Clinical Outcomes and Quality of Life of Patients Receiving Multi-Solid-Organ Transplants in Childhood Are Excellent: Results From a 20-Year Cohort Study

Advances in medicine allow children with previously fatal conditions to survive longer and present as transplant candidates; some requiring multiple solid-organ transplants (MSOT). There is limited data on clinical outcomes and no data on quality of life (QoL). In this mixed methods cohort study clinical outcomes from the NHSBT registry were analysed for all patients who received a kidney and one other solid-organ transplant as a child between 2000 and 2021 in the UK. QoL was measured using the PedsQL 3.0 Transplant Module questionnaire. 92 children met the inclusion criteria: heart/heart-lung and kidney (n = 15), liver and kidney (n = 72), pancreas and kidney (n = 4) and multivisceral (n = 1). Results showed excellent patient and graft survival, comparable to single-organ transplants. Allograft survival and rejection were significantly better in patients with combined liver and kidney transplants compared to patients with sequential liver and kidney transplants. QoL was excellent with a mean score of 74%. Key findings included a significant improvement in QoL post-transplant. This is the first study to look at clinical and QoL outcomes in MSOT recipients. The results indicate excellent long-term outcomes. All children born with conditions leading to end-stage disease in multiple solid-organs should be assessed as transplant candidates

The ionising photon production efficiency at z~6 for a sample of bright Lyman-alpha emitters using JEMS and MUSE

We study the ionising photon production efficiency at the end of the Epoch of Reionisation ($z \sim 5.4 - 6.6$) for a sample of 35 bright Lyman-$\alpha$ emitters, this quantity is crucial to infer the ionising photon budget of the Universe. These objects were selected to have reliable spectroscopic redshifts, assigned based on the profile of their Lyman-$\alpha$ emission line, detected in the MUSE deep fields. We exploit medium-band observations from the JWST extragalactic medium band survey (JEMS) to find the flux excess corresponding to the redshifted \ha\ emission line. We estimate the UV luminosity by fitting the full JEMS photometry, along with several HST photometric points, with \texttt{Prospector}. We find a median ultra-violet continuum slope of $\beta = -2.21^{+0.26}_{-0.17}$ for the sample, indicating young stellar populations with little-to-no dust attenuation. Supported by this, we derive $\xi_{ion,0}$ with no dust attenuation and find a median value of log$\frac{\xi_{ion,0}}{\text{Hz erg}^{-1}} = 26.36^{+0.17}_{-0.14}$. If we perform dust attenuation corrections and assume a Calzetti attenuation law, our values are lowered by $\sim 0.1$ dex. Our results suggest Lyman-$\alpha$ emitters at the Epoch of Reionisation have enhanced $\xi_{ion,0}$ compared to previous estimations from literature, in particular, when compared to the non-Lyman-$\alpha$ emitting population. This initial study provides a promising outlook on the characterisation of ionising photon production in the early Universe. In the future, a more extensive study will be performed on the entire dataset provided by the JWST Advanced Deep Extragalactic Survey (JADES). Thus, for the first time, allowing us toComment: 11 pages, 5 figures in main paper. 10 pages, 30 figures in appendix. Submitted to MNRA

A Systematic Search for Galaxies with Extended Emission Lines and Potential Outflows in JADES Medium-band Images

For the first time, we present a systematic search for galaxies with extended emission lines and potential outflow features using JWST medium-band images in the GOODS South field. This is done by comparing the morphology in medium-band images to adjacent continuum and UV bands. We look for galaxies that have a maximum extent 50% larger, an excess area 30% greater, or an axis ratio difference of more than 0.3 in the medium band compared to the reference bands. After visual inspection, we find 326 candidate galaxies at 1.4 < z < 8.4, with a peak in the population near cosmic noon, benefiting from the good coverage of the medium-band filters. By fitting their spectral energy distributions, we find that the candidate galaxies are at least 20% more bursty in their star-forming activity and have 50% more young stellar populations compared to a control sample selected based on the continuum band flux. Additionally, these candidates exhibit a significantly higher production rate of ionizing photons. We further find that candidates hosting known active galactic nuclei (AGN) produce extended emission that is more anisotropic compared to non-AGN candidates. A few of our candidates have been spectroscopically confirmed to have prominent outflow signatures through NIRSpec observations, showcasing the robustness of the photometric selection. Future spectroscopic follow-up will better help verify and characterize the kinematics and chemical properties of these systems

