturan. Model UAN online, bisa dijadikan alternatif solusi
Patent Trend in Research Centers at Cibinong Science and Technology Park Surrounding for Determining Technology Focus
. Focusing in a specific technology sector would be a great strategy for early developed Science and Technology Park (STP) especially in Indonesia. Each STP has its own concept considering the resources and technology supply. This should be main considerations in determining STP focus. Cibinong Science and Technology Park (CSTP) is surrounded by 4 research centers, and Center for Innovation. Their patent database within 5 years has been studied to determine CSTP focus. By using qualitative method and descriptive analysis, the results showed that the top priority is agriculture, followed by pharmaceutical. Moreover, the strategic areas for development in agriculture sector include: soil working; horticulture; preservation of bodies; and biocides. And in pharmaceutical sub sector includes: preparations for medical, dental, or toilet purposes; specific therapeutic activity of chemical compounds or medicinal preparations; and heterocyclic compounds. Furthermore, China can be a benchmark for technology development in agriculture, while US for technology development in pharmaceutical
Industri Genteng Di Desa Sidoluhur Kecamatan Godean Kabupaten Sleman
Desa Sidoluhur sebagai salah satu contoh pusat industri kecil dan rumah tangga dalam pembuatan genteng yang jumlahnya mencapai 416 unit. Penelitian ini menggunakan pendekatan ekologikal karena memanfaatkan tanah liat sebagai bahan baku dan pengaruh kondisi lingkungan terhadap proses produksi. Penelitian menggunakan metode survei. Responden dalam penelitian ini adalah pengusaha industri genteng di Desa Sidoluhur dengan pertimbangan bahwa wilayah dimana masing-masing bagian terambil sampelnya secara acak disetiap dusun. Jumlah responden yang diambil dengan menggunakan metode proporsional random sampling yaitu sebesar 81 pengusaha. Metode analisis yang digunakan adalah statistika deskriptif dengan dibantu tabel frekuensi dan statistik inferensia dengan dibantu tabel silang dan analisis regresi berganda. Hasil penelitian menunjukan bahwa (1) Desa Sidoluhur menunjukan karakteristik skala industri rumah tangga. (2) Faktor produksi yang paling berpengaruh terhadap jumlah produksi yaitu modal. (3) pendapatan pengusaha dari industri genteng menjadi kemampuan andalan perekonomian pengusaha sebesar 78,75 % dalam pendapatan total pengusaha
Keterdidikan Perempuan Sunda Dalam Cerita Nini Anteh
Penelitian ini berpijak pada fenomena bahwa cerita rakyat memiliki fungsi sistem proyeksi bagi masyarakatnya. Sebagai sosok yang terdapat dalam cerita rakyat Sunda, Nini Anteh dikisahkan sebagai perempuan yang setara dengan laki-laki. Kesetaraan tersebut dibangun melalui keterdidikan Nini Anteh sebagai subjek terdidik sehingga memiliki kesadaran kritis mengenai potensi dan posisinya dalam keluarga dan masyarakat. Tujuan penelitian ini adalah mendeskripsikan keterdidikan perempuan Sunda dalam cerita Nini Anteh yang tampak melalui struktur narasi, konteks, dan fungsi cerita Nini Anteh dengan metode deskriptif kualitatif. Hasil penelitian menunjukkan Nini Anteh sebagai perempuan terdidik mampu mencapai kesetaraan gender, bahkan dirinya mampu mencapai derajat yang tinggi dengan kemandirian yang dimilikinya. Cerita Nini Anteh memiliki fungsi sistem proyeksi yang memposisikan Nini Anteh sebagai sosok subjek terdidik. This research rests on the phenomenon that folklore has function of projection system for their society. As a figure in sundanese folklore, Nini Anteh represented as a symbol of gender equality. The equality is built because Nini Anteh is an educated subject so she has critical awarness about her potential and position in her family and society. The purpose of this research is to describe sundanese women education which appeared in structure of narration, context, amd the function of Nini Anteh Story with descriptive qualitative method. The reseult shows that Nini Anteh as a well educated women achieved gender equality, and also her independency can make her has a high degree as a women. Nini Anteh story having a projection system that positioned her as a well educated subject
Application of Macro and Micro Fertilizers on Upland Rice Crops Inoculation of Biofertilizers in Bengkulu Coastal Land
Coastal land located in the lowlands near the coast has a marginal Entisol soil type. Entisols have the following characteristics: loose soil aggregate, sensitive to erosion, and low levels of nutrients, organic matter, water holding capacity, and soil fertility. The nature of this Entisol is less able to produce maximum upland rice production. The technology used to overcome this problem is by applying macro and micro fertilizers to the soil, which is planted with upland rice seeds, inoculated with biological fertilizers so that it is hoped that upland rice production can be maximized. The purpose of this study was to obtain high upland rice production in coastal areas. The research was carried out from June to December 2020 in Beringin Raya Village, Muara Bangkahulu District, Bengkulu City. The research location is located at coordinates S 03?45'23'' E 102?15'41''. The experimental design used was Completely Randomized Block Design (CRBD) with 2 factors, namely types of fertilizers and varieties of upland rice. The first factor consists