New Technology and Experimental Study on Snow-Melting Heated Pavement System in Tunnel Portal

In recent years, with the rapid growth of economy and sharp rise of motor vehicles in China, the pavement skid resistance in tunnel portals has become increasingly important in cold region. However, the deicing salt, snow removal with machine, and other antiskid measures adopted by highway maintenance division have many limitations. To improve the treatment effect, we proposed a new snow-melting approach employing electric heat tracing, in which heating cables are installed in the structural layer of road. Through the field experiment, laboratory experiment, and numerical investigation, structure type, heating power, and preheating time of the flexible pavement heating system in tunnel portal were systematically analyzed, and advantages of electric heat tracing technology in improving the pavement skid resistance in tunnel portal were also presented. Therefore, such new technology, which offers new snow-melting methods for tunnel portal, bridge, mountainous area, and large longitudinal slope in cold region, has promising prospect for extensive application

Revisiting the Knowledge Injection Frameworks

In recent years, large language models (LLMs), such as GPTs, have attained great impact worldwide. However, how to adapt these LLMs to better suit the vertical domain-specific tasks by utilizing external knowledge remains not completely solved. Indeed, there have emerged a few works on this line where most of them rely on an alignment heuristic that is built to inject the corresponding knowledge tuple into the associated text sample. However, despite the promise, we identify a pivotal problem in this work ubiquitously. Simply put, we find that injecting unaligned (i.e., random) knowledge tuple into the LLMs achieves comparable (and sometimes better) results than the aligned knowledge being injected. We therefore take a thorough investigation of this frustrating finding on a variety of related prior work and further provide a chain of potential interpretations for the phenomenon. Based on all that, we offer a simple remediated technique. Briefly, the core of this technique is rooted in an ideological emphasis on the pruning and purification of the external knowledge base to be injected into LLMs. At last, we show that by integrating this technique into most (if not all) knowledge injection frameworks and recent LLMs, it manages to overcome the aforementioned sanity problem and further pushes the boundary of the performance of the domain-adaptive LLMs.Comment: 9 pages, 6 figures, accepted by EMNLP 2023 Mai

Investigation Progresses and Applications of Fractional Derivative Model in Geotechnical Engineering

Over the past couple of decades, as a new mathematical tool for addressing a number of tough problems, fractional calculus has been gaining a continually increasing interest in diverse scientific fields, including geotechnical engineering due primarily to geotechnical rheology phenomenon. Unlike the classical constitutive models in which simulation analysis gradually fails to meet the reasonable accuracy of requirement, the fractional derivative models have shown the merits of hereditary phenomena with long memory. Additionally, it is traced that the fractional derivative model is one of the most effective and accurate approaches to describe the rheology phenomenon. In relation to this, an overview aimed first at model structure and parameter determination in combination with application cases based on fractional calculus was provided. Furthermore, this review paper shed light on the practical application aspects of deformation analysis of circular tunnel, rheological settlement of subgrade, and relevant loess researches subjected to the achievements acquired in geotechnical engineering. Finally, concluding remarks and important future investigation directions were pointed out

Static Analytical Approach of Moderately Thick Cylindrical Ribbed Shells Based on First-Order Shear Deformation Theory

The classical shell theory (CST) without considering the shear deformation has been commonly used in the calculation of shells structures recently. However, the impact of theory of plates and shells subjected to the shear deformation on the calculation is increasingly pronounced along with the wide use of composite laminated structures. In this paper, based on first-order shear deformation theory (FSDT) of cylindrical shells, the displacement control differential equation of moderately thick cylindrical shells has been obtained, so has been the edge force at longitudinal of the shells. Meanwhile, a group of unit force is introduced to deduce the displacement of edge beam under the action of edge force. A join condition of moderately thick cylindrical ribbed shells is established according to the continuity of displacement as well. Most notably, the displacement analytical solution of bending problems of moderately thick cylindrical ribbed shells is obtained, which has profound theoretical significance for further improving the analytical solution of moderately thick cylindrical shells

In Situ Test of Grouting Reinforcement for Water-Enriched Sandy Gravel Ground in River Floodplain

