A systematic review of nonrandomized controlled trials on the curative effects of aquatic exercise

Hiroharu Kamioka1, Kiichiro Tsutani2, Yoshiteru Mutoh3, Hiroyasu Okuizum4, Miho Ohta5, Shuichi Handa4, Shinpei Okada6, Jun Kitayuguchi7, Masamitsu Kamada7, Nobuyoshi Shiozawa8, Sang-Jun Park4, Takuya Honda4, Shoko Moriyama41Faculty of Regional Environment Science, Tokyo University of Agriculture, Tokyo, Japan; 2Department of Drug Policy and Management, Graduate School of Pharmaceutical Sciences, 3Department of Physical and Health Education, Graduate School of Education, The University of Tokyo, Tokyo, Japan; 4Mimaki Onsen (Spa) Clinic, Tomi City, Japan; 5Laboratory of Aqua, Health, and Sports Medicine, 6Physical Education and Medicine Research Foundation, Nagano, Japan; 7Physical Education and Medicine Research Center Unnan, Unnan City, Japan; 8Department of Longevity and Social Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, JapanBackground: The objectives of this review were to integrate the evidence of curative effects through aquatic exercise and assess the quality of studies based on a review of nonrandomized controlled trials (nRCTs).Methods: Study design was a systematic review of nonrandomized controlled trials. Trials were eligible if they were nonrandomized clinical trials. Studies included one treatment group in which aquatic exercise was applied. We searched the following databases from 2000 up to July 20, 2009: MEDLINE via PubMed, CINAHL, and Ichushi-Web.Results: Twenty-one trials met all inclusion criteria. Languages included were English (N = 9), Japanese (N = 11), and Korean (N = 1). Target diseases were knee and/or hip osteoarthritis, poliomyelitis, chronic kidney disease, discomforts of pregnancy, cardiovascular diseases, and rotator cuff tears. Many studies on nonspecific disease (healthy participants) were included. All studies reported significant effectiveness in at least one or more outcomes. However results of evaluations with the TREND and CLEAR-NPT checklists generally showed a remarkable lack of description in the studies. Furthermore, there was the problem of heterogeneity, and we were therefore not able to perform a meta-analysis.Conclusion: Because there was insufficient evidence on aquatic exercise due to poor methodological and reporting quality and heterogeneity of nRCTs, we were unable to offer any conclusions about the effects of this intervention. However, we were able to identify problems with current nRCTs of aquatic exercise, and propose a strategy of strengthening study quality, stressing the importance of study feasibility as a future research agenda objective.Keywords: aquatic exercise, systematic review, nonrandomized controlled trials&nbsp

Effect of kaempferol ingestion on physical activity and sleep quality: a double-blind, placebo-controlled, randomized, crossover trial

BackgroundKaempferol (KMP), a flavonoid in edible plants, exhibits diverse pharmacological effects. Growing body of evidence associates extended lifespan with physical activity (PA) and sleep, but KMP’s impact on these behaviors is unclear. This double-blind, placebo-controlled, crossover trial assessed KMP’s effects on PA and sleep.MethodsA total of 33 city workers (17 males and 16 females) participated in this study. They were randomly assigned to take either 10 mg of KMP or placebo for 2 weeks in the order allocated, with a 7-day washout period in between. All participants wore an accelerometer-based wearable device (Fitbit Charge 4), which monitored daily PA, heart rate (HR), and HR variability during sleep.ResultsThe duration of wearing the device was 23.73 ± 0.04 h/day. HR decreased in each PA level, and the mean daily step count and distance covered increased significantly during KMP intake compared to placebo. The outing rate, number of trips, number of recreational activities, and time spent in recreation on weekends increased. Sleep quality improved following KMP intake. The decrease in HR and increase in RMSSD may be important in mediating the effects of these KMPs.ConclusionKMP leads to behavioral changes that subsequently improve sleep quality and potentially improve long-term quality of life.Clinical Trial Registrationhttps://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048447, UMIN000042438

IMiD/CELMoD-induced growth suppression of adult T-cell leukemia/lymphoma cells via cereblon through downregulation of target proteins and their downstream effectors

