469 research outputs found
Detecting Eating Episodes with an Ear-mounted Sensor
In this paper, we propose Auracle, a wearable earpiece that can automatically recognize eating behavior. More specifically, in free-living conditions, we can recognize when and for how long a person is eating. Using an off-the-shelf contact microphone placed behind the ear, Auracle captures the sound of a person chewing as it passes through the bone and tissue of the head. This audio data is then processed by a custom analog/digital circuit board. To ensure reliable (yet comfortable) contact between microphone and skin, all hardware components are incorporated into a 3D-printed behind-the-head framework. We collected field data with 14 participants for 32 hours in free-living conditions and additional eating data with 10 participants for 2 hours in a laboratory setting. We achieved accuracy exceeding 92.8% and F1 score exceeding 77.5% for eating detection. Moreover, Auracle successfully detected 20-24 eating episodes (depending on the metrics) out of 26 in free-living conditions. We demonstrate that our custom device could sense, process, and classify audio data in real time. Additionally, we estimateAuracle can last 28.1 hours with a 110 mAh battery while communicating its observations of eating behavior to a smartphone over Bluetooth
An objective validation of polyp and instrument segmentation methods in colonoscopy through Medico 2020 polyp segmentation and MedAI 2021 transparency challenges
Automatic analysis of colonoscopy images has been an active field of research
motivated by the importance of early detection of precancerous polyps. However,
detecting polyps during the live examination can be challenging due to various
factors such as variation of skills and experience among the endoscopists, lack
of attentiveness, and fatigue leading to a high polyp miss-rate. Deep learning
has emerged as a promising solution to this challenge as it can assist
endoscopists in detecting and classifying overlooked polyps and abnormalities
in real time. In addition to the algorithm's accuracy, transparency and
interpretability are crucial to explaining the whys and hows of the algorithm's
prediction. Further, most algorithms are developed in private data, closed
source, or proprietary software, and methods lack reproducibility. Therefore,
to promote the development of efficient and transparent methods, we have
organized the "Medico automatic polyp segmentation (Medico 2020)" and "MedAI:
Transparency in Medical Image Segmentation (MedAI 2021)" competitions. We
present a comprehensive summary and analyze each contribution, highlight the
strength of the best-performing methods, and discuss the possibility of
clinical translations of such methods into the clinic. For the transparency
task, a multi-disciplinary team, including expert gastroenterologists, accessed
each submission and evaluated the team based on open-source practices, failure
case analysis, ablation studies, usability and understandability of evaluations
to gain a deeper understanding of the models' credibility for clinical
deployment. Through the comprehensive analysis of the challenge, we not only
highlight the advancements in polyp and surgical instrument segmentation but
also encourage qualitative evaluation for building more transparent and
understandable AI-based colonoscopy systems
Disease-Associated Mutations That Alter the RNA Structural Ensemble
Genome-wide association studies (GWAS) often identify disease-associated mutations in intergenic and non-coding regions of the genome. Given the high percentage of the human genome that is transcribed, we postulate that for some observed associations the disease phenotype is caused by a structural rearrangement in a regulatory region of the RNA transcript. To identify such mutations, we have performed a genome-wide analysis of all known disease-associated Single Nucleotide Polymorphisms (SNPs) from the Human Gene Mutation Database (HGMD) that map to the untranslated regions (UTRs) of a gene. Rather than using minimum free energy approaches (e.g. mFold), we use a partition function calculation that takes into consideration the ensemble of possible RNA conformations for a given sequence. We identified in the human genome disease-associated SNPs that significantly alter the global conformation of the UTR to which they map. For six disease-states (Hyperferritinemia Cataract Syndrome, ÎČ-Thalassemia, Cartilage-Hair Hypoplasia, Retinoblastoma, Chronic Obstructive Pulmonary Disease (COPD), and Hypertension), we identified multiple SNPs in UTRs that alter the mRNA structural ensemble of the associated genes. Using a Boltzmann sampling procedure for sub-optimal RNA structures, we are able to characterize and visualize the nature of the conformational changes induced by the disease-associated mutations in the structural ensemble. We observe in several cases (specifically the 5âČ UTRs of FTL and RB1) SNPâinduced conformational changes analogous to those observed in bacterial regulatory Riboswitches when specific ligands bind. We propose that the UTR and SNP combinations we identify constitute a âRiboSNitch,â that is a regulatory RNA in which a specific SNP has a structural consequence that results in a disease phenotype. Our SNPfold algorithm can help identify RiboSNitches by leveraging GWAS data and an analysis of the mRNA structural ensemble
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
Measurement of the ratios of branching fractions and
The ratios of branching fractions
and are measured, assuming isospin symmetry, using a
sample of proton-proton collision data corresponding to 3.0 fb of
integrated luminosity recorded by the LHCb experiment during 2011 and 2012. The
tau lepton is identified in the decay mode
. The measured values are
and
, where the first uncertainty is
statistical and the second is systematic. The correlation between these
measurements is . Results are consistent with the current average
of these quantities and are at a combined 1.9 standard deviations from the
predictions based on lepton flavor universality in the Standard Model.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-039.html (LHCb
public pages
- âŠ