Adaptive receiver for visible light communication system

The future of visible light communication (VLC) systems relies on achieving moderate to high data rates and the ability to design a low complexity system, as these will play a major role in the next generation communication networks. In this paper, we propose, design, and evaluate the use of an adaptive receiver to mitigate the inter-symbol interference (ISI) and improve the overall VLC system performance while using a single element wide field of view (FOV) photodetector. In addition, we optimise the adaptive receiver by employing a different number of buffers to find the optimum configurations in terms of reducing the complexity and achieving the best performance. The proposed adaptive receiver is able to provide data rates of 1 Gbps with a BER of 10¯⁵ for OOK modulation in the worst case scenario

Clinical and histopathological observations of autologous bone marrow stromal cells implantation on the regeneration of sciatic nerve neurotmesis in rabbit

The peripheral nerve injuries (PNI) is due to stretching and laceration. Therefore, the epineural repair technique is currently accepted as a standard method for peripheral nerve repair. Thirty-two (32) rabbits were divided equally into perineural nerve sutures as control group (CG) and bone marrow stromal cells (BMSCs) as the treatment group (TG). The aim of this study was to investigate the effect of the autologous BMSCs implantation on the regeneration of sciatic nerve neurotmesis in rabbits. There was significant improvement (p<0.05) of the motor and sensory functions in the TG animals as compared to the CG. Histopathological examinations of the proximal nerve stump in the CG showed mild adherence surrounding an anastomosed area, few vacuolation and plenty of collagen at the peri and epineurium. The anastomosed site showed the degeneration, disorientation and giant cell surrounding the stitches, while intraneurial scar tissues were seen in the distal segment at the 112th post operation day (POD). The histopathology of TG showed the activated Schwann cells, good myelination, minimum scar tissue, good orientation and remarkable angiogenesis at the 112th POD. BMSCs are capable of improving the motor and sensory functions and significantly promote the regeneration of sciatic nerve neurotmesis in rabbits.Key words: Clinical, histopathological, bone marrow stromal cells (BMSCs), neurotmesis, sciatic nerve, rabbit

Artificial Neural Network for LiDAL Systems

In this paper, we introduce an intelligent light detection and localization (LiDAL) system that uses artificial neural networks (ANN). The LiDAL systems of interest are MIMO LiDAL and MISO IMG LiDAL systems. A trained ANN with the LiDAL system of interest is used to distinguish a human (target) from the background obstacles (furniture) in a realistic indoor environment. In the LiDAL systems, the received reflected signals in the time domain have different patterns corresponding to the number of targets and their locations in an indoor environment. The indoor environment with background obstacles (furniture) appears as a set of patterns in the time domain when the transmitted optical signals are reflected from objects in LiDAL systems. Hence, a trained neural network that has the ability to classify and recognize the received signal patterns can distinguish the targets from the background obstacles in a realistic environment, especially given the mobility of targets (humans) which distinguishes them from static obstacles (furniture). The LiDAL systems with ANN are evaluated in a realistic indoor environment through computer simulation

Parallel Data Transmission in Indoor Visible Light Communication Systems

This paper presents an indoor visible light communication (VLC) system in conjunction with an imaging receiver with parallel data transmission (spatial multiplexing) to reduce the effects of the inter-symbol interference (ISI). To distinguish between light units (transmitters) and to match the light units used to convey the data with the pixels of the imaging receiver, we propose the use of subcarrier multiplexing (SCM) tones. Each light unit transmission is multiplexed with a unique tone. At the receiver, a SCM tone decision system is utilized to measure the power level of each SCM tone and consequently associate each pixel with a light unit. In addition, the level of co-channel interference (CCI) between light units is estimated using the SCM tones. Our proposed system is examined in two indoor environments taking into account reflective components (first and second order reflections). The results show that this system has the potential to achieve an aggregate data rate of 8 Gb/s with a bit error rate of 10 –6 for each light unit, using simple on-off-keying (OOK)