of P0 = No fertilizer; P1 = compound micro fertilizer; P2 = Fertilizer recommended for upland rice from the Institute for Agricultural Research and Technology). The second factor consists of V1 = red upland rice; V2 = white upland rice) The results showed that there was an interaction between the type of fertilizer and upland rice varieties on soil pH (KCl 1:2.5 w/v). the interaction of microfertilizers with white upland rice varieties resulted in the highest soil pH (5.06). The best type of fertilizer is micro-compound fertilizer which produces soil pH (KCl 1:2.5 w/v), P nutrient uptake, the highest root colonization and the highest number of production tillers and the highest grain weight per plant and upland rice yield per plot. The best upland rice variety was the white variety which produced the highest uptake of P nutrients, the number of productive tillers, the weight of grain per plant and the highest yield per plot
Increasing Education of Family Support for Decreasing Depression Level Towards Elderly
The elderly was a natural process that can not be avoided. The many changing occurred due to biological aspects, psychological, social, economic, and health. The brain aging process was a part of the degeneration process caused neuropsychological disorder varieties. The present study aimed at analyzing the family support depression level of the elderly before and after being given an education. It used a randomized pre-experimental design with pretest and posttest One Group Only Design (in form of the community trial). The research was conducted in Selemadeg village for 4 months i.e. July to October 2016. The study population was all elderly in Selemadeg village. The sampling techniques with total sampling, which meets the criteria for inclusion and exclusion amounted to 400 people. Based on the data analysis showed that there was the very significant positive difference between family support with the depression level in the elderly before being given education as indicated by the value t < p-value (t = -39.001) and p = 0:01)
Formulation, Development and Characterization of Nateglinide Loaded Nanosponges for the treatment of Type II Diabetes Mellitus
Unfortunately, there are number of potential drug candidates that have poor aqueous solubility is increasing progressively. The invention of Nanosponges has become a significant step towards overcoming these problems.
These small sponges can circulate around the body until they encounter the target site and stick on the surface and began to release the drug in a controlled and predictable manner which is more effective for a particular dosage form.
The purpose of this research was to prepare Nateglinide loaded Nanosponges for controlled release of drug, and to improve the aqueous solubility of nateglinide, reduce dosing frequency and to improve the patient compliance.
Nateglinide is a poorly soluble drug with a short half life, thus selected as a model drug for Nanosponge Drug Delivery System and to release the drug in a controlled manner for prolonged period.
Nateglinide is formulated as Nanosponges by Emulsion Solvent Diffusion method using
Ethyl Cellulose as polymer and Polyvinyl alcohol as a stabilizer.
❖ The physical compatibility of Nateglinide with excipients was studied. The drug and exicipients were physically compatible with each other.
❖ The chemical compatibility studies of Nateglinide with excipients was carried out using FT-IR Spectrometer. It revealed that no interaction between the drug and excipients.
❖ Melting point of drug was determined. It matches with the standard value.
❖ Calibration curve was plotted for Nateglinide and it was found that the solutions show linearity (0.999) and obeyed Beer-Lambert’s law.
❖ Solubility of pure drug was determined. Nateglinide pure drug in distilled water and phosphate buffer pH 6.8 was found to be insoluble.
❖ Formulation study design was developed by using box behnken design (Design Expert (version 8.0.7.1., Stat Ease.,Inc)), the formulation design were predicted and statistically analysed.
❖ The independent variables selected were Ethyl cellulose (A), Polyvinyl alcohol (B) and Stirring speed (C) and the dependent variable choosen were Particle size (Y1), PDI (Y) and Entrapment efficiency (Y3).
❖ The formulations were optimized using Box Behnken design by comparing the predicted values with the observed values.
❖ The design predicted the values of optimized formulation which was then formulated and evaluated.
❖ The optimized formulation was evaluated for FT-IR Study and it is clearly evident that the optimized Nanosponge formulation showed the presence of characteristics bands of Nateglinide. This indicates the absence of chemical interaction between the Nateglinide and the excipients.
❖ The formulated Nateglinide loaded nanosponge was evaluated for their percentage yield and was found to be 96.98%.
❖ The solubility of optimized formulation in distilled water and phosphate buffer pH 6.8 was compared with that of pure drug and concluded that optimized nanosponge shows increased solubility compared to pure drug.
❖ The UV-visible spectrophotometric method was used to determine the drug content of optimized nanosonge formulation. The drug content was found to be 96.91%.
❖ The entrapment efficiency of the optimized formulation was determined and their entrapment efficiency of the formulations was observed to be 90.49%.
