Variations in the slope of the resolved star-forming main sequence: A tool for constraining the mass of star-forming regions

The correlation between galaxies' integrated stellar masses and star formation rates (the 'star formation main sequence', SFMS) is a well-established scaling relation. Recently, surveys have found a relationship between the star formation rate (SFR) and stellar mass surface densities on kpc and sub-kpc scales (the 'resolved SFMS', rSFMS). In this work, we demonstrate that the rSFMS emerges naturally in Feedback In Realistic Environments 2 (FIRE-2) zoom-in simulations of Milky Way-mass galaxies. We make SFR and stellar mass maps of the simulated galaxies at a variety of spatial resolutions and star formation averaging time-scales and fit the rSFMS using multiple methods from the literature. While the absolute value of the SFMS slope (αMS) depends on the fitting method, the slope is steeper for longer star formation time-scales and lower spatial resolutions regardless of the fitting method employed. We present a toy model that quantitatively captures the dependence of the simulated galaxies' αMS on spatial resolution and use it to illustrate how this dependence can be used to constrain the characteristic mass of star-forming clumps

Towards robust determination of non-parametric morphologies in marginal astronomical data: Resolving uncertainties with cosmological hydrodynamical simulations

Quantitative morphologies, such as asymmetry and concentration, have long been used as an effective way to assess the distribution of galaxy starlight in large samples. Application of such quantitative indicators to other data products could provide a tool capable of capturing the 2-dimensional distribution of a range of galactic properties, such as stellar mass or star-formation rate maps. In this work, we utilize galaxies from the Illustris and IllustrisTNG simulations to assess the applicability of concentration and asymmetry indicators to the stellar mass distribution in galaxies. Specifically, we test whether the intrinsic values of concentration and asymmetry (measured directly from the simulation stellar mass particle maps) are recovered after the application of measurement uncertainty and a point spread function (PSF). We find that random noise has a non-negligible systematic effect on asymmetry that scales inversely with signal-to-noise, particularly at signal-to-noise less than 100. We evaluate different methods to correct for the noise contribution to asymmetry at very low signal-to-noise, where previous studies have been unable to explore due to systematics. We present algebraic corrections for noise and resolution to recover the intrinsic morphology parameters. Using Illustris as a comparison dataset, we evaluate the robustness of these fits in the presence of a different physics model, and confirm these correction methods can be applied to other datasets. Lastly, we provide estimations for the uncertainty on different correction methods at varying signal-to-noise and resolution regimes.STFC ER

The diversity of the circumgalactic medium around z = 0 Milky Way-mass galaxies from the Auriga simulations

Galaxies are surrounded by massive gas reservoirs (i.e. the circumgalactic medium; CGM) which play a key role in their evolution. The properties of the CGM, which are dependent on a variety of internal and environmental factors, are often inferred from absorption line surveys which rely on a limited number of single lines-of-sight. In this work we present an analysis of 28 galaxy haloes selected from the Auriga project, a cosmological magnetohydrodynamical zoom-in simulation suite of isolated Milky Way-mass galaxies, to understand the impact of CGM diversity on observational studies. Although the Auriga haloes are selected to populate a narrow range in halo mass, our work demonstrates that the CGM of L galaxies is extremely diverse: column densities of commonly observed species span ∼3 − 4 dex and their covering fractions range from ∼5 to 90 per cent. Despite this diversity, we identify the following correlations: 1) the covering fractions (CF) of hydrogen and metals of the Auriga haloes positively correlate with stellar mass, 2) the CF of H I, C IV, and Si II anticorrelate with active galactic nucleus luminosity due to ionization effects, and 3) the CF of H I, C IV, and Si II positively correlate with galaxy disc fraction due to outflows populating the CGM with cool and dense gas. The Auriga sample demonstrates striking diversity within the CGM of L galaxies, which poses a challenge for observations reconstructing CGM characteristics from limited samples, and also indicates that long-term merger assembly history and recent star formation are not the dominant sculptors of the CGM