LiDAL: Light Detection and Localization

In this paper, we present the first indoor light-based detection and localization system that builds on concepts from radio detection and ranging (radar) making use of the expected growth in the use and adoption of visible light communication (VLC), which can provide the infrastructure for our Light Detection and Localization (LiDAL) system. Our system enables active detection, counting, and localization of people, in addition to being fully compatible with the existing VLC systems. In order to detect human (targets), LiDAL uses the visible light spectrum. It sends pulses using a VLC transmitter and analyses the reflected signal collected by a photodetector receiver. Although we examine the use of the visible spectrum here, LiDAL can be used in the infrared spectrum and other parts of the light spectrum. We introduce LiDAL with different transmitter-receiver configurations and optimum and sub-optimum detectors considering the fluctuation of the received reflected signal from the target in the presence of Gaussian noise. We design an efficient multiple input multiple output (MIMO) LiDAL system with a wide field of view (FOV) single photodetector receiver, and also design a multiple input single output (MISO) LiDAL system with an imaging receiver to eliminate the ambiguity in target detection and localization. We develop models for the human body and its reflections and consider the impact of the color and texture of the cloth used as well as the impact of target mobility. A number of detection and localization methods are developed for our LiDAL system, including cross correlation and a background subtraction method. These methods are considered to distinguish a mobile target from the ambient reflections due to background obstacles (furniture) in a realistic indoor environment

Field site selection: getting it right first time around

The selection of suitable field sites for integrated control of Anopheles mosquitoes using the sterile insect technique (SIT) requires consideration of the full gamut of factors facing most proposed control strategies, but four criteria identify an ideal site: 1) a single malaria vector, 2) an unstructured, relatively low density target population, 3) isolation of the target population and 4) actual or potential malaria incidence. Such a site can exist in a diverse range of situations or can be created. Two contrasting SIT field sites are examined here: the desert-flanked Dongola Reach of the Nile River in Northern State, Sudan, where malaria is endemic, and the island of La Reunion, where autochthonous malaria is rare but risk is persistent. The single malaria-transmitting vector at both sites is Anopheles arabiensis. In Sudan, the target area is a narrow 500 km corridor stretching from the rocky terrain at the Fourth Cataract - just above the new Merowe Dam, to the northernmost edge of the species range, close to Egypt. Vector distribution and temporal changes in density depend on the Nile level, ambient temperature and human activities. On La Reunion, the An. arabiensis population is coastal, limited and divided into three areas by altitude and exposure to the trade winds on the east coast. Mosquito vectors for other diseases are an issue at both sites, but of primary importance on La Reunion due to the recent chikungunya epidemic. The similarities and differences between these two sites in terms of suitability are discussed in the context of area-wide integrated vector management incorporating the SIT

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

We identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa (arRP) in eight consanguineous families of Pakistani descent. The p.D25E alteration decreased CLCC1 channel function accompanied by accumulation of mutant protein in granules within the ER lumen, while siRNA knockdown of CLCC1 mRNA induced apoptosis in cultured ARPE-19 cells. TALEN KO in zebrafish was lethal 11 days post fertilization. The depressed electroretinogram (ERG) cone response and cone spectral sensitivity of 5 dpf KO zebrafish and reduced eye size, retinal thickness, and expression of rod and cone opsins could be rescued by injection of wild type CLCC1 mRNA. Clcc1+/- KO mice showed decreased ERGs and photoreceptor number. Together these results strongly suggest that intracellular chloride transport by CLCC1 is a critical process in maintaining retinal integrity, and CLCC1 is crucial for survival and function of retinal cells

Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa

This is the final version. Available on open access from Public Library of Science via the DOI in this recordData Availability: Exome and genome .vcf files and SNP array data are available from Dryad Digital Repository: https://doi.org/10.5061/dryad.3vv31qqWe identified a homozygous missense alteration (c.75C>A, p.D25E) in CLCC1, encoding a presumptive intracellular chloride channel highly expressed in the retina, associated with autosomal recessive retinitis pigmentosa (arRP) in eight consanguineous families of Pakistani descent. The p.D25E alteration decreased CLCC1 channel function accompanied by accumulation of mutant protein in granules within the ER lumen, while siRNA knockdown of CLCC1 mRNA induced apoptosis in cultured ARPE-19 cells. TALEN KO in zebrafish was lethal 11 days post fertilization. The depressed electroretinogram (ERG) cone response and cone spectral sensitivity of 5 dpf KO zebrafish and reduced eye size, retinal thickness, and expression of rod and cone opsins could be rescued by injection of wild type CLCC1 mRNA. Clcc1+/- KO mice showed decreased ERGs and photoreceptor number. Together these results strongly suggest that intracellular chloride transport by CLCC1 is a critical process in maintaining retinal integrity, and CLCC1 is crucial for survival and function of retinal cells