A method to estimate the significance of coincident gravitational-wave observations from compact binary coalescence

Coalescing compact binary systems consisting of neutron stars and/or black holes should be detectable with upcoming advanced gravitational-wave detectors such as LIGO, Virgo, GEO and {KAGRA}. Gravitational-wave experiments to date have been riddled with non-Gaussian, non-stationary noise that makes it challenging to ascertain the significance of an event. A popular method to estimate significance is to time shift the events collected between detectors in order to establish a false coincidence rate. Here we propose a method for estimating the false alarm probability of events using variables commonly available to search candidates that does not rely on explicitly time shifting the events while still capturing the non-Gaussianity of the data. We present a method for establishing a statistical detection of events in the case where several silver-plated (3--5$\sigma$) events exist but not necessarily any gold-plated ($>5\sigma$) events. We use LIGO data and a simulated, realistic, blind signal population to test our method

Unraveling Heterogeneity in Epithelial Cell Fates of the Mammary Gland and Breast Cancer.

Fluidity in cell fate or heterogeneity in cell identity is an interesting cell biological phenomenon, which at the same time poses a significant obstacle for cancer therapy. The mammary gland seems a relatively straightforward organ with stromal cells and basal- and luminal- epithelial cell types. In reality, the epithelial cell fates are much more complex and heterogeneous, which is the topic of this review. Part of the complexity comes from the dynamic nature of this organ: the primitive epithelial tree undergoes extensively remodeling and expansion during puberty, pregnancy, and lactation and, unlike most other organs, the bulk of mammary gland development occurs late, during puberty. An active cell biological debate has focused on lineage commitment to basal- and luminal- epithelial cell fates by epithelial progenitor and stem cells; processes that are also relevant to cancer biology. In this review, we discuss the current understanding of heterogeneity in mammary gland and recent insights obtained through lineage tracing, signaling assays, and organoid cultures. Lastly, we relate these insights to cancer and ongoing efforts to resolve heterogeneity in breast cancer with single-cell RNAseq approaches

In Situ Diazotroph Population Dynamics Under Different Resource Ratios in the North Pacific Subtropical Gyre.

Major advances in understanding the diversity, distribution, and activity of marine N2-fixing microorganisms (diazotrophs) have been made in the past decades, however, large gaps in knowledge remain about the environmental controls on growth and mortality rates. In order to measure diazotroph net growth rates and microzooplankton grazing rates on diazotrophs, nutrient perturbation experiments and dilution grazing experiments were conducted using free-floating in situ incubation arrays in the vicinity of Station ALOHA in March 2016. Net growth rates for targeted diazotroph taxa as well as Prochlorococcus, Synechococcus and photosynthetic picoeukaryotes were determined under high (H) and low (L) nitrate:phosphate (NP) ratio conditions at four depths in the photic zone (25, 45, 75, and 100 m) using quantitative PCR and flow cytometry. Changes in the prokaryote community composition in response to HNP and LNP treatments were characterized using 16S rRNA variable region tag sequencing. Microzooplankton grazing rates on diazotrophs were measured using a modified dilution technique at two depths in the photic zone (15 and 125 m). Net growth rates for most of the targeted diazotrophs after 48 h were not stimulated as expected by LNP conditions, rather enhanced growth rates were often measured in HNP treatments. Interestingly, net growth rates of the uncultivated prymnesiophyte symbiont UCYN-A1 were stimulated in HNP treatments at 75 and 100 m, suggesting that N used for growth was acquired through continuing to fix N2 in the presence of nitrate. Net growth rates for UCYN-A1, UCYN-C, Crocosphaera sp. (UCYN-B) and the diatom symbiont Richelia (associated with Rhizosolenia) were uniformly high at 45 m (up to 1.6 ± 0.5 d-1), implying that all were growing optimally at the onset of the experiment at that depth. Differences in microzooplankton grazing rates on UCYN-A1 and UCYN-C in 15 m waters indicate that the grazer assemblage preyed preferentially on UCYN-A1. Deeper in the water column (125 m), both diazotrophs were grazed at substantial rates, suggesting grazing pressure may increase with depth in the photic zone. Constraining in situ diazotroph growth and mortality rates are important steps for improving parameterization for diazotrophs in global ecosystem models

Solar Urban Planning: Addressing barriers and conflicts specific to Renewable Energy Policy and the current field and practice of Urban Planning within the context of a changing Climate

The world is in a period of rapid urbanization while experiencing unprecedented rise in global temperature as a result of climate change. Questions have been raised as to how strategies for urbanization will be able to address the fetish for energy, while halting carbon emissions produced by traditional energy sources for urban inhabitants around the world. First, this paper seeks to look to cities, at the intersection of solar energy and the field of urban planning, looking into the opportunities and challenges that are currently surfacing. Conflicts and barriers in traditional urban land use patterns emerge as a topic of discussion alongside urban morphologies and constraints posed towards a broad-reaching application of solar energy in dense cities, both domestically in the United States, and by way of international case studies. Conflicts in land use practice along with community level net zero benchmarking are discussed as well to better understand tools for progress in urban planning addressing climate change mitigation. Additionally, local action and the impacts of Green Communities Legislation are investigated alongside the need for Federal action such as bold renewable energy portfolio standards as macro policy solutions. Lastly, the conflict between the traditional role for utilities and the emergence of distributed generation technologies and subsequent policy support including the potential impact of micro grids, are included in an analysis of the energy production and delivery system for the urban environment at present. Within this paper, two in-person qualitative interviews are included to bring perspectives from active professionals and policymakers into the research. New thinking and conclusions illustrate the need for specific policy action across local, state, and federal spheres, and the need for urban planners and urban practitioners to act with intention and rapidity relating to the climate imperative

Evolution of the bilayer nu = 1 quantum Hall state under charge imbalance

We use high-mobility bilayer hole systems with negligible tunneling to examine how the bilayer nu = 1 quantum Hall state evolves as charge is transferred from one layer to the other at constant total density. We map bilayer nu = 1 state stability versus imbalance for five total densities spanning the range from strongly interlayer coherent to incoherent. We observe competition between single-layer correlations and interlayer coherence. Most significantly, we find that bilayer systems that are incoherent at balance can develop spontaneous interlayer coherence with imbalance, in agreement with recent theoretical predictions.Comment: 4 pages, 4 figure