Selective Migration and Health

We investigate the proposition that the health of migrants does not constitute a random sample of the health of the sending region using data from the Panel Study of Income Dynamics on internal migration within the United States. Panel data is crucial, as it enables us to observe geographic mobility as well as the health of the migrant prior to migration. We find that, for men and women below 60 years of age, a move from the middle to the bottom of the health distribution reduces mobility by 32-40% and 12-18%, respectively. Nonrandom attrition from the panel implies that these estimates are lower bounds. By contrast, we find evidence that, among older people, there is higher mobility at the top and bottom of the health distribution than there is at the middle. We consider two explanations for this: first that elderly persons may migrate to be closer to a family network once they fall ill, and second that non-random attrition may also be causing an upwards bias in the estimated effect of illness on mobility.Migration, Health, Selection, Attrition

Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson’s disease:A task-based fMRI study

Background: The neural substrates of visual hallucinations remain an enigma, due primarily to the difficulties associated with directly interrogating the brain during hallucinatory episodes. Aims: To delineate the functional patterns of brain network activity and connectivity underlying visual hallucinations in Parkinson’s disease. Methods: In this study, we combined functional magnetic resonance imaging (MRI) with a behavioral task capable of eliciting visual misperceptions, a confirmed surrogate for visual hallucinations, in 35 patients with idiopathic Parkinson’s disease. We then applied an independent component analysis to extract time series information for large-scale neuronal networks that have been previously implicated in the pathophysiology of visual hallucinations. These data were subjected to a task-based functional connectivity analysis, thus providing the first objective description of the neural activity and connectivity during visual hallucinations in patients with Parkinson’s disease. Results: Correct performance of the task was associated with increased activity in primary visual regions; however, during visual misperceptions, this same visual network became actively coupled with the default mode network (DMN). Further, the frequency of misperception errors on the task was positively correlated with the strength of connectivity between these two systems, as well as with decreased activity in the dorsal attention network (DAN), and with impaired connectivity between the DAN and the DMNs, and ventral attention networks. Finally, each of the network abnormalities identified in our analysis were significantly correlated with two independent clinical measures of hallucination severity. Conclusions: Together, these results provide evidence that visual hallucinations are due to increased engagement of the DMN with the primary visual system, and emphasize the role of dysfunctional engagement of attentional networks in the pathophysiology of hallucinations

Growth of Bali Bulls Fattened with Forage Tree Legumes in Eastern Indonesia: Leucaena leucocephala in Sumbawa

The contribution of West Nusa Tenggara Province to domestic beef supply in Indonesia is relatively small, however, beef cattle are very important for the livelihoods of smallholder farmers in the region. Bali cattle (Boss javanicus) are the predominant breed as they are adapted to harsh nutritional conditions, are highly fertile and have low calf mortality (Toelihere 2003). While genetically capable of achieving a growth rate of 0.85 kg/d (Mastika 2003), Panjaitan (2012) identified poor nutrition as a severe limitation to animal growth in traditional village systems. Improving feed quality and supply is vital to increasing growth rates and product quality. Forage tree legumes such as leucaena (Leucaena leucocephala) offer the best chance of providing high quality feed to fatten Bali bulls in village systems where leucaena is well-adapted. Indeed, the feeding of leucaena has been practiced for about two decades in Sumbawa district of West Nusa Tenggara although the practice is limited to specific villages, mostly Balinese, even though farmers nearby have similar biophysical conditions and nutritional problems. The objective of this work was to characterize the best practices employed by farmers in Sumbawa that maximize growth rates by feeding leucaena so that their detailed knowledge can be passed onto other villagers in a pilot roll-out program (Kana Hau 2013)

Diurnal Urinary Excretion of DHP in Steers Fed \u3cem\u3eLeucaena leucocephala\u3c/em\u3e

Leucaena (Leucaena leucocephala) contains the toxin mimosine which is quickly degraded by rumen microorganisms to isomers of dihydroxypyridine (DHP). DHP is detrimental to animal production, causing reduced thyroid hormones, reduced weight gain, goiter and severe deficiencies in essential minerals (Tsai and Ling 1971; Hammond 1995). There are several methods of testing for exposure to DHP toxicity but the simplest is the colorimetric urine spot test (Graham et al. 2013). Several researchers have noted high variability in the excretion of DHP among animals on similar leucaena diets (Dalzell et al. 2012; Phaikaew et al. 2012) and even in the same animal over sequential samplings (O\u27Reagain and Shelton 2013). They noted that it was possible to obtain samples with very low DHP in unprotected animals on high leucaena diets, leading to the false conclusion that the animal was successfully degrading DHP in the rumen. This study examined the extent and possible causes of variation of DHP concentration in spot urine samples taken over a 6-week period, including an intensive sampling over a 24 hour period

Growth of Bali Bulls on Rations Containing \u3cem\u3eSesbania grandiflora\u3c/em\u3e in Central Lombok, Indonesia

