Aplikasi Marka Ssr Pada Keanekaragaman Genetik Durian (Durio Zibethinus Murr.) Di Kabupaten Deli Serdang, Sumatra Utara

Kabupaten Deli Serdang merupakan salah satu kontributor untuk produksi durian (Durio zibethinus Murr.) Provinsi Sumatra Utara. Durian Deli Serdang memiliki varietas yang banyak dikenal di pasar buah domestik, diantaranya; Bintana, Ginting, dan Sikapal. Pada penelitian ini, dilakukan analisis keanekaragaman genetik pada durian asal Deli Serdang untuk memperoleh informasi keragaman genetik dan hubungan antar aksesi dengan menggunakan 6 lokus Simple Sequence Repeats (SSR). Hasil menunjukkan bahwa 9 aksesi durian yang dikoleksi dari Kabupaten Deli Serdang berhasil diamplifikasi dan bersifat polimorfik. Hal ini dibuktikan dengan hasil visualisasi lokus SSR yang menghasilkan 23 fragmen DNA berukuran 72-255 bp yang didapat melalui bantuan piranti lunak GeneMarker V2.6.7. Hasil penelitian juga menampilkan konstruksi dendogram yang menunjukkan kemiripan antar aksesi durian Deli Serdang yang didapat melalui bantuan perangkat lunak NTSYSpc V2.0.2. Susunan antar aksesi pada pohon dendogram terlihat menyerupai pohon filogenetik, aksesi terpisah dan menyebar pada koefisien 0,54-0,95 yang tidak dipengaruhi oleh sebaran geografis. Data ini dapat menjadi dasar penelitian budidaya dan konservasi buah durian di Indonesia khususnya di Sumatra Utara

Individual leader to interdependent leadership: A case study in leadership development and tripartite evaluation

This article is available open access through the publisher’s website at the link below. Copyright @ 2013 Sage Publications.The Problem - In this case study we see a move away from orthodox views of school leadership as “headship” to a more contemporary model of educational leadership wherein we note a departure from functional, curricula-based school leadership toward more human resource development (HRD) approaches. The aim of this study was to consider the effectiveness of an educational development program for middle leaders within an educational establishment. The Solution - We examined the impact of a bespoke higher education leadership development intervention in Leadership (and Change) on the formation and cohesiveness of a newly formed innovative leadership structure. The Stakeholders - The leadership development intervention was designed through a tripartite collaboration including a university, senior school leaders, and staff. The intervention was designed to shift leadership from individual leader agency to interdependent human leadership agency. Through tripartite evaluation we uncover leadership development praxis that transcends the boundaries of conventional educational leadership and reemphasizes the benefits of bridging the academic/practitioner divide and the application of theory to praxis

Olfactory function and viral recovery in COVID-19

Olfactory and taste disorders were reported in up to 30%-80% of COVID-19 patients. The purpose of our study was to objectively assess smell impairment in COVID-19 patients and to correlate olfactory function with viral recovery

The practices of apartheid as a war crime: a critical analysis

The human suffering caused by the political ideology of apartheid in South Africa during the Apartheid era (1948-1994) prompted worldwide condemnation and a variety of diplomatic and legal responses. Amongst these responses was the attempt to have apartheid recognised both as a crime against humanity in the 1973 Apartheid Convention as well as a war crime in Article 85(4)(c) of Additional Protocol I. This article examines the origins, nature and current status of the practices of apartheid as a war crime and its possible application to the Israeli-Palestinian conflict

Unlocking Women's Leadership Potential: A Curricular Example for Developing Female Leaders in Academia

Women in academia face unique challenges when it comes to advancing to professorship. Using latest research about gender and academic leadership, we present a training curriculum that is sensitive to the unique demands of women in and aspiring to leadership positions in academia. The context-specific and evidence-based approach and a focus on self-directed leadership development are unique characteristics of the training. It aims to enhance women's motivation to lead, increase their knowledge about academic leadership, and empower them to seek the support they need to proactively work toward appointment to a professorship. We also delineate an evaluation framework, which addresses these targeted outcomes. The findings from a pilot program in Germany confirmed that the curriculum is effective in developing women as academic leaders. The discussion highlights the significance of a context-specific and evidence-based approach to women's leadership development in academia

Identification, replication and characterization of epigenetic remodelling in the aging genome:A cross population analysis

Aging is a complex biological process regulated by multiple cellular pathways and molecular mechanisms including epigenetics. Using genome-wide DNA methylation data measured in a large collection of Scottish old individuals, we performed discovery association analysis to identify age-methylated CpGs and replicated them in two independent Danish cohorts. The double-replicated CpGs were characterized by distribution over gene regions and location in relation to CpG islands. The replicated CpGs were further characterized by involvement in biological pathways to study their functional implications in aging. We identified 67,604 age-associated CpG sites reaching genome-wide significance of FWE

Long-Run Consequences of Natural Disasters: Evidence from Tangshan

Exploiting Tangshan 1976 - the deadliest earthquake in the 20th century - as a source of exogenous variation, we estimate the cohort-specific effects of a historical shock on contemporary socio-economic outcomes. While cohorts born after the earthquake were considerably larger, the adverse post-disaster conditions did not translate into lasting impacts on schooling and labour market outcomes. Cohorts at schooling age during the earthquake, however, exhibit considerably lower education levels today, particularly among the female. Despite lower education, there is no evidence for adverse labour market outcomes. We conduct extensive robustness checks and argue that the effect is causal

An improved pig reference genome sequence to enable pig genetics and genomics research.

BACKGROUND: The domestic pig (Sus scrofa) is important both as a food source and as a biomedical model given its similarity in size, anatomy, physiology, metabolism, pathology, and pharmacology to humans. The draft reference genome (Sscrofa10.2) of a purebred Duroc female pig established using older clone-based sequencing methods was incomplete, and unresolved redundancies, short-range order and orientation errors, and associated misassembled genes limited its utility. RESULTS: We present 2 annotated highly contiguous chromosome-level genome assemblies created with more recent long-read technologies and a whole-genome shotgun strategy, 1 for the same Duroc female (Sscrofa11.1) and 1 for an outbred, composite-breed male (USMARCv1.0). Both assemblies are of substantially higher (>90-fold) continuity and accuracy than Sscrofa10.2. CONCLUSIONS: These highly contiguous assemblies plus annotation of a further 11 short-read assemblies provide an unprecedented view of the genetic make-up of this important agricultural and biomedical model species. We propose that the improved Duroc assembly (Sscrofa11.1) become the reference genome for genomic research in pigs

The International Law of Secession and the Protection of the Human Rights of Oppressed Sub-State Groups: Yesterday, Today and Tomorrow

This paper focuses on significant patterns/features in the historical development of the international law of secession and its contribution over time (or the lack thereof) to the struggle to afford greater protection to oppressed sub-state groups the world over. It was Crawford Young who once observed that “the state as an analytical quarry is an elusive and complex prey.” With the necessary modifications, this observation applies with almost equal force to the international law of secession. Complexity and confusion loom too large in this area of international law. For example, there is, at best, little clarity in the literature of the discipline of international law and in related fields of study regarding the existence or otherwise of an international legal entitlement to secession in favor of even the most highly oppressed and subjugated sub-state groups