Moyross Community Mapping Survey

This report provides the results of a community mapping exercise completed in and around the Moyross area. The report is intended to act as a guide to the services available in Moyross and act as a catalyst for collaboration. Wherever possible, organization were contacted personally. In some cases, alternative secondary sources were the only available references. Approximately 50 organizations, ranging from schools, to churches, to community groups, are listed with details of their mission, services provided, and contact information.This research was supported by the International Undergraduate Research Opportunities Program (I-UROP)

Securitization and Community-Based Protection Among Chin Refugees in Kuala Lumpur

This article examines refugee-led community organizations among Chin refugees from Myanmar in Kuala Lumpur. It uses a structuration analysis that recognizes refugee-led organizations as complex governance entities engaged in a dynamic relationship with (among others) national policies of securitization of forced migration and international humanitarian governance. This approach expands the existing literature on the securitization of forced migration by exploring refugees’ lived experiences in a context of south–south migration. It expands the literature on community-based protection by going beyond recognizing the existence of refugee-led organizations to analyse their construction, constitution and consequences. Three primary areas of work by Chin refugee groups are analysed in relation to their immediate activity and longer term effects: organization (‘building ethnic unity in adversity’), documentation (‘asserting a bureaucratic identity’) and socialization (‘learning to be illegal’). These long-term effects indicate the possible impact of local protection activities on macrostructural processes such as identity construction and migration choices.construction, constitution and consequences. Three primary areas of work by Chin refugee groups are analysed in relation to their immediate activity and longer term effects: organization (‘building ethnic unity in adversity’), documentation (‘asserting a bureaucratic identity’) and socialization (‘learning to be illegal’). These long-term effects indicate the possible impact of local protection activities on macrostructural processes such as identity construction and migration choices

Beam-forming module for backhaul link in a Relay-aided 4G network

YesA novel beam-forming module based on Wilkinson power divider technology, including attenuators and phase shifter chips is designed, fabricated and evaluated to be incorporated in a Relay Station connecting it with the Base Station under a 4G network. The proposed module is a 1:8 port circuit, utilizing two substrates, providing approximately 700 MHz bandwidth over 3.5 GHz frequency band and less than −20 dB transmission line coupling. Moreover an external control unit that feeds the beam-forming module with code-words that define the proper amplitude/phase of the excitation currents is established and described. The presented module is connected to a planar array and tested for two beam-forming scenarios, providing satisfactory radiation patterns

A full scale comparative study of methods for generation of functional Dendritic cells for use as cancer vaccines

<p/> <p>Background</p> <p>Dendritic cells (DCs) are professional antigen-presenting cells with the ability to induce primary T-cell responses and are commonly produced by culturing monocytes in the presence of IL-4 and GM-CSF for 5–7 days (Standard DC). Recently, Dauer and co-workers presented a modified protocol for differentiation of human monocytes into mature DCs within 48 hours (Fast DC). Here we report a functional comparison of the two strategies for generation of DCs from human monocytes with adaptions for large-scale clinical use.</p> <p>Methods</p> <p>The Elutra Cell Selection System was used to isolate monocytes after collection of leukapheresis product. The enriched monocytes were cultured in gas permeable Teflon bags with IL-4 and GM-CSF for 24 hours (Fast DC) or 5 days (Standard DC) to obtain immature DCs. The cells were then transfected with mRNA from the leukemia cell line Jurkat E6 by electroporation and incubated for additional 24 h or 2 days in the presence of pro-inflammatory cytokines (TNFα, IL-1β, IL-6 and PGE₂) to obtain mature DCs.</p> <p>Results</p> <p>Mature Fast DC and Standard DC displayed comparable levels of many markers expressed on DC, including HLA-DR, CD83, CD86, CD208 and CCR7. However, compared to Standard DC, mature Fast DC was CD14^highCD209^low. Fast DC and Standard DC transfected with Jurkat E6-cell mRNA were equally able to elicit T cell specifically recognizing transfected DCs in vitro. IFNγ-secreting T cells were observed in both the CD4+ and CD8+ subsets.</p> <p>Conclusion</p> <p>Our results indicate that mature Fast DC are functional antigen presenting cells (APCs) capable of inducing primary T-cell responses, and suggest that these cells may be valuable for generation of anti-tumor vaccines.</p

Immunotherapy with allotumour mRNA-transfected dendritic cells in androgen-resistant prostate cancer patients

Here, we present results from a clinical trial employing a new vaccination method using dendritic cells (DCs) transfected with mRNA from allogeneic prostate cancer cell lines (DU145, LNCaP and PC-3). In all, 20 patients were enrolled and 19 have completed vaccination. Each patient received at least four weekly injections with 2 × 107 transfected DCs either intranodally or intradermally. Safety and feasibility of vaccination were determined. Immune responses were measured as delayed-type hypersensitivity and by in vitro immunoassays including ELISPOT and T-cell proliferation in pre- and postvaccination peripheral blood samples. Serum prostate-specific antigen (PSA) levels and bone scans were monitored. No toxicity or serious adverse events related to vaccinations were observed. A total of 12 patients developed a specific immune response to tumour mRNA-transfected DCs. In total, 13 patients showed a decrease in log slope PSA. This effect was strengthened by booster vaccinations. Clinical outcome was significantly related to immune responses (n=19, P=0.002, r=0.68). Vaccination with mRNA-transfected DCs is safe and results in cellular immune responses specific for antigens encoded by mRNA derived from the prostate cancer cell lines. The observation that in some patients vaccination affected the PSA level suggests that this approach may become useful as a treatment modality for prostate cancer patients

A precise bathymetric map of the world’s deepest seafloor, Challenger Deep in the Mariana Trench

Data from three bathymetric surveys by R/V Kairei using a 12-kHz multibeam echosounder and differential GPS were used to create an improved topographic model of the Challenger Deep in the southwestern part of the Mariana Trench, which is known as the deepest seafloor in the world. The strike of most of the elongated structures related to plate bending accompanied by subduction of the Pacific plate is N70°E and is not parallel to the trench axis. The bending-related structures were formed by reactivation of seafloor spreading fabric. Challenger Deep consists of three en echelon depressions along the trench axis, each of which is 6-10 km long, about 2 km wide, and deeper than 10,850 m. The eastern depression is the deepest, with a depth of 10,920 ± 5 m