Sex, Gender, Sexuality and the Law: social and legal issues facing individuals, couples and families

In the past decade, people whose bodies, genders or sexualities differ from socially expected norms have become more visible and have been granted greater recognition within the law. Yet despite this, many service providers do not have a strong understanding of the social and legal issues that continue to have a significant impact on these diverse groups of people and their relationships and families. In order to address this knowledge gap, this book brings together research findings from often disparate disciplines into an accessible and useful form for practitioners, as well as for researchers, academics, students, and the general public. Part one defines key terms, and addresses the psychosocial and legal issues faced by trans or gender diverse, intersex, and/or non-heterosexual individuals. Part two looks at the psychosocial and legal aspects of couple relationships. Part three considers parenting and families. Part four discusses practical tips for professionals working with this client group, including specific content for lawyers and mediators. As a whole, this book both questions the presumed neutrality of the law, yet insists that it is possible for the law to play a key role in challenging cisgenderism and heterosexism

Planning Library Promotions: An Idea Workshop

Planning library promotions: An idea workshop Anyone who works with social media or marketing events and programs for their library knows that it can be hard to keep the creative juices flowing. During the course of this workshop we will: Engage in creativity boosting exercises and activities Brainstorm ideas, activities, and resources Discuss the importance of planning cross-channel promotions Learn how to spot opportunities to promote the work of other organizations and promotions from other organizations that can be shared Learn from each other’s experiences of the difficulties and triumphs of working with social media Whether you are running the one-person social media show or working with a team, this workshop will give you the tools you need to design unique and eye-catching promotions without breaking the bank or spending hours on one post

Peace Revolution’s Online Social Platform: From Inner Revolution to Global Evolution of Ethical Media Production

This paper describes a project called Peace Revolution [http://peacerevolution.net], which provides an opportunity for young people from around the world to learn and share positive messages and activities relating to peace. The Peace Revolution project aims to empower young people via a unique process related to youth development, helping young people to make informed and moral choices about how they live their lives and actively participate in society. Through its online social platform, Peace Revolution aims to promote the practice of inner peace as a common denominator for people throughout the world, build cross-cultural partnerships and ultimately, through individual change and cooperation with others, establish an international network of active agents for change

A aplicação do jogo Jukugeemu : é possível aprender vocabulário e ideogramas de língua japonesa jogando?

