6,125 research outputs found
Full polar cap cascade scenario: -ray and X-ray luminosities from spin-powered pulsars
We modify polar cap cascade picture to include the ICS of the higher
generation pairs. In such a ``full-cascade'' scenario, not only the
perpendicular portion of the energy of the pairs goes to high energy radiation
via SR, but the parallel portion of the energy of the pairs can also contribute
to high energy emission via ICS with the soft thermal photons from either the
full neutron star surface or the hot polar cap. An important output of such a
scenario is that the soft tail of the ICS spectrum can naturally result in a
non-thermal X-ray component which can contribute to the luminosities observed
by ROSAT and ASCA. Here we present an analytic description of such a full polar
cap cascade scenario within the framework of Harding & Muslimov acceleration
model. We present the theoretical predictions of the -ray luminosities,
the thermal and non-thermal X-ray luminosities for the known spin-powered X-ray
pulsars. Our results show that the observed different dependences of the high
energy luminosities on the pulsar spin-down luminosities, i.e., and , are well
reproduced. Our model predicts that the {\em pulsed} soft X-rays in the ROSAT
band from most of the millisecond pulsars might be of thermal origin if there
is no strong multipole field components near the surfaces of these pulsars.Comment: 23 pages, emulateapj style, final version to appear in the
Astrophysical Journa
Resistance of superconducting nanowires connected to normal metal leads
We study experimentally the low temperature resistance of superconducting
nanowires connected to normal metal reservoirs. We find that a substantial
fraction of the nanowires is resistive, down to the lowest temperature
measured, indicative of an intrinsic boundary resistance due to the
Andreev-conversion of normal current to supercurrent. The results are
successfully analyzed in terms of the kinetic equations for diffusive
superconductors
Cost-effectiveness of methenamine hippurate compared with antibiotic prophylaxis for the management of recurrent urinary tract infections in secondary care: a multicentre, open-label, randomised, non-inferiority trial
\ua9 Author(s) (or their employer(s)) 2024.Objectives To estimate the cost-effectiveness of methenamine hippurate compared with antibiotic prophylaxis in the management of recurrent urinary tract infections. Design Multicentre, open-label, randomised, non-inferiority trial. Setting Eight centres in the UK, recruiting from June 2016 to June 2018. Participants Women aged â„18 years with recurrent urinary tract infections, requiring prophylactic treatment. Interventions Women were randomised to receive once-daily antibiotic prophylaxis or twice-daily methenamine hippurate for 12 months. Treatment allocation was not masked and crossover between arms was allowed. Primary and secondary outcome measures The primary economic outcome was the incremental cost per quality-adjusted life year (QALY) gained at 18 months. All costs were collected from a UK National Health Service perspective. QALYs were estimated based on responses to the EQ-5D-5L administered at baseline, 3, 6, 9, 12 and 18 months. Incremental costs and QALYs were estimated using an adjusted analysis which controlled for observed and unobserved characteristics. Stochastic sensitivity analysis was used to illustrate uncertainty on a cost-effectiveness plane and a cost-effectiveness acceptability curve. A sensitivity analysis, not specified in the protocol, considered the costs associated with antibiotic resistance. Results Data on 205 participants were included in the economic analysis. On average, methenamine hippurate was less costly (â\ua340; 95% CI: â684 to 603) and more effective (0.014 QALYs; 95% CI: â0.05 to 0.07) than antibiotic prophylaxis. Over the range of values considered for an additional QALY, the probability of methenamine hippurate being considered cost-effective ranged from 51% to 67%. Conclusions On average, methenamine hippurate was less costly and more effective than antibiotic prophylaxis but these results are subject to uncertainty. Methenamine hippurate is more likely to be considered cost-effectiv
Sites of Biosynthesis of Outer and Inner Membrane Proteins of Neurospora crassa Mitochondria
Outer and inner membranes of Neurospora crassa mitochondria were separated by the combined swelling, shrinking, sonication procedure. Membranes were characterized by electron microscopy and by marker enzyme activities. A red carotenoid pigment was found to be concentrated in the outer membrane. The inner mitochondrial membrane was resolved into about 20 protein bands on polyacrylamide gel electrophoresis, whereas the outer membrane shows essentially one single protein band. Only negligible incorporation of radioactive amino acids occurs into outer membrane when isolated mitochondria are synthesizing polypeptide chains. In agreement with this observation labeling of outer membrane protein is almost entirely blocked, when whole Neurospora cells are incubated with radioactive amino acids in the presence of cycloheximide, an inhibitor of cytoplasmic protein synthesis. Finally, the essential electrophoretic protein band from outer membrane does not become labeled when mitochondria are incubated with radioactive amino acids either in vitro or in vivo in the presence of cycloheximide. It is concluded that the vast majority, if not all, of the outer membrane protein is synthesized by the cytoplasmic system and that polypeptide chains formed by the mitochondrial ribosomes are integrated into the inner mitochondrial membrane
Data mining: a tool for detecting cyclical disturbances in supply networks.
