Plasma properties downstream of a low-power Hall thruster

Triple Langmuir probes and emissive probes were used to measure the electron number density, electron temperature, and plasma potential downstream of a low-power Hall thruster. The results show a polytropic relation between electron temperature and electron number density throughout the sampled region. Over a large fraction of the plume, the plasma potential obeys the predictions of ambipolar expansion. Near the thruster centerline, however, observations show larger gradients of plasma potential than can be accounted for by this means. Radial profiles of plasma potential in the very-near-field plume are shown to contain large gradients that correspond in location to the boundaries of a visually intense plasma region.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/87761/2/123503_1.pd

The Antiferromagnetic Band Structure of La2CuO4 Revisited

Using the Becke-3-LYP functional, we have performed band structure calculations on the high temperature superconductor parent compound, La2CuO4. Under the restricted spin formalism (rho(alpha) equal to rho(beta)), the R-B3LYP band structure agrees well with the standard LDA band structure. It is metallic with a single Cu x2-y2/O p(sigma) band crossing the Fermi level. Under the unrestricted spin formalism (rho(alpha) not equal to rho(beta)), the UB3LYP band structure has a spin polarized antiferromagnetic solution with a band gap of 2.0 eV, agreeing well with experiment. This state is 1.0 eV (per formula unit) lower than that calculated from the R-B3LYP. The apparent high energy of the spin restricted state is attributed to an overestimate of on-site Coulomb repulsion which is corrected in the unrestricted spin calculations. The stabilization of the total energy with spin polarization arises primarily from the stabilization of the x2-y2 band, such that the character of the eigenstates at the top of the valence band in the antiferromagnetic state becomes a strong mixture of Cu x2-y2/O p(sigma) and Cu z2/O' p(z). Since the Hohenberg-Kohn theorem requires the spin restricted and spin unrestricted calculations give exactly the same ground state energy and total density for the exact functionals, this large disparity in energy reflects the inadequacy of current functionals for describing the cuprates. This calls into question the use of band structures based on current restricted spin density functionals (including LDA) as a basis for single band theories of superconductivity in these materials.Comment: 13 pages, 8 figures, to appear in Phys. Rev. B, for more information see http://www.firstprinciples.co

Naturally-derived porphyrin and chlorin photosensitizers for photodynamic therapy

In oncologic applications of photodynamic therapy (PDT), the discriminating localization of porphyrin-type compounds in solid tumors is exploited for the selective ablation of neoplastic tissue with minimal destruction and irritation to normal tissue. PDT is a locoregional, binary cancer therapy in which a photosensitizer—light-activated drug—absorbs light of an appropriate wavelength and excites to the singlet state. This photosensitizer in the excited singlet state can undergo an internal transition to the excited triplet state, a relatively long-lived and high-energy species that transfers its excess energy to molecular oxygen. Molecular oxygen subsequently excites from the stable triplet state to the highly reactive singlet state. With no spin-state restriction, singlet oxygen is cytotoxic, readily reacting with electron-rich biomolecules such as unsaturated lipids, amino acids and DNA consequently destroying the tumor cell. Singlet oxygen has a limited range of diffusion. Therefore, the site of its generation is also the site of initial damage. Mono-L-aspartyl chlorin e6, a chlorophyll a derivative also known as talaporfin and subsequently referred to here as NPe6, is a 2nd-generation photosensitizer currently in advanced-stage clinical trials for PDT. NPe6 is obtained by transesterification of the phytyl ester group of chlorophyll a with a methyl ester group to form pheophorbide a. Subsequent isocyclic ring opening forms chlorin e6 trimethyl ester. Alkaline hydrolysis of the methyl esters and then activation and coupling to a protected aspartic acid followed by deprotections yields NPe6. The structural elucidation of NPe6 has been performed employing a classical methodology of an unambiguous synthesis used adjunctively with modern NMR techniques. The synthesis of NPe6 has been made more efficient via the optimization of the isocyclic ring opening and coupling reaction. Natural reactivities of chlorophyll a derivatives have been exploited to synthesize two regiosomers of NPe6 for biological property investigation. A novel route to a 173 chlorin e6 derivative has been generated. Because to date no chlorin photosensitizers have received FDA approval in the United States, various amino-acid porphyrin conjugates- specifically PPIX conjugates- have been synthesized and their preliminary biological evaluation, which demonstrates that subtle differences in structure can correlate to huge differences in function, is described

Moral Foundations and Student Perceptions of Academic Dishonesty: A Mixed Methods Study

This mixed methods study explored students’ hypothetical choices of behavior in a series of ten academic vignettes. In addition, it examined student judgments of academic behaviors as acceptable or dishonest. Finally, it compared scores on the Moral Foundations Questionnaire-2 to the importance of factors that might influence student behavioral choices in real world scenarios and explored the differences in perceptions among demographic groups. Twenty-five undergraduate students participated in the study. In a semi-structured interview, each student discussed ten academic vignettes: predicting their own hypothetical behavioral choice, judging target behaviors as honest or dishonest, and identifying factors that would most influence their choice of behaviors. Students also completed the Moral Foundations Questionnaire-2. Data analysis showed that most of the ten target behaviors were judged as dishonest by most students; however, some students were willing to engage in behaviors that they had labeled as dishonest. Students’ choices of factors that most influenced their behaviors were weakly positively related to their scores on the Moral Foundations Questionnaire-2. Some differences were found between demographic groups in perceptions, choices, and MFQ-2 scores

