Comment on ``Cosmological Gamma Ray Bursts and the Highest Energy Cosmic Rays''

In a letter with the above title, published some time ago in PRL, Waxman made the interesting suggestion that cosmological gamma ray bursts (GRBs) are the source of the ultra high energy cosmic rays (UHECR). This has also been proposed independently by Milgrom and Usov and by Vietri. However, recent observations of GRBs and their afterglows and in particular recent data from the Akeno Great Air Shwoer Array (AGASA) on UHECR rule out extragalactic GRBs as the source of UHECR.Comment: Comment on a letter with the above title published by E. Waxman in PRL 75, 386 (1995). Submitted for publication in PRL/Comment

Full polar cap cascade scenario: γ\gamma-ray and X-ray luminosities from spin-powered pulsars

We modify polar cap cascade picture to include the ICS of the higher generation pairs. In such a ``full-cascade'' scenario, not only the perpendicular portion of the energy of the pairs goes to high energy radiation via SR, but the parallel portion of the energy of the pairs can also contribute to high energy emission via ICS with the soft thermal photons from either the full neutron star surface or the hot polar cap. An important output of such a scenario is that the soft tail of the ICS spectrum can naturally result in a non-thermal X-ray component which can contribute to the luminosities observed by ROSAT and ASCA. Here we present an analytic description of such a full polar cap cascade scenario within the framework of Harding & Muslimov acceleration model. We present the theoretical predictions of the $\gamma$-ray luminosities, the thermal and non-thermal X-ray luminosities for the known spin-powered X-ray pulsars. Our results show that the observed different dependences of the high energy luminosities on the pulsar spin-down luminosities, i.e., $L_\gamma \propto (L_{\rm sd})^{1/2}$ and $L_x \sim 10^{-3} L_{\rm sd}$, are well reproduced. Our model predicts that the {\em pulsed} soft X-rays in the ROSAT band from most of the millisecond pulsars might be of thermal origin if there is no strong multipole field components near the surfaces of these pulsars.Comment: 23 pages, emulateapj style, final version to appear in the Astrophysical Journa

Resistance of superconducting nanowires connected to normal metal leads

We study experimentally the low temperature resistance of superconducting nanowires connected to normal metal reservoirs. We find that a substantial fraction of the nanowires is resistive, down to the lowest temperature measured, indicative of an intrinsic boundary resistance due to the Andreev-conversion of normal current to supercurrent. The results are successfully analyzed in terms of the kinetic equations for diffusive superconductors

The Effects Of Female Size On Fecundity In A Large Marine Gastropod Rapana Venosa (Muricidae)

The life history strategy of the veined rapa whelk Rapana venosa, a temperate marine gastropod, includes generation times of 1 y, individual longevity of \u3e 10 y, annual production of egg cases, and an adult size range of 40 to \u3e 160 mm shell length (SL). This life history combined with the animal\u27s generalist ecological preferences and broad physiological tolerances makes rapa whelks well suited for ecological success along a gradient of habitat and community types. Ballast water transport of veliger larvae across traditional zoogeographic boundaries has resulted in the establishment of invasive rapa whelk populations in Chesapeake Bay, USA, as well as European habitats. Although the need for a quantitative understanding of rapa whelk reproductive biology in terms of annual embryo production or fecundity is acknowledged as a necessary step in assessing the biological and ecological consequences of such an invasion, rapa whelk fecundity in relation to size for the entire adult size range (40-\u3e 160 mm SL) has not previously been quantified. The relationships between rapa whelk female size and egg case height, number of embryos egg case(-1), number of egg cases produced female whelk(-1) yr(-1) and fecundity, and the number of embryos female-(1) yr(-1), are described for a size range of individuals from Chesapeake Bay. In 2001 and 2003, egg laying began in mid to late May at water temperatures of approximately 18 degrees C and salinities 14-20 ppt and continued for 11-12 wk. The smallest rapa whelk observed (45 mm SL, 5.8 g wet tissue weight) laid egg cases with heights of approximately 7 mm. The largest whelk (163 mm SL, 220 g) laid egg cases with heights 30-33 mm. The number of embryos observed in egg cases produced by Chesapeake Bay rapa whelks ranged from 123 embryos in a 7.4 mm high egg case to 3,673 embryos in a 33.5 mm high egg case. Rapa whelk fecundity (number of embryos female(-1)yr(-1)) increased with female size. Egg case production was observed in rapa whelks that had hatched from egg cases and recruited within the previous year (\u3c 1 y old). Small (\u3c 80 mm SL, \u3c 28 g wet tissue weight) rapa whelks have relatively lower annual fecundities (1 x 10(5) embryos fernale(-1) yr(-1)) than large (\u3e 80 mm SL, \u3e 28 g wet tissue weight) rapa whelks that may produce between 1 x 10(6) and 4 x 10(6) embryos female(-1) yr(-1). Estimates of rapa whelk fecundity, even for small rapa whelks, are at least an order of magnitude greater than similar estimates for native United States Atlantic coast gastropods