Adult T-cell leukemia/lymphoma (ATL) is an aggressive T-cell neoplasia associated with human T-cell leukemia virus type 1 (HTLV-1) infection and has an extremely poor prognosis. Lenalidomide (LEN; a second-generation immunomodulatory drug [IMiD]) has been employed as an additional therapeutic option for ATL since 2017, but its mechanism of action has not been fully proven, and recent studies reported emerging concerns about the development of second primary malignancies in patients treated with long-term IMiD therapy. Our purpose in this study was to elucidate the IMiD-mediated anti-ATL mechanisms. Thirteen ATL-related cell lines were divided into LEN-sensitive or LEN-resistant groups. CRBN knockdown (KD) led to a loss of LEN efficacy and IKZF2-KD-induced LEN efficacy in resistant cells. DNA microarray analysis demonstrated distinct transcriptional alteration after LEN treatment between LEN-sensitive and LEN-resistant ATL cell lines. Oral treatment of LEN for ATL cell-transplanted severe combined immunodeficiency (SCID) mice also indicated clear suppressive effects on tumor growth. Finally, a novel cereblon modulator (CELMoD), iberdomide (IBE), exhibited a broader and deeper spectrum of growth suppression to ATL cells with efficient IKZF2 degradation, which was not observed in other IMiD treatments. Based on these findings, our study strongly supports the novel therapeutic advantages of IBE against aggressive and relapsed ATL

Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus

Gangliosides are particularly abundant in the central nervous system (CNS) and thought to play important roles in memory formation, neuritogenesis, synaptic transmission, and other neural functions. Although several molecular species of gangliosides have been characterized and their individual functions elucidated, their differential distribution in the CNS are not well understood. In particular, whether the different molecular species show different distribution patterns in the brain remains unclear. We report the distinct and characteristic distributions of ganglioside molecular species, as revealed by imaging mass spectrometry (IMS). This technique can discriminate the molecular species, raised from both oligosaccharide and ceramide structure by determining the difference of the mass-to-charge ratio, and structural analysis by tandem mass spectrometry. Gangliosides in the CNS are characterized by the structure of the long-chain base (LCB) in the ceramide moiety. The LCB of the main ganglioside species has either 18 or 20 carbons (i.e., C18- or C20-sphingosine); we found that these 2 types of gangliosides are differentially distributed in the mouse brain. While the C18-species was widely distributed throughout the frontal brain, the C20-species selectively localized along the entorhinal-hippocampus projections, especially in the molecular layer (ML) of the dentate gyrus (DG). We revealed development- and aging-related accumulation of the C-20 species in the ML-DG. Thus it is possible to consider that this brain-region specific regulation of LCB chain length is particularly important for the distinct function in cells of CNS

Imaging Mass Spectrometry Technology and Application on Ganglioside Study; Visualization of Age-Dependent Accumulation of C20-Ganglioside Molecular Species in the Mouse Hippocampus

Gangliosides are particularly abundant in the central nervous system (CNS) and thought to play important roles in memory formation, neuritogenesis, synaptic transmission, and other neural functions. Although several molecular species of gangliosides have been characterized and their individual functions elucidated, their differential distribution in the CNS are not well understood. In particular, whether the different molecular species show different distribution patterns in the brain remains unclear. We report the distinct and characteristic distributions of ganglioside molecular species, as revealed by imaging mass spectrometry (IMS). This technique can discriminate the molecular species, raised from both oligosaccharide and ceramide structure by determining the difference of the mass-to-charge ratio, and structural analysis by tandem mass spectrometry. Gangliosides in the CNS are characterized by the structure of the long-chain base (LCB) in the ceramide moiety. The LCB of the main ganglioside species has either 18 or 20 carbons (i.e., C18- or C20-sphingosine); we found that these 2 types of gangliosides are differentially distributed in the mouse brain. While the C18-species was widely distributed throughout the frontal brain, the C20-species selectively localized along the entorhinal-hippocampus projections, especially in the molecular layer (ML) of the dentate gyrus (DG). We revealed development- and aging-related accumulation of the C-20 species in the ML-DG. Thus it is possible to consider that this brain-region specific regulation of LCB chain length is particularly important for the distinct function in cells of CNS