Constraining the major merger history of z ∼ 3–9 galaxies using JADES: dominant in situ star formation

We present a comprehensive analysis of galaxy close-pair fractions and major merger rates to evaluate the importance of mergers in the hierarchical growth of galaxies over cosmic time. This study focuses on the previously poorly understood redshift range of using JADES observations. Our mass-complete sample includes primary galaxies with stellar masses of , having major companions (mass ratio ) selected by pkpc projected separation and redshift proximity criteria. Pair fractions are measured using a statistically robust method incorporating photometric redshift posteriors and available spectroscopic data. The pair fraction evolves with redshift and shows dependence on the stellar mass: at there is an increase up to , followed by a turnover, while at higher stellar masses there is a flattening and weak decline with increasing redshift. Similarly, the derived galaxy major merger rate increases and flattens beyond to per galaxy, showing a weak scaling with stellar mass, driven by the evolution of the galaxy stellar mass function. A comparison between the cumulative mass accretion from major mergers and the mass assembled through star formation indicates that major mergers contribute approximately to the total mass growth over the studied redshift range, which is in agreement with the ex situ mass fraction estimated from our simple numerical model. These results highlight that major mergers contribute little to the direct stellar mass growth compared to in situ star formation but could still play an indirect role by driving star formation itself

Use of an outbred rat hepacivirus challenge model for design and evaluation of efficacy of different immunization strategies for hepatitis C virus

Background and Aims The lack of immunocompetent small animal models for hepatitis C virus (HCV) has greatly hindered the development of effective vaccines. Using rodent hepacivirus (RHV), a homolog of HCV that shares many characteristics of HCV infection, we report the development and application of an RHV outbred rat model for HCV vaccine development. Approach and Results Simian adenovirus (ChAdOx1) encoding a genetic immune enhancer (truncated shark class II invariant chain) fused to the nonstructural (NS) proteins NS3‐NS5B from RHV (ChAd‐NS) was used to vaccinate Sprague‐Dawley rats, resulting in high levels of cluster of differentiation 8–positive (CD8+) T‐cell responses. Following RHV challenge (using 10 or 100 times the minimum infectious dose), 42% of vaccinated rats cleared infection within 6‐8 weeks, while all mock vaccinated controls became infected with high‐level viremia postchallenge. A single, 7‐fold higher dose of ChAd‐NS increased efficacy to 67%. Boosting with ChAd‐NS or with a plasmid encoding the same NS3‐NS5B antigens increased efficacy to 100% and 83%, respectively. A ChAdOx1 vector encoding structural antigens (ChAd‐S) was also constructed. ChAd‐S alone showed no efficacy. Strikingly, when combined with ChAd‐NS, ChAD‐S produced 83% efficacy. Protection was associated with a strong CD8+ interferon gamma–positive recall response against NS4. Next‐generation sequencing of a putative RHV escape mutant in a vaccinated rat identified mutations in both identified immunodominant CD8+ T‐cell epitopes. Conclusions A simian adenovirus vector vaccine strategy is effective at inducing complete protective immunity in the rat RHV model. The RHV Sprague‐Dawley rat challenge model enables comparative testing of vaccine platforms and antigens and identification of correlates of protection and thereby provides a small animal experimental framework to guide the development of an effective vaccine for HCV in humans

Resolving the nature and putative nebular emission of GS9422: an obscured AGN without exotic stars

