Modelling of seismic amplitude anomalies observed during sub-surface gas injection monitoring

Seismic amplitude anomalies have been observed at the Maguelone site in the course of sub-surface gas injection experiments. To allow the interpretation of the seismic monitoring in terms of physical parameter changes, various modelling attempts were conducted that all share the elastic wave theory principles. We show in this presentation that we cannot reproduce the experimental results with this theory, thus some form of anelastic energy dissipation would be required

Time-lapse electrical resistivity monitoring of subsurface CO2 storage at the maguelone experimental site (France)

CO2 geological storage remains a recent research field and many questions are still open, particularly for saline formations, which are expected to provide over time a larger storage capacity than depleted hydrocarbon reservoirs. The Maguelone shallow experimental site for shallow CO2 injection (Mediterranean coastline, Gulf of Lions, France) has been developed to study in an integrated manner surface and in-situ (downhole) monitoring methods. The presence of two small reservoirs with impermeable boundaries (R1: 13-16 m and R2: 8-9 m) provides an opportunity to study a saline formation for gas geological storage both in the field and in a laboratory context. During the shallow injection experiment (~48 m3 of CO2 was injected over ~2 hours on December 4, 2014), traces of the CO2 plume were detected by time-lapse downhole and surface electrical resistivity monitoring techniques, although some of the injected CO2 appeared to leak along the new injection hole, which should be corrected in the future with additional cementing around the new holes

Discovery of an MLLT1/3 YEATS domain chemical probe

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Dysregulation of these modified lysine binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterisation of the first small molecule chemical probe, SGC‐iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). SGC‐iMLLT is a potent and selective inhibitor of MLLT1/3 ‐ histone interactions. Excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains was observed. Furthermore, our probe displays cellular target engagement of MLLT1 and MLLT3. The first small molecule X‐ray co‐crystal structures with the MLLT1 YD are also reported. This first in class probe molecule can be used to understand MLLT1/3 associated biology and the therapeutic potential of small molecule YD inhibitors

Discovery of an MLLT1/3 YEATS domain chemical probe

YEATS domain (YD) containing proteins are an emerging class of epigenetic targets in drug discovery. Dysregulation of these modified lysine binding proteins has been linked to the onset and progression of cancers. We herein report the discovery and characterisation of the first small molecule chemical probe, SGC‐iMLLT, for the YD of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3). SGC‐iMLLT is a potent and selective inhibitor of MLLT1/3 ‐ histone interactions. Excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains was observed. Furthermore, our probe displays cellular target engagement of MLLT1 and MLLT3. The first small molecule X‐ray co‐crystal structures with the MLLT1 YD are also reported. This first in class probe molecule can be used to understand MLLT1/3 associated biology and the therapeutic potential of small molecule YD inhibitors

Community-developed checklists for publishing images and image analyses

Images document scientific discoveries and are prevalent in modern biomedical research. Microscopy imaging in particular is currently undergoing rapid technological advancements. However, for scientists wishing to publish obtained images and image-analysis results, there are currently no unified guidelines for best practices. Consequently, microscopy images and image data in publications may be unclear or difficult to interpret. Here, we present community-developed checklists for preparing light microscopy images and describing image analyses for publications. These checklists offer authors, readers and publishers key recommendations for image formatting and annotation, color selection, data availability and reporting image-analysis workflows. The goal of our guidelines is to increase the clarity and reproducibility of image figures and thereby to heighten the quality and explanatory power of microscopy data.Toxicolog