675 research outputs found
ADAM9 Is Present At Endothelial Cell - Cell Junctions And Regulates Monocyte – Endothelial Transmigration
We have found that A Disintegrin And Metalloproteinase-9 (ADAM9) localises to cell-cell junctions with VE-Cadherin in confluent endothelial monolayers. Co-cultures of cells separately transfected with ADAM9-EGFP or ADAM9-HA showed expression is required in two adjacent cells for localisation to cell-cell junctions suggesting the ADAM9 ectodomain may self-associate. A direct interaction between ADAM9 ectodomains was confirmed using recombinant proteins and an ELISA based method. As the ADAM9 ectodomain can also exist as a soluble form physiologically, we examined if this could inhibit endothelial functions dependent on cell-cell junctions. The soluble ADAM9 ectodomain could not increase endothelial monolayer permeability or inhibit monocyte-endothelial adhesion, but could inhibit monocyte-endothelial transmigration. These novel findings point to ADAM9 playing an important role in endothelial cell biology that is distinct from the other ADAMs
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Caisson UNI-1 study provide permanent structure around the cassion fill pipe
This document is an Engineering Study and analysis to determine the best way to provide a permanent structure around the UNI-1 Caisson fill pipe
Interchannel coupling effects in the spin polarization of energetic photoelectrons
Effects of the interchannel coupling on the spin polarization of energetic
photoelectrons emitted from atomic Ne valence subshells are examined. Like
previously obtained results for cross sections and angular distributions, the
photoelectron spin polarization parameters too are found considerably
influenced by the coupling. The result completes a series of studies to finally
conclude that the independent particle description is inadequate for the {\em
entire} range of photoionization dynamics over the {\em full} spectral energy
domainComment: 7 pages, 5 figures, accepted in Phys. Rev.
Quasi Free 238U (e,e'f)-Cross Section in Macroscopic-Microscopic Approach
We present the result of a theoretical study of inclusive quasi free
electrofission of U. The off-shell cross sections for the quasi free
reaction stage have been calculated within the Plane Wave Impulse Approximation
(PWIA), using a Macroscopic -Microscopic description of the proton and neutron
single particle momentum distributions. Electron wave function distortion
corrections were included using the effective momentum approximation, and the
Final State Interaction (FSI) effects were calculated using an optical
potential. The fissility for the proton single hole excited states of the
residual nucleus Pa was calculated both without and with contributions
of the pre-equilibrium emission of the particles. The fissility for
residual nuclei was calculated within the compound nucleus model.
The cross sections thus obtained were compared with available
experimental data.Comment: 26 pages, 7 figure
Quasicondensate and superfluid fraction in the 2D charged-boson gas at finite temperature
The Bogoliubov - de Gennes equations are solved for the Coulomb Bose gas
describing a fluid of charged bosons at finite temperature. The approach is
applicable in the weak coupling regime and the extent of its quantitative
usefulness is tested in the three-dimensional fluid, for which diffusion Monte
Carlo data are available on the condensate fraction at zero temperature. The
one-body density matrix is then evaluated by the same approach for the
two-dimensional fluid with e^2/r interactions, to demonstrate the presence of a
quasi-condensate from its power-law decay with increasing distance and to
evaluate the superfluid fraction as a function of temperature at weak coupling.Comment: 9 pages, 2 figure
Fractional Langevin equation
We investigate fractional Brownian motion with a microscopic random-matrix
model and introduce a fractional Langevin equation. We use the latter to study
both sub- and superdiffusion of a free particle coupled to a fractal heat bath.
We further compare fractional Brownian motion with the fractal time process.
The respective mean-square displacements of these two forms of anomalous
diffusion exhibit the same power-law behavior. Here we show that their lowest
moments are actually all identical, except the second moment of the velocity.
This provides a simple criterion which enables to distinguish these two
non-Markovian processes.Comment: 4 page
Combined CI+MBPT calculations of energy levels and transition amplitudes in Be, Mg, Ca, and Sr
Configuration interaction (CI) calculations in atoms with two valence
electrons, carried out in the V(N-2) Hartree-Fock potential of the core, are
corrected for core-valence interactions using many-body perturbation theory
(MBPT). Two variants of the mixed CI+MBPT theory are described and applied to
obtain energy levels and transition amplitudes for Be, Mg, Ca, and Sr
Can ChatGPT outperform a neurosurgical trainee? A prospective comparative study
Purpose
This study aimed to compare the performance of ChatGPT, a large language model (LLM), with human neurosurgical applicants in a neurosurgical national selection interview, to assess the potential of artificial intelligence (AI) and LLMs in healthcare and provide insights into their integration into the field.