Kinematics of the Local Group gas and galaxies in the hestia simulations

We investigate the kinematic properties of gas and galaxies in the Local Group (LG) using high-resolution simulations performed by the hestia (High-resolution Environmental Simulations of The Immediate Area) collaboration. Our simulations include the correct cosmography surrounding LG-like regions consisting of two main spiral galaxies of ∼1012 M⊙, their satellites and minor isolated galaxies, all sharing the same large-scale motion within a volume of a few Mpc. We characterize the gas and galaxy kinematics within the simulated LGs, from the perspective of the Sun, to compare with observed trends from recent HST/COS absorption-line observations and LG galaxy data. To analyse the velocity pattern of LG gas and galaxies seen in the observational data, we build sky maps from the local standard of rest, and the Galactic and LG barycentre frames. Our findings show that the establishment of a radial velocity dipole at low/high latitudes, near the preferred barycentre direction, is a natural outcome of simulation kinematics for material outside the Milky Way virial radius after removing Galaxy rotation when the two main LG galaxies are approaching. Our results favour a scenario where gas and galaxies stream towards the LG barycentre producing a velocity dipole resembling observations. While our study shows in a qualitative way the global matter kinematics in the LG as part of its ongoing assembly, quantitative estimates of gas-flow rates and physical conditions of the LG gas have to await a more detailed modelling of the ionization conditions, which will be presented in a follow-up paper

Cold and hot gas distribution around the Milky-Way - M31 system in the HESTIA simulations

Recent observations have revealed remarkable insights into the gas reservoir in the circumgalactic medium (CGM) of galaxy haloes. In this paper, we characterize the gas in the vicinity of Milky Way and Andromeda analogues in the hestia (High resolution Environmental Simulations of The Immediate Area) suite of constrained Local Group (LG) simulations. The hestia suite comprise of a set of three high-resolution arepo-based simulations of the LG, run using the Auriga galaxy formation model. For this paper, we focus only on the z = 0 simulation data sets and generate mock skymaps along with a power spectrum analysis to show that the distributions of ions tracing low-temperature gas (H i and Si iii) are more clumpy in comparison to warmer gas tracers (O vi, O vii, and O viii). We compare to the spectroscopic CGM observations of M31 and low-redshift galaxies. hestia underproduces the column densities of the M31 observations, but the simulations are consistent with the observations of low-redshift galaxies. A possible explanation for these findings is that the spectroscopic observations of M31 are contaminated by gas residing in the CGM of the Milky Way

Iraq War mortality estimates: A systematic review

<p>Abstract</p> <p>Background</p> <p>In March 2003, the United States invaded Iraq. The subsequent number, rates, and causes of mortality in Iraq resulting from the war remain unclear, despite intense international attention. Understanding mortality estimates from modern warfare, where the majority of casualties are civilian, is of critical importance for public health and protection afforded under international humanitarian law. We aimed to review the studies, reports and counts on Iraqi deaths since the start of the war and assessed their methodological quality and results.</p> <p>Methods</p> <p>We performed a systematic search of 15 electronic databases from inception to January 2008. In addition, we conducted a non-structured search of 3 other databases, reviewed study reference lists and contacted subject matter experts. We included studies that provided estimates of Iraqi deaths based on primary research over a reported period of time since the invasion. We excluded studies that summarized mortality estimates and combined non-fatal injuries and also studies of specific sub-populations, e.g. under-5 mortality. We calculated crude and cause-specific mortality rates attributable to violence and average deaths per day for each study, where not already provided.</p> <p>Results</p> <p>Thirteen studies met the eligibility criteria. The studies used a wide range of methodologies, varying from sentinel-data collection to population-based surveys. Studies assessed as the highest quality, those using population-based methods, yielded the highest estimates. Average deaths per day ranged from 48 to 759. The cause-specific mortality rates attributable to violence ranged from 0.64 to 10.25 per 1,000 per year.</p> <p>Conclusion</p> <p>Our review indicates that, despite varying estimates, the mortality burden of the war and its sequelae on Iraq is large. The use of established epidemiological methods is rare. This review illustrates the pressing need to promote sound epidemiologic approaches to determining mortality estimates and to establish guidelines for policy-makers, the media and the public on how to interpret these estimates.</p

