Improvement Effect of 5-Aminolevulinic Acid on Hyperlipidemia in Miniature Schnauzer Dogs: An Open Study in 5 Cases of One Pedigree

This is the first study to examine the long-term effect of 5-aminolevulinic acid mainly on serum lipoproteins in dogs with hyperlipidemia. We studied 5 Miniature Schnauzer cases whose fasting serum total triglyceride and very-low-density lipoprotein of triglyceride levels were extremely high (635 ± 116 and 520 ± 92 mg/dL, respectively). Although the total cholesterol values were normal, the very-low-density lipoprotein of cholesterol level was high (49 ± 7 mg/dL). Each dog received a 5-aminolevulinic acid supplement (5 mg/day) orally for 6 months. The mean values of total triglyceride, verylow- density lipoprotein of both triglyceride and cholesterol decreased significantly after the treatment period (319 ± 29, 245 ± 18, and 27 ± 2 mg/dL, respectively, P < 0.05). Our present results may present evidence that 5-ALA administration contributes to improvement of hyperlipidemia in Miniature Schnauzer

Six-body Light-Front Tamm-Dancoff approximation and wave functions for the massive Schwinger model

The spectrum of the massive Schwinger model in the strong coupling region is obtained by using the light-front Tamm-Dancoff (LFTD) approximation up to including six-body states. We numerically confirm that the two-meson bound state has a negligibly small six-body component. Emphasis is on the usefulness of the information about states (wave functions). It is used for identifying the three-meson bound state among the states below the three-meson threshold. We also show that the two-meson bound state is well described by the wave function of the relative motion.Comment: 19 pages, RevTeX, 7 figures are available upon request; Minor errors have been corrected; Final version to appear in Phys.Rev.

Generation of scalar-tensor gravity effects in equilibrium state boson stars

Boson stars in zero-, one-, and two-node equilibrium states are modeled numerically within the framework of Scalar-Tensor Gravity. The complex scalar field is taken to be both massive and self-interacting. Configurations are formed in the case of a linear gravitational scalar coupling (the Brans-Dicke case) and a quadratic coupling which has been used previously in a cosmological context. The coupling parameters and asymptotic value for the gravitational scalar field are chosen so that the known observational constraints on Scalar-Tensor Gravity are satisfied. It is found that the constraints are so restrictive that the field equations of General Relativity and Scalar-Tensor gravity yield virtually identical solutions. We then use catastrophe theory to determine the dynamically stable configurations. It is found that the maximum mass allowed for a stable state in Scalar-Tensor gravity in the present cosmological era is essentially unchanged from that of General Relativity. We also construct boson star configurations appropriate to earlier cosmological eras and find that the maximum mass for stable states is smaller than that predicted by General Relativity, and the more so for earlier eras. However, our results also show that if the cosmological era is early enough then only states with positive binding energy can be constructed.Comment: 20 pages, RevTeX, 11 figures, to appear in Class. Quantum Grav., comments added, refs update

Dynamics of the Light-Cone Zero Modes: Theta Vacuum of the Massive Schwinger Model

The massive Schwinger model is quantized on the light cone with great care on the bosonic zero modes by putting the system in a finite (light-cone) spatial box. The zero mode of $A_{-}$ survives Dirac's procedure for the constrained system as a dynamical degree of freedom. After regularization and quantization, we show that the physical space condition is consistently imposed and relates the fermion Fock states to the zero mode of the gauge field. The vacuum is obtained by solving a Schr\"odinger equation in a periodic potential, so that the theta is understood as the Bloch momentum. We also construct a one-meson state in the fermion-antifermion sector and obtained the Schr\"odinger equation for it.Comment: 23 pages, RevTex, no figure

Mesons in the massive Schwinger model on the light-cone

We investigate mesons in the bosonized massive Schwinger model in the light-front Tamm-Dancoff approximation in the strong coupling region. We confirm that the three-meson bound state has a few percent fermion six-body component in the strong coupling region when expressed in terms of fermion variables, consistent with our previous calculations. We also discuss some qualitative features of the three-meson bound state based on the information about the wave function.Comment: 19 pages, RevTex, included 6 figures which are compressed and uuencode

Effect of X-Irradiation at Different Stages in the Cell Cycle on Individual Cell?Based Kinetics in an Asynchronous Cell Population

