The social cognition of medical knowledge, with special reference to childhood epilepsy

This paper arose out of an engagement in medical communication courses at a Gulf university. It deploys a theoretical framework derived from a (critical) sociocognitive approach to discourse analysis in order to investigate three aspects of medical discourse relating to childhood epilepsy: the cognitive processes that are entailed in relating different types of medical knowledge to their communicative context; the types of medical knowledge that are constituted in the three different text types analysed; and the relationship between these different types of medical knowledge and the discursive features of each text type. The paper argues that there is a cognitive dimension to the human experience of understanding and talking about one specialized from of medical knowledge. It recommends that texts be studied in medical communication courses not just in terms of their discrete formal features but also critically, in terms of the knowledge which they produce, transmit and reproduce

Constraining Anisotropic Baryon Oscillations

We present an analysis of anisotropic baryon acoustic oscillations and elucidate how a mis-estimation of the cosmology, which leads to incorrect values of the angular diameter distance, d_A, and Hubble parameter, H, manifest themselves in changes to the monopole and quadrupole power spectrum of biased tracers of the density field. Previous work has focused on the monopole power spectrum, and shown that the isotropic "dilation" combination d_A^2/H is robustly constrained by an overall shift in the scale of the baryon feature. We extend this by demonstrating that the quadrupole power spectrum is sensitive to an anisotropic "warping" mode d_A H, allowing one to break the degeneracy between d_A and H. We describe a method for measuring this warping, explicitly marginalizing over the form of redshift space distortions. We verify this method on N-body simulations and estimate that d_A H can be measured with a fractional accuracy of ~ 3/sqrt(V) % where the survey volume is estimated in (Gpc/h)^3.Comment: 4 pages, 2 fig

Decorrelating the Power Spectrum of Galaxies

It is shown how to decorrelate the (prewhitened) power spectrum measured from a galaxy survey into a set of high resolution uncorrelated band-powers. The treatment includes nonlinearity, but not redshift distortions. Amongst the infinitely many possible decorrelation matrices, the square root of the Fisher matrix, or a scaled version thereof, offers a particularly good choice, in the sense that the band-power windows are narrow, approximately symmetric, and well-behaved in the presence of noise. We use this method to compute band-power windows for, and the information content of, the Sloan Digital Sky Survey, the Las Campanas Redshift Survey, and the IRAS 1.2 Jy Survey.Comment: 11 pages, including 8 embedded PostScript figures. Minor changes to agree with published versio

Antioxidants and the Autoxidation of Fats v. Mode of Action of Anti- and Pro-Oxidants

Experiments on the oxidation of purified methyl oleate support the view that its induction period, and probably that of natural oils, is due to the presence of inhibitors and that purified unsaturated compounds have no induction period, other than the time required for gaseous oxygen to diffuse into the liquid

Measuring the galaxy power spectrum with future redshift surveys

Precision measurements of the galaxy power spectrum P(k) require a data analysis pipeline that is both fast enough to be computationally feasible and accurate enough to take full advantage of high-quality data. We present a rigorous discussion of different methods of power spectrum estimation, with emphasis on the traditional Fourier method, the linear (Karhunen-Loeve; KL), and quadratic data compression schemes, showing in what approximations they give the same result. To improve speed, we show how many of the advantages of KL data compression and power spectrum estimation may be achieved with a computationally faster quadratic method. To improve accuracy, we derive analytic expressions for handling the integral constraint, since it is crucial that finite volume effects are accurately corrected for on scales comparable to the depth of the survey. We also show that for the KL and quadratic techniques, multiple constraints can be included via simple matrix operations, thereby rendering the results less sensitive to galactic extinction and mis-estimates of the radial selection function. We present a data analysis pipeline that we argue does justice to the increases in both quality and quantity of data that upcoming redshift surveys will provide. It uses three analysis techniques in conjunction: a traditional Fourier approach on small scales, a pixelized quadratic matrix method on large scales and a pixelized KL eigenmode analysis to probe anisotropic effects such as redshift-space distortions.Comment: Major revisions for clarity. Matches accepted ApJ version. 23 pages, with 2 figs included. Color figure and links at http://www.sns.ias.edu/~max/galpower.html (faster from the US), from http://www.mpa-garching.mpg.de/~max/galpower.html (faster from Europe) or from [email protected]