α-Synuclein Concentration Increases Over Time in Plasma Supernatant of Single Donor Platelets

OBJECTIVES: In platelets, α-synuclein is important in calcium-dependent granule release. Notably, cells release α-synuclein in setting of cell damage or death. Therefore, we investigated α-synuclein levels in plasma of single donor platelet (SDP) units during storage. METHODS: Aliquots were obtained from same SDP units for 7 days from day of donation. Additionally, randomly sampled SDP units at same storage time points were also assayed by enzyme-linked immunosorbent assay. RESULTS: α-Synuclein in SDP plasma increased continuously over time at each assayed time point. Significant increases were measured on day 3 (11.7 ± 9.6 ng/mL, P = 0.025), day 5 (15.3 ± 5.9 ng/mL, P = 0.002), and highest on day 7 (23.7 ± 5.6 ng/mL, P \u3c 0.0001) compared to day 0 (1.1 ± 0.8 ng/mL). Similar significant results were obtained in randomly sampled SDP units at same corresponding time points. Flow cytometry showed that platelets had strong expression of α-synuclein and lacked expression of other synucleins. CONCLUSIONS: Increases of α-synuclein during SDP storage is a steady and continuous process that increases with time. Our findings indicate that α-synuclein may represent a biomarker of platelet biological state during storage. Further research will be needed to determine how α-synuclein increases correlate with platelets\u27 function

Spatial Attention to Social Cues is not a Monolithic Process

Social stimuli are a highly salient source of information, and seem to possess unique qualities that set them apart from other well-known categories. One characteristic is their ability to elicit spatial orienting, whereby directional stimuli like eyegaze and pointing gestures act as exogenous cues that trigger automatic shifts of attention that are difficult to inhibit. This effect has been extended to non-social stimuli, like arrows, leading to some uncertainty regarding whether spatial orienting is specialized for social cues. Using a standard spatial cueing paradigm, we found evidence that both a pointing hand and arrow are effective cues, but that the hand is encoded more quickly, leading to overall faster responses. We then extended the paradigm to include multiple cues in order to evaluate congruent vs. incongruent cues. Our results indicate that faster encoding of the social cue leads to downstream effects on the allocation of attention resulting in faster orientin

Use of a Whole-Cell ELISA to Detect Additional Antibodies in Setting of Suspected Heparin-Induced Thrombocytopenia

OBJECTIVES: Type II heparin-induced thrombocytopenia (HIT) is mediated by formation of antibodies to platelet factor 4 (PF4)-heparin complexes. We evaluated anti-PF4-heparin-negative samples for the presence of additional anti-platelet and anti-red blood cell (RBC) antibodies using whole-cell platelet/ RBC ELISAs we developed. METHODS: Seventy-three samples tested for anti-PF4-heparin by ELISA were included: 62 tested negative, 9 tested positive, and 2 had equivocal results. Plasma specimens from healthy donors were used as controls. RESULTS: 100% (9/9) anti-PF4-positive samples had anti-platelet antibodies detected by whole-cell platelet ELISA. 42.2% (27/64) anti-PF4-heparin-negative samples were negative for anti-platelet and anti-RBC antibodies. 32.8% (21/64) negative samples showed reactivity to both platelets and RBC; 12.5% (8/64) negative samples were each reactive with either platelet or RBC ELISA, respectively. Additionally, two samples that tested equivocal by anti-PF4-heparin ELISA had antibodies to both platelets and RBC by whole-cell ELISA. CONCLUSIONS: Our study suggests that patients with thrombocytopenia testing negative for anti-PF4-heparin may still harbor antibodies to platelets. However, additional research is needed to determine the significance of these antibodies. Nevertheless, these findings may encourage clinicians to further investigate patients with possible immune-mediated etiologies of thrombocytopenia and anemia