Magnetism of Superconducting UPt3

The phase diagram of superconducting $U\!Pt_{3}$ in pressure-temperature plane, together with the neutron scattering data is studied within a two component superconducting order parameter scenario. In order to give a qualitative explanation to the experimental data a set of two linearly independent antiferromagnetic moments which emerge appropriately at the temperature \mbox{$T_{N}\sim 10\cdot T_{c}$} and \mbox{$T_{m}\sim T_{c}$} and couple to superconductivity is proposed. Several constraints on the fourth order coefficients in the Ginzburg-Landau free energy are obtained.Comment: 17 pages, figures available on request to [email protected]

Alzheimer\u27s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway

The microbiota-gut-brain axis is a bidirectional communication system that is poorly understood. Alzheimer\u27s disease (AD), the most common cause of dementia, has long been associated with bacterial infections and inflammation-causing immunosenescence. Recent studies examining the intestinal microbiota of AD patients revealed that their microbiome differs from that of subjects without dementia. In this work, we prospectively enrolled 108 nursing home elders and followed each for up to 5 months, collecting longitudinal stool samples from which we performed metagenomic sequencing and in vitro T84 intestinal epithelial cell functional assays for P-glycoprotein (P-gp) expression, a critical mediator of intestinal homeostasis. Our analysis identified clinical parameters as well as numerous microbial taxa and functional genes that act as predictors of AD dementia in comparison to elders without dementia or with other dementia types. We further demonstrate that stool samples from elders with AD can induce lower P-gp expression levels in vitro those samples from elders without dementia or with other dementia types. We also paired functional studies with machine learning approaches to identify bacterial species differentiating the microbiome of AD elders from that of elders without dementia, which in turn are accurate predictors of the loss of dysregulation of the P-gp pathway. We observed that the microbiome of AD elders shows a lower proportion and prevalence of bacteria with the potential to synthesize butyrate, as well as higher abundances of taxa that are known to cause proinflammatory states. Therefore, a potential nexus between the intestinal microbiome and AD is the modulation of intestinal homeostasis by increases in inflammatory, and decreases in anti-inflammatory, microbial metabolism.IMPORTANCE Studies of the intestinal microbiome and AD have demonstrated associations with microbiome composition at the genus level among matched cohorts. We move this body of literature forward by more deeply investigating microbiome composition via metagenomics and by comparing AD patients against those without dementia and with other dementia types. We also exploit machine learning approaches that combine both metagenomic and clinical data. Finally, our functional studies using stool samples from elders demonstrate how the c microbiome of AD elders can affect intestinal health via dysregulation of the P-glycoprotein pathway. P-glycoprotein dysregulation contributes directly to inflammatory disorders of the intestine. Since AD has been long thought to be linked to chronic bacterial infections as a possible etiology, our findings therefore fill a gap in knowledge in the field of AD research by identifying a nexus between the microbiome, loss of intestinal homeostasis, and inflammation that may underlie this neurodegenerative disorder

The high prevalence of Clostridioides difficile among nursing home elders associates with a dysbiotic microbiome

Clostridioides difficile disproportionally affects the elderly living in nursing homes (NHs). Our objective was to explore the prevalence of C. difficile in NH elders, over time and to determine whether the microbiome or other clinical factors are associated with C. difficile colonization. We collected serial stool samples from NH residents. C. difficile prevalence was determined by quantitative polymerase-chain reaction detection of Toxin genes tcdA and tcdB; microbiome composition was determined by shotgun metagenomic sequencing. We used mixed-effect random forest modeling machine to determine bacterial taxa whose abundance is associated with C. difficile prevalence while controlling for clinical covariates including demographics, medications, and past medical history. We enrolled 167 NH elders who contributed 506 stool samples. Of the 123 elders providing multiple samples, 30 (24.4%) elders yielded multiple samples in which C. difficile was detected and 78 (46.7%) had at least one C. difficile positive sample. Elders with C. difficile positive samples were characterized by increased abundances of pathogenic or inflammatory-associated bacterial taxa and by lower abundances of taxa with anti-inflammatory or symbiotic properties. Proton pump inhibitor (PPI) use is associated with lower prevalence of C. difficile (Odds Ratio 0.46; 95%CI, 0.22-0.99) and the abundance of bacterial species with known beneficial effects was higher in PPI users and markedly lower in elders with high C. difficile prevalence.C. difficile is prevalent among NH elders and a dysbiotic gut microbiome associates with C. difficile colonization status. Manipulating the gut microbiome may prove to be a key strategy in the reduction of C. difficile in the NH