カソ コウレイカ ノ ススム ノウソンチョウソン ニ オケル チイキシンダン ト イリョウヒカンレンシヒョウ ノ ケントウ

本研究は,総務省が平成17年(2005)年に分類した小規模自治体を対象として,次のことを明らかにすることを目的とした。1)保健医療福祉の関連指標について,類似する自治体間で比較を行うこと,つまり地域診断を実施すること,2)介護及び医療費に関連する因子を明らかにすることである。対象となる類似自治体は,総務省類型分類(人口及び産業構造から分類)で,平成17(2005)年度に山梨県小菅村が該当した「町村I-1(人口5,000人未満で,第二,三次産業従事者が80%以上,第三次産業従事者55%未満),54自治体」であった。本研究開始時の平成20(2008)年8月時点において,54町村すべての合併状況を確認した結果,独立して存続している町村は11であった。用いた指標は,老人医療費,入院費,介護費,人口,高齢化率,核家族世帯数,第一次・二次・三次の各産業従事者割合,要介護認定率,平均寿命などあった。11町村の中で,特徴的だった例を4つ列挙する。1)長野県天竜村は平均寿命が長く,医療費と介護費も低い傾向にあった(医療費・介護費併用型)。2)小菅村と山梨県鳴沢村は,医療費や介護費,介護認定率が低かった(医療費・介護費安価型)。3)東京都御蔵島村と群馬県上野村は,医療費は低いが介護費が高かった(介護費依存型)。4)沖縄県北大東村は,寿命は長いが,介護費が高かった(その他型)。重回帰分析の結果,医療費と有意な相関があったのは,入院費であった。介護費と有意な相関があったのは,65歳以上の親族のいる核家族世帯数であった。小規模自治体において,介護保険依存と医療費依存の方向性を有する自治体があり,保健医療福祉の評価には,両者を合わせて検討する必要性が示唆された。サンプルサイズが小さいということや,検討に用いることができたデータの内容について限界はあるが,核家族と入院が介護費用と医療費に影響を及ぼしている可能性があることが示された。The objectives of this study were to compare medical expenses of similar local governments, and to clarify the factors related to expenses for care and medicine. The subjects of our investigation were local governments with a national classification in fiscal 2005 that was similar to Kosuge village in Yamanashi based on population and industrial structure : the population was smaller than 5000, the total percentage of secondary and tertiary industry was more than 80%, and the percentage of tertiary industry was less than 55%. These criteria were met by 54 local governments. When we started this investigation in August 2008, 11 governments remained unconsolidated. The indices consisted of medical expenses for the aged, hospital expenses, nursing-care expenses, population size, aging population, the number of nuclear families, the industrial structure, the percentage of advanced nursing care, and life expectancy. The outstanding points were as follows : 1) Tenryu village in Nagano showed long life expectancy and low medical and nursing-care expenses (combination type by medical and nursing-care expenses) ; 2) Kosuge and Narusawa village in Yamanashi showed low medical and nursing-care expenses and a low percentage of advanced nursing-care (low-cost type of medical and nursing-care expenses) ; 3) Mikurajima village in Tokyo and Ueno village in Gunma showed low medical expenses and high nursing-care expenses (dependent type by nursing-care expense) ; and 4) Kitadaito village in Okinawa showed long life expectancy and high nursing-care expenses (other type). In multiple regression analysis, only hospital expense was found to explain medical expenses, and the number of nuclear families consisting of the elderly was found to explain nursing-care expenses. These results imply that there are two types of local governments that must be considered in health care analyses : one depends on nursing-care, and the other depends on medicine. In spite of the small sample size as statistical data discussion for interpretation, results from this study suggest that nuclear families and hospitalization affect nursing-care and medical expenses