Understanding the sources that power nebular emission in high-redshift galaxies is fundamentally important not only for shedding light on to the drivers of reionization, but to constrain stellar populations and the growth of black holes. Here, we focus on an individual object, GS9422, a galaxy at with exquisite data from the JWST Advanced Deep Extragalactic Survey (JADES), JWST Extragalactic Medium-band Survey (JEMS), and First Reionization Epoch Spectroscopically Complete Observations (FRESCO) surveys, including 14-band JWST/NIRCam photometry and deep NIRSpec prism and grating spectroscopy. We map the continuum emission and nebular emission lines across the galaxy on 0.2-kpc scales. GS9422 has been claimed to have nebular-dominated continuum and an extreme stellar population with top-heavy initial mass function. We find clear evidence for different morphologies in the emission lines, the rest-ultraviolet and rest-optical continuum emission, demonstrating that the full continuum cannot be dominated by nebular emission. While multiple models reproduce the spectrum reasonably well, our preferred model with a type-2 active galactic nucleus (AGN) and local damped Ly (DLA) clouds can explain both the spectrum and the wavelength-dependent morphology. The AGN powers the off-planar nebular emission, giving rise to the Balmer jump and the emission lines, including Ly, which therefore does not suffer DLA absorption. A central, young stellar component dominates the rest-UV emission and – together with the DLA clouds – leads to a spectral turn over. A disc-like, older stellar component explains the flattened morphology in the rest-optical continuum. We conclude that GS9422 is consistent with being a normal galaxy with an obscured, type-2 AGN – a simple scenario, without the need for exotic stellar populations

Resolving the nature and putative nebular emission of GS9422: an obscured AGN without exotic stars

Understanding the sources that power nebular emission in high-redshift galaxies is fundamentally important not only for shedding light onto the drivers of reionisation, but to constrain stellar populations and the growth of black holes. Here we focus on an individual object, GS9422, a galaxy at $z_{\rm spec}=5.943$ with exquisite data from the JADES and JEMS surveys, including 14-band JWST/NIRCam photometry and deep NIRSpec prism and grating spectroscopy. We map the continuum emission and nebular emission lines across the galaxy on 0.2-kpc scales. GS9422 has been claimed to have nebular-dominated continuum and an extreme stellar population with top-heavy initial mass function. We find clear evidence for different morphologies in the emission lines, the rest-UV and rest-optical continuum emission, demonstrating that the full continuum cannot be dominated by nebular emission. While multiple models reproduce the spectrum reasonably well, our preferred model with a type-2 active galactic nucleus (AGN) and local damped Ly-$\alpha$ (DLA) clouds can explain both the spectrum and the wavelength-dependent morphology. The AGN powers the off-planar nebular emission, giving rise to the Balmer jump and the emission lines, including Ly-$\alpha$, which therefore does not suffer DLA absorption. A central, young stellar component dominates the rest-UV emission and -- together with the DLA clouds -- leads to a spectral turn-over. A disc-like, older stellar component explains the flattened morphology in the rest-optical continuum. We conclude that GS9422 is consistent with being a normal galaxy with an obscured, type-2 AGN -- a simple scenario, without the need for exotic stellar populations.Comment: 19 pages, 13 figures, submitted to MNRAS. Comments welcom

JWST-JADES. Possible Population III signatures at z=10.6 in the halo of GN-z11

Finding the first generation of stars formed out of pristine gas in the early Universe, known as Population III (PopIII) stars, is one of the most important goals of modern astrophysics. Recent models suggest that PopIII stars may form in pockets of pristine gas in the halo of more evolved galaxies. Here we present NIRSpec-IFU and NIRSpec-MSA observations of the region around GN-z11, an exceptionally luminous galaxy at $z=10.6$, which reveal a $>$5$\sigma$ detection of a feature consistent with being HeII$\lambda$1640 emission at the redshift of GN-z11. The very high equivalent width of the putative HeII emission in this clump (170 A), and the lack of metal lines, can be explained in terms of photoionisation by PopIII stars, while photoionisation by PopII stars is inconsistent with the data. It would also indicate that the putative PopIII stars likely have a top-heavy initial mass function (IMF), with an upper cutoff reaching at least 500 M$_\odot$. The PopIII bolometric luminosity inferred from the HeII line would be $\sim 2\times 10^{10}~L_\odot$, which (with a top-heavy IMF) would imply a total stellar mass formed in the burst of $\sim 6\times 10^{5}~M_\odot$. We find that photoionisation by the Active Galactic Nucleus (AGN) in GN-z11 cannot account for the HeII luminosity observed in the clump, but can potentially be responsible for additional HeII emission observed closer to GN-z11. We also consider the possibility of in-situ photoionisation by an accreting Direct Collapse Black Hole (DCBH) hosted by the HeII clump; we find that this scenario is less favoured, but it remains a possible alternative interpretation. We also report the detection of a Ly$\alpha$ halo stemming out of GN-z11 and extending out to $\sim$2 kpc, as well as resolved, funnel-shaped CIII] emission, likely tracing the ionisation cone of the AGN.Comment: Submitted to A&A, 13 pages, 8 figures; some typos corrected and some minor additional information added to match submitted versio

