260 research outputs found
Serodiagnosis of infectious mononucleosis by using recombinant Epstein-Barr virus antigens and enzyme-linked immunosorbent assay technology
Four recombinant, diagnostically useful Epstein-Barr virus (EBV) proteins representative of the viral capsid antigen (p150), diffuse early antigen (p54), the major DNA-binding protein (p138), and the EBV nuclear antigen (p72) (W. Hinderer, H. Nebel-Schickel, H.H. Sonneborn, M. Motz, R. KΓΌhbeck, and H. Wolf, J. Exp. Clin. Cancer Res. 7[Suppl.]:132, 1988) were used to set up individual enzyme-linked immunosorbent assays (ELISAs) for the qualitative and quantitative detection of immunoglobulin M (IgM) and IgG antibodies. In direct comparison with results obtained by standard immunofluorescence or immunoperoxidase assays, it was then shown that the recombinant EBV ELISAs provide the means for specific and sensitive serodiagnosis of infectious mononucleosis (IM) caused by EBV. The most useful markers in sera from such patients proved to be IgM antibodies against p54, p138, and p150. Additional positive markers for recent or ongoing IM apparently were IgG antibodies against p54 and p138. In contrast, anti-p72 IgG had a high preference for sera from healthy blood donors and, therefore, can be considered indicative of past exposure to the virus. Altogether, the individual ELISAs proved to be as specific and at least as sensitive for the diagnosis of IM as the currently available standard techniques are. Moreover, our findings suggest that, by combining individual test antigens, a workable ELISA system consisting of three assays (IgM against p54, p138, and p150; IgG against p54 and p138; and IgG against p72) can be established for the standardized rapid diagnosis of acute EBV infections
ΠΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΡ ΡΠΈΡΡΠΎΠ²ΡΡ ΡΠ΅Ρ Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΠΏΡΠΎΡΠ΅ΡΡ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΠΌ ΡΠ·ΡΠΊΠ°ΠΌ
Π ΡΡΠ°ΡΡΠ΅ ΠΎΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΡΠΈΡΡΠΎΠ²ΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΠΏΡΠ΅ΠΏΠΎΠ΄Π°Π²Π°Π½ΠΈΠΈ ΠΈΠ½ΠΎΡΡΡΠ°Π½Π½ΡΡ
ΡΠ·ΡΠΊΠΎΠ². ΠΠ±ΡΡΠΆΠ΄Π°ΡΡΡΡ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΡΠ΅ ΡΡΡΠ΄Π½ΠΎΡΡΠΈ ΠΈ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½ΠΈΡ Π²Π½Π΅Π΄ΡΠ΅Π½ΠΈΡ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ. ΠΠΎΠ΄ΡΠ΅ΡΠΊΠΈΠ²Π°Π΅ΡΡΡ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΡ ΡΠΈΡΡΠ΅ΠΌΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅Π³ΡΠ°ΡΠΈΠΈ ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² ΡΡΠ΅Π±Π½ΡΠΉ ΠΏΡΠΎΡΠ΅ΡΡ ΠΊΠ°ΠΊ ΠΏΡΠΈ Π°ΡΠ΄ΠΈΡΠΎΡΠ½ΠΎΠΉ ΡΠ°ΠΊ ΠΈ ΠΏΡΠΈ ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΠ°Π±ΠΎΡΠ΅, Π° ΡΠ°ΠΊΠΆΠ΅ Π²Π°ΠΆΠ½ΠΎΡΡΡ Π°Π΄Π΅ΠΊΠ²Π°ΡΠ½ΠΎΠΉ ΠΌΠ΅ΡΠΎΠ΄ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΊΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΡΠ΅ΠΌΡΡ
ΡΠ΅Ρ
Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ
Induced measures in the space of mixed quantum states
We analyze several product measures in the space of mixed quantum states. In
particular we study measures induced by the operation of partial tracing. The
natural, rotationally invariant measure on the set of all pure states of a N x
K composite system, induces a unique measure in the space of N x N mixed states
(or in the space of K x K mixed states, if the reduction takes place with
respect to the first subsystem). For K=N the induced measure is equal to the
Hilbert-Schmidt measure, which is shown to coincide with the measure induced by
singular values of non-Hermitian random Gaussian matrices pertaining to the
Ginibre ensemble. We compute several averages with respect to this measure and
show that the mean entanglement of pure states behaves as lnN-1/2.Comment: 12 latex pages, 2 figures in epsf, submited to J. Phys. A. ver.3,
some improvements and a few references adde
Forward K+ production in subthreshold pA collisions at 1.0 GeV
K+ meson production in pA (A = C, Cu, Au) collisions has been studied using
the ANKE spectrometer at an internal target position of the COSY-Juelich
accelerator. The complete momentum spectrum of kaons emitted at forward angles,
theta < 12 degrees, has been measured for a beam energy of T(p)=1.0 GeV, far
below the free NN threshold of 1.58 GeV. The spectrum does not follow a thermal
distribution at low kaon momenta and the larger momenta reflect a high degree
of collectivity in the target nucleus.Comment: 4 pages, 3 figure