The demand for meat in Indonesia is currently growing by up to 8% per year, with beef cattle fattening identified as a major livestock industry (Purwantara et al. 2012). Bali cattle (Bos javanicus) account for almost 27% of total beef cattle in Indonesia; they are the predominant breed in the eastern islands and are highly favoured by smallholder farmers for their high fertility, low calf mortality and generally higher price at markets (Purwantara et al. 2012). Lombok in west Nusa Tenggara is one of the biggest suppliers of Bali cattle in Indonesia. A major constraint to improving the overall productivity of Bali cattle is their slow growth rate, due to lack of readily available, inexpensive, high-quality protein sources. Fodder tree legumes, such as sesbania (Sesbania grandiflora), offer a fast-growing, low-cost source of protein (Evans and Rotar 1987). Farmers in Lombok have established a unique and productive integrated farming system by planting sesbania trees along the bunds of rice paddies, providing forage and timber without significantly compromising rice yield (Dahlanuddin and Shelton 2005). As only the central part of Lombok is intensively planted with sesbania, a collaborative project funded by the Australian Centre for International Agricultural Research (ACIAR) is underway aiming to: (1) characterise the existing cattle fattening system; and (2) assess the impact of differing levels of sesbania feeding on the growth rate of Bali bulls from weaning to maturity (about 30 months old)

Leucaena Toxicity: A New Perspective on the Most Widely Used Forage Tree Legume

The tree legume Leucaena leucocephala (leucaena) is a high quality ruminant feed, vitally important for livestock production in the tropics despite the presence of mimosine in the leaves. This toxic non-protein amino acid has the potential to limit productivity and adversely affect the health of animals. The discovery and subsequent distribution in Australia of the ruminal bacterium Synergistes jonesii as an oral inoculum was shown in the 1980s to overcome these toxic effects. However, recent surveys of the status of toxicity worldwide; improved understanding of the chemistry and mode of action of the toxins; new techniques for molecular sequencing; and concerns about the efficacy of the in vitro inoculum; have cast doubt on some past understanding of leucaena toxicity and provides new insights into the geographical spread of S. jonesii. There is also confusion and ignorance regarding the occurrence and significance of toxicity in many countries worldwide. Ongoing research into the taxonomy and ecology of the Synergistes phylum, improved methods of inoculation, improved management solutions, along with awareness-raising extension activities, are vital for the future success of leucaena feeding systems

Cardiac induced localised motion of the human torso detected by a long period grating fibre optic sensing scheme

Cardiovascular health of the human population is a major concern for medical clinicians, with cardiovascular diseases responsible for 48% of all deaths worldwide, according to the World Health Organisation. Therefore the development of new practicable and economical diagnostic tools to scrutinise the cardiovascular health of humans is a major driver for clinicians. We offer a new technique to obtain seismocardiographic signals covering both ballistocardiography (below 20Hz) and audible heart sounds (20Hz upwards). The detection scheme is based upon an array of curvature/displacement sensors using fibre optic long period gratings interrogated using a variation of the derivative spectroscopy interrogation technique. © 2014 SPIE

The Efficacy of \u3cem\u3ein vitro Synergistes jonesii\u3c/em\u3e Inoculum in Preventing DHP Toxicity in Steers Fed Leucaena-Grass Diets

Leucaena leucocephala (leucaena) is a valuable forage tree legume for tropical animal production that contains the toxin mimosine. The breakdown products of mimosine in ruminants (3,4-DHP and 2,3-DHP) can adversely affect their health and limit weight gains (Jones and Hegarty 1984). The rumen bacterium Synergistes jonesii, introduced into Australia in 1983 was shown to completely and rapidly degrade these toxins to safe levels (Jones and Megarrity 1986). Since 1996, an in vitro produced inoculum has been made commercially available to Australian graziers (Klieve et al. 2002). Accordingly, the issue of leucaena toxicity in Australia was thought to be resolved. However, extensive testing in 2004 found that up to 50% of Queensland cattle herds consuming leucaena were excreting high levels of urinary DHP suggesting sub-clinical toxicity remained an issue for graziers (Dalzell et al. 2012). Some of these herds had previously been inoculated with in vitro S. jonesii suggesting the inoculum may not be able to either persist within a herd, or remain effective in degrading DHP. The aim of this study was to assess the capability of the in vitro S. jonesii inoculum to efficiently break down DHP in a controlled feeding trial environment

Risk factors for human brucellosis in northern Tanzania

Little is known about the epidemiology of human brucellosis in sub-Saharan Africa. This hampers prevention and control efforts at the individual and population levels. To evaluate risk factors for brucellosis in northern Tanzania, we conducted a study of patients presenting with fever to two hospitals in Moshi, Tanzania. Serum taken at enrollment and at 4–6 week follow-up was tested by Brucella microagglutination test. Among participants with a clinically compatible illness, confirmed brucellosis cases were defined as having a ≥ 4-fold rise in agglutination titer between paired sera or a blood culture positive for Brucella spp., and probable brucellosis cases were defined as having a single reciprocal titer ≥ 160. Controls had reciprocal titers < 20 in paired sera. We collected demographic and clinical information and administered a risk factor questionnaire. Of 562 participants in the analysis, 50 (8.9%) had confirmed or probable brucellosis. Multivariable analysis showed that risk factors for brucellosis included assisting goat or sheep births (Odds ratio [OR] 5.9, 95% confidence interval [CI] 1.4, 24.6) and having contact with cattle (OR 1.2, 95% CI 1.0, 1.4). Consuming boiled or pasteurized dairy products was protective against brucellosis (OR 0.12, 95% CI 0.02, 0.93). No participants received a clinical diagnosis of brucellosis from their healthcare providers. The under-recognition of brucellosis by healthcare workers could be addressed with clinician education and better access to brucellosis diagnostic tests. Interventions focused on protecting livestock keepers, especially those who assist goat or sheep births, are needed