Landscape genetics goes to sea

A recent study revealing geographical and environmental barriers to gene flow in the harbour porpoise shows the great potential of 'landscape genetics' when applied to marine organisms

Konspirationsteorier under COVID-19-pandemien i Danmark

Denne hvidbog undersøger karakteren og udbredelsen af konspirationsteorier under COVID-19-pandemien i Danmark. Dens formål er at kvalificere den nuværende debat ved at undersøge fænomenet konspirationsteorier fra forskellige metodiske vinkler. Dansksprogede facebookopslag er udgangspunktet for undersøgelsen. Først undersøger vi den konspiratoriske retorik i danske facebookopslag for at beskrive de typiske argumentative træk. Dernæst analyserer vi, hvordan indhold, der er blevet markeret som misinformation, har spredt sig på onlineplatforme, og hvorvidt indhold, der kan betragtes som konspiratorisk, har spillet en særlig rolle. Til sidst undersøger vi, hvorvidt omfanget af konspiratorisk indhold er steget i udvalgte coronakritiske facebookgrupper under pandemien. Hvidbogen tager ikke et specifikt normativt standpunkt i undersøgelsen af data, men tilstræber snarere at give en nuanceret og empirisk funderet vurdering af karakteren og udbredelsen af konspiratorisk tænkning i Danmark både i forhold til kvalitet og kvantitet. Hvidbogen er udarbejdet i fællesskab af forskere, der er tilknyttet DataPublics og AlterPublics projekterne samt Center for Nyhedsforskning på Roskilde Universitet. Vi vil gerne takke Thomas Hedin og alle hos TjekDet for at give indblik i deres faktatjek- metoder samt bistand med indsamling af data. Vi vil også gerne takke Illum-fondet for økonomisk støtte til projektet

Restrictive versus standard IV fluid therapy in adult ICU patients with septic shock-Bayesian analyses of the CLASSIC trial.

BACKGROUND The CLASSIC trial assessed the effects of restrictive versus standard intravenous (IV) fluid therapy in adult intensive care unit (ICU) patients with septic shock. This pre-planned study provides a probabilistic interpretation and evaluates heterogeneity in treatment effects (HTE). METHODS We analysed mortality, serious adverse events (SAEs), serious adverse reactions (SARs) and days alive without life-support within 90 days using Bayesian models with weakly informative priors. HTE on mortality was assessed according to five baseline variables: disease severity, vasopressor dose, lactate levels, creatinine values and IV fluid volumes given before randomisation. RESULTS The absolute difference in mortality was 0.2%-points (95% credible interval: -5.0 to 5.4; 47% posterior probability of benefit [risk difference <0.0%-points]) with restrictive IV fluid. The posterior probabilities of benefits with restrictive IV fluid were 72% for SAEs, 52% for SARs and 61% for days alive without life-support. The posterior probabilities of no clinically important differences (absolute risk difference ≤2%-points) between the groups were 56% for mortality, 49% for SAEs, 90% for SARs and 38% for days alive without life-support. There was 97% probability of HTE for previous IV fluid volumes analysed continuously, that is, potentially relatively lower mortality of restrictive IV fluids with higher previous IV fluids. No substantial evidence of HTE was found in the other analyses. CONCLUSION We could not rule out clinically important effects of restrictive IV fluid therapy on mortality, SAEs or days alive without life-support, but substantial effects on SARs were unlikely. IV fluids given before randomisation might interact with IV fluid strategy