Disturbances in supply chains may be either exogenous or endogenous. The ability automatically to detect, diagnose, and distinguish between the causes of disturbances is of prime importance to decision makers in order to avoid uncertainty. The spectral principal component analysis (SPCA) technique has been utilized to distinguish between real and rogue disturbances in a steel supply network. The data set used was collected from four different business units in the network and consists of 43 variables; each is described by 72 data points. The present paper will utilize the same data set to test an alternative approach to SPCA in detecting the disturbances. The new approach employs statistical data pre-processing, clustering, and classification learning techniques to analyse the supply network data. In particular, the incremental k-means
clustering and the RULES-6 classification rule-learning algorithms, developed by the present authorsâ team, have been applied to identify important patterns in the data set. Results show that the proposed approach has the capability automatically to detect and characterize network-wide cyclical disturbances and generate hypotheses about their root cause
Discovery of Gamma-ray Pulsations from the Transitional Redback PSR J1227-4853
The 1.69 ms spin period of PSR J1227-4853 was recently discovered in radio
observations of the low-mass X-ray binary XSS J12270-4859 following the
announcement of a possible transition to a rotation-powered millisecond pulsar
state, inferred from decreases in optical, X-ray, and gamma-ray flux from the
source. We report the detection of significant (5) gamma-ray pulsations
after the transition, at the known spin period, using ~1 year of data from the
Large Area Telescope on board the Fermi Gamma-ray Space Telescope. The
gamma-ray light curve of PSR J1227-4853 can be fit by one broad peak, which
occurs at nearly the same phase as the main peak in the 1.4 GHz radio profile.
The partial alignment of light-curve peaks in different wavebands suggests that
at least some of the radio emission may originate at high altitude in the
pulsar magnetosphere, in extended regions co-located with the gamma-ray
emission site. We folded the LAT data at the orbital period, both pre- and
post-transition, but find no evidence for significant modulation of the
gamma-ray flux. Analysis of the gamma-ray flux over the mission suggests an
approximate transition time of 2012 November 30. Continued study of the pulsed
emission and monitoring of PSR J1227-4853, and other known redback systems, for
subsequent flux changes will increase our knowledge of the pulsar emission
mechanism and transitioning systems.Comment: 5 figures, 1 table, accepted for publication in ApJ, updated to
reflect accepted version and add additional coautho
Research encounters, reflexivity and supervision
Reflexivity in qualitative and ethnographic social science research can provide a rich source of data, especially regarding the affective, performative and relational aspects of interviews with research subjects. This paper explores by means of three case examples different ways of accessing and using such reflexivity. The examples are drawn from an empirical psycho-social study into the identity transitions of first-time mothers in an inner-city multicultural environment. Fieldnotes and supervision were used to engage with researcher subjectivity, to enhance the productive use of reflexivity and to address the emotional work of research. The methodology of the supervision was psychoanalytic, in its use of a boundaried frame and of psychoanalytic forms of noticing oneself, of staying engaged emotionally as well as creating a reflective distance. The examples illustrate how this can enhance the knowledge gained about the research subjects
Spectroscopic Discovery of the Supernova 2003dh Associated with GRB 030329
We present early observations of the afterglow of the Gamma-Ray Burst (GRB)
030329 and the spectroscopic discovery of its associated supernova SN 2003dh.
We obtained spectra of the afterglow of GRB 030329 each night from March 30.12
(0.6 days after the burst) to April 8.13 (UT) (9.6 days after the burst). The
spectra cover a wavelength range of 350 nm to 850 nm. The early spectra consist
of a power-law continuum (F_nu ~ nu^{-0.9}) with narrow emission lines
originating from HII regions in the host galaxy, indicating a low redshift of
z=0.1687. However, our spectra taken after 2003 Apr. 5 show broad peaks in flux
characteristic of a supernova. Correcting for the afterglow emission, we find
the spectrum of the supernova is remarkably similar to the type Ic `hypernova'
SN 1998bw. While the presence of supernovae have been inferred from the light
curves and colors of GRB afterglows in the past, this is the first direct,
spectroscopic confirmation that a subset of classical gamma-ray bursts
originate from supernovae.Comment: published by ApJ Letters; additional material avilable at
http://cfa-www.harvard.edu/cfa/oir/Research/GRB
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