Dissertação (mestrado)—Universidade de Brasília, Instituto de Letras, Departamento de Línguas Estrangeiras e Tradução, Programa de Pós-Graduação em Linguística Aplicada, 2019.Esta dissertação consiste em um estudo quali-quantitativo da aplicabilidade do jogo jukugeemu como ferramenta de aquisição de ideogramas e vocabulário em língua japonesa. Buscando para isso coletar dados quantitativos referentes à experiência do jogar com o jogo e dados qualitativos acerca de sua experiência, percepções e crenças acerca da aplicabilidade do jogo. Para isso um total de 41 participantes se prontificaram em diferentes etapas de coleta, resultando num total de 199 partidas observadas, bem como as opiniões qualitativas de 31 jogadores. Os objetivos desta investigação foram verificar se existe uma correlação entre o desempenho no jogo e tempo de estudo da língua japonesa, ou a familiaridade com jogos eletrônicos. Também foi observada a correlação entre a percepção de satisfação com o jogo e o tempo de estudo no idioma. Além disso foram observadas as crenças e percepções acerca do jogo e sua aplicabilidade. O aporte teórico foi dividido em dois grandes grupos. O de aquisição de um novo sistema de escrita (BASSETTI; COOK, 2005; BASSETTI, 2006) e a aquisição do sistema de escrita de ideogramas japonês (FILHO, 2006; FRELLESVIG, 2010; IWAKAMI, 1992; KESS; MIYAMOTO, 1999; OLIVEIRA, 2013; OGASSAWARA, 2006), e o aprendizado mediado por jogos eletrônicos (GEE, 2003; SALEN; ZIMMERMAN, 2003; PETRY, 2016; PRESNKY, 2001), sua possibilidade de analogia com fatores humanos e sociais (HUIZINGA, 1999) e sua aplicabilidade à aquisição do idioma japonês (DEHAAN, 2005a; 2005b; 2013; DEHAAN; REED; KUWADA, 2010). Para a análise de dados utilizou-se um aporte teórico tanto quantitativo (FONSECA, 2002; GATTI, 2004) quanto qualitativo (MINAYO, DESLANDES, et al., 2002) lançando mão dos seguintes instrumentos de coleta de dados a) o próprio jogo jukugeemu e sua criação de históricos de partida, b) observação não participante, c) questionário online e d) entrevista semiestruturada. Os resultados obtidos indicam a existência de uma correlação fraca entre o desempenho no jogo e o tempo de estudo em língua japonesa ou a familiaridade com jogos eletrônicos. As análises também indicam uma fraca correlação entre a percepção de satisfação e o tempo de estudo em língua japonesa. Além disso a pesquisa mostra que o jogo aparenta ser benéfico à aquisição de ideogramas e palavras em língua japonesa, especialmente ideogramas, por propiciar um ambiente de testagem de hipóteses com feedback imediato que pode possibilitar o desenvolvimento do pensamento crítico.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES).This essay consists in a quali-quantitative study of the applicability of the game jukugeemu as a tool for Japanese language’s vocabulary and ideogram acquisition. Looking into collecting quantitative data regarding the experience of playing the game and qualitative data about the experience, perception and beliefs related to the applicability of the game. For such a total of 41 participants volunteered in different steps of the data collection, resulting in a total of 199 observed matches, as well as the qualitative insights of 31 players. The goals of this investigation were to identify if there is a correlation between the performance in game and the time of studies in Japanese language, or the familiarity with electronic games. It was also noted the correlation between the perception of enjoyment with the game and the time of studies in the language, likewise it was observed the beliefs and perceptions regarding the game and its applicability. The theoretical input was divided in two major groups. One for the acquisition of a new writing system (BASSETTI; COOK, 2005; BASSETTI, 2006) and the acquisition of the Japanese ideogram-based system of writing (FILHO, 2006; FRELLESVIG, 2010; IWAKAMI, 1992; KESS; MIYAMOTO, 1999; OLIVEIRA, 2013; OGASSAWARA, 2006), and another for the learning mediated through electronic gaming (GEE, 2003; SALEN; ZIMMERMAN, 2003; PETRY, 2016; PRESNKY, 2001), its possible analogy to social and human factors (HUIZINGA, 1999), and its applicability towards the acquiring of the Japanese language (DEHAAN, 2005a; 2005b; 2013; DEHAAN; REED; KUWADA, 2010). For the data analysis the theoretical input used was both quantitative (FONSECA, 2002; GATTI, 2004) and qualitative (MINAYO, DESLANDES, et al., 2002) by means of the following data collecting tools a) the jukugeemu itself through the creation of a match-history library, b) bystander observation, c) online questionnaire and d) semi-structured interview. The obtained results indicate that there is a weak correlation among the performance in game and the time of studies in Japanese language or familiarity with electronic games. The analysis have also indicated a weak connection between the perceived enjoyment and the time of studies in Japanese language. Besides that the research has shown that the game seems to be beneficial to the acquisition of Japanese ideogram and words, especially ideogram, due to providing an environment of hypothesis testing, with immediate feedback which can allow the development of critical thinking

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Critical cancer pathways often cannot be targeted because of limited efficiency crossing cell membranes. Here we report the development of a Salmonella-based intracellular delivery system to address this challenge. We engineer genetic circuits that (1) activate the regulator flhDC to drive invasion and (2) induce lysis to release proteins into tumor cells. Released protein drugs diffuse from Salmonella containing vacuoles into the cellular cytoplasm where they interact with their therapeutic targets. Control of invasion with flhDC increases delivery over 500 times. The autonomous triggering of lysis after invasion makes the platform self-limiting and prevents drug release in healthy organs. Bacterial delivery of constitutively active caspase-3 blocks the growth of hepatocellular carcinoma and lung metastases, and increases survival in mice. This success in targeted killing of cancer cells provides critical evidence that this approach will be applicable to a wide range of protein drugs for the treatment of solid tumors