Word Recognition for Temporally and Spectrally Distorted Materials:The Effects of Age and Hearing Loss

Objectives: The purpose of Experiment 1 was to measure word recognition in younger adults with normal hearing when speech or babble was temporally or spectrally distorted. In Experiment 2, older listeners with near-normal hearing and with hearing loss (for pure tones) were tested to evaluate their susceptibility to changes in speech level and distortion types. The results across groups and listening conditions were compared to assess the extent to which the effects of the distortions on word recognition resembled the effects of age-related differences in auditory processing or pure-tone hearing loss. Design: In Experiment 1, word recognition was measured in 16 younger adults with normal hearing using Northwestern University Auditory Test No. 6 words in quiet and the Words-in-Noise test distorted by temporal jittering, spectral smearing, or combined jittering and smearing. Another 16 younger adults were evaluated in four conditions using the Words-in-Noise test in combinations of unaltered or jittered speech and unaltered or jittered babble. In Experiment 2, word recognition in quiet and in babble was measured in 72 older adults with near-normal hearing and 72 older adults with hearing loss in four conditions: unaltered, jittered, smeared, and combined jittering and smearing. Results: For the listeners in Experiment 1, word recognition was poorer in the distorted conditions compared with the unaltered condition. The signal to noise ratio at 50% correct word recognition was 4.6 dB for the unaltered condition, 6.3 dB for the jittered, 6.8 dB for the smeared, 6.9 dB for the double-jitter, and 8.2 dB for the combined jitter-smear conditions. Jittering both the babble and speech signals did not significantly reduce performance compared with jittering only the speech. In Experiment 2, the older listeners with near-normal hearing and hearing loss performed best in the unaltered condition, followed by the jitter and smear conditions, with the poorest performance in the combined jitter-smear condition in both quiet and noise. Overall, listeners with near-normal hearing performed better than listeners with hearing loss by ∼30% in quiet and ∼6 dB in noise. In the quiet distorted conditions, when the level of the speech was increased, performance improved for the hearing loss group, but decreased for the older group with near-normal hearing. Recognition performance of younger listeners in the jitter-smear condition and the performance of older listeners with near-normal hearing in the unaltered conditions were similar. Likewise, the performance of older listeners with near-normal hearing in the jitter-smear condition and the performance of older listeners with hearing loss in the unaltered conditions were similar. Conclusions: The present experiments advance our understanding regarding how spectral or temporal distortions of the fine structure of speech affect word recognition in older listeners with and without clinically significant hearing loss. The Speech Intelligibility Index was able to predict group differences, but not the effects of distortion. Individual differences in performance were similar across all distortion conditions with both age and hearing loss being implicated. The speech materials needed to be both spectrally and temporally distorted to mimic the effects of age-related differences in auditory processing and hearing loss

Simulation of a Hall Effect Thruster with Krypton Propellant

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/143098/1/6.2017-4633.pd

Across-talker effects on non-native listeners' vowel perecption in noise

Journal ArticleThis study explored how across-talker differences influence non-native vowel perception. American English (AE) and Korean listeners were presented with recordings of 10 AE vowels in /bVd/ context. The stimuli were mixed with noise and presented for identification in a 10-alternative forced-choice task. The two listener groups heard recordings of the vowels produced by 10 talkers at three signal-to-noise ratios. Overall the AE listeners identified the vowels 22% more accurately than the Korean listeners. There was a wide range of identification accuracy scores across talkers for both AE and Korean listeners. At each signal-to-noise ratio, the across-talker intelligibility scores were highly correlated for AE and Korean listeners. Acoustic analysis was conducted for 2 vowel pairs that exhibited variable accuracy across talkers for Korean listeners but high identification accuracy for AE listeners. Results demonstrated that Korean listeners? error patterns for these four vowels were strongly influenced by variability in vowel production that was within the normal range for AE talkers. These results suggest that non-native listeners are strongly influenced by across-talker variability perhaps because of the difficulty they have forming native-like vowel categories

Mindfulness-Based Cognitive Therapy (MBCT) For Health Anxiety (Hypochondriasis): Rationale, Implementation and Case Illustration.

Recent research has shown that mindfulness-based cognitive therapy (MBCT) could be a useful alternative approach to the treatment of health anxiety and deserves further investigation. In this paper, we outline the rationale for using MBCT in the treatment of this condition, namely its hypothesised impact on the underlying mechanisms which maintain health anxiety, such as rumination and avoidance, hypervigilance to body sensations and misinterpretation of such sensations. We also describe some of the adaptations which were made to the MBCT protocol for recurrent depression in this trial and discuss the rationale for these adaptations. We use a case example from the trial to illustrate how MBCT was implemented and outline the experience of one of the participants who took part in an 8-week MBCT course. Finally, we detail some of the more general experiences of participants and discuss the advantages and possible limitations of this approach for this population, as well as considering what might be useful avenues to explore in future research