Distinctive Left-Sided Distribution of Adrenergic-Derived Cells in the Adult Mouse Heart

Adrenaline and noradrenaline are produced within the heart from neuronal and non-neuronal sources. These adrenergic hormones have profound effects on cardiovascular development and function, yet relatively little information is available about the specific tissue distribution of adrenergic cells within the adult heart. The purpose of the present study was to define the anatomical localization of cells derived from an adrenergic lineage within the adult heart. To accomplish this, we performed genetic fate-mapping experiments where mice with the cre-recombinase (Cre) gene inserted into the phenylethanolamine-n-methyltransferase (Pnmt) locus were cross-mated with homozygous Rosa26 reporter (R26R) mice. Because Pnmt serves as a marker gene for adrenergic cells, offspring from these matings express the β-galactosidase (βGAL) reporter gene in cells of an adrenergic lineage. βGAL expression was found throughout the adult mouse heart, but was predominantly (89%) located in the left atrium (LA) and ventricle (LV) (p<0.001 compared to RA and RV), where many of these cells appeared to have cardiomyocyte-like morphological and structural characteristics. The staining pattern in the LA was diffuse, but the LV free wall displayed intermittent non-random staining that extended from the apex to the base of the heart, including heavy staining of the anterior papillary muscle along its perimeter. Three-dimensional computer-aided reconstruction of XGAL+ staining revealed distribution throughout the LA and LV, with specific finger-like projections apparent near the mid and apical regions of the LV free wall. These data indicate that adrenergic-derived cells display distinctive left-sided distribution patterns in the adult mouse heart

Tyrosine kinase chromosomal translocations mediate distinct and overlapping gene regulation events

<p>Abstract</p> <p>Background</p> <p>Leukemia is a heterogeneous disease commonly associated with recurrent chromosomal translocations that involve tyrosine kinases including BCR-ABL, TEL-PDGFRB and TEL-JAK2. Most studies on the activated tyrosine kinases have focused on proximal signaling events, but little is known about gene transcription regulated by these fusions.</p> <p>Methods</p> <p>Oligonucleotide microarray was performed to compare mRNA changes attributable to BCR-ABL, TEL-PDGFRB and TEL-JAK2 after 1 week of activation of each fusion in Ba/F3 cell lines. Imatinib was used to control the activation of BCR-ABL and TEL-PDGFRB, and TEL-JAK2-mediated gene expression was examined 1 week after Ba/F3-TEL-JAK2 cells were switched to factor-independent conditions.</p> <p>Results</p> <p>Microarray analysis revealed between 800 to 2000 genes induced or suppressed by two-fold or greater by each tyrosine kinase, with a subset of these genes commonly induced or suppressed among the three fusions. Validation by Quantitative PCR confirmed that eight genes (Dok2, Mrvi1, Isg20, Id1, gp49b, Cxcl10, Scinderin, and collagen Vα1(Col5a1)) displayed an overlapping regulation among the three tested fusion proteins. Stat1 and Gbp1 were induced uniquely by TEL-PDGFRB.</p> <p>Conclusions</p> <p>Our results suggest that BCR-ABL, TEL-PDGFRB and TEL-JAK2 regulate distinct and overlapping gene transcription profiles. Many of the genes identified are known to be involved in processes associated with leukemogenesis, including cell migration, proliferation and differentiation. This study offers the basis for further work that could lead to an understanding of the specificity of diseases caused by these three chromosomal translocations.</p