Разработка инвестиционного проекта «Пасека» в развитии агротуризма

Материалы V Междунар. науч. конф. студентов, аспирантов и молодых ученых, Гомель, 24 мая 2012

Long Leukocyte Telomere Length at Diagnosis Is a Risk Factor for Dementia Progression in Idiopathic Parkinsonism

Telomere length (TL) is regarded as a marker of cellular aging due to the gradual shortening by each cell division, but is influenced by a number of factors including oxidative stress and inflammation. Parkinson's disease and atypical forms of parkinsonism occur mainly in the elderly, with oxidative stress and inflammation in afflicted cells. In this study the relationship between blood TL and prognosis of 168 patients with idiopathic parkinsonism (136 Parkinson's disease [PD], 17 Progressive Supranuclear Palsy [PSP], and 15 Multiple System Atrophy [MSA]) and 30 controls was investigated. TL and motor and cognitive performance were assessed at baseline (diagnosis) and repeatedly up to three to five years follow up. No difference in TL between controls and patients was shown at baseline, nor any significant difference in TL stability or attrition during follow up. Interestingly, a significant relationship between TL at diagnosis and cognitive phenotype at follow up in PD and PSP patients was found, with longer mean TL at diagnosis in patients that developed dementia within three years

Telomere length (RTL) at baseline and risk (HR) of disease progression in PD.

<p><i>Age  =  covariate.</i></p><p>Telomere length (RTL) at baseline and risk (HR) of disease progression in PD.</p

Dementia progression in PD patients with long and short telomeres at diagnosis.

<p>Proportion of patients without dementia with long (RTL>0.75) vs. short (RTL≤0.75) leukocyte telomeres using Kaplan-Meier with the log-rank test.</p

Baseline characteristics of 168 patients with idiopathic parkinsonism and 30 controls.

<p><i>*  = p<0.05 vs control</i>, n =  number, UPDRS: Unified Parkinson's Disease Rating Scale, PD: Parkinson's disease, PSP: Progressive supranuclear palsy, MSA: Multiple system atrophy, MCI: Mild cognitive impairment.</p><p>Baseline characteristics of 168 patients with idiopathic parkinsonism and 30 controls.</p

Telomere length characteristics at baseline.

<p>A) Mean relative telomere length (RTL) at baseline in control (n = 30), PD (n = 124), PSP (n = 17) and MSA (n = 13) samples. Age-adjusted p-values comparing control with patient subgroups. B) RTL as a function of age at baseline with regression lines. Correlation between telomere length and age in control and patient subgroups examined using the Pearson's correlation coefficient. No significant (p = 0.394) difference in the relationship between RTL and age was found in control and patient groups.</p

Telomere length dynamics.

<p>A) Individual relative telomere length (RTL) at diagnosis and at repeated follow up for up to five years in control, PD, PSP and MSA groups. RTL quartiles marked in each individual. B–C) Std.Dev (B) and CV% (C) of RTL in control, PD, PSP and MSA groups from baseline and up to five years follow up. D–E) Individuals RTL change between baseline and three year follow up in control (D) and PD (E).</p

RTL and disease progression.

<p>Relative telomere length (RTL) at diagnosis was analyzed in relation to dementia progression and motor severity stage within three years from diagnosis. A, C) Mean RTL was significantly longer in A) PD (p = 0.007) and C) PSP (p = 0.037) patients who developed dementia within three years from diagnosis. B, D) Mean RTL in patients by motor severity defined as Hoehn and Yahr stage <3 or stage 3 or higher did not differ in B) PD (p = 0.107) or D) PSP (p = 0.271) groups.</p

Mean RTL at diagnosis and up to five year follow up.

<p>Mean RTL at diagnosis and up to five year follow up.</p