High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels
Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary habits, and serum lipids has not been characterized in detail. We measured conserved proportions of cholesterol high and low-converter types in individuals with and without obesity from two distinct, independent low-carbohydrate high-fat (LCHF) dietary intervention studies. Across both cohorts, cholesterol conversion increased in previous low-converters after LCHF diet and was positively correlated with the fecal relative abundance of Eubacterium coprostanoligenes. Lean cholesterol high-converters had increased serum triacylglycerides and decreased HDL-C levels before LCHF diet and responded to the intervention with increased LDL-C, independently of fat, cholesterol, and saturated fatty acid intake. Our findings identify the cholesterol high-converter type as a microbiome marker, which in metabolically healthy lean individuals is associated with increased LDL-C in response to LCHF.publishedVersio
Identification of Radiopure Titanium for the LZ Dark Matter Experiment and Future Rare Event Searches
The LUX-ZEPLIN (LZ) experiment will search for dark matter particle
interactions with a detector containing a total of 10 tonnes of liquid xenon
within a double-vessel cryostat. The large mass and proximity of the cryostat
to the active detector volume demand the use of material with extremely low
intrinsic radioactivity. We report on the radioassay campaign conducted to
identify suitable metals, the determination of factors limiting radiopure
production, and the selection of titanium for construction of the LZ cryostat
and other detector components. This titanium has been measured with activities
of U~1.6~mBq/kg, U~0.09~mBq/kg,
Th~~mBq/kg, Th~~mBq/kg, K~0.54~mBq/kg, and Co~0.02~mBq/kg (68\% CL).
Such low intrinsic activities, which are some of the lowest ever reported for
titanium, enable its use for future dark matter and other rare event searches.
Monte Carlo simulations have been performed to assess the expected background
contribution from the LZ cryostat with this radioactivity. In 1,000 days of
WIMP search exposure of a 5.6-tonne fiducial mass, the cryostat will contribute
only a mean background of (stat)(sys) counts.Comment: 13 pages, 3 figures, accepted for publication in Astroparticle
Physic
Anti-Search for the Glueball Candidate f_J(2220) in Two-Photon Interactions
Using 13.3 fb^{-1} of e^+e^- data recorded with the CLEO II and CLEO II.V
detector configurations at CESR, we have searched for f_J(2220) decays to
K^0_{S} K^0_{S} in untagged two-photon interactions. We report an upper limit
on the product of the two-photon partial width and the branching fraction,
Gamma_gamma gamma cdot B (f_J(2220) to K^0_{S} K^0_{S}) of less than 1.1 eV at
the 95% C.L: systematic uncertainties are included. This dataset is four times
larger than that used in the previous CLEO publication.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, Submitted to PRD (R
Linguistics and natural logic
Evidence is presented to show that the role of a generative grammar of a natural language is not merely to generate the grammatical sentences of that language, but also to relate them to their logical forms. The notion of logical form is to be made sense of in terms a βnatural logicβ, a logical for natural language, whose goals are to express all concepts capable of being expressed in natural language, to characterize all the valid inferences that can be made in natural language, and to mesh with adequate linguistic descriptions of all natural languages. The latter requirement imposes empirical linguistic constraints on natural logic. A number of examples are discussed.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/43819/1/11229_2004_Article_BF00413602.pd
Ultra-Early and Short-Term Tranexamic Acid Treatment in Patients With Good- and Poor-Grade Aneurysmal Subarachnoid Hemorrhage
The results of the ULTRA trial showed that ultra-early and short-term treatment with tranexamic acid (TXA) does not improve clinical outcome after aneurysmal subarachnoid hemorrhage (aSAH). Possibly, the lack of a beneficial effect in all patients with aSAH is masked by antagonistic effects of TXA in certain subgroups. In this post hoc subgroup analysis, we investigated the effect of TXA on clinical outcome in patients with good-grade and poor-grade aSAH
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