カソ コウレイカ ノ ススム ノウソンチョウソン ニ オケル チイキシンダン ト イリョウヒカンレンシヒョウ ノ ケントウ

本研究は,総務省が平成17年(2005)年に分類した小規模自治体を対象として,次のことを明らかにすることを目的とした。1)保健医療福祉の関連指標について,類似する自治体間で比較を行うこと,つまり地域診断を実施すること,2)介護及び医療費に関連する因子を明らかにすることである。対象となる類似自治体は,総務省類型分類(人口及び産業構造から分類)で,平成17(2005)年度に山梨県小菅村が該当した「町村I-1(人口5,000人未満で,第二,三次産業従事者が80%以上,第三次産業従事者55%未満),54自治体」であった。本研究開始時の平成20(2008)年8月時点において,54町村すべての合併状況を確認した結果,独立して存続している町村は11であった。用いた指標は,老人医療費,入院費,介護費,人口,高齢化率,核家族世帯数,第一次・二次・三次の各産業従事者割合,要介護認定率,平均寿命などあった。11町村の中で,特徴的だった例を4つ列挙する。1)長野県天竜村は平均寿命が長く,医療費と介護費も低い傾向にあった(医療費・介護費併用型)。2)小菅村と山梨県鳴沢村は,医療費や介護費,介護認定率が低かった(医療費・介護費安価型)。3)東京都御蔵島村と群馬県上野村は,医療費は低いが介護費が高かった(介護費依存型)。4)沖縄県北大東村は,寿命は長いが,介護費が高かった(その他型)。重回帰分析の結果,医療費と有意な相関があったのは,入院費であった。介護費と有意な相関があったのは,65歳以上の親族のいる核家族世帯数であった。小規模自治体において,介護保険依存と医療費依存の方向性を有する自治体があり,保健医療福祉の評価には,両者を合わせて検討する必要性が示唆された。サンプルサイズが小さいということや,検討に用いることができたデータの内容について限界はあるが,核家族と入院が介護費用と医療費に影響を及ぼしている可能性があることが示された。The objectives of this study were to compare medical expenses of similar local governments, and to clarify the factors related to expenses for care and medicine. The subjects of our investigation were local governments with a national classification in fiscal 2005 that was similar to Kosuge village in Yamanashi based on population and industrial structure : the population was smaller than 5000, the total percentage of secondary and tertiary industry was more than 80%, and the percentage of tertiary industry was less than 55%. These criteria were met by 54 local governments. When we started this investigation in August 2008, 11 governments remained unconsolidated. The indices consisted of medical expenses for the aged, hospital expenses, nursing-care expenses, population size, aging population, the number of nuclear families, the industrial structure, the percentage of advanced nursing care, and life expectancy. The outstanding points were as follows : 1) Tenryu village in Nagano showed long life expectancy and low medical and nursing-care expenses (combination type by medical and nursing-care expenses) ; 2) Kosuge and Narusawa village in Yamanashi showed low medical and nursing-care expenses and a low percentage of advanced nursing-care (low-cost type of medical and nursing-care expenses) ; 3) Mikurajima village in Tokyo and Ueno village in Gunma showed low medical expenses and high nursing-care expenses (dependent type by nursing-care expense) ; and 4) Kitadaito village in Okinawa showed long life expectancy and high nursing-care expenses (other type). In multiple regression analysis, only hospital expense was found to explain medical expenses, and the number of nuclear families consisting of the elderly was found to explain nursing-care expenses. These results imply that there are two types of local governments that must be considered in health care analyses : one depends on nursing-care, and the other depends on medicine. In spite of the small sample size as statistical data discussion for interpretation, results from this study suggest that nuclear families and hospitalization affect nursing-care and medical expenses

チイキザイジュウコウレイシャ ニ オケル テントウヨボウジココウリョクカン ト HDL コレステロール オヨビ シンタイノウリョク トノ カンレン コスゲムラオウダンケンキュウ