Overlapping-gate architecture for silicon Hall bar MOSFET devices in the low electron density regime

We report the fabrication and study of Hall bar MOSFET devices in which an overlapping-gate architecture allows four-terminal measurements of low-density 2D electron systems, while maintaining a high density at the ohmic contacts. Comparison with devices made using a standard single gate show that measurements can be performed at much lower densities and higher channel resistances, despite a reduced peak mobility. We also observe a voltage threshold shift which we attribute to negative oxide charge, injected during electron-beam lithography processing.Comment: 4 pages, 4 figures, submitted for Applied Physics Letter

The Berry phase of dislocations in graphene and valley conserving decoherence

We demonstrate that dislocations in the graphene lattice give rise to electron Berry phases equivalent to quantized values {0,1/3,-1/3} in units of the flux quantum, but with an opposite sign for the two valleys. An elementary scale consideration of a graphene Aharonov-Bohm ring equipped with valley filters on both terminals, encircling a dislocation, says that in the regime where the intervalley mean free path is large compared to the intravalley phase coherence length, such that the valley quantum numbers can be regarded as conserved on the relevant scale, the coherent valley-polarized currents sensitive to the topological phases have to traverse the device many times before both valleys contribute, and this is not possible at intermediate temperatures where the latter length becomes of order of the device size, thus leading to an apparent violation of the basic law of linear transport that magnetoconductance is even in the applied flux. We discuss this discrepancy in the Feynman path picture of dephasing, when addressing the transition from quantum to classical dissipative transport. We also investigate this device in the scattering matrix formalism, accounting for the effects of decoherence by the Buttiker dephasing voltage probe type model which conserves the valleys, where the magnetoconductance remains even in the flux, also when different decoherence times are allowed for the individual, time reversal connected, valleys.Comment: 14 pages, 7 figures; revised text, added figure, accepted for publication by PR

Water intoxication presenting as maternal and neonatal seizures: a case report.

Introduction We present an unusual case of fitting in the mother and newborn child, and the challenges faced in the management of their hyponatraemia due to water intoxication. Case presentation A previously well 37-year-old, primigravid Caucasian woman presented with features mimicking eclampsia during labour. These included confusion, reduced consciousness and seizures but without a significant history of hypertension, proteinuria or other features of pre-eclampsia. Her serum sodium was noted to be low at 111 mmol/litre as was that of her newborn baby. She needed anti-convulsants with subsequent intubation to stop the fitting and was commenced on a hypertonic saline infusion with frequent monitoring of serum sodium. There is a risk of long-term neurological damage from central pontine myelinolysis if the hyponatraemia is corrected too rapidly. Mother and baby went on to make a full recovery without any long-term neurological complications. Conclusion There is little consensus on the treatment of life-threatening hyponatraemia. Previous articles have outlined several possible management strategies as well as their risks. After literature review, an increase in serum sodium concentration of no more than 8–10 mmol/litre in 24 hours is felt to be safe but can be exceeded with extreme caution if life-threatening symptoms do not resolve. Formulae exist to calculate the amount of sodium needed and how much hypertonic intravenous fluid will be required to allow safer correction. We hypothesise the possible causes of hyponatraemia in this patient and underline its similarity in symptom presentation to eclampsia

Manifolds with 1/4-pinched flag curvature

We say that a nonnegatively curved manifold $(M,g)$ has quarter pinched flag curvature if for any two planes which intersect in a line the ratio of their sectional curvature is bounded above by 4. We show that these manifolds have nonnegative complex sectional curvature. By combining with a theorem of Brendle and Schoen it follows that any positively curved manifold with strictly quarter pinched flag curvature must be a space form. This in turn generalizes a result of Andrews and Nguyen in dimension 4. For odd dimensional manifolds we obtain results for the case that the flag curvature is pinched with some constant below one quarter, one of which generalizes a recent work of Petersen and Tao