Facilitating Humanitarian Access to Pharmaceutical and Agricultural Innovation

Calls for intellectual property licensing strategies in the pharmaceutical and agricultural sectors that promote humanitarian access to product innovations for the benefit of the disadvantaged. Includes profiles of successful and promising strategies

Stephen A. Douglas and the Dilemmas of Democratic Equality

Studying The Little Giant\u27s Political Career The purpose of James L. Huston\u27s biography of Stephen A. Douglas is to examine the unfolding principles of democracy and equality during the middle part of nineteenth century America (viii). Huston has done an outstanding job in capturing the b...

Decided on the Battlefield: Grant, Sherman, Lincoln and the Election of 1864

At the Intersection of Military Policy and Politics The purpose of David Alan Johnson’s book, Decided on the Battlefield: Grant, Sherman, Lincoln and the Election of 1864, is to examine the critical factors in 1864 that led to the re-election of Abraham Lincoln. Written for the ...

Multiple-channel generalization of Lellouch-Luscher formula

We generalize the Lellouch-Luscher formula, relating weak matrix elements in finite and infinite volumes, to the case of multiple strongly-coupled decay channels into two scalar particles. This is a necessary first step on the way to a lattice QCD calculation of weak decay rates for processes such as D -> pi pi and D -> KK. We also present a field theoretic derivation of the generalization of Luscher's finite volume quantization condition to multiple two-particle channels. We give fully explicit results for the case of two channels, including a form of the generalized Lellouch-Luscher formula expressed in terms of derivatives of the energies of finite volume states with respect to the box size. Our results hold for arbitrary total momentum and for degenerate or non-degenerate particles.Comment: 16 pages, 2 figures. v3: Added references, clarified relation to and corrected comments about previous work, and minor stylistic improvements. v4: Minor clarifications added, typos fixed, references updated---matches published versio

Identification of structure in condensed matter with the topological cluster classification

We describe the topological cluster classification (TCC) algorithm. The TCC detects local structures with bond topologies similar to isolated clusters which minimise the potential energy for a number of monatomic and binary simple liquids with $m\leq13$ particles. We detail a modified Voronoi bond detection method that optimizes the cluster detection. The method to identify each cluster is outlined, and a test example of Lennard-Jones liquid and crystal phases is considered and critically examined.Comment: 28 pages, 28 figure

Multicenter Evaluation of the QIAstat-Dx Respiratory Panel for the Detection of Viruses and Bacteria in Nasopharyngeal Swab Specimens

The QIAstat-Dx Respiratory Panel (QIAstat-Dx RP) is a multiplex in vitro diagnostic test for the qualitative detection of 20 pathogens directly from nasopharyngeal swab (NPS) specimens. The assay is performed using a simple sample-to-answer platform with results available in approximately 69 min. The pathogens identified are adenovirus, coronavirus 229E, coronavirus HKU1, coronavirus NL63, coronavirus OC43, human metapneumovirus A and B, influenza A, influenza A H1, influenza A H3, influenza A H1N1/2009, influenza B, parainfluenza virus 1, parainfluenza virus 2, parainfluenza virus 3, parainfluenza virus 4, rhinovirus/enterovirus, respiratory syncytial virus A and B, Bordetella pertussis, Chlamydophila pneumoniae, and Mycoplasma pneumoniae. This multicenter evaluation provides data obtained from 1,994 prospectively collected and 310 retrospectively collected (archived) NPS specimens with performance compared to that of the BioFire FilmArray Respiratory Panel, version 1.7. The overall percent agreement between QIAstat-Dx RP and the comparator testing was 99.5%. In the prospective cohort, the QIAstat-Dx RP demonstrated a positive percent agreement of 94.0% or greater for the detection of all but four analytes: coronaviruses 229E, NL63, and OC43 and rhinovirus/enterovirus. The test also demonstrated a negative percent agreement of ≥97.9% for all analytes. The QIAstat-Dx RP is a robust and accurate assay for rapid, comprehensive testing for respiratory pathogens

A Microfluidic Device for Kinetic Optimization of Protein Crystallization and In Situ Structure Determination

The unprecedented economies of scale and unique mass transport properties of microfluidic devices made them viable nano-volume protein crystallization screening platforms. However, realizing the full potential of microfluidic crystallization requires complementary technologies for crystal optimization and harvesting. In this paper, we report a microfluidic device which provides a link between chip-based nanoliter volume crystallization screening and structure analysis through “kinetic optimization” of crystallization reactions and in situ structure determination. Kinetic optimization through systematic variation of reactor geometry and actuation of micromechanical valves is used to screen a large ensemble of kinetic trajectories that are not practical with conventional techniques. Using this device, we demonstrate control over crystal quality, reliable scale-up from nanoliter volume reactions, facile harvesting and cryoprotectant screening, and protein structure determination at atomic resolution from data collected in-chip

Pilgrim’s Progress: Lessons in Shared Governance

In the Spring of 2006, Southern Illinois University Edwardsville (SIUE) initiated a conversation to define a “Teacher-Scholar” Philosophy appropriate for the campus. In an experience similar to John Bunyan’s protagonist, Christian, in the classic 1678 allegory Pilgrim’s Progress, the SIUE faculty and administrators set off on a 21st century journey of discovery.[2] Our journey, however, was toward shared governance, rather than down the path to salvation. Like Bunyan’s Christian, we traveled metaphorically through the Town of Vanity, the Valley of Humiliation, the Slough of Despond, the Hill of Difficulty, and the Castle of Doubt. Unlike Christian, however, our journey of discovery ended before we crossed the River of Death and entered the Celestial City

Scaling properties of a low-actuation pressure microfluidic valve

Using basic physical arguments, we present a design and method for the fabrication of microfluidic valves using multilayer soft lithography. These on-off valves have extremely low actuation pressures and can be used to fabricate active functions, such as pumps and mixers in integrated microfluidic chips. We characterized the performance of the valves by measuring both the actuation pressure and flow resistance over a wide range of design parameters, and compared them to both finite element simulations and alternative valve geometries