1,304 research outputs found
Characterizing random-singlet state in two-dimensional frustrated quantum magnets and implications for the double perovskite SrCuTeWO
Motivated by experimental observation of the non-magnetic phase in the
compounds with frustration and disorder, we study the ground state of the
spin- square-lattice Heisenberg model with randomly distributed
nearest-neighbor and next-nearest-neighbor couplings. By using the
density matrix renormalization group (DMRG) calculation on cylinder system with
circumference up to lattice sites, we identify a disordered phase between
the N\'eel and stripe magnetic phase with growing in the presence
of strong randomness. The vanished spin-freezing parameter indicates the absent
spin glass order. The large-scale DMRG results unveil the size-scaling
behaviors of the spin-freezing parameter, the power-law decay of average spin
correlation, and the exponential decay of typical spin correlation, which all
agree with the corresponding behavior in the one-dimensional random singlet
(RS) state and characterize the RS nature of this non-magnetic state. The DMRG
simulation also opens new insight and opportunities for characterizing a class
of non-magnetic states in two-dimensional frustrated magnets with disorder. We
also compare with existing experiments and suggest more measurements for
understanding the spin-liquid-like behavior in the double perovskite
SrCuTeWO.Comment: 11 pages,10 figure
N-Benzyl-2-propynamide
Pale-yellow crystals of the title compound, C10H9NO, have been obtained by the reaction of benzylamine and methyl propiolate. Weak intermolecular hydrogen bonding is observed between acetylenic H and carbonyl O atoms. The crystal packing is stabilized by these C—H⋯O and by N—H⋯O intermolecular hydrogen-bonding interactions
The Mass of the Planet-hosting Giant Star Beta Geminorum Determined from its p-mode Oscillation Spectrum
We use precise radial velocity measurements and photometric data to derive
the frequency spacing of the p-mode oscillation spectrum of the planet-hosting
star Beta Gem. This spacing along with the interferometric radius for this star
is used to derive an accurate stellar mass. A long time series of over 60 hours
of precise stellar radial velocity measurements of Beta Gem were taken with an
iodine absorption cell and the echelle spectrograph mounted on the 2m Alfred
Jensch Telescope. Complementary photometric data for this star were also taken
with the MOST microsatellite spanning 3.6 d. A Fourier analysis of the radial
velocity data reveals the presence of up to 17 significant pulsation modes in
the frequency interval 10-250 micro-Hz. Most of these fall on a grid of
equally-spaced frequencies having a separation of 7.14 +/- 0.12 micro-Hz. An
analysis of 3.6 days of high precision photometry taken with the MOST space
telescope shows the presence of up to 16 modes, six of which are consistent
with modes found in the spectral (radial velocity) data. This frequency spacing
is consistent with high overtone radial pulsations; however, until the
pulsation modes are identified we cannot be sure if some of these are nonradial
modes or even mixed modes. The radial velocity frequency spacing along with
angular diameter measurements of Beta Gem via interferometry results in a
stellar mass of M = 1.91 +/- 0.09 solar masses. This value confirms the
intermediate mass of the star determined using stellar evolutionary tracks.