Threshold electric field in unconventional density waves

As it is well known most of charge density wave (CDW) and spin density wave (SDW) exhibit the nonlinear transport with well defined threshold electric field E_T. Here we study theoretically the threshold electric field of unconventional density waves. We find that the threshold field increases monotonically with temperature without divergent behaviour at T_c, unlike the one in conventional CDW. The present result in the 3D weak pinning limit appears to describe rather well the threshold electric field observed recently in the low-temperature phase (LTP) of alpha-(BEDT-TTF)_2KHg(SCN)_4.Comment: 4 pages, 2 figure

Impurity scattering in unconventional density waves

We have investigated the effect of nonmagnetic impurities on the quasi-one-dimensional unconventional density wave (UDW) ground state. The thermodynamics were found to be close to those of a d-wave superconductor in the Born limit. Four different optical conductivity curves were found depending on the direction of the applied electric field and on the wavevector dependence of the gap.Comment: 14 pages, 9 figure

Neuromotor Changes in Participants with a Concussion History can be Detected with a Custom Smartphone App

Neuromotor dysfunction after a concussion is common, but balance tests used to assess neuromotor dysfunction are typically subjective. Current objective balance tests are either cost- or space-prohibitive, or utilize a static balance protocol, which may mask neuromotor dysfunction due to the simplicity of the task. To address this gap, our team developed an Android-based smartphone app (portable and cost-effective) that uses the sensors in the device (objective) to record movement profiles during a stepping-in-place task (dynamic movement). The purpose of this study was to examine the extent to which our custom smartphone app and protocol could discriminate neuromotor behavior between concussed and non-concussed participants. Data were collected at two university laboratories and two military sites. Participants included civilians and Service Members (N = 216) with and without a clinically diagnosed concussion. Kinematic and variability metrics were derived from a thigh angle time series while the participants completed a series of stepping-in-place tasks in three conditions: eyes open, eyes closed, and head shake. We observed that the standard deviation of the mean maximum angular velocity of the thigh was higher in the participants with a concussion history in the eyes closed and head shake conditions of the stepping-in-place task. Consistent with the optimal movement variability hypothesis, we showed that increased movement variability occurs in participants with a concussion history, for which our smartphone app and protocol were sensitive enough to capture

Iwasawa theory and p-adic L-functions over Zp2-extensions

We construct a two-variable analogue of Perrin-Riou’s p-adic regulator map for the Iwasawa cohomology of a crystalline representation of the absolute Galois group of Q p , over a Galois extension whose Galois group is an abelian p-adic Lie group of dimension 2. We use this regulator map to study p-adic representations of global Galois groups over certain abelian extensions of number fields whose localisation at the primes above p is an extension of the above type. In the example of the restriction to an imaginary quadratic field of the representation attached to a modular form, we formulate a conjecture on the existence of a “zeta element”, whose image under the regulator map is a p-adic L-function. We show that this conjecture implies the known properties of the 2-variable p-adic L-functions constructed by Perrin-Riou and Kim

Impurity effects in unconventional density waves in the unitary limit

We investigate the effect of strong, nonmagnetic impurities on quasi-one-dimensional conventional and unconventional density waves (DW and UDW). The conventional case remains unaffected similarly to s-wave superconductors in the presence of weak, nonmagnetic impurities. The thermodynamic properties of UDW were found to be identical to those of a d-wave superconductor in the unitary limit. The real and imaginary part of the optical conductivity is determined for electric fields applied in the perpendicular directions. A new structure can be present corresponding to excitations from the bound state at the Fermi energy to the gap maximum in addition to the usual peak at 2\Delta. In the dc limit, universal electric conductivity is found.Comment: 9 pages, 5 figure

Extent of Low-accumulation 'Wind Glaze' Areas on the East Antarctic Plateau: Implications for Continental Ice Mass Balance

Persistent katabatic winds form widely distributed localized areas of near-zero net surface accumulation on the East Antarctic ice sheet (EAIS) plateau. These areas have been called 'glaze' surfaces due to their polished appearance. They are typically 2-200 square kilometers in area and are found on leeward slopes of ice-sheet undulations and megadunes. Adjacent, leeward high-accumulation regions (isolated dunes) are generally smaller and do not compensate for the local low in surface mass balance (SMB). We use a combination of satellite remote sensing and field-gathered datasets to map the extent of wind glaze in the EAIS above 1500m elevation. Mapping criteria are derived from distinctive surface and subsurface characteristics of glaze areas resulting from many years of intense annual temperature cycling without significant burial. Our results show that 11.2 plus or minus 1.7%, or 950 plus or minus 143 x 10(exp 3) square kilometers, of the EAIS above 1500m is wind glaze. Studies of SMB interpolate values across glaze regions, leading to overestimates of net mass input. Using our derived wind-glaze extent, we estimate this excess in three recent models of Antarctic SMB at 46-82 Gt. The lowest-input model appears to best match the mean in regions of extensive wind glaze

p-Adic Mathematical Physics

A brief review of some selected topics in p-adic mathematical physics is presented.Comment: 36 page