The future of public sector funding of regeneration project in England

This report describes the policy framework through which urban regeneration is promoted and highlights the difficulties encountered in co-ordinating the current public funding initiatives to secure effective urban regeneration and maximise value for money

Paraphilias: definition, diagnosis and treatment

There is a great deal of controversy concerning paraphilia, and defining what is normal versus deviant or disordered, given that this is to some degree dependent on cultural views of acceptability. In this article, we outline these issues and describe recent progress in diagnosing and treating paraphilias

Evaluation of a programme of transferable skills development within the PhD: views of late stage students

Recent years have seen an increasing emphasis placed upon the development of transferable skills within PhD degree programmes. This paper reports on steps taken to evaluate a programme of transferable skills development at a research intensive university in the UK, focussing on the views of late stage PhD students in the science, engineering and medical disciplines. It shows that most students report a positive impact from having taken part in transferable skills initiatives and that they have a positive attitude towards them. Participants report an enduring positive impact on their behaviour and consider that the training meets their perceived needs as they progress as researchers. However, amongst the population as a whole, there were differences in views. For example, it was found that females, overseas students and those mainly motivated to do the PhD by career-related reasons attach the greatest importance to such opportunities to develop transferable skills

A Comparison of the NZTM and FPS Models of the New Zealand Economy

This paper investigates and compares the dynamic properties of the New Zealand Treasury model (NZTM) and the current version of the Reserve Bank’s Forecasting and Policy System model (FPS). The main use of both two models is to produce macroeconomic forecasts. The NZTM model produces forecasts that are used as an input into the final forecast numbers presented in the Economic and Fiscal Updates. The FPS model is used to produce the published forecasts in the Reserve Bank’s quarterly Monetary Policy Statement. Both models contain a number of judgements around the structure of the economy, the key shocks that impact on the economy, and how the economy evolves in response to these shocks. The paper concludes that one of the main differences between the two models occurs in the impact of a world price shock on the real exchange rate and subsequently on exports and imports. Another key difference is the mechanism through which the net foreign asset position returns towards equilibrium. In FPS, the external balance is partly attained by forward-looking consumers who adjust spending to reach desired wealth positions. In contrast, the real exchange rate is the key mechanism in NZTM for re-establishing equilibrium.New Zealand; NZTM; FPS; Macroeconomic forecasts; Net foreign asset position; forwarding-looking consumers; Real exchange rate

‘A productive and happy collaboration’: maximising impact through project design

This case study describes a highly collaborative project created to develop an online self-assessment tool that offers students the opportunity to plan their preparedness to enter the work place named the Preparation for Placement Assessment Tool. The aim of the project was to develop an artefact that aidsall students to think about and prepare for placements, and more broadly to be work-ready. It also aims to help disabled students to identify and manage their individual needs. Working in collaboration with students is offered as an effective strategy for improving project outcomes and managing the tensions for academics of balancing research, teaching, learning and scholarly activities.This paper discusses the project background, design and delivery, which includes the engagement of a diverse mix of students, and the practice research methodologies used. Discussion focuses on the project’s impact, particularly on the students involved. Four key factors: student power, methodology, the use of funding and slow burn are identified as significant for success

The fungal ecology of seabird nesting sites in the Falkland Islands indicates a niche for mycoparasites

Our work is supported by the BBSRC (BB/M010996/1, BB/N005058/1, BB/P020224/1) (JH, PvW), NERC (NE/P007570/1) (PvW), The South Atlantic Environmental Research Institute (SAERI) (JH) and the University of Aberdeen (PvW). We would like to thank the Pole-Evans family for giving us permission to sample on their land.Peer reviewedPostprin

The Cytochrome P450 Inhibitor, Ketoconazole, Inhibits Oxidized Linoleic Acid Metabolite-Mediated Peripheral Inflammatory Pain

