1,385 research outputs found
Development of a Type 2 Diabetes Risk Model From a Panel of Serum Biomarkers From the Inter99 Cohort
Thromboprophylaxis only during hospitalisation in fast-track hip and knee arthroplasty, a prospective cohort study
OBJECTIVES: International guidelines recommend thrombosis prophylaxis after total hip arthroplasty (THA) and total knee arthroplasty (TKA) for up to 35â
days. However, previous studies often have hospital stays (length of stay; LOS) of 8â12â
days and not considering early mobilisation, which may reduce incidence of venous thromboembolic events (VTE). We investigated the incidence of any symptomatic thromboembolic events (TEEs) with only in-hospital prophylaxis if LOS â¤5â
days after fast-track THA and TKA. DESIGN: A prospective descriptive multicentre cohort study in fast-track THA and TKA from February 2010 to December 2011, with complete 90-day follow-up through the Danish National Patient Registry and patient files. SETTING: 6 Danish high-volume centres with a similar standardised fast-track setup, including spinal anaesthesia, opioid-sparing analgesia, early mobilisation, functional discharge criteria and discharge to own home. PARTICIPANTS: 4924 consecutive unselected unilateral primary THA and TKAs in patients âĽ18â
years with no preoperative use of continuous âpotentâ anticoagulative therapy (vitamin K antagonists). EXPOSURE: Prophylaxis with low-molecular-weight heparin or factor Xa-inhibitors only during hospitalisation when LOS â¤5â
days. OUTCOMES: Incidence of symptomatic TEE-related, VTE-related and VTE-related mortality â¤90â
days postoperatively. RESULTS: LOS â¤5â
days and thromboprophylaxis only during hospitalisation occurred in 4659 procedures (94.6% of total). Median LOS and prophylaxis duration was 2â
days (IQR 2â3) with 0.84% (95% CI 0.62% to 1.15%) TEE and 0.41% (0.26% to 0.64%) VTE during 90-day follow-up. VTE consisted of five pulmonary embolisms (0.11% (0.05% to 0.25%)) and 14 deep venous thrombosis (0.30% (0.18% to 0.50%)). There were four (0.09% (0.04% to 0.23%)) surgery-related deaths, of which 1 (0.02% (0.00% to 0.12%)) was due to pulmonary embolism, and 6 (0.13% (0.06% to 0.28%)) deaths of unknown causes after discharge. CONCLUSIONS: The low incidence of TEE and VTE suggests that in-hospital prophylaxis only, is safe in fast-track THA and TKA patients with LOS of â¤5â
days. Guidelines on thromboprophylaxis may need reconsideration in fast-track elective surgery. TRIAL REGISTRATION: ClinicalTrials.gov: NCT0155772
Readout for intersatellite laser interferometry: Measuring low frequency phase fluctuations of HF signals with microradian precision
Precision phase readout of optical beat note signals is one of the core
techniques required for intersatellite laser interferometry. Future space based
gravitational wave detectors like eLISA require such a readout over a wide
range of MHz frequencies, due to orbit induced Doppler shifts, with a precision
in the order of at frequencies between
and . In this paper, we present phase
readout systems, so-called phasemeters, that are able to achieve such
precisions and we discuss various means that have been employed to reduce noise
in the analogue circuit domain and during digitisation. We also discuss the
influence of some non-linear noise sources in the analogue domain of such
phasemeters. And finally, we present the performance that was achieved during
testing of the elegant breadboard model of the LISA phasemeter, that was
developed in the scope of an ESA technology development activity.Comment: submitted to Review of Scientific Instruments on April 30th 201
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