Anisotropic acoustical properties of sintered fibrous metals

A combined theoretical and experimental study is carried out to investigate the anisotropic acoustic properties of sintered fibrous metals. In the theoretical model, based on the transversal and longitudinal dynamic mass densities and effective bulk modulus of randomly placed parallel fibers, the dynamic mass densities and effective dynamic bulk modulus of a sintered fibrous metal in the direction normal and parallel to its surface are obtained. Sound absorption coefficient, sound speed and attenuation coefficient in each of the two directions are calculated once the dynamic mass densities and effective dynamic bulk modulus are determined. For validation, experimental measurements are performed, with good agreement between theoretical prediction and measurement data achieved. Subsequent numerical investigations focus on the influence of fiber diameter and porosity on the anisotropic acoustical properties of the sintered fibrous metal. The sintered fibrous metal exhibits better sound absorption/attenuation performance in the parallel direction than in the normal direction. The anisotropy in acoustical properties increases with decreasing fiber diameter and porosity due mainly to increasing interactions between adjacent fibers

The trans-ancestral genomic architecture of glycemic traits

Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 x 10(-8)), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.A trans-ancestry meta-analysis of GWAS of glycemic traits in up to 281,416 individuals identifies 99 novel loci, of which one quarter was found due to the multi-ancestry approach, which also improves fine-mapping of credible variant sets.Diabetes mellitus: pathophysiological changes and therap

Enhancing mechanical properties of AZ31 magnesium alloy through simultaneous addition of aluminum and nano-Al2O3

10.1115/IMECE2010-39901ASME International Mechanical Engineering Congress and Exposition, Proceedings (IMECE)12145-15

Development of new magnesium based alloys and their nanocomposites

10.1016/j.jallcom.2011.06.020Journal of Alloys and Compounds509348522-8529JALC

Influence of nano-alumina and sub-micron copper on mechanical properties of magnesium alloy AZ31

10.1016/j.compositesb.2013.06.041Composites Part B: Engineering55486-491CPBE