Performing Haydn\u27s The Creation: Reconstructing the Earliest Renditions. By A. Peter Brown

Reviews and critiques Brown\u27s 1986 book

Cupid\u27s Wings

One sunny day as Cupid lay, In rosy dreams asleep I stole his fairy wings away, And biding him a fond adieu, I quickly donned the pennons gay, That I might fly to you One sunny day as Cupid lay, In rosy dreams asleep, I stole his fairy wings away, That I might fly. That I might fly. to you

The construction of an aptitude test for particular ability in the bookkeeping and accounting field.

Thesis (Ed.D.)--Boston University

Moessbauer spectroscopy and scanning electron microscopy of the Murchison meteorite

Meteorites provide a wealth of information about the solar system's formation, since they have similar building blocks as the Earth's crust but have been virtually unaltered since their formation. Some stony meteorites contain minerals and silicate inclusions, called chondrules, in the matrix. Utilizing Moessbauer spectroscopy, we identified minerals in the Murchison meteorite, a carbonaceous chondritic meteorite, by the gamma ray resonance lines observed. Absorption patterns of the spectra were found due to the minerals olivine and phyllosilicate. We used a scanning electron microscope to describe the structure of the chondrules in the Murchison meteorite. The chondrules were found to be deformed due to weathering of the meteorite. Diameters varied in size from 0.2 to 0.5 mm. Further enhancement of the microscopic imagery using a digital image processor was used to describe the physical characteristics of the inclusions

Sampling Procedures in Estrogen Receptor Determinations

To determine the significance of proteolysis and delayed freezing of tumor samples on estrogen receptor levels, values from 19 of 31 biopsy specimens were compared with that in remaining tumor at the completion of mastectomy. There was a 15-100% decrease in receptor content. Time-decay studies on selected postmastectomy samples showed a further decrease in estrogen receptor content inversely proportional to the time it was exposed to room temperature. Factors that govern the valid measurement of receptor levels include tumor cell concentration, tumor necrosis, and time between devascularization of the specimen to freezing. A carefully procured histologically confirmed sample of fresh tumor is necessary for reliable estrogen receptor values

A study of the science laboratories in the secondary schools

Thesis (Ed.M.)--Boston University, 194

Making sense of motivation: Stories of high-achieving African American middle school students.

The outcomes of this study will exhibit students maintaining high-academic achievements are equally intrinsically and extrinsically motivated. Their meaning making is synonymous with that of the literature, as the students' stories are consistent with the constructs of internal and external control, as well as locus of causality. The faith-based descriptions or reasons for achievement were unanticipated findings, yet significant to the purposely selected sample population included.Recommendations for future study include a dire need for more in-depth, uni-cultural phenomenological studies, versus multicultural contrasts and comparisons. Additionally, the students suggest student ownership of their classrooms to achieve a class-total desire for academic achievement. Lastly, in a faith-based educational environment, synonymous teacher/faculty-student beliefs are more important than that of the staffs' educational accomplishment when fostering caring, productive intrinsically driven classrooms of excellence producing significant educational achievements.This qualitative study explored the making sense of motivation, as defined by African American middle school high-achieving students in a faith-based private school in Europe. These high-achievers were active duty military dependants of enlisted men, voluntarily enrolled at a private Christian academy. The data were collected using a survey and observations during one face-to-face collective group interview, utilizing open-ended questions in a structured format. There were three participants in this research project. While it was not the original focus of the project, the faith-based beliefs and scripturally referenced style of parenting and teacher cooperation may have contributed significantly to the findings. The participants were sixth and eighth grades, two were female and one male. Content analysis was used to determine rich, thick descriptions of the data. This study was significant because it extends descriptions of current motivation theories to illustrate how high-academic achievers may not be autonomously driven by intrinsic motivation, but may more realistically integrate various orientations of intrinsic or extrinsic motivation to optimize their goals. The salient results of this qualitative phenomenology will assist future educational researchers in understanding the student perspective on the aforementioned constructs: motivation and academic achievement

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection.

HIV infection induces phenotypic and functional changes to CD8+ T cells defined by the coordinated upregulation of a series of negative checkpoint receptors that eventually result in T cell exhaustion and failure to control viral replication. We report that effector CD8+ T cells during HIV infection in blood and SIV infection in lymphoid tissue exhibit higher levels of the negative checkpoint receptor TIGIT. Increased frequencies of TIGIT+ and TIGIT+ PD-1+ CD8+ T cells correlated with parameters of HIV and SIV disease progression. TIGIT remained elevated despite viral suppression in those with either pharmacological antiretroviral control or immunologically in elite controllers. HIV and SIV-specific CD8+ T cells were dysfunctional and expressed high levels of TIGIT and PD-1. Ex-vivo single or combinational antibody blockade of TIGIT and/or PD-L1 restored viral-specific CD8+ T cell effector responses. The frequency of TIGIT+ CD4+ T cells correlated with the CD4+ T cell total HIV DNA. These findings identify TIGIT as a novel marker of dysfunctional HIV-specific T cells and suggest TIGIT along with other checkpoint receptors may be novel curative HIV targets to reverse T cell exhaustion

Temporal and Spatial Patterns of Ambient Endotoxin Concentrations in Fresno, California

BackgroundEndotoxins are found in indoor dust generated by human activity and pets, in soil, and adsorbed onto the surfaces of ambient combustion particles. Endotoxin concentrations have been associated with respiratory symptoms and the risk of atopy and asthma in children.ObjectiveWe characterized the temporal and spatial variability of ambient endotoxin in Fresno/Clovis, California, located in California's Central Valley, to identify correlates and potential predictors of ambient endotoxin concentrations in a cohort of children with asthma [Fresno Asthmatic Children's Environment Study (FACES)].MethodsBetween May 2001 and October 2004, daily ambient endotoxin and air pollutants were collected at the central ambient monitoring site of the California Air Resources Board in Fresno and, for shorter time periods, at 10 schools and indoors and outdoors at 84 residences in the community. Analyses were restricted to May-October, the dry months during which endotoxin concentrations are highest.ResultsDaily endotoxin concentration patterns were determined mainly by meteorologic factors, particularly the degree of air stagnation. Overall concentrations were lowest in areas distant from agricultural activities. Highest concentrations were found in areas immediately downwind from agricultural/pasture land. Among three other measured air pollutants [fine particulate matter, elemental carbon (a marker of traffic in Fresno), and coarse particulate matter (PMc)], PMc was the only pollutant correlated with endotoxin. Endotoxin, however, was the most spatially variable.ConclusionsOur data support the need to evaluate the spatial/temporal variability of endotoxin concentrations, rather than relying on a few measurements made at one location, in studies of exposure and and respiratory health effects, particularly in children with asthma and other chronic respiratory diseases

Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.

Microglia, the resident immune cells of the brain, rapidly change states in response to their environment, but we lack molecular and functional signatures of different microglial populations. Here, we analyzed the RNA expression patterns of more than 76,000 individual microglia in mice during development, in old age, and after brain injury. Our analysis uncovered at least nine transcriptionally distinct microglial states, which expressed unique sets of genes and were localized in the brain using specific markers. The greatest microglial heterogeneity was found at young ages; however, several states-including chemokine-enriched inflammatory microglia-persisted throughout the lifespan or increased in the aged brain. Multiple reactive microglial subtypes were also found following demyelinating injury in mice, at least one of which was also found in human multiple sclerosis lesions. These distinct microglia signatures can be used to better understand microglia function and to identify and manipulate specific subpopulations in health and disease