BACKGROUND: Oxidized linoleic acid metabolites (OLAMs) are a class of endogenous agonists to the transient receptor potential V1 (TRPV1) receptor. Although TRPV1 mediates inflammatory heat hyperalgesia, it is not known if the OLAMs contribute to the peripheral activation of this receptor during tissue inflammation. In the present study, we evaluated whether the OLAM system is activated during inflammation and whether cytochrome P450 enzymes mediate OLAM contributions to heat hyperalgesia using the complete Freund’s adjuvant (CFA) model of inflammation. RESULTS: Our results demonstrate that the intraplantar (ipl) injection of anti-OLAM antibodies significantly reversed CFA-induced heat hyperalgesia. Moreover, application of lipid extracts from inflamed rat skin to cultured sensory neurons triggered a significant release of iCGRP that is blocked by co-treatment with I-RTX, a TRPV1 antagonist. To determine the role of CYP enzymes in mediating OLAM effects, we used a broad spectrum CYP inhibitor, ketoconazole. Pretreatment with ketoconazole inhibited the release of TRPV1 agonists in lipid extracts from inflamed skin and significantly reversed CFA-induced heat hyperalgesia by a peripheral mechanism of action. Moreover, the ipl injection of linoleic acid to rats 24 hr after CFA evoked spontaneous nocifensive behaviors that were significantly reduced by capsazepine, by knockout of the TRPV1 gene, or by pretreatment with either anti-OLAM antibodies or ketoconazole. CONCLUSIONS: Taken together, our data suggests that OLAMs contribute to inflammatory nociception in the periphery and that cytochrome P450 enzymes play a crucial role in mediating OLAM contributions to inflammatory heat hyperalgesia

Research Review: Early Childhood and the ‘Intergenerational Cycle of Domestic Violence’

This rapid evidence review was commissioned by the NSPCC to increase our understanding of the complex surrounding the evidence about domestic violence and the potential for this to impact on children's own violent behaviour, and any evidence of effectiveness of targeted interventions aimed at young families

A combined microfinance and training intervention can reduce HIV risk behaviour in young female participants.

OBJECTIVE: To assess effects of a combined microfinance and training intervention on HIV risk behavior among young female participants in rural South Africa. DESIGN: : Secondary analysis of quantitative and qualitative data from a cluster randomized trial, the Intervention with Microfinance for AIDS and Gender Equity study. METHODS: Eight villages were pair-matched and randomly allocated to receive the intervention. At baseline and after 2 years, HIV risk behavior was assessed among female participants aged 14-35 years. Their responses were compared with women of the same age and poverty group from control villages. Intervention effects were calculated using adjusted risk ratios employing village level summaries. Qualitative data collected during the study explored participants' responses to the intervention including HIV risk behavior. RESULTS: After 2 years of follow-up, when compared with controls, young participants had higher levels of HIV-related communication (adjusted risk ratio 1.46, 95% confidence interval 1.01-2.12), were more likely to have accessed voluntary counseling and testing (adjusted risk ratio 1.64, 95% confidence interval 1.06-2.56), and less likely to have had unprotected sex at last intercourse with a nonspousal partner (adjusted risk ratio 0.76, 95% confidence interval 0.60-0.96). Qualitative data suggest a greater acceptance of intrahousehold communication about HIV and sexuality. Although women noted challenges associated with acceptance of condoms by men, increased confidence and skills associated with participation in the intervention supported their introduction in sexual relationships. CONCLUSIONS: In addition to impacts on economic well being, women's empowerment and intimate partner violence, interventions addressing the economic and social vulnerability of women may contribute to reductions in HIV risk behavior

The Consequences of the COVID-19 Lockdown on Stalking Victimisation

Stalking involves repeated unwanted communication, harassment, and intrusive behaviour. This brief report draws on a service evaluation undertaken immediately prior to and during the 2020 COVID-19 crisis. The pandemic creates a paradox when considering safety in the home, but it is important to recognise the dangers this presents to many victims of stalking. The information presented in this report is based on existing literature and early evidence from semi-structured interviews and discussions with 15 victims and six practitioners. Whilst lockdown measures might appear to be a time when victims are less accessible to their stalkers, early evidence from this study suggests that their vulnerability is increased. Technology has helped to facilitate stalking behaviours by providing stalkers with new approaches to control, humiliate, threaten and isolate their victims. Some lockdown restrictions have provided increased opportunities for stalkers to monitor their victims and the professional uncertainty and recognition around stalking has continued, coupled with delays in the criminal justice system. The COVID-19 crisis has reversed gains made by stalking victims and has imprisoned some victims in their homes making their whereabouts easier to monitor. Stalking behaviour has not ceased as a result of the COVID-19 restrictions and the risk of harm to victims remains significant. Effective practice, policy and legal responses are required for both the victims and perpetrators of stalking during the pandemic and afterwards