Methods
In a prospective comparative study, a set of neurosurgical national selection-style interview questions were asked to eight human participants and ChatGPT in an online interview. All participants were doctors currently practicing in the UK who had applied for a neurosurgical National Training Number. Interviews were recorded, anonymised, and scored by three neurosurgical consultants with experience as interviewers for national selection. Answers provided by ChatGPT were used as a template for a virtual interview. Interview transcripts were subsequently scored by neurosurgical consultants using criteria utilised in real national selection interviews. Overall interview score and subdomain scores were compared between human participants and ChatGPT.
Results
For overall score, ChatGPT fell behind six human competitors and did not achieve a mean score higher than any individuals who achieved training positions. Several factors, including factual inaccuracies and deviations from expected structure and style may have contributed to ChatGPT's underperformance.
Conclusions
LLMs such as ChatGPT have huge potential for integration in healthcare. However, this study emphasises the need for further development to address limitations and challenges. While LLMs have not surpassed human performance yet, collaboration between humans and AI systems holds promise for the future of healthcare
Using the past to constrain the future: how the palaeorecord can improve estimates of global warming
Climate sensitivity is defined as the change in global mean equilibrium
temperature after a doubling of atmospheric CO2 concentration and provides a
simple measure of global warming. An early estimate of climate sensitivity,
1.5-4.5{\deg}C, has changed little subsequently, including the latest
assessment by the Intergovernmental Panel on Climate Change.
The persistence of such large uncertainties in this simple measure casts
doubt on our understanding of the mechanisms of climate change and our ability
to predict the response of the climate system to future perturbations. This has
motivated continued attempts to constrain the range with climate data, alone or
in conjunction with models. The majority of studies use data from the
instrumental period (post-1850) but recent work has made use of information
about the large climate changes experienced in the geological past.
In this review, we first outline approaches that estimate climate sensitivity
using instrumental climate observations and then summarise attempts to use the
record of climate change on geological timescales. We examine the limitations
of these studies and suggest ways in which the power of the palaeoclimate
record could be better used to reduce uncertainties in our predictions of
climate sensitivity.Comment: The final, definitive version of this paper has been published in
Progress in Physical Geography, 31(5), 2007 by SAGE Publications Ltd, All
rights reserved. \c{opyright} 2007 Edwards, Crucifix and Harriso
Prevalence and predictors of complementary and alternative medicine modalities in patients with chronic hepatitis B
Background & Aims
The use of complementary and alternative medicine (CAM) in patients with chronic hepatitis B (CHB) can interact with antiviral treatment or influence health‐seeking behaviour. We aimed to study the use of individual CAM modalities in CHB and explore determinants of use, particularly migration‐related, socio‐economic and clinical factors.
Methods
A total of 436 CHB outpatients who attended the Toronto Centre for Liver Disease in 2015‐2016 were included in this cross‐sectional study. Using the comprehensive I‐CAM questionnaire and health records, data were collected on socio‐demographic and clinical variables and on usage of 16 CAM modalities in the last year.
Results
Sixty percent of patients were male, 74% were Asian and 46% were using antiviral treatment. Three‐hundred and nine (71%) patients used CAM. Vitamin/mineral preparations (45% of patients) were most commonly used. Overall CAM use and the specific use of potentially injurious CAM, such as green tea extract (9.2%) and St. John's wort (0.2%), were not associated with liver disease severity. Female sex, family history of CHB, lower serum HBV DNA, and higher socio‐economic status were independently associated with bio‐holistic CAM use, the clinically most‐relevant CAM group (P < 0.05); ethnicity, antiviral therapy use and liver disease severity were not.
Conclusions
CAM use among CHB patients was extensive, especially use of vitamin and mineral preparations, but without direct influence on liver disease severity. Bio‐holistic CAM use appeared to be associated with socio‐economic status rather than with ethnicity or liver disease severity. Despite the rare use of hepatotoxins, physicians should actively inquire about it
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