The performance of the ground treatment is always critical for a tunnel excavated in unstable stratum. Laodongnanlu Xiangjiang Tunnel (Changsha, China) across the Xiangjiang River will be constructed in a sandy gravel ground which is characterized by loose structure, extensive porosity, elevated sensitivity, poor stability, and a high groundwater table. Permeation grouting will be employed to improve the bearing capacity and mitigate groundwater movement into the excavation. In order to seek suitable injection parameters and grouting method, a field trial of vertical grouting was conducted in the sandy gravel stratum in river floodplain. A series of tests focusing on grout material, grouting sequence of boreholes, injection pressure, and grouting volume were performed to improve the sandy gravel mass strength and reduce water permeability. The examination of the results obtained during water pressure testing and core drilling on completion of the grouting trial successfully demonstrated that the specified injection criteria had led to an expected effect. Grouting control method of this saturated sandy gravel stratum was concluded after the test, which would contribute to the future pregrouting work during the tunnelling

Stress Analysis of CFG Pile Composite Foundation in Consolidating Saturated Mine Tailings Dam

Cement fly-ash gravel (CFG) pile is a widely used ground reinforcement technique. This paper aims to address the mechanical characteristics of CFG composite foundation in consolidating saturated mine tailings (MTs) dam. The field static load tests were employed to explore the bearing capacity of the CFG composite foundation, and finite element (FE) models in three dimensions validated through comparison with experimental results were used to discuss the pile-soil stress distribution and pile-soil stress ratio of the CFG composite foundation. The results indicate that the distribution of earth pressure and pile stress is relatively homogeneous and stable over depth and load, while the development of CFG composite foundation bearing capacity is insufficient, in which the developed bearing capacity of CFG piles is less than 50% of its characteristic value. Additionally, compared with the laboratory model test results, the pile-soil stress ratio decreases with the increasing of the load in FEM results proved to better conform to the actual engineering conditions. Furthermore, the deformation modulus and thickness of cushion exert significant influence on pile-soil stress ratio and integral bearing capacity of CFG composite foundation

The immunosuppressive effects and mechanisms of loureirin B on collagen-induced arthritis in rats

IntroductionRheumatoid arthritis (RA) is a common disease mainly affecting joints of the hands and wrists. The discovery of autoantibodies in the serum of patients revealed that RA belonged to the autoimmune diseases and laid a theoretical basis for its immunosuppressive therapy. The pathogenesis of autoimmune diseases mainly involves abnormal activation and proliferation of effector memory T cells, which is closely related to the elevated expression of Kv1.3, a voltage-gated potassium (Kv) channel on the effector memory T cell membrane. Drugs blocking the Kv1.3 channel showed a strong protective effect in RA model animals, suggesting that Kv1.3 is a target for the discovery of specific RA immunosuppressive drugs.MethodsIn the present study, we synthesized LrB and studied the effects of LrB on collagen- induced arthritis (CIA) in rats. The clinical score, paw volume and joint morphology of CIA model rats were compared. The percentage of CD3+, CD4+ and CD8+ T cells in rat peripheral blood mononuclear and spleen were analyzed with flow cytometry. The concentrations of inflammatory cytokines interleukin (IL)-1b, IL-2, IL-4, IL-6, IL-10 and IL-17 in the serum of CIA rats were analyzed with enzyme-linked immunosorbent assay. The IL-1b and IL-6 expression in joints and the Kv1.3 expression in peripheral blood mononuclear cells (PBMCs) were quantified by qPCR. To further study the mechanisms of immunosuppressive effects of LrB, western blot and immunofluorescence were utilized to study the expression of Kv1.3 and Nuclear Factor of Activated T Cells 1 (NFAT1) in two cell models - Jurkat T cell line and extracted PBMCs.ResultsLrB effectively reduced the clinical score and relieved joint swelling. LrB could also decrease the percentage of CD4+ T cells, while increase the percentage of CD8+ T cells in peripheral blood mononuclear and spleen of rats with CIA. The concentrations of inflammatory cytokines interleukin (IL)-1b, IL-2, IL-6, IL-10 and IL-17 in the serum of CIA rats were significantly reduced by LrB. The results of qPCR showed that Kv1.3 mRNA in the PBMCs of CIA rats was significantly higher than that of the control and significantly decreased in the LrB treatment groups. In addition, we confirmed in cell models that LrB significantly decreased Kv1.3 protein on the cell membrane and inhibited the activation of Nuclear Factor of Activated T Cells 1 (NFAT1) with immune stimulus.ConclusionIn summary, this study revealed that LrB could block NFAT1 activation and reduce Kv1.3 expression in activated T cells, thus inhibiting the proliferation of lymphocytes and the release of inflammatory cytokines, thereby effectively weakening the autoimmune responses in CIA rats. The effects of immunosuppression due to LrB revealed its potential medicinal value in the treatment of RA