Beta Gem is confirmed to be an intermediate mass star. Stellar pulsations in
giant stars along with interferometric radius measurements can provide accurate
determinations of the stellar mass of planet hosting giant stars. These can
also be used to calibrate stellar evolutionary tracks.Comment: Accepted by Astronomy and Astrophysic
Analysis of Powder Rheometry of FT4: Effect of Air Flow
Understanding of particle flow behaviour as a function of strain rate is of great interest in many items of equipment of industrial processes, such as screw conveyors, impeller mixers, and feeders, etc. The traditional commercial instruments for bulk powder flow characterisation, such as shear cells, operate at low shear strain rates, and are not representative of unit operations under dynamic conditions. In recent years, the FT4 powder rheometer of Freeman Technology has emerged as a widely used technique for characterising particle flow under dynamic conditions of shear strain rate; yet little is known about its underlying powder mechanics. We analyse the effect of gas flow on the flow behaviour of cohesionless particles in FT4 both experimentally and by numerical simulations using the combined discrete element method (DEM) and computational fluid dynamics (CFD). The results show that the effect of gas flow on the flow energy could be described by the resultant fluid-induced drag on the particles above the blade position as the impeller penetrates the bed. The strain rate in front of the blade is mainly determined by the impeller tip speed, and is not sensitive to the gas flow and particle size. The flow energy correlates well with the shear stress in front of the blade. They both increase with the strain rate and are significantly reduced by the upward gas flow
Molecular recognition of benzoin and bi-beta-naphthol analogues by Chirex 3001-based chiral stationary phase
The simplified model of (R)-phenylglycine based chiral stationary phase (Chirex 3001) was built to investigate the process of chiral recognition of benzoin and bi-beta-naphthol and their analogues by molecular mechanics methods. The results showed that the driving force of chiral recognition came from the pi-pi stacking, hydrogen bond and van der Waals interactions between the host and the guest molecule. The host preferred to bind with S-enantiomers of benzoin and its analogues 1 similar to 3, and preferred to bind with R-enantiomers of bi-beta-naphthol and its analogues 4 similar to 6. This was consistent with the HPLC experimental results. The separation factors were 1.02, 1.04 and 1.11 respectively for compounds 1 similar to 3 when n-hexane/1,2-dichloroethane/ethanol (V : V : V=83.5 : 15 : 1.5) was used as mobile phase, and the R-enantiomers were eluted first. The separation factors were 1.23, 1.26 and 1.11 respectively when n-hexane/chloroform/ethanol (V : V : V=78.5 : 20 : 1.5) was used as mobile phase, and the S-enantiomers were eluted first
Research on the Stability of a Rabbit Dry Eye Model Induced by Topical Application of the Preservative Benzalkonium Chloride
Dry eye is a common disease worldwide, and animal models are critical for the study of it. At present, there is no research about the stability of the extant animal models, which may have negative implications for previous dry eye studies. In this study, we observed the stability of a rabbit dry eye model induced by the topical benzalkonium chloride (BAC) and determined the valid time of this model.). Decreased levels of mucin-5 subtype AC (MUC5AC), along with histopathological and ultrastructural disorders of the cornea and conjunctiva could be observed in Group BAC-W4 and particularly in Group BAC-W5 until day 21.A stable rabbit dry eye model was induced by topical 0.1% BAC for 5 weeks, and after BAC removal, the signs of dry eye were sustained for 2 weeks (for the mixed type of dry eye) or for at least 3 weeks (for mucin-deficient dry eye)
Molecular mechanisms of severe acute respiratory syndrome (SARS)
Severe acute respiratory syndrome (SARS) is a new infectious disease caused by a novel coronavirus that leads to deleterious pulmonary pathological features. Due to its high morbidity and mortality and widespread occurrence, SARS has evolved as an important respiratory disease which may be encountered everywhere in the world. The virus was identified as the causative agent of SARS due to the efforts of a WHO-led laboratory network. The potential mutability of the SARS-CoV genome may lead to new SARS outbreaks and several regions of the viral genomes open reading frames have been identified which may contribute to the severe virulence of the virus. With regard to the pathogenesis of SARS, several mechanisms involving both direct effects on target cells and indirect effects via the immune system may exist. Vaccination would offer the most attractive approach to prevent new epidemics of SARS, but the development of vaccines is difficult due to missing data on the role of immune system-virus interactions and the potential mutability of the virus. Even in a situation of no new infections, SARS remains a major health hazard, as new epidemics may arise. Therefore, further experimental and clinical research is required to control the disease