❖ The prepared optimized nanosponge shows significantly higher dissolution rate compared to that of pure drug. It was observed that the drug release rate decreased by the concentration of polymer.
❖ In vitro release of optimized formulation showed a rapid initial burst, followed by a very slow drug release.
❖ The optimized formulation were characterized for surface morphology, particle size analysis and zeta potential.
❖ The shape and surface morphology of optimized formulations were observed in SEM.
It shows that the Nanosponges were spherical with numerous pores on their surface, uniform and spongy in nature. The presence of pores may be due to the diffusion of the solvent (dichloromethane).
❖ The particle size distribution and polydispersity were carried out using Horiba Scientific particle size analyzer. The mean particle size and Z average of optimized formulation was found to be 181.4 nm and 264 nm (within nanometric range).
❖ Polydispersity of optimized formulation was found out to be 0.326, indicating uniformity of particle size within formulation.
❖ The zeta potential study was done by zeta sizer. The zeta potential for the optimized formulations was found to be be - 33.7mV which showed that the formulation is stable.
❖ Flow property measurements (Bulk density, Tapped density, Angle of repose, Carr’s index and Hausner’s ratio) were studied for Nateglinde pure drug and optimized Nanosponge. It revealed that the flow property of pure drug was very poor, but the optimized Nanosponge has good flow property.
❖ The release kinetics of the optimized formulations was fitted to various kinetic models and the optimized formulation was best fitted to Zero order kinetics. The zero order kinetics explains the controlled release of the prepared Nanosponges over the period of 12 hours.
❖ Higuchi plot show linearity, which indicates the rate of drug release through the mode of diffusion and the slope of the Korsmeyer Peppas plot (0.636) indicating the diffusion was anomalous diffusion (Non Fickian diffusion).
❖ Thus, the release kinetics of the optimized formulation was best fitted into Higuchi model and showed zero order drug release with Non Fickian diffusion mechanism.
❖ The optimized formulation was subjected to room temperature, accelerated stability study (temperature 40°C±2°C and RH 75±5%) and refrigerator temperature (4±20C).
The results show no significant change in appearance, drug entrapment efficiency and drug content of optimized formulation after one month.
❖ The foregoing results attempt to suggest that for poorly soluble drugs like Nateglinide, Nanosponge approach would be a possible alternative delivery system to conventional oral formulation to improve its bioavailability.
FUTURE PLAN:
• The optimized nateglinide nanosponge can be loaded in capsule and evaluated.
• In vivo studies.
• Pharamcokonetics & Biodistribution studie
Preliminary studies on parasitization potential of Braconid Wasp (Bracon hebetor Say) against certain Lepidopteran insect pest
A study on parasitization percentage of Bracon hebetor Say on certain lepidopteran insect pest on Rice moth (Corcyra cephalonica Stainton), Tomato fruit borer (Helicoverpa armigera Hubner),Tobacco leaf eating caterpillar (Spodoptera litura Fabricius) and okra fruit borer (Earias vitella Fabricius), studied at ordinary room temperature under invitro conditions and revealed that C. cephalonica was the most suitable host for the development of B. hebetor among the host species tested regarding the parasitization percentage was high in C. cephalonica followed by S. litura, H. armigera and E. vitella
Role of Rhizome Powder of Turmeric in the management of Madhumeha w.s.r. to Diabetes Mellitus - A Case Study
Diabetes mellitus is a group of metabolic disorders characterized by chronic hyperglycemia associated with disturbances of carbohydrates, fat, protein metabolism due to absolute or relative deficiency in insulin secretion, that metabolic disorder is considered as the Madhumeha in Ayurveda based on their symptoms. It is one of the types of Vataja Prameha. It results from various etiological factors. Here objective was to evaluate the efficacy of Ayurveda treatment in management of Madhumeha. A 35years old male came to SDM College of Ayurveda Hospital Kayachikitsa special OPD with complaint of Prabhoothamutra, Karapada Daha, Avila Mutrata and Kshudaathi Pravrthi. Examination, investigations and history leads to diabetes mellitus. So patient was treated with Haridra Choorna, Pathya, Apathya and Yogasananas. Ayurveda treatment has effective results in the management of Madhumeha by single drug administration orally
A Review on Gamification in e-learning: Effects and Challenges
Information technology has brought us a great deal of technological advancement, opening up endless possibilities for distance education. E-Learning platforms make it possible to connect people around the globe. Using the various technologies that are available, Gamification enhances the performance of e-learning platforms. Gamification of e-learning platforms helps in providing an engaging learning experience for users of all ages. Applying gamification in a non-gaming environment motivates students and also keeps them engaged in learning. This paper summarizes various game elements such as points, leader boards, badges, provided to the users for better e-learning experience by gamifying the environment and discussing the impact of gamification
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