Using an asynchronously growing cell population, we investigated how X-irradiation at different stages of the cell cycle influences individual cell-based kinetics. To visualize the cellcycle phase, we employed the fluorescent ubiquitination-based cell cycle indicator (Fucci). After 5 Gy irradiation, HeLa cells no longer entered M phase in an order determined by their previous stage of the cell cycle, primarily because green phase (S and G2) was less prolonged in cells irradiated during the red phase (G1) than in those irradiated during the green phase. Furthermore, prolongation of the green phase in cells irradiated during the red phase gradually increased as the irradiation timing approached late G1 phase. The results revealed that endoreduplication rarely occurs in this cell line under the conditions we studied. We next established a method for classifying the green phase into early S, mid S, late S, and G2 phases at the time of irradiation, and then attempted to estimate the duration of G2 arrest based on certain assumptions. The value was the largest when cells were irradiated in mid or late S phase and the smallest when they were irradiated in G1 phase. In this study, by closely following individual cells irradiated at different cell-cycle phases, we revealed for the first time the unique cell-cycle kinetics in HeLa cells that follow irradiation

Gravitational Waves in Brans-Dicke Theory : Analysis by Test Particles around a Kerr Black Hole

Analyzing test particles falling into a Kerr black hole, we study gravitational waves in Brans-Dicke theory of gravity. First we consider a test particle plunging with a constant azimuthal angle into a rotating black hole and calculate the waveform and emitted energy of both scalar and tensor modes of gravitational radiation. We find that the waveform as well as the energy of the scalar gravitational waves weakly depends on the rotation parameter of black hole $a$ and on the azimuthal angle. Secondly, using a model of a non-spherical dust shell of test particles falling into a Kerr black hole, we study when the scalar modes dominate. When a black hole is rotating, the tensor modes do not vanish even for a ``spherically symmetric" shell, instead a slightly oblate shell minimizes their energy but with non-zero finite value, which depends on Kerr parameter $a$. As a result, we find that the scalar modes dominate only for highly spherical collapse, but they never exceed the tensor modes unless the Brans-Dicke parameter \omega_{BD} \lsim 750 for $a/M=0.99$ or unless \omega_{BD} \lsim 20,000 for $a/M=0.5$, where $M$ is mass of black hole. We conclude that the scalar gravitational waves with \omega_{BD} \lsim several thousands do not dominate except for very limited situations (observation from the face-on direction of a test particle falling into a Schwarzschild black hole or highly spherical dust shell collapse into a Kerr black hole). Therefore observation of polarization is also required when we determine the theory of gravity by the observation of gravitational waves.Comment: 24 pages, revtex, 18 figures are attached with ps file

Dynamical evolution of boson stars in Brans-Dicke theory

We study the dynamics of a self-gravitating scalar field solitonic object (boson star) in the Jordan-Brans-Dicke (BD) theory of gravity. We show dynamical processes of this system such as (i) black hole formation of perturbed equilibrium configuration on an unstable branch; (ii) migration of perturbed equilibrium configuration from the unstable branch to stable branch; (iii) transition from excited state to a ground state. We find that the dynamical behavior of boson stars in BD theory is quite similar to that in general relativity (GR), with comparable scalar wave emission. We also demonstrate the formation of a stable boson star from a Gaussian scalar field packet with flat gravitational scalar field initial data. This suggests that boson stars can be formed in the BD theory in much the same way as in GR.Comment: 13 pages by RevTeX, epsf.sty, 16 figures, comments added, refs updated, to appear in Phys. Rev.

NO-1886, a lipoprotein lipase activator, attenuates contraction of rat intestinal ring preparations

Various intestinal symptoms or diseases are closely associated with intestinal motility, which may be altered by metabolic disturbances associated with diabetes and obesity. It is therefore important that drugs used in the treatment of metabolic disorders should not have any adverse effects on the intestine. In the present study, we examined whether [4-(4-bromo-2-cyano-phenylcarbamoyl)-benzyl]-phosphonic acid diethyl ester (NO-1886), a lipoprotein lipase activator with anti-diabetic and/or anti-obese activity, affects stimulant-induced intestinal contractility. Administration of NO-1886 to intestinal ring preparations of ileum, rectum and colon isolated from Wistar rats attenuated or relaxed contraction induced by a high K+ environment or acetylcholine (ACh). This effect of NO-1886 was dependent on extracellular Ca2+ and intracellular myosin light chain kinase activity. Our results also showed that ACh-induced colonic contraction was significantly higher in the obese Otsuka Long-Evans Tokushima Fatty (OLETF) than in the non-obese Long-Evans Tokushima Otsuka (LETO) rats. The hypercontractility observed in the colons of OLETF rats occurred concomitantly with an elevation in muscarinic M3 ACh receptor protein levels. Administration of NO-1886 attenuated the obesity-induced hypercontractility of the colonic rings of OLETF rats. Thus, intestinal contractile system would be a novel pharmacological target of the lipoprotein lipase activator NO-1886