Evolution of Cosmological Perturbations in the Long Wavelength Limit

The relation between the long wavelength limit of solutions to the cosmological perturbation equations and the perturbations of solutions to the exactly homogeneous background equations is investigated for scalar perturbations on spatially flat cosmological models. It is shown that a homogeneous perturbation coincides with the long wavelength limit of some inhomogeneous perturbation only when the former satisfies an additional condition corresponding to the momentum constraint if the matter consists only of scalar fields. In contrast, no such constraint appears if the fundamental variables describing the matter contain a vector field as in the case of a fluid. Further, as a byproduct of this general analysis, it is shown that there exist two universal exact solutions to the perturbation equations in the long wavelength limit, which are expressed only in terms of the background quantities. They represent adiabatic growing and decaying modes, and correspond to the well-known exact solutions for perfect fluid systems and scalar field systems.Comment: 16 pages, no figure, submitted to PR

An adaptogenic role for omega-3 fatty acids in stress; a randomised placebo controlled double blind intervention study (pilot) [ISRCTN22569553]

BACKGROUND: There is evidence for an adaptive role of the omega -3 fatty acid, docosahexaenoic acid (DHA) during stress. Mechanisms of action may involve regulation of stress mediators, such as the catecholamines and proinflammatory cytokines. Prevention of stress-induced aggression and hostility were demonstrated in a series of clinical trials. This study investigates whether perceived stress is ameliorated by DHA in stressed university staff. METHODS: Subjects that scored ≥ 17 on the Perceived Stress Scale were randomised into a 6-week pilot intervention study. The diet reactive group was supplemented with 6 g of fish oil containing 1.5 g per day DHA, while the placebo group was supplemented with 6 g a day of olive oil. The groups were compared with each other and a wider cross sectional study population that did not receive either active or placebo intervention. RESULTS: There was a significant reduction in perceived stress in both the fish oil and the placebo group from baseline. There was also a significant between-group difference between the fish oil group and the no-treatment controls in the rate of stress reduction (p < 0.05). However, there was not a significant between-group difference between the fish oil and the placebo group, nor the placebo group and the control group. These results are discussed in the context of several methodological limitations. The significant stress reductions in both the fish oil and the placebo group are considered in view of statistical regression, an effect likely to have been exaggerated by the time course of the study, a large placebo effect and the possibility of an active effect from the placebo. CONCLUSION: There were significant differences (p < 0.05) in the fish oil group compared with no-treatment controls. This effect was not demonstrated in the placebo group. As a pilot study, it was not sufficiently powered to find the difference between the fish oil group and the placebo group significant. Further work needs to be undertaken to conclusively demonstrate these data trends. However, the findings from this research support the literature in finding a protective or 'adaptogenic' role for omega-3 fatty acids in stress

Evolution of Cosmological Perturbations in the Universe dominated by Multiple Scalar Fields

By efforts of several authors, it is recently established that the dynamical behavior of the cosmological perturbation on superhorizon scales is well approximated in terms of that in the long wavelength limit, and the latter can be constructed from the evolution of corresponding exactly homogeneous universe. Using these facts, we investigate the evolution of the cosmological perturbation on superhorizon scales in the universe dominated by oscillating multiple scalar fields which are generally interacting with each other, and the ratio of whose masses is incommensurable. Since the scalar fields oscillate rapidly around the local minimum of the potential, we use the action angle variables. We found that this problem can be formulated as the canonical perturbation theory in which the perturbed part appearing as the result of the expansion of the universe and the interaction of the scalar fields is bounded by the negative power ot time. We show that by constructing the canonical transformations properly, the transformed hamiltonian becomes simple enough to be solved. As the result of the invetigation using the long wavelength limit and the canonical perturbation theory, under the sufficiently general conditions, we prove that for the adiabatic growing mode the Bardeen parameter stays constant and that for all the other modes the Bardeen parameter decays. From the viewpoint of the ergodic theory, it is discussed that as for the Bardeen parameter, the sigularities appear probabilistically. This analysis serves the understanding of the evolution of the cosmological perturbations on superhorizon scales during reheating.Comment: 31 Pages; Latex, No figure