Thalamic Activation Modulates the Responses of Neurons in Rat Primary Auditory Cortex: An In Vivo Intracellular Recording Study
Auditory cortical plasticity can be induced through various approaches. The medial geniculate body (MGB) of the auditory thalamus gates the ascending auditory inputs to the cortex. The thalamocortical system has been proposed to play a critical role in the responses of the auditory cortex (AC). In the present study, we investigated the cellular mechanism of the cortical activity, adopting an in vivo intracellular recording technique, recording from the primary auditory cortex (AI) while presenting an acoustic stimulus to the rat and electrically stimulating its MGB. We found that low-frequency stimuli enhanced the amplitudes of sound-evoked excitatory postsynaptic potentials (EPSPs) in AI neurons, whereas high-frequency stimuli depressed these auditory responses. The degree of this modulation depended on the intensities of the train stimuli as well as the intervals between the electrical stimulations and their paired sound stimulations. These findings may have implications regarding the basic mechanisms of MGB activation of auditory cortical plasticity and cortical signal processing
Properties of Graphene: A Theoretical Perspective
In this review, we provide an in-depth description of the physics of
monolayer and bilayer graphene from a theorist's perspective. We discuss the
physical properties of graphene in an external magnetic field, reflecting the
chiral nature of the quasiparticles near the Dirac point with a Landau level at
zero energy. We address the unique integer quantum Hall effects, the role of
electron correlations, and the recent observation of the fractional quantum
Hall effect in the monolayer graphene. The quantum Hall effect in bilayer
graphene is fundamentally different from that of a monolayer, reflecting the
unique band structure of this system. The theory of transport in the absence of
an external magnetic field is discussed in detail, along with the role of
disorder studied in various theoretical models. We highlight the differences
and similarities between monolayer and bilayer graphene, and focus on
thermodynamic properties such as the compressibility, the plasmon spectra, the
weak localization correction, quantum Hall effect, and optical properties.
Confinement of electrons in graphene is nontrivial due to Klein tunneling. We
review various theoretical and experimental studies of quantum confined
structures made from graphene. The band structure of graphene nanoribbons and
the role of the sublattice symmetry, edge geometry and the size of the
nanoribbon on the electronic and magnetic properties are very active areas of
research, and a detailed review of these topics is presented. Also, the effects
of substrate interactions, adsorbed atoms, lattice defects and doping on the
band structure of finite-sized graphene systems are discussed. We also include
a brief description of graphane -- gapped material obtained from graphene by
attaching hydrogen atoms to each carbon atom in the lattice.Comment: 189 pages. submitted in Advances in Physic
Effects of MDM2, MDM4 and TP53 Codon 72 Polymorphisms on Cancer Risk in a Cohort Study of Carriers of TP53 Germline Mutations
Previous studies have shown that MDM2 SNP309 and p53 codon 72 have modifier effects on germline P53 mutations, but those studies relied on case-only studies with small sample sizes. The impact of MDM4 polymorphism on tumor onset in germline mutation carriers has not previously been studied.We analyzed 213 p53 germline mutation carriers including 168(78.9%) affected with cancer and 174 who had genotypic data. We analyzed time to first cancer using Kaplan-Meier and Cox proportional hazards methods, comparing risks according to polymorphism genotypes. For MDM2 SNP309, a significant difference of 9.0 years in the average age of cancer diagnosis was observed between GG/GT and TT carriers (18.6 versus 27.6 years, P = 0.0087). The hazards ratio was 1.58 (P = 0.03) comparing risks among individuals with GG/GT to risk among TT, but this effect was only significant in females (HR = 1.60, P = 0.02). Compared to other genotypes, P53 codon 72 PP homozygotes had a 2.24 times (P = 0.03) higher rate for time to develop cancer. We observed a multiplicative joint effect of MDM2 and p53 codon72 polymorphism on risk. The MDM4 polymorphism had no significant effects.Our results suggest that the MDM2 SNP309 G allele is associated with cancer risk in p53 germline mutation carriers and accelerates time to cancer onset with a pronounced effect in females. A multiplicative joint effect exists between the MDM2 SNP309 G allele and the p53 codon 72 G allele in the risk of cancer development. Our results further define cancer risk in carriers of germline p53 mutations
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