Extreme emission line galaxies detected in JADES JWST/NIRSpec – I. Inferred galaxy properties

© 2024 The Author(s). Published by Oxford University Press on behalf of Royal Astronomical Society. This is an open access article distributed under the Creative Commons Attribution License, to view a copy of the license, see: https://creativecommons.org/licenses/by/4.0/Extreme emission line galaxies (EELGs) exhibit large equivalent widths (EW) in their rest-optical emission lines ([O iii]$\lambda 5007$ or H $\alpha$ rest-frame EW$\gt 750$ Å) which can be tied to a recent upturn in star formation rate (SFR), due to the sensitivity of the nebular line emission and the rest-optical continuum to young ($\lt 10$ Myr) and evolved stellar populations, respectively. By studying a sample of 85 star-forming galaxies (SFGs), spanning the redshift and magnitude interval $3 \lt z\lt 9.5$ and $-16\gt$M$\rm _{UV}\gt -21$, in the JWST Advanced Deep Extragalactic Survey (JADES) with NIRSpec/prism spectroscopy, we determine that SFGs initiate an EELG phase when entering a significant burst of star formation, with the highest EWs observed in EELGs with the youngest luminosity-weighted ages ($\lt 5$ Myr) and the highest burst intensity (those with the greatest excess between their current and long-term average SFR). We spectroscopically confirm that a greater proportion of SFGs are in an EELG phase at high redshift in our UV-selected sample ($61\pm 4~{{\ \rm per\ cent}}$ in our $z\gt 5.7$ high-redshift bin, compared to $23^{+4}_{-1}\%$ in our lowest redshift bin $3\lt z\lt 4.1$) due to the combined evolution of metallicity, ionization parameter, and star formation histories with redshift. We report that the EELGs within our sample exhibit a higher average ionization efficiency ($\log _{10}(\xi _\mathrm{ion}^\mathrm{HII}/{\rm erg^{-1}Hz}) =25.5\pm 0.2$) than the non-EELGs. High-redshift EELGs therefore comprise a population of efficient ionizing photon producers. Additionally, we report that 53 per cent (9/17) of EELGs at $z\gt 5.7$ have observed Ly $\alpha$ emission, potentially lying within large ionized regions. The high detection rate of Ly $\alpha$ emitters in our EELG selection suggests that the physical conditions associated with entering an EELG phase also promote the escape of Ly $\alpha$ photons.Peer reviewe

Inside the bubble: exploring the environments of reionisation-era Lyman-α emitting galaxies with JADES and FRESCO⋆

© 2024 The Author(s). Published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License (CC BY), https://creativecommons.org/licenses/by/4.0/We present a study of the environments of 17 Lyman-α emitting galaxies (LAEs) in the reionisation-era (5.8 5%) observed in our sample of LAEs, suggesting the presence of ionised hydrogen along the line of sight towards at least eight out of 17 LAEs. We find minimum physical 'bubble'sizes of the order of R ion ∼ 0.1- 1pMpc are required in a patchy reionisation scenario where ionised bubbles containing the LAEs are embedded in a fully neutral IGM. Around half of the LAEs in our sample are found to coincide with large-scale galaxy overdensities seen in FRESCO at z ∼ 5.8- 5.9 and z ∼ 7.3, suggesting Lyman-α transmission is strongly enhanced in such overdense regions, and underlining the importance of LAEs as tracers of the first large-scale ionised bubbles. Considering only spectroscopically confirmed galaxies, we find our sample of UV-faint LAEs (M UV ≳ -20mag) and their direct neighbours are generally not able to produce the required ionised regions based on the Lyman-α transmission properties, suggesting lower-luminosity sources likely play an important role in carving out these bubbles. These observations demonstrate the combined power of JWST multi-object and slitless spectroscopy in acquiring a unique view of the early Universe during cosmic reionisation via the most distant LAEs.Peer reviewe