Prenatal THC Exposure Induces Sex-Dependent Neuropsychiatric Endophenotypes in Offspring and Long-Term Disruptions in Fatty-Acid Signaling Pathways Directly in the Mesolimbic Circuitry

Despite increased prevalence of maternal cannabis use, little is understood regarding potential long-term effects of prenatal cannabis exposure (PCE) on neurodevelopmental outcomes. While neurodevelopmental cannabis exposure increases the risk of developing affective/mood disorders in adulthood, the precise neuro-pathophysiological mechanisms in male and female offspring are largely unknown. Given the interconnectivity of the endocannabinoid (ECb) system and the brain’s fatty acid pathways, we hypothesized that prenatal exposure to ∆9-tetrahydrocannabinol (THC) may dysregulate fetal neurodevelopment through alterations of fatty-acid dependent synaptic and neuronal function in the mesolimbic system. To investigate this, pregnant Wistar rats were exposed to vehicle or THC (3 mg/kg) from gestational day (GD)7 until GD22. Anxiety-like, depres-sive-like, and reward-seeking behavior, electrophysiology, and molecular assays were performed on adult male/female offspring. Imaging of fatty acids using matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI IMS) was performed at prepubescence and adulthood. We report that PCE induces be-havioral, neuronal, and molecular alterations in the mesolimbic system in male and female offspring, resem-bling neuropsychiatric endophenotypes. Additionally, PCE resulted in profound dysregulation of critical fatty acid pathways in the developing brain lipidome. Female progeny exhibited significant alterations to fatty acid levels at prepubescence but recovered from these deficits by early adulthood. In contrast, males exhibited persistent fatty acid deficits into adulthood. Moreover, both sexes maintained enduring abnormalities in gluta-matergic/GABAergic function in the nucleus accumbens (NAc). These findings identify several novel long-term risks of maternal cannabis use and demonstrate for the first time, sex-related effects of maternal cannabinoid exposure directly in the developing neural lipidome

Dual Mechanism of Interleukin-3 Receptor Blockade by an Anti-Cancer Antibody

SummaryInterleukin-3 (IL-3) is an activated T cell product that bridges innate and adaptive immunity and contributes to several immunopathologies. Here, we report the crystal structure of the IL-3 receptor α chain (IL3Rα) in complex with the anti-leukemia antibody CSL362 that reveals the N-terminal domain (NTD), a domain also present in the granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-5, and IL-13 receptors, adopting unique “open” and classical “closed” conformations. Although extensive mutational analyses of the NTD epitope of CSL362 show minor overlap with the IL-3 binding site, CSL362 only inhibits IL-3 binding to the closed conformation, indicating alternative mechanisms for blocking IL-3 signaling. Significantly, whereas “open-like” IL3Rα mutants can simultaneously bind IL-3 and CSL362, CSL362 still prevents the assembly of a higher-order IL-3 receptor-signaling complex. The discovery of open forms of cytokine receptors provides the framework for development of potent antibodies that can achieve a “double hit” cytokine receptor blockade

Using haloperidol as an anti-emetic in palliative care: informing practice through evidence from cancer treatment and post-operative contexts

YesNausea and vomiting are common symptoms in palliative care. Haloperidol is often used as an antiemetic in this context, although direct evidence supporting this practice is limited. To evaluate the efficacy and clinical use of haloperidol as an antiemetic in nonpalliative care contexts to inform practice, the authors conducted a rapid review of (i) published evidence to supplement existing systematic reviews, and (ii) practical aspects affecting the use of haloperidol including formulations and doses that are commonly available internationally. In nausea and vomiting related to cancer treatment, haloperidol was superior to control in two small studies. In postoperative nausea and vomiting (PONV), two randomized controlledtrials found treatment with haloperidol comparable to ondansetron. In palliative care, an observational study found a complete response rate of 24% with haloperidol (one in four patients) which would be consistent with a number needed to treat (NNT) of 3 to 5 derived from PONV. There remains insufficient direct evidence to definitively support the use of haloperidol for the management of nausea and vomiting in palliative care. However, generalizing evidence from other clinical contexts may have some validity