Good Management of European UNESCO Industrial World Heritage Sites in the Context of Urban and Regional Planning

This paper addresses the general theme of conservation and/or change of heritage sites in urban and regional planning. The particular focus is on the management of UNESCO industrial World Heritage sites in Europe. Industrial heritage refers back to historic innovation and continues to be embedded today in innovation-orientated urban and regional development. The question that our study examines is: In which aspects does the management of an industrial World Heritage site coincide with (or differ from) that of areas of innovation? We identified criteria both for the management of industrial heritage sites (“Good Practice Wheel”) and areas of innovation (success factors for European Science and Technology Parks). In an online survey, we asked managers of heritage sites to evaluate management criteria. Completed survey responses were obtained for 22 of 38 European sites (58%) in 12 of 15 countries concerned (80%). Our study clearly shows an overlap of conservation and innovation priorities even in the management of UNESCO industrial World Heritage sites, and underlines the importance of integrative, “good” heritage management.Peer Reviewe

Transition from hexagons to optical turbulence

4 pages, 3 figures.-- PACS nrs.: 42.65.Sf, 47.20.Ky, 47.54.+r, 89.75.Kd.We characterize the different dynamical regimes and bifurcations in the transition from a stationary hexagonal pattern to optical turbulence. In order to characterize the bifurcations we perform linear stability analysis of stationary hexagonal patterns and Floquet analysis of oscillating hexagons. The interplay between space and time leads to a series of bifurcations showing spatial-period multiplying and quasiperiodicity.The authors acknowledge financial support from the MCyT (Spain, Project Nos. PB97-0141-C02-02, BFM2000-1108, and BFM2001-0341-C02-02).Peer reviewe

Investigation of the influence of active dopant and co-dopant on the luminescent properties of the phosphor based on calcium aluminate

In the present study the luminescent properties of calcium aluminate activated by Eu3+ and Dy3+ions are investigated. The phosphor on the basis of calcium aluminate was obtained via citric-nitrate sol gel method using a microwave radiation. It was determined by X-ray diffraction method and by electron microprobe analysis that rare earth elements (REE) ions incorporate into lattice of calcium aluminate and don't form own phases. Luminescent properties of calcium aluminate activated by REE ions were studied by spectrofluorimeter. Luminescent spectrum of Ca0,95Eu0,05Al2O4 contains five bands groups of emission between 580-710 nm which correspond to 5D0 - 7Fj transitions of Eu3+(λ=254 nm). Present maxima lie in the red area of the spectrum and determine the obtainment of red glow phosphor. Excitation spectrum of Ca0,95Dy0,05Al2O4 contains two bands with maxima at 240 and 380 nm. Exciting the sample by the far ultraviolet (240 nm), two bands with maxima at 420 and 490 nm conditioning a blue glow of phosphor under overlapping of violet (4G11/2 - 6H15/2 transition of Dy3+) and blue-green (4F9/2 - 6H15/2 transition of Dy3+) radiations, respectively, were observed. Exciting the sample by the near ultraviolet (380 nm), one intense band at 420 nm and bright violet glowing were observed. Emission spectrum of the phosphor obtaining by co-activation of calcium aluminate by two test REE ions is identical to the emission spectrum of calcium aluminate activated by Dy3+ ions. Transitions of Eu3+ in this case are not observed. Nevertheless, the increase of band intensity conditioning more bright violet glowing was observed

Blood pressure target attainment in the background of guidelines: the very elderly in Swiss primary care

Background There are only a few trials for the very elderly population (>79 years). No consensus, which blood pressure (BP) goals and substances should be applied, has been found yet. This survey was undertaken to investigate how octogenarians are treated and attain BP targets in the Swiss primary care. Methods Data from 4594 hypertensive patients were collected within 7 days. Eight hundred and seventy-seven patients met the requirement to be >79 years. We assessed substances/combinations and investigated pulse pressure and target blood pressure attainment (TBPA) using three different recommendations [Canadian Hypertension Education Program (CHEP), Swiss Society of Hypertension (SSH), European Society of Hypertension-European Society of Cardiology (ESH-ESC)]. Secondarily, we compared TBPA attained by angiotensin-converting enzyme inhibitor (ACEI)/diuretic (D), angiotensin receptor blocker (ARB)/D and calcium channel blocker (CCB)/D with any other dual therapy and investigated whether Ds/beta-blockers (BBs) or Ds/renin angiotensin-converting enzyme inhibitors (RAAS-Is) lead to higher TBPA. Finally, we assessed the impact of drug administration, practical work experience, location and specialization of GPs on TBPA. Results Octogenarians attained target blood pressure (TBP) between 44% (ESH-ESC) and 74% (SSH). Optimal/normal BP was reached in 22.8% of patients. Pulse pressure <65 mmHg was shown in 66.4% of patients. Monotherapy was most commonly applied followed by dual single-pill combination with ARB/D (46.5%) or ACEI/D (36.0%). No benefit in TBPA was found comparing a RAASI/D and CCB/D treatment with any other dual combination. There was also no difference between BB/D and RAAS-I/D combination therapy and between single-pill combination and dual free combinations. Conclusions GPs adhere to the use of substances proven in outcome trials and attain high TBP. No difference in meeting BP goals could be found using different drug classes. There is an unmet need to harmonize recommendations and to add additional information for the treatment of octogenarian

The oxygen-independent coproporphyrinogen III oxidase HemN utilizes harderoporphyrinogen as a reaction intermediate during conversion of coproporphyrinogen III to protoporphyrinogen IX

During heme biosynthesis the oxygen-independent coproporphyrinogen III oxidase HemN catalyzes the oxidative decarboxylation of the two propionate side chains on rings A and B of coproporphyrinogen III to the corresponding vinyl groups to yield protoporphyrinogen IX. Here, the sequence of the two decarboxylation steps during HemN catalysis was investigated. A reaction intermediate of HemN activity was isolated by HPLC analysis and identified as monovinyltripropionic acid porphyrin by mass spectrometry. This monovinylic reaction intermediate exhibited identical chromatographic behavior during HPLC analysis as harderoporphyrin (3-vinyl-8,13,17-tripropionic acid-2,7,12,18- tetramethylporphyrin). Furthermore, HemN was able to utilize chemically synthesized harderoporphyrinogen as substrate and converted it to protoporphyrinogen IX. These results suggest that during HemN catalysis the propionate side chain of ring A of coproporphyrinogen III is decarboxylated prior to that of ring B. © by Walter de Gruyter