Letter on “Sharing trial results directly with trial participants and other stakeholders after the SARS-CoV-2 pandemic hit the UK:experience from the ActWELL trial

Acknowledgements We would like to thank our ActWELL participants who attended the events for their interest and enthusiasm in making the events a success. We would like to thank Susan MacAskill for giving us permission to use a quote from her email to us. We are also grateful to the technical support who got us through all events, Cormac Staunton (of stauntonmedia.ie). We would also like to acknowledge and thank Dr Katie Gillies and Dr Seonaidh Cotton for their contribution to the design of the evaluation survey. HSRU is core funded by the Chief Scientist Office of the Scottish Government Health and Social Care Directorates. This work was supported by The Scottish Government, grant number BC/ Screening/17/01.Peer reviewedPublisher PD

A stakeholder analysis to prepare for real-world evaluation of integrating artificial intelligent algorithms into breast screening (PREP-AIR study) : a qualitative study using the WHO guide

Funding This project was funded by the Innovate UK - part of UK Research and Innovation (Project No: 20378). The funders had no role in the study design, data collection and analysis, publication decision, or manuscript preparation. Acknowledgements This work is supported by the Industrial Centre for AI Research in digital Diagnostics (iCAIRD) which is funded by Innovate UK on behalf of UK Research and Innovation (UKRI) [project number: 104690]. We thank all participants in the study. We thank all co-authors for their contributions. We also thank Graham Scotland for interpreting findings around economic evaluation and the rest of the iCAIRD team (including Moragh Boyle, Roger Staff) for contributing towards Phases 3 and 4 of this study. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.Peer reviewe

Collaborative resonant writing and musical improvisation to explore the concept of resonance

Resonance is often used to characterize relationships, but it is acomplex concept that explains quite different physical,physiological and psychological processes. With the aim of gainingdeeper insight into the concept of resonance, a group of ten musictherapy researchers, all colleagues, embarked on a joint journey ofexploration. This included an aim of letting the internal learningprocess be disseminated in a way that could give others insight, notonly from the findings, but also from the process. Findings includea dual understanding of resonance as (1) a visible and orderedphenomenon consisting of physical vibrations and acousticsounding that offers a clear logic, and (2) a metaphoricalconceptualization used to describe and understand complexpsychological processes of human relationships. The process ofcollaborative writing led to the discovery or development of a ninestepprocedure including different collaborative resonant writingprocedures and musical improvisation, as well as of a series ofmetaphors to explain therapeutic interaction, resonant learning andways of resonant exploration

The International Bathymetric Chart of the Arctic Ocean (IBCAO) Version 3.0

[1] The International Bathymetric Chart of the Arctic Ocean (IBCAO) released its first gridded bathymetric compilation in 1999. The IBCAO bathymetric portrayals have since supported a wide range of Arctic science activities, for example, by providing constraint for ocean circulation models and the means to define and formulate hypotheses about the geologic origin of Arctic undersea features. IBCAO Version 3.0 represents the largest improvement since 1999 taking advantage of new data sets collected by the circum-Arctic nations, opportunistic data collected from fishing vessels, data acquired from US Navy submarines and from research ships of various nations. Built using an improved gridding algorithm, this new grid is on a 500 meter spacing, revealing much greater details of the Arctic seafloor than IBCAO Version 1.0 (2.5 km) and Version 2.0 (2.0 km). The area covered by multibeam surveys has increased from ∼6% in Version 2.0 to ∼11% in Version 3.0

FUSIONS Definitional Framework for Food Waste

none21To develop reliable food waste estimates, which can be accurately repeated over time, it is necessary to produce data within a robust methodological framework. This must comprise a consistent definition of food waste and its components, and consistent system boundaries for the food supply chain. The absence of a framework for defining food waste to date has led to the production of datasets that are not always comparable or transparent as to which fractions are included. A common definitional framework will support policy-makers at both EU and Member State level, and stakeholders across the food supply chain, by enabling them to accurately track the rate of food waste reduction, and the effectiveness of their waste prevention strategies. The development of this framework for defining food waste signals a key step towards improving our understanding of the food waste challenge in Europe and its consistent use will help measure progress towards both resource efficiency and food security goals.openKarin Östergren; Jenny Gustavsson; Hilke Bos-Brouwers; Toine Timmermans; Ole-Jørgen Hansen; Hanne Møller; Gina Anderson; Clementine O’Connor; Han Soethoudt; Tom Quested; Sophie Easteal; Alessandro Politano; Cecilia Bellettato; Massimo Canali; Luca Falasconi; Silvia Gaiani; Matteo Vittuari; Felicitas Schneider; Graham Moates; Keith Waldron; Barbara RedlingshöferKarin Östergren; Jenny Gustavsson; Hilke Bos-Brouwers; Toine Timmermans; Ole-Jørgen Hansen; Hanne Møller; Gina Anderson; Clementine O’Connor; Han Soethoudt; Tom Quested; Sophie Easteal; Alessandro Politano; Cecilia Bellettato; Massimo Canali; Luca Falasconi; Silvia Gaiani; Matteo Vittuari; Felicitas Schneider; Graham Moates; Keith Waldron; Barbara Redlingshöfe

Secondary insults following traumatic brain injury enhance complement activation in the human brain and release of the tissue damage marker S100B

To access publisher full text version of this article. Please click on the hyperlink in Additional Links field.OBJECT: Complement activation has been suggested to play a role in the development of secondary injuries following traumatic brain injury (TBI). The present study was initiated in order to analyze complement activation in relation to the primary brain injury and to secondary insults, frequently occurring following TBI. METHODS: Twenty patients suffering from severe TBI (Glasgow coma score ≤ 8) were included in the study. The "membrane attack complex," C5b9, which is the cytolytic end product of the complement system was analyzed in cerebrospinal fluid (CSF). The degree of brain tissue damage was assessed using the release of S100B and neuron-specific enolase (NSE) to the CSF and blood. The blood-brain barrier was assessed using the CSF/serum quotient of albumin (Q (A)). RESULTS: Following impact, initial peaks (0-48 h) of C5b9, S100B, and NSE with a concomitant loss of integrity of the blood-brain barrier were observed. Secondary insults at the intensive care unit were monitored. Severe secondary insults were paralleled by a more pronounced complement activation (C5b9 in CSF) as well as increased levels of S100B (measured in CSF), but not with NSE. CONCLUSION: This human study indicates that complement activation in the brain is triggered not only by the impact of trauma per se but also by the amount of secondary insults that frequently occur at the scene of accident as well as during treatment in the neurointensive care unit. Complement activation and in particular the end product C5b9 may in turn contribute to additional secondary brain injuries by its membrane destructive properties