Relation between Tunneling and Particle Production in Vacuum Decay

The field-theoretical description of quantum fluctuations on the background of a tunneling field $\sigma$ is revisited in the case of a functional Schrodinger approach. We apply this method in the case when quantum fluctuations are coupled to the $\sigma$ field through a mass-squared term, which is 'time-dependent' since we include the dynamics of $\sigma$ . The resulting mode functions of the fluctuation field, which determine the quantum state after tunneling, display a previously unseen resonance effect when their mode number is comparable to the curvature scale of the bubble. A detailed analysis of the relation between the excitations of the field about the true vacuum (interpreted as particle creation) and the phase shift coming from tunneling is presented.Comment: 20 pages, 4 figures, submitted to PR

Self Excitation of the Tunneling Scalar Field in False Vacuum Decay

A method to determine the quantum state of a scalar field after $O(4)$-symmetric bubble nucleation has been developed recently. The method has an advantage that it concisely gives us a clear picture of the resultant quantum state. In particular, one may interpret the excitations as a particle creation phenomenon just as in the case of particle creation in curved spacetime. As an application, we investigate in detail the spectrum of quantum excitations of the tunneling field when it undergoes false vacuum decay. We consider a tunneling potential which is piece-wise quadratic, hence is simple enough to allow us an analytical treatment. We find a strong dependence of the excitation spectrum upon the shape of the potential on the true vacuum side. We then discuss features of the excitation spectrum common to general tunneling potentials not restricted to our simple model.Comment: 24 pages, uuencoded compressed postscript fil

Bubble fluctuations in Ω<1\Omega<1 inflation

In the context of the open inflationary universe, we calculate the amplitude of quantum fluctuations which deform the bubble shape. These give rise to scalar field fluctuations in the open Friedman-Robertson-Walker universe which is contained inside the bubble. One can transform to a new gauge in which matter looks perfectly smooth, and then the perturbations behave as tensor modes (gravitational waves of very long wavelength). For $(1-\Omega)<<1$, where $\Omega$ is the density parameter, the microwave temperature anisotropies produced by these modes are of order $\delta T/T\sim H(R_0\mu l)^{-1/2} (1-\Omega)^{l/2}$. Here, $H$ is the expansion rate during inflation, $R_0$ is the intrinsic radius of the bubble at the time of nucleation, $\mu$ is the bubble wall tension and $l$ labels the different multipoles ($l>1$). The gravitational backreaction of the bubble has been ignored. In this approximation, $G\mu R_0<<1$, and the new effect can be much larger than the one due to ordinary gravitational waves generated during inflation (unless, of course, $\Omega$ gets too close to one, in which case the new effect disappears).Comment: 17 pages, 3 figs, LaTeX, epsfig.sty, available at ftp://ftp.ifae.es/preprint/ft/uabft387.p

Quantized gravitational waves in the Milne universe

The quantization of gravitational waves in the Milne universe is discussed. The relation between positive frequency functions of the gravitational waves in the Milne universe and those in the Minkowski universe is clarified. Implications to the one-bubble open inflation scenario are also discussed.Comment: 26 pages, 1 figure, revtex. submitted to Phys. Rev. D1

Long-term efficacy and safety of migalastat treatment in Fabry disease: 30-month results from the open-label extension of the randomized, phase 3 ATTRACT study

Results from the 18-month randomized treatment period of the phase 3 ATTRACT study demonstrated the efficacy and safety of oral migalastat compared with enzyme replacement therapy (ERT) in patients with Fabry disease who previously received ERT. Here, we report data from the subsequent 12-month, migalastat-only, open-label extension (OLE) period. ATTRACT (Study AT1001–012; NCT01218659) was a randomized, open-label, active-controlled study in patients aged 16–74 years with Fabry disease, an amenable GLA variant, and an estimated glomerular filtration rate (eGFR) ≥30 mL/min/1.73 m2. During the OLE, patients who received migalastat 150 mg every other day (QOD) during the randomized period continued receiving migalastat (Group 1 [MM]); patients who received ERT every other week discontinued ERT and started migalastat treatment (Group 2 [EM]). Outcome measures included eGFR, left ventricular mass index (LVMi), composite clinical outcome (renal, cardiac or cerebrovascular events), and safety. Forty-six patients who completed the randomized treatment period continued into the OLE (Group 1 [MM], n = 31; Group 2 [EM], n = 15). eGFR remained stable in both treatment groups. LVMi decreased from baseline at month 30 in Group 1 (MM) in patients with left ventricular hypertrophy at baseline. Only 10% of patients experienced a new composite clinical event with migalastat treatment during the OLE. No new safety concerns were reported. In conclusion, in patients with Fabry disease and amenable GLA variants, migalastat 150 mg QOD was well tolerated and demonstrated durable, long-term stability of renal function and reduction in LVMi