1,732 research outputs found
3D Printable Sensorized Soft Gelatin Hydrogel for Multi-Material Soft Structures
The ability to 3D print soft materials with integrated strain sensors enables significant flexibility for the design and fabrication of soft robots. Hydrogels provide an interesting alternative to traditional soft robot materials, allowing for more varied fabrication techniques. In this work, we investigate the 3D printing of a gelatin-glycerol hydrogel, where transglutaminase is used to catalyse the crosslinking of the hydrogel such that its material properties can be controlled for 3D printing. By including electron-conductive elements (aqueous carbon black) in the hydrogel we can create highly flexible and linear soft strain sensors. We present a first investigation into adapting a desktop 3D printer and optimizing its control parameters to fabricate sensorized 2D and 3D structures which can undergo >300% strain and show a response to strain which is highly linear and synchronous. To demonstrate the capabilities of this material and fabrication approach, we produce some example 2D and 3D structures and show their sensing capabilities
Usefulness of standard plasma coagulation tests in the management of perioperative coagulopathic bleeding: is there any evidence?
Standard laboratory coagulation tests (SLTs) such as prothrombin time/international normalized ratio or partial thromboplastin time are frequently used to assess coagulopathy and to guide haemostatic interventions. However, this has been challenged by numerous reports, including the current European guidelines for perioperative bleeding management, which question the utility and reliability of SLTs in this setting. Furthermore, the arbitrary definition of coagulopathy (i.e. SLTs are prolonged by more than 1.5-fold) has been questioned. The present study aims to review the evidence for the usefulness of SLTs to assess coagulopathy and to guide bleeding management in the perioperative and massive bleeding setting. Medline was searched for investigations using results of SLTs as a means to determine coagulopathy or to guide bleeding management, and the outcomes (i.e. blood loss, transfusion requirements, mortality) were reported. A total of 11 guidelines for management of massive bleeding or perioperative bleeding and 64 studies investigating the usefulness of SLTs in this setting were identified and were included for final data synthesis. Referenced evidence for the usefulness of SLTs was found in only three prospective trials, investigating a total of 108 patients (whereby microvascular bleeding was a rare finding). Furthermore, no data from randomized controlled trials support the use of SLTs. In contrast, numerous investigations have challenged the reliability of SLTs to assess coagulopathy or guide bleeding management. There is actually no sound evidence from well-designed studies that confirm the usefulness of SLTs for diagnosis of coagulopathy or to guide haemostatic therap
Quantum tunneling dynamics of an interacting Bose-Einstein condensate through a Gaussian barrier
The transmission of an interacting Bose-Einstein condensate incident on a
repulsive Gaussian barrier is investigated through numerical simulation. The
dynamics associated with interatomic interactions are studied across a broad
parameter range not previously explored. Effective 1D Gross-Pitaevskii equation
(GPE) simulations are compared to classical Boltzmann-Vlasov equation (BVE)
simulations in order to isolate purely coherent matterwave effects. Quantum
tunneling is then defined as the portion of the GPE transmission not described
by the classical BVE. An exponential dependence of transmission on barrier
height is observed in the purely classical simulation, suggesting that
observing such exponential dependence is not a sufficient condition for quantum
tunneling. Furthermore, the transmission is found to be predominately described
by classical effects, although interatomic interactions are shown to modify the
magnitude of the quantum tunneling. Interactions are also seen to affect the
amount of classical transmission, producing transmission in regions where the
non-interacting equivalent has none. This theoretical investigation clarifies
the contribution quantum tunneling makes to overall transmission in
many-particle interacting systems, potentially informing future tunneling
experiments with ultracold atoms.Comment: Close to the published versio
Optically guided linear Mach Zehnder atom interferometer
We demonstrate a horizontal, linearly guided Mach Zehnder atom interferometer
in an optical waveguide. Intended as a proof-of-principle experiment, the
interferometer utilises a Bose-Einstein condensate in the magnetically
insensitive |F=1,mF=0> state of Rubidium-87 as an acceleration sensitive test
mass. We achieve a modest sensitivity to acceleration of da = 7x10^-4 m/s^2.
Our fringe visibility is as high as 38% in this optically guided atom
interferometer. We observe a time-of-flight in the waveguide of over half a
second, demonstrating the utility of our optical guide for future sensors.Comment: 6 pages, 3 figures. Submitted to Phys. Rev.
