End-effects of strongly charged polyelectrolytes - a molecular dynamics study

We investigate end-effects in the ion distribution around strongly charged, flexible polyelectrolytes with a quenched charge distribution by molecular dynamics simulations of dilute polyelectrolyte solutions. We take the counterions explicitly into account and calculate the full Coulomb interaction via an Ewald summation method. We find that the free counterions of the solution are distributed in such a way that a fraction of the chain charges is effectively neutralized. This in turn leads to an effective charge distribution which is similar to those found for weakly charged titrating polyelectrolytes that have an annealed charge distribution. The delicate interplay between the electrostatic interactions, the chain conformation and the counterion distribution is studied in detail as a function of different system parameters such as the chain length Nm, the charge fraction f, the charged particle density rho, the ionic strength and the solvent quality. Comparisons are made with predictions from a scaling theory.Comment: 20 pages, 10 figures. J. Chem. Phys, to appear June 200

Tunneling dynamics of few bosons in a double well

We study few-boson tunneling in a one-dimensional double well. As we pass from weak interactions to the fermionization limit, the Rabi oscillations first give way to highly delayed pair tunneling (for medium coupling), whereas for very strong correlations multi-band Rabi oscillations emerge. All this is explained on the basis of the exact few-body spectrum and without recourse to the conventional two-mode approximation. Two-body correlations are found essential to the understanding of the different tunnel mechanisms. The investigation is complemented by discussing the effect of skewing the double well, which offers the possibility to access specific tunnel resonancesComment: 10 pages, 8 figure

Clout, Activists and Budget: The Road to Presidency

Political campaigns involve, in the simplest case, two competing campaign groups which try to obtain a majority of votes. We propose a novel mathematical framework to study political campaign dynamics on social networks whose constituents are either political activists or persuadable individuals. Activists are convinced and do not change their opinion and they are able to move around in the social network to motivate persuadable individuals to vote according to their opinion. We describe the influence of the complex interplay between the number of activists, political clout, budgets, and campaign costs on the campaign result. We also identify situations where the choice of one campaign group to send a certain number of activists already pre-determines their victory. Moreover, we show that a candidate's advantage in terms of political clout can overcome a substantial budget disadvantage or a lower number of activists, as illustrated by the US presidential election 2016.Comment: 23 pages, 10 figure

Designing for Economies of Scale vs. Economies of Focus in Hospital Departments

Subject/Research problem: Hospitals traditionally segregate resources into centralized functional departments such as diagnostic departments, ambulatory care centres, and nursing wards. In recent years this organizational model has been challenged by the idea that higher quality of care and efficiency in service delivery can be achieved when services are organized around patient groups. Examples are specialized clinics for breast cancer patients and clinical pathways for diabetes patients. Hospitals are struggling with the question whether to become more centralized to achieve economies of scale or more decentralized to achieve economies of focus. In this paper service and patient group characteristics are examined to determine conditions where a centralized model is more efficient and conversely where a decentralized model is more efficient. - Research Question: When organizing hospital capacity what service and patient group characteristics indicate efficiency can be gained through economies of scale vs. economies of focus? - Approach: Using quantitative Queueing Theory and Simulation models the performance of centralized and decentralized hospital clinics is compared. This is done for a variety of services and patient groups. - Result: The study results in a model measuring the tradeoffs between economies of scale and economies of focus. From this model management guidelines are derived. - Application: The general results support strategic planning for a new facility at the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital. A model developed during this research is also applied in the Chemotherapy Department of the same hospital

Efficiency evaluation for pooling resources in health care

Hospitals traditionally segregate resources into centralized functional departments such as diagnostic departments, ambulatory care centers, and nursing wards. In recent years this organizational model has been challenged by the idea that higher quality of care and efficiency in service delivery can be achieved when services are organized around patient groups. Examples include specialized clinics for breast cancer patients and clinical pathways for diabetes patients. Hospitals are struggling with the question of whether to become more centralized to achieve economies of scale or more decentralized to achieve economies of focus. In this paper we examine service and patient group characteristics to study the conditions where a centralized model is more efficient, and conversely, where a decentralized model is more efficient. This relationship is examined analytically with a queuing model to determine themost influential factors and then with simulation to fine-tune the results. The tradeoffs between economies of scale and economies of focus measured by these models are used to derive general management guidelines

Efficiency evaluation for pooling resources in health care: An interpretation for managers

Subject/Research problem\ud Hospitals traditionally segregated resources into centralized functional departments such as diagnostic departments, ambulatory care centres, and nursing wards. In recent years this organizational model has been challenged by the idea that higher quality of care and efficiency in service delivery can be achieved when services are organized around patient groups. Examples are specialized clinics for breast cancer patients and clinical pathways for diabetes patients. Hospitals are grappling more and more with the question, should we become more centralized to achieve economies of scale or more decentralized to achieve economies of focus. In this paper service and patient group characteristics are examined to determine conditions where a centralized model is more efficient and conversely where a decentralized model is more efficient.\ud Research Question\ud When organizing hospital capacity what service and patient group characteristics indicate that efficiency can be gained through economies of scale vs. economies of focus?\ud Approach\ud Using quantitative models from the Queueing Theory and Simulation disciplines the performance of centralized and decentralized hospital clinics are compared. This is done for a variety of services and patient groups. \ud Result\ud The study results in a model measuring the tradeoffs between economies of scale and economies of focus. From this model “rules of thumb” for managers are derived.\ud Application\ud The general results support strategic planning for a new facility at the Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital. A model developed during this study is also applied in the Chemotherapy Department of the same hospital.\u