Systems, Social Order, and the Global Debt Crisis

Part I examines the global rise of both public and private debt and its recent manifestations in the US housing bubble and the financial panic of 2007-8. A review of the most popular theories of the debt crisis is provided, including an explication of securitized banking and economic theory. The underlying condition of increasing ecological and energetic scarcity is accorded central significance in the broad trajectory of world growth and debt, Part II explicates systems theories of social order and the social significance of markets. The theories of Niklas Luhmann, Talcott Parsons, Mario Bunge, Anthony Giddens, and Jürgen Habermas are evaluated with respect to their theories of social order and crisis. A central finding is that, although declining rates of exergy production inhibit the global economic recovery as measured by conventional economic tools, this fact is not likely to be widely recognized. A central theme of Part II is how social systems handle uncertainty, risk, and to what extent complex social systems can be regulated normatively by the public sphere. As global society becomes increasingly interconnected and dependent upon the depletion of material and energy resources, the communication channels that facilitate the self-understanding of modern society at the same time proliferate, becoming increasingly disconnected and self-referential. Luhmann’s systems theory is used to explain why collective recognition and action is at once rendered more necessary and increasingly unlikely given the complexity of global society that Earth’s terrestrial stock of nonrenewable energy resources has engendered

The Falling Rate of Profit Thesis Reassessed: Toward a Sociology of Marx’s Value Theory of Labor

Marx considered his theory of the falling rate of profit to be one of the most important discoveries in the field of political economy. According to Marx’s theory, productivity increases put downward pressure on prices and hence profits. Recurrent crises of capital devaluation are both the consequence and solution to this pressure, aggravating the loss of profits initially, but enabling the pursuit of profits via accumulation to once again ensue. Marx’s argument, however, has been the subject of intense dispute for over a century. His critics charge that Marx’s thesis is not only improbable but impossible. This study is an attempt at arbitration of this dispute, inspired by recent quantitative reinterpretations of Marx’s critique of political economy. In the interest of providing a detailed review of the theoretical and empirical literature surrounding this issue, I specifically address the debate about the “transformation” of values into prices. Resolving this issue not only removes some a priori objections to Marx’s value theory, it also provides a coherent interpretation of Marx’s falling profit rate thesis. It appears, then, that the alleged refutations of Marx have themselves been refuted. In addition to investigating the logical validity of Marx’s argument, I attempt to ascertain whether and to what extent his argument is supported empirically. I therefore conduct a multivariate time-series regression analysis of various profit rates in the United States. I test several partially competing hypotheses concerning the most important determinants of the profit rate. Most importantly, I operationalize Marx’s concept of value by calculating an aggregate ratio of total price to total labor hours. I find that accelerating value accumulation correlates with a falling rate of profit, which is entirely consistent with Marx’s thesis. Sociology, knowingly or not, has always been the study of modern society. Because of this, I suggest that there are certain core processes at work that are necessary for its reconstitution and which therefore retain a spatial and temporal contiguity. My aim in this study is to help reclaim for sociology the investigation of one of modern society’s most fundamental processes: the accumulation of value

Community Impact of Public Processions

Research into the impact of public processions on community life in Scoltand.  The research paid particular attention to the impact of problematic processions, and how these processions could be better policed and managed

Prospectus, February 7, 1979

VETERANS AT PARKLAND; Student suggests how to resell books; Could Pc King be solution for apathy?; Carry supplies for winter road dangers; Prospectus… It\u27s a start; PBDT appearing at Parkland; Divorce discussed; Womens forum to meet Tues.; Remedy is available; Speakers Bureau sponsored by Parkland Womens Program; Speech synthesizer to be finished soon; PC singers seeking help; Fewer part-time students at PC; Workshop to be at PC Feb. 17; Student Elections; Canteen increases food prices at PC; Two Parkland veterans tell their stories; PC veterans receive answers; PC rockers lead a double life; PC could be underfunded; New group gets mixed reactions; Classifieds; PC Womens Program gives weekly workshops; WPCD\u27s Hit List for the week of Feb. 5; Ag-business seminars; PCD schedules health program; Creative writing class is now PC radio series; Cobras lose two in weekend play; Track win big in Chicago, look toward region meethttps://spark.parkland.edu/prospectus_1979/1027/thumbnail.jp

Identification of a regulatory pathway inhibiting adipogenesis via RSPO2

Healthy adipose tissue remodeling depends on the balance between de novo adipogenesis from adipogenic progenitor cells and the hypertrophy of adipocytes. De novo adipogenesis has been shown to promote healthy adipose tissue expansion, which confers protection from obesity-associated insulin resistance. Here, we define the role and trajectory of different adipogenic precursor subpopulations and further delineate the mechanism and cellular trajectory of adipogenesis, using single-cell RNA-sequencing datasets of murine adipogenic precursors. We identify Rspo2 as a functional regulator of adipogenesis, which is secreted by a subset of CD142$^{+}$ cells to inhibit maturation of early progenitors through the receptor Lgr4. Increased circulating RSPO2 in mice leads to adipose tissue hypertrophy and insulin resistance and increased RSPO2 levels in male obese individuals correlate with impaired glucose homeostasis. Taken together, these findings identify a complex cellular crosstalk that inhibits adipogenesis and impairs adipose tissue homeostasis

Banner News

https://openspace.dmacc.edu/banner_news/1311/thumbnail.jp

Perioperative Vision Loss in Cervical Spinal Surgery.