Eclogites and basement terrane tectonics in the northern arm of the Grenville orogen, NW Scotland
The presence of eclogites within continental crust is a key indicator of collisional orogenesis. Eclogites within the Eastern Glenelg basement inlier of the Northern Highland Terrane (NHT) have been re-dated in order to provide more accurate constraints on the timing of collision within the northern arm of the Grenville Orogen. The eclog-ites yield dates of ca.1200 Ma which are interpreted to record the onset of continent-continent interaction, and the NHT as a whole is thought to represent the lower plate in successive 1200-1000 Ma collision events. The Eastern Glenelg basement inlier is viewed as a fragment of the leading edge of the NHT continental basement that was partially subducted along a suture and then exhumed back up the subduction channel. Differences in ages of igneous protoliths and intrusive histories, and metamorphic events (this paper) between the NHT basement and the Laurentian foreland, suggests that they were separate crustal blocks until after ca. 1600 Ma. We therefore suggest that: (1) the NHT represents a fragment of Archean-Paleoproterozoic crust that was reworked within the ca. 1.7-1.6 Ga Labradorian-Gothian belt, although whether it was derived from Laurentia or Baltica is uncertain, and (2) amalgamation of the NHT with the Laurentian foreland did not occur until the terminal stages of the Grenville collision at ca. 1000 Ma
The Impact of Same Gender Speed-Mentoring on Women's Perceptions of a Career in Surgery â A Prospective Cohort Study
BACKGROUND: Mentoring is critically important for the personal and professional development of a surgeon. Early career stage mentoring by same-gender role models may help ameliorate the gender imbalance in surgery based on our understanding of barriers for women pursuing surgical careers. A novel method of establishing these relationships is speed mentoring. This study aims to examine the impact of a one-day speed-mentoring session with same gender mentors on a cohort's perceptions of a career in surgery. DESIGN: This prospective pre-post study compared attitudes and perceptions of a career in surgery before and after a speed-mentoring session with female surgeons. Mentees were assigned into groups of 1 or 2 and were paired with a female surgeon for 8 minutes. Each mentee group then rotated to another mentor for the same amount of time and this process continued for a total of twelve sessions. Mentees completed a 19-point questionnaire before and after the speed mentoring intervention. Setting: This multicenter study included participants from across the United Kingdom. PARTICIPANTS: Inclusion criteria were female gender and medical student or foundation year doctor (internship year 1 or 2) status. Three hundred and forty participants participated in the intervention, 191 were included in the analysis. RESULTS: Following intervention, the percentage of participants who agreed that having a family would negatively impact a woman's surgical career progression significantly decreased from 46.6% to 23.0%. The percentage of participants who agreed that an âold boysâ clubâ attitude exists in surgery also significantly decreased (73.8%-58.1%). The percentage of participants who agreed it was more difficult for a woman to succeed in her surgical career than a man significantly decreased (73.8%-64.9%). One hundred and eighty-three (96%) participants agreed that mentorship is important for career progression and 153 (71.2%) participants stated that they did not have someone who they considered a mentor. CONCLUSIONS: Conducting a speed mentoring program with same-gender role models significantly changed female medical studentsâ and junior doctorsâ perceptions of women in surgery. The results suggest that such programs may be effective tools for facilitating mentor-mentee relationships and could be employed by surgical organizations to encourage a diverse uptake into surgery
Observation of a Modulational Instability in Bose-Einstein condensates
We observe the breakup dynamics of an elongated cloud of condensed Rb
atoms placed in an optical waveguide. The number of localized spatial
components observed in the breakup is compared with the number of solitons
predicted by a plane-wave stability analysis of the nonpolynomial nonlinear
Schr\"odinger equation, an effective one-dimensional approximation of the
Gross-Pitaevskii equation for cigar-shaped condensates. It is shown that the
numbers predicted from the fastest growing sidebands are consistent with the
experimental data, suggesting that modulational instability is the key
underlying physical mechanism driving the breakup.Comment: 6 pages, 5 figure
Inelastic collisions of CaH with He at cryogenic temperatures
Using helium buffer gas cooling, we have prepared dense samples of ground-state molecular calcium monohydride (CaH X 2ÎŁ) at cryogenic temperatures. We have used optical pumping to polarise the spin state of the CaH molecules and we have measured the inelastic collisions of molecular CaH with atomic helium at temperatures from 2 to 7 K. The measured CaH electronic spin depolarisation rate coefficient increases rapidly with increasing temperature, increasing from 2 Ă 10â13 cm3 sâ1 to over 10â11 cm3 sâ1. The strong dependence of rate coefficient on temperature is attributed to the CaH population in the first excited rotational state
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