背景 : 本研究の目的は,転倒予防自己効力感とHDLコレステロール及び身体能力との関連性を調べることであった。方法 : 対象者は山梨県小菅村に在住する65歳以上の高齢者339名で,本調査には132名(38.9%)が参加した。移動能力として10m全力歩行,最大一歩幅,40cm踏台昇降を,バランス能力としてつぎ足歩行を測定した。血液性状の中で,主要なアウトカムとして,HDLコレステロールを用いた。転倒予防自己効力感は,10項目,4リッカートスケールからなる質問紙で評価した。研究デザインは,転倒恐怖の有無による2群間比較の横断研究である。結果 : 転倒予防自己効力感とHDLコレステロールの間に有意な関連はなかったが,転倒予防自己効力感が低い群では有意に移動能力が低かった。また,膝痛や腰痛を伴う男性では,転倒予防自己効力感が低かった。結論 : 自己効力感とHDLコレステロールとの関連は認められなかったが,本研究は地域在住で独立生活を営む高齢者に限定されているため,今後,良くデザインされた大規模な観察研究が必要だと考えられた。Background : The aim of the current study was to clarify relationships between self-efficacy and high-density lipoprotein cholesterol (HDL-C) and physical strength.Methods : Target participants were 339 elderly residents aged 65 years or older from Kosuge Village, Yamanashi Prefecture in Japan. One hundred and thirty two persons participated in the study (38.9%). Outcome measurements included the 10-m walking time, the maximal step length and 40-cm step test as moving ability, the tandem gait as balance ability, and HDL-C. Fall-prevention self-efficacy (FPSE) was evaluated using a questionnaire that examined 10 items (actions) and 4 Likert scale. A total of 40 points could be awarded. This research design was a cross-sectional study that divided the elderly into two groups by the existence of a fear of falling.Results : Although there was no significant relationship between fall-prevention self-efficacy and HDL-C, we demonstrated that a group with poor self-efficacy had significantly deteriorated moving ability and that only one male participant with knee pain and/or lumbago exhibited poor self-efficacy.Conclusions : We could not find significant relationships between self-efficacy and HDL-C. But this study is limited to the independent elderly people in a local area, and further studies should be conducted to detect the relationships

ジョセイカイゴシャ ニ オケル ヨウツウ ノ ジッタイ ト カンレンヨウイン ニ カンスル オウダンケンキュウ

本研究は,横断研究により,女性介護者における腰痛との関連要因を明らかにすることを目的とした。4カ所の特別養護老人ホームに勤務する女性介護職員88人を対象として,腰痛の有無,経験年数,Body Mass Index(BMI),握力,長座体前屈,指床間距離(Finger-Floor Distance : FFD),抑うつ自己評価スコア(the Center for Epidemiologic Study Depression Scale : CES-D),SF-8による身体的健康度(Physical Health Score : PHS)と精神的健康度(Mental Health Score : MHS),疲労の自覚症状を調査した。腰痛の有無を目的変数とし,その他の変数を説明変数とした多重ロジスティック回帰分析を行った。49人(55.7%)が,慢性的な腰痛を訴えていた。多重ロジスティック回帰分析の結果,腰痛の発生は,身長がオッズ比(OR)1.12,95%信頼区間(95%CI)1.02-1.23,SF-8による身体的健康度(PHS)が,OR : 0.89(95%CI : 0.86-0.97),精神的健康度(MHS)がOR : 0.90(95%CI : 0.81-0.99)で有意であった。本研究は,身長が高いことは中腰姿勢を助長し,腰痛を起こす原因になるかもしれないこと,身体・精神的な健康の程度は,腰痛と関係があることが明らかになった。今後,交代勤務に伴う睡眠障害や慢性疲労との関連性も含めて検討すべきであることが示唆された。The objective of this cross-sectional study was to reveal the actual conditions and related factors of low back pain among female caregivers in special nursing homes for the elderly.The participants were 88 female caregivers in four facilities for the elderly. We surveyed the existence of low back pain, employment period, Body Mass Index (BMI), grip power, sitting forward flexion, Finger-Floor Distance (FFD), the Center for Epidemiologic Study Depression Scale (CES-D), Physical Health Score (PHS) and Mental Health Score (MHS) by using SF-8 and subjective symptoms of fatigue. Multinomial logistic regression model was used to investigate how far low back pain was related to mental and physical health status, flexibility, power, employment period, and BMI.55.7% (N=46) of the participants notified the presence of chronic lumbago. The result of multinomial logistic regression model showed that the existence of low back pain was significant in the following variables : 1) Odds ratio (OR)=1.12 (95% confidence interval : 95%CI=1.02-1.23) for height, 2) OR=0.89 (95% CI=0.81-0.97) for PHS, 3) OR=0.90 (95% CI=0.81-0.99) for MHS.Our findings suggest that height may reinforce a half-crouching position, thus it can be a cause of low back pain, and that the degree of physical and mental health is related to low back pain. It was also suggested that lumbago prevention and/or reduction strategy should include the relevance of sleep interruption and chronic fatigue with shift work when this problem is examined in future