STUDY DESIGN: Retrospective multicenter case series. OBJECTIVE: To assess the rate of perioperative vision loss following cervical spinal surgery. METHODS: Medical records for 17 625 patients from 21 high-volume surgical centers from the AOSpine North America Clinical Research Network who received cervical spine surgery (levels from C2 to C7) between January 1, 2005, and December 31, 2011, inclusive, were reviewed to identify occurrences of vision loss following surgery. RESULTS: Of the 17 625 patients in the registry, there were 13 946 patients assessed for the complication of blindness. There were 9591 cases that involved only anterior surgical approaches; the remaining 4355 cases were posterior and/or circumferential fusions. There were no cases of blindness or vision loss in the postoperative period reported during the sampling period. CONCLUSIONS: Perioperative vision loss following cervical spinal surgery is exceedingly rare

Transient Storage as a Function of Geomorphology, Discharge, and Permafrost Active Layer Conditions in Arctic Tundra Streams

Transient storage of solutes in hyporheic zones or other slow-moving stream waters plays an important role in the biogeochemical processes of streams. While numerous studies have reported a wide range of parameter values from simulations of transient storage, little field work has been done to investigate the correlations between these parameters and shifts in surface and subsurface flow conditions. In this investigation we use the stream properties of the Arctic (namely, highly varied discharges, channel morphologies, and subchannel permafrost conditions) to isolate the effects of discharge, channel morphology, and potential size of the hyporheic zone on transient storage. We repeated stream tracer experiments in five morphologically diverse tundra streams in Arctic Alaska during the thaw season (May–August) of 2004 to assess transient storage and hydrologic characteristics. We compared transient storage model parameters to discharge (Q), the Darcy-Weisbach friction factor (f), and unit stream power (ω). Across all studied streams, permafrost active layer depths (i.e., the potential extent of the hyporheic zone) increased throughout the thaw season, and discharges and velocities varied dramatically with minimum ranges of eight-fold and four-fold, respectively. In all reaches the mean storage residence time (tstor) decreased exponentially with increasing Q, but did not clearly relate to permafrost active layer depths. Furthermore, we found that modeled transient storage metrics (i.e., tstor, storage zone exchange rate (αOTIS), and hydraulic retention (Rh)) correlated better with channel hydraulic descriptors such as f and ω than they did with Q or channel slope. Our results indicate that Q is the first-order control on transient storage dynamics of these streams, and that f and ω are two relatively simple measures of channel hydraulics that may be important metrics for predicting the response of transient storage to perturbations in discharge and morphology in a given stream

Expression of a barley cystatin gene in maize enhances resistance against phytophagous mites by altering their cysteine-proteases

Phytocystatins are inhibitors of cysteine-proteases from plants putatively involved in plant defence based on their capability of inhibit heterologous enzymes. We have previously characterised the whole cystatin gene family members from barley (HvCPI-1 to HvCPI-13). The aim of this study was to assess the effects of barley cystatins on two phytophagous spider mites, Tetranychus urticae and Brevipalpus chilensis. The determination of proteolytic activity profile in both mite species showed the presence of the cysteine-proteases, putative targets of cystatins, among other enzymatic activities. All barley cystatins, except HvCPI-1 and HvCPI-7, inhibited in vitro mite cathepsin L- and/or cathepsin B-like activities, HvCPI-6 being the strongest inhibitor for both mite species. Transgenic maize plants expressing HvCPI-6 protein were generated and the functional integrity of the cystatin transgene was confirmed by in vitro inhibitory effect observed against T. urticae and B. chilensis protein extracts. Feeding experiments impaired on transgenic lines performed with T. urticae impaired mite development and reproductive performance. Besides, a significant reduction of cathepsin L-like and/or cathepsin B-like activities was observed when the spider mite fed on maize plants expressing HvCPI-6 cystatin. These findings reveal the potential of barley cystatins as acaricide proteins to protect plants against two important mite pests

Eradication of chronic myeloid leukemia stem cells: a novel mathematical model predicts no therapeutic benefit of adding G-CSF to imatinib

Imatinib mesylate induces complete cytogenetic responses in patients with chronic myeloid leukemia (CML), yet many patients have detectable BCR-ABL transcripts in peripheral blood even after prolonged therapy. Bone marrow studies have shown that this residual disease resides within the stem cell compartment. Quiescence of leukemic stem cells has been suggested as a mechanism conferring insensitivity to imatinib, and exposure to the Granulocyte-Colony Stimulating Factor (G-CSF), together with imatinib, has led to a significant reduction in leukemic stem cells in vitro. In this paper, we design a novel mathematical model of stem cell quiescence to investigate the treatment response to imatinib and G-CSF. We find that the addition of G-CSF to an imatinib treatment protocol leads to observable effects only if the majority of leukemic stem cells are quiescent; otherwise it does not modulate the leukemic cell burden. The latter scenario is in agreement with clinical findings in a pilot study administering imatinib continuously or intermittently, with or without G-CSF (GIMI trial). Furthermore, our model predicts that the addition of G-CSF leads to a higher risk of resistance since it increases the production of cycling leukemic stem cells. Although the pilot study did not include enough patients to draw any conclusion with statistical significance, there were more cases of progression in the experimental arms as compared to continuous imatinib. Our results suggest that the additional use of G-CSF may be detrimental to patients in the clinic