The Content-Dependence of Imaginative Resistance

An observation of Hume’s has received a lot of attention over the last decade and a half: Although we can standardly imagine the most implausible scenarios, we encounter resistance when imagining propositions at odds with established moral (or perhaps more generally evaluative) convictions. The literature is ripe with ‘solutions’ to this so-called ‘Puzzle of Imaginative Resistance’. Few, however, question the plausibility of the empirical assumption at the heart of the puzzle. In this paper, we explore empirically whether the difficulty we witness in imagining certain propositions is indeed due to claim type (evaluative v. non-evaluative) or whether it is much rather driven by mundane features of content. Our findings suggest that claim type plays but a marginal role, and that there might hence not be much of a ‘puzzle’ to be solved

Ultrasonic detection of flaws in fusion butt welds

Reliable and accurate Delta technique, a nondestructive ultrasonics method, uses redirection of energy to detect randomly oriented imperfections in fusion butt welds. Data on flaws can be read from either an oscilloscope or a printout

Investigation to relate the chlorophyll and suspended sediment content in the waters of the lower Chesapeake Bay to ERTS-1 imagery

There are no author-identified significant results in this report

Individuality and slow dynamics in bacterial growth homeostasis

Microbial growth and division are fundamental processes relevant to many areas of life science. Of particular interest are homeostasis mechanisms, which buffer growth and division from accumulating fluctuations over multiple cycles. These mechanisms operate within single cells, possibly extending over several division cycles. However, all experimental studies to date have relied on measurements pooled from many distinct cells. Here, we disentangle long-term measured traces of individual cells from one another, revealing subtle differences between temporal and pooled statistics. By analyzing correlations along up to hundreds of generations, we find that the parameter describing effective cell-size homeostasis strength varies significantly among cells. At the same time, we find an invariant cell size which acts as an attractor to all individual traces, albeit with different effective attractive forces. Despite the common attractor, each cell maintains a distinct average size over its finite lifetime with suppressed temporal fluctuations around it, and equilibration to the global average size is surprisingly slow (> 150 cell cycles). To demonstrate a possible source of variable homeostasis strength, we construct a mathematical model relying on intracellular interactions, which integrates measured properties of cell size with those of highly expressed proteins. Effective homeostasis strength is then influenced by interactions and by noise levels, and generally varies among cells. A predictable and measurable consequence of variable homeostasis strength appears as distinct oscillatory patterns in cell size and protein content over many generations. We discuss the implications of our results to understanding mechanisms controlling division in single cells and their characteristic timescalesComment: In press with PNAS. 50 pages, including supplementary informatio

Pengaruh Alokasi Kredit Sektor-sektor Ekonomi terhadap Pertumbuhan Produk Domestik Regional Bruto (PDRB) Sulawesi Utara

Alokasi kredit yang terus bertumbuh akan menyebabkan pertumbuhan yang juga terus terjadi di dalam perkembangan Produk Domestik Regional Bruto (PDRB) yang dicapai oleh pemerintah yang secara otomatis meningkatkan pertumbuhan ekonomi yang dicapai oleh Provinsi Sulawesi Utara. Penelitian ini dilakukan untuk melihat seberapa besar pengaruh yang dapat disebabkan oleh alokasi serta realisasi kredit terhadap PDRB dan melihat hubungan yang ditimbulkan antara realisasi kredit yang terjadi dengan tingkat suku bunga yang ditetapkan oleh pemerintah dalam hal ini Bank Indonesia. Penelitian ini menganalisis data sekunder kuantitatif kwartalan pada rentang waktu tahun 2008 sampai 2012. Metode ekonometrik yang digunakan dalam penelitian ini yaitu model regresi berganda dengan metode kuadrat terkecil sederhana (Ordinary Least Square). Analisis ini dilakukan dengan bantuan program eviews dengan tujuan untuk melihat pengaruh variabel-variabel independen terhadap variabel dependennya. Hasil estimasi menunjukan bahwa alokasi kredit pada sektor-sektor ekonomi dan suku bunga kredit berpengaruh positif dan signifikan terhadap PDRB Sulawesi Utara baik secara simultan maupun secara parsial. Kata kunci: produk domestik regional bruto, alokasi kredit,dan tingkat suku bunga

Serum biochemistry and hematology in blue fox (Vulpes lagopus)

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Radiotherapy and Immunotherapy Combinations in Non-small Cell Lung Cancer: A Promising Future?

The goal of re-programming the host immune system to target malignancy with durable anti-tumour clinical responses has been speculated for decades. In the last decade such speculation has been transformed into reality with unprecedented and durable responses to immune checkpoint inhibitors seen in solid tumours. This mini-review considers the mechanism of action of immune modulating agents and the potential for combination with radiotherapy in the treatment of non-small cell lung cancer.</p

Effect of carotenoid supplement on production